Assessing the neuronal serotonergic target-based antidepressant stratagem: Impact of in vivo interaction studies and knockout models

Current Neuropharmacology

Volumn 6, Issue 3, 2008, Pages 215-234

  Rajkumar, R ^a,b   Mahesh, R ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Depression; Interaction studies; Knockout models; Preclinical screening; Serotonin; Target; Trophic factors

Indexed keywords

ANTIDEPRESSANT AGENT; ARGIPRESSIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BUSPIRONE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DESIPRAMINE; FLESINOXAN; FLUOXETINE; GLUTAMATE RECEPTOR; NEUROKININ; NEUROTROPHIN; PAROXETINE; PRUVANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SUBSTANCE P; TACHYKININ RECEPTOR; TYROSINE KINASE RECEPTOR; UNINDEXED DRUG; VENLAFAXINE;

CELL PROLIFERATION; DEPRESSION; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ELECTRIC SHOCK; HUMAN; IN VIVO STUDY; MOLECULAR MECHANICS; MONOTHERAPY; NERVE CELL; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; UNSPECIFIED SIDE EFFECT;

EID: 53249107835     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015908785777256     Document Type: Review

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