Attenuation of equine influenza viruses through truncations of the NS1 protein

Journal of Virology

Volumn 79, Issue 13, 2005, Pages 8431-8439

  Quinlivan, Michelle ^a,b   Zamarin, Dmitriy ^a   Garcia Sastre, Adolfo ^a   Cullinane, Ann ^c   Chambers, Thomas ^d   Palese, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LIMERICK   (Ireland)

^c IRISH EQUINE CENTRE   (Ireland)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; INTERFERON; NS1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EQUINE INFLUENZA VIRUS; FEMALE; FETUS; GENE DELETION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA; INFLUENZA VIRUS; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ATTENUATION; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS REPLICATION; ZYGOTE;

ANIMALS; CELL LINE; DOGS; HORSES; INFLUENZA A VIRUS; KIDNEY; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SEQUENCE DELETION; VIRAL NONSTRUCTURAL PROTEINS;

EQUIDAE; EQUINE INFLUENZA VIRUS; EQUUS CABALLUS; HUMAN INFLUENZA VIRUS;

EID: 20744448799     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.13.8431-8439.2005     Document Type: Article

References (38)

1. Aragon, T., S. de la Luna, I. Novoa, L. Carrasco, J. Ortín, and A. Nieto. 2000. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol. Cell. Biol. 20:6259-6268.
2. Donelan, N. R., C. F. Basler, and A. García-Sastre. 2003. A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J. Virol. 77:13257-13266.
3. Egorov, A., S. Brandt, S. Sereinig, J. Romanova, B. Ferko, D. Katinger, A. Grassauer, G. Alexandrova, H. Katinger, and T. Muster. 1998. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J. Virol. 72:6437-6441.
4. Fodor, E., L. Devenish, O. G. Engelhardt, P. Palese, G. G. Brownlee, and A. García-Sastre. 1999. Rescue of influenza A virus from recombinant DNA. J. Virol. 73:9679-9682.
5. García-Sastre, A., A. Egorov, D. Matassov, S. Brandt, D. E. Levy, J. E. Durbin, P. Palese, and T. Muster. 1998. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252:324-330.
6. Gorse, G. J., and R. B. Belshe. 1990. Enhancement of anti-influenza A virus cytotoxicity following influenza A virus vaccination in older, chronically ill adults. J. Clin. Microbiol. 28:2539-2550.
7. Gorse, G. J., M. J. Campbell, E. E. Otto, D. C. Powers, G. W. Chambers, and F. K. Newman. 1995. Increased anti-influenza A virus cytotoxic T cell activity following vaccination of the chronically ill elderly with live attenuated or inactivated influenza virus vaccine. J. Infect. Dis. 172:1-10.
8. Hoffmann, E., G. Neumann, Y. Kawaoka, G. Hobom, and R. G. Webster. 2000. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. USA 97:6108-6113.
9. Kittel, C., S. Sereinig, B. Ferko, J. Stasakova, J. Romanova, A. Wolkerstorfer, H. Katinger, and A. Egorov. 2004. Rescue of influenza virus expressing GFP from the NS1 reading frame. Virology 324:67-73.
10. Le Bon, A., G. Schiavoni, G. D'Agostino, I. Gresser, F. Belardelli, and D. F. Tough. 2001. Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14:461-470.
11. Li, S., C. Liu, A. Klimov, K. Subbarao, M. L. Perdue, D. Mo, Y. Ji, L. Woods, S. Hietala, and M. Bryant. 1999. Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses. J. Infect. Dis. 179: 1132-1138.
12. Lopez, C. B., A. García-Sastre, B. R. Williams, and T. M. Moran. 2003. Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses. J. Infect. Dis. 187:1126-1136.
13. Lu, Y., X. Y. Qian, and R. M. Krug. 1994. The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev. 8:1817-1828.
14. Lunn, D. P., S. Hussey, R. Sebing, K. E. Rushlow, S. V. Radecki, P. Whitaker-Dowling, J. S. Youngner, T. M. Chambers, R. E. Holland, Jr., and D. W. Horohov. 2001. Safety, efficacy, and immunogenicity of a modified-live equine influenza virus vaccine in ponies after induction of exercise-induced immunosuppression. J. Am. Vet. Med. Assoc. 218:900-906.
15. Maassab, H. F., and M. L. Bryant. 1999. The development of live attenuated cold-adapted influenza virus vaccine for humans. Rev. Med. Virol. 9:237-244.
16. Morahan, P. S., and S. E. Grossberg. 1970. Age-related cellular resistance of the chicken embryo to viral infections. I. Interferon and natural resistance to myxoviruses and vesicular stomatitis virus. J. Infect. Dis. 121:615-623.
17. Morley, P. S., H. G. Townsend, J. R. Bogdan, and D. M. Haines. 1999. Efficacy of a commercial vaccine for preventing disease caused by influenza virus infection in horses. J. Am. Vet. Med. Assoc. 215:61-66.
18. Mumford, E. L., J. L. Traub-Dargatz, M. D. Salman, J. K. Collins, D. M. Getzy, and J. Carman. 1998. Monitoring and detection of acute viral respiratory tract disease in horses. J. Am. Vet. Med. Assoc. 213:385-390.
19. Nelson, K. M., B. R. Schram, M. W. McGregor, A. S. Sheoran, C. W. Olsen, and D. P. Lunn. 1998. Local and systemic isotype-specific antibody responses to equine influenza virus infection versus conventional vaccination. Vaccine 16:1306-1313.
20. Nemeroff, M. E., S. M. Barabino, Y. Li, W. Keller, and R. M. Krug. 1998. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3' end formation of cellular pre-mRNAs. Mol. Cell 1:991-1000.
21. Neumann, G., T. Watanabe, H. Ito, S. Watanabe, H. Goto, P. Gao, M. Hughes, D. R. Perez, R. Donis, E. Hoffmann, G. Hobom, and Y. Kawaoka. 1999. Generation of influenza A viruses entirely from cloned cDNAs. Proc. Natl. Acad. Sci. USA 96:9345-9350.
22. Niwa, H., K. Yamamura, and J. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199.
23. Park, M. S., A. García-Sastre, J. F. Cros, C. F. Basler, and P. Palese. 2003. Newcastle disease virus V protein is a determinant of host range restriction. J. Virol. 77:9522-9532.
24. Pleschka, S., R. Jaskunas, O. G. Engelhardt, T. Zurcher, P. Palese, and A. García-Sastre. 1996. A plasmid-based reverse genetics system for influenza A virus. J. Virol. 70:4188-4192.
25. Proietti, E., L. Bracci, S. Puzelli, T. Di Pucchio, P. Sestili, E. De Vincenzi, M. Venditti, I. Capone, I. Seif, E. De Maeyer, D. Tough, I. Donatelli, and F. Belardelli. 2002. Type I IFN as a natural adjuvant for a protective immune response: lessons from the influenza vaccine model. J. Immunol. 169:375-383.
26. Qian, X. Y., C. Y. Chien, Y. Lu, G. T. Montelione, and R. M. Krug. 1995. An ammo-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure. RNA 1:948-956.
27. Qiu, Y., and R. M. Krug. 1994. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J. Virol. 68:2425-2432.
28. Sekellick, M. J., W. J. Biggers, and P. I. Marcus. 1990. Development of the interferon system. I. In chicken cells development in ovo continues on time in vitro. In Vitro Cell Dev. Biol. 26:997-1003.
29. Sekellick, M. J., and P. I. Marcus. 1985. Interferon induction by viruses. XIV. Development of interferon inducibility and its inhibition in chick embryo cells "aged" in vitro. J. Interferon Res. 5:651-667.
30. Seo, S. H., E. Hoffmann, and R. G. Webster. 2004. The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res. 103:107-113.
31. Soboll, G., K. M. Nelson, E. S. Leuthner, R. J. Clark, R. Drape, M. D. Macklin, W. F. Swain, C. W. Olsen, and D. P. Lunn. 2003. Mucosal coadministration of cholera toxin and influenza virus hemagglutinin-DNA in ponies generates a local IgA response. Vaccine 21:3081-3092.
32. Sovinová, O., B. Tümová, F. Pouska, and J. Nemec. 1958. Isolation of a virus causing respiratory disease in horses. Acta Virol. 2:52-61.
33. Stojdl, D. F., B. D. Lichty, B. R. tenOever, J. M. Paterson, A. T. Power, S. Knowles, R. Marius, J. Reynard, L. Poliquin, H. Atkins, E. G. Brown, R. K. Durbin, J. E. Durbin, J. Hiscott, and J. C. Bell. 2003. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4:263-275.
34. Talon, J., M. Salvatore, R. E. O'Neill, Y. Nakaya, H. Zheng, T. Muster, A. García-Sastre, and P. Palese. 2000. Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proc. Natl. Acad. Sci. USA 97: 4309-4314.
35. Townsend, H. G., S. J. Penner, T. C. Watts, A. Cook, J. Bogdan, D. M. Haines, S. Griffin, T. Chambers, R. E. Holland, P. Whitaker-Dowling, J. S. Youngner, and R. W. Sebring. 2001. Efficacy of a cold-adapted, intranasal, equine influenza vaccine: challenge trials. Equine Vet. J. 33:637-643.
36. Wadell, G. H., M. B. Teigland, and M. M. Siegel. 1963. A new influenza virus associated with equine respiratory disease. J. Am. Vet. Med. Assoc. 143: 587-590.
37. Wang, X., C. F. Basler, B. R. Williams, R. H. Silverman, P. Palese, and A. García-Sastre. 2002. Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains. J. Virol. 76:12951-12962.
38. Webster, R. G. 1993. Are equine 1 influenza viruses still present in horses? Equine Vet. J. 25:537-538.