Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins

Journal of General Virology

Volumn 86, Issue 10, 2005, Pages 2817-2821

  Falcón, Ana M ^a,c   Fernandez Sesma, Ana ^b   Nakaya, Yurie ^b   Moran, Thomas M ^b   Ortín, Juan ^a   García Sastre, Adolfo ^b  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

STIMULATORY GUANINE NUCLEOTIDE BINDING 1 PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR IMMUNITY; CORRELATION ANALYSIS; HUMORAL IMMUNITY; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TEMPERATURE SENSITIVE MUTANT; VIRUS ATTENUATION; VIRUS DETECTION; VIRUS MUTANT; WILD TYPE;

ANIMALS; DEFECTIVE VIRUSES; DISEASE MODELS, ANIMAL; GENES, VIRAL; GENETIC ENGINEERING; IMMUNIZATION; INFLUENZA A VIRUS; INFLUENZA VACCINES; MICE; RNA; TEMPERATURE; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

INFLUENZA A VIRUS; INFLUENZA VIRUS;

EID: 26244458739     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.80991-0     Document Type: Article

References (23)

1. Aragón, T., de La Luna, S., Novoa, I., Carrasco, L., Orrin, J. & Nieto, A. (2000). Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol 20, 6259-6268.
2. Enami, M., Luytjes, W., Krystal, M. & Palese, P. (1990). Introduction of site-specific mutations into the genome of influenza virus. Proc Natl Acad Sci U S A 87, 3802-3805.
3. Falcón, A. M., Marión, R. M., Zürcher, T., Gómez, P., Portela, A., Nieto, A. & Ortin, J. (2004). Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. J Virol 78, 3880-3888.
4. Ferko, B., Stasakova, J., Sereinig, S., Romanova, J., Katinger, D., Niebler, B., Katinger, H. & Egorov, A. (2001). Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice. J Virol 75, 8899-8908.
5. Ferko, B., Stasakova, J., Romanova, J., Kittel, C., Sereinig, S., Katinger, H. & Egorov, A. (2004). Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J Virol 78, 13037-13045.
6. Fodor, E., Devenish, L., Engelhardt O. G., Palese, P., Brownlee, G. G. & García-Sastre, A. (1999). Rescue of influenza A virus from recombinant DNA. J Virol 73, 9679-9682.
7. Fortes, P., Beloso, A. & Ortín, J. (1994). Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J 13, 704-712.
8. García-Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P. & Muster, T. (1998). Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252, 324-330.
9. López, C. B., García-Sastre, A., Williams, B. R. G. & Moran, T. M. (2003). Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses. J Infect Dis 187, 1126-1136.
10. Lu, Y., Qian, X. Y. & Krug, R. M. (1994). The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev 8, 1817-1828.
11. Murata, K., García-Sastre, A., Tsuji, M. & 7 other authors (1996). Characterization of in vivo primary and secondary CD8 + T cell responses induced by recombinant influenza and vaccinia viruses. Cell Immunol 173, 96-107.
12. Neumann, G., Watanabe, T., Ito, H. & 9 other authors (1999). Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96, 9345-9350.
13. Noah, D. L., Twu, K. Y. & Krug, R. M. (2003). Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS. Virology 307, 386-395.
14. Palese, P. & García-Sastre, A. (2002). Influenza vaccines: present and future. J Clin Invest 110, 9-13.
15. Qiu, Y. & Krug, R. M. (1994). The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J Virol 68, 2425-2432.
16. Schultz-Cherry, S., Dybdahl-Sissoko, N., Neumann, G., Kawaoka, Y. & Hinshaw, V. S. (2001). Influenza virus NS1 protein induces apoptosis in cultured cells. J Virol 75, 7875-7881.
17. Stasakova, J., Ferko, B., Kittel, C., Sereinig, S., Romanova, J., Katinger, H. & Egorov, A. (2005). Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. J Gen Virol 86, 185-195.
18. Takasuka, N., Enami, M., Itamura, S. & Takemori, T. (2002). Intranasal inoculation of a recombinant influenza virus containing exogenous nucleotides in the NS segment induces mucosal immune response against the exogenous gene product in mice. Vaccine 20, 1579-1585.
19. Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P. & García-Sastre, A. (2000a). Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74, 7989-7996.
20. Talon, J., Salvatore, M., O'Neill, R. E., Nakaya, Y., Zheng, H., Muster, T., García-Sastre, A. & Palese, P. (2000b). Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proc Natl Acad Sci U S A 97, 4309-4314.
21. Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J. & Fukuda, K. (2003). Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289, 179-186.
22. Webster, R. G. (2002). The importance of animal influenza for human disease. Vaccine 20, S16-S20.
23. Zhirnov, O. P., Konakova, T. E., Wolff, T. & Klenk, H. D. (2002). NS1 protein of influenza A virus down-regulates apoptosis. J Virol 76, 1617-1625.