A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 11, 2008, Pages 4381-4386

  Jackson, David ^a   Hossain, Md Jaber ^b   Hickman, Danielle ^b   Perez, Daniel R ^b   Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

H5N1 influenza; Influenza reverse genetics; Mouse model for influenza; PDZ domains; PDZ ligand

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; BINDING PROTEIN; NONSTRUCTURAL PROTEIN 1; PDZ BINDING PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; INTERFERON; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EMBRYO; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INFLUENZA; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H1N5; LETHAL DOSE; LUNG ALVEOLITIS; LUNG HEMORRHAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SURVIVAL TIME; VIRUS VIRULENCE; WEIGHT REDUCTION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DISEASE MODEL; DOG; GENETIC RECOMBINATION; GENETICS; INFLUENZA VIRUS A H5N1; LUNG DISEASE; METABOLISM; MOLECULAR GENETICS; MUTATION; PATHOGENICITY; PATHOLOGY; VIRULENCE;

AVIAN INFLUENZA VIRUS; MUS; ORTHOMYXOVIRIDAE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INTERFERONS; LUNG DISEASES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINATION, GENETIC; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRULENCE FACTORS;

EID: 41949123710     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800482105     Document Type: Article

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