메뉴 건너뛰기




Volumn 329, Issue 1, 1997, Pages 27-35

Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT(5A) receptor antagonistic activity

Author keywords

5 HT (5 hydroxytryptamine, serotonin) re uptake inhibition; 5 HT(2A) receptor antagonistic activity; Antidepressant; Olfactory bulbectomized rat; Tail suspension test; YM992

Indexed keywords

2 [[(7 FLUORO 4 INDANYL)OXY]METHYL]MORPHOLINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 HYDROXYTRYPTOPHAN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; NEW DRUG; OXOTREMORINE; PHENYLEPHRINE; SEROTONIN 2A ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TRAZODONE; UNCLASSIFIED DRUG;

EID: 0031577189     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)10108-X     Document Type: Article
Times cited : (41)

References (28)
  • 1
    • 0009644628 scopus 로고
    • Some quantitative uses of drug antagonists
    • Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:1959;46-58.
    • (1959) Br. J. Pharmacol. , vol.14 , pp. 46-58
    • Arunlakshana, O.1    Schild, H.O.2
  • 3
    • 0028287265 scopus 로고
    • Current advances and trends in the treatment of depression
    • Blier P., De Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol. Sci. 15:1994;220-225.
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 220-225
    • Blier, P.1    De Montigny, C.2
  • 4
    • 0025231342 scopus 로고
    • A role for the serotonin system in the mechanism of action of antidepressants
    • Blier P., De Montigny C., Chaput Y. A role for the serotonin system in the mechanism of action of antidepressants. J. Clin. Psychiatry. 51(Suppl. 1):1990;14-20.
    • (1990) J. Clin. Psychiatry , vol.51 , Issue.SUPPL. 1 , pp. 14-20
    • Blier, P.1    De Montigny, C.2    Chaput, Y.3
  • 5
    • 0001469440 scopus 로고
    • Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan
    • Bogdanski D.F., Weissbach H., Udenfriend S. Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan. J. Pharmacol. Exp. Ther. 122:1958;182-194.
    • (1958) J. Pharmacol. Exp. Ther. , vol.122 , pp. 182-194
    • Bogdanski, D.F.1    Weissbach, H.2    Udenfriend, S.3
  • 6
    • 0018254802 scopus 로고
    • A new model for the detection of antidepressant drugs: Olfactory bulbectomy in the rat compared with exiting models
    • Cairncross K.D., Cox B., Forster C., Wren A.F. A new model for the detection of antidepressant drugs: olfactory bulbectomy in the rat compared with exiting models. J. Pharmacol. Methods. 1:1978;131-143.
    • (1978) J. Pharmacol. Methods , vol.1 , pp. 131-143
    • Cairncross, K.D.1    Cox, B.2    Forster, C.3    Wren, A.F.4
  • 7
    • 0018397442 scopus 로고
    • The effect of psychoactive drugs on plasma corticosterone levels and behavior in the bulbectomized rat
    • Cairncross K.D., Wren A., Foster C., Cox B., Schnieden H. The effect of psychoactive drugs on plasma corticosterone levels and behavior in the bulbectomized rat. Pharmacol. Biochem. Behav. 10:1979;353-359.
    • (1979) Pharmacol. Biochem. Behav. , vol.10 , pp. 353-359
    • Cairncross, K.D.1    Wren, A.2    Foster, C.3    Cox, B.4    Schnieden, H.5
  • 8
    • 0026348807 scopus 로고
    • Presynaptic and postsynaptic modification of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat
    • Chaput Y., De Montigny C., Blier P. Presynaptic and postsynaptic modification of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology. 5:1991;219-229.
    • (1991) Neuropsychopharmacology , vol.5 , pp. 219-229
    • Chaput, Y.1    De Montigny, C.2    Blier, P.3
  • 9
    • 0025453129 scopus 로고
    • Antidepressant: Current concepts of mode of action
    • Cowen P.J. Antidepressant: current concepts of mode of action. Int. Clin. Psychopharmacol. 5(Suppl. 3):1990;45-55.
    • (1990) Int. Clin. Psychopharmacol. , vol.5 , Issue.SUPPL. 3 , pp. 45-55
    • Cowen, P.J.1
  • 10
    • 0025899924 scopus 로고
    • Serotonin receptor subtypes: Implications for psychopharmacology
    • Cowen P.J. Serotonin receptor subtypes: implications for psychopharmacology. Br. J. Psychiatry. 159(Suppl. 12):1991;7-14.
    • (1991) Br. J. Psychiatry , vol.159 , Issue.SUPPL. 12 , pp. 7-14
    • Cowen, P.J.1
  • 14
    • 0022445945 scopus 로고
    • Adrenoceptor blocking and cardiovascular effects of the optical isomers of amosulalol (YM-09538), a combined α-and β-adrenoceptor blocking agent, and the corresponding deoxy derivative (YM-11133) in rats
    • Honda K., Nakagawa C., Inagaki O., Shibasaki M., Takenaka T., Takeda M. Adrenoceptor blocking and cardiovascular effects of the optical isomers of amosulalol (YM-09538), a combined α-and β-adrenoceptor blocking agent, and the corresponding deoxy derivative (YM-11133) in rats. Jpn. J. Pharmacol. 41:1986;459-466.
    • (1986) Jpn. J. Pharmacol. , vol.41 , pp. 459-466
    • Honda, K.1    Nakagawa, C.2    Inagaki, O.3    Shibasaki, M.4    Takenaka, T.5    Takeda, M.6
  • 15
    • 0027290988 scopus 로고
    • 2 receptors in rat brain: An autoradiographic study
    • 2 receptors in rat brain: an autoradiographic study. Synapse. 14:1993;324-331.
    • (1993) Synapse , vol.14 , pp. 324-331
    • Hrdina, P.D.1    Vu, T.B.2
  • 16
    • 0019811805 scopus 로고
    • The effects of antidepressant drugs on conditioned taste of aversion learning of the olfactory bulbectomized rat
    • Janscar S.M., Leonard B.E. The effects of antidepressant drugs on conditioned taste of aversion learning of the olfactory bulbectomized rat. Neuropharmacology. 20:1981;1341-1345.
    • (1981) Neuropharmacology , vol.20 , pp. 1341-1345
    • Janscar, S.M.1    Leonard, B.E.2
  • 17
    • 0022615366 scopus 로고
    • Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats
    • Jesberger J.A., Richardson J.S. Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats. Behav. Neurosci. 100:1986;256-274.
    • (1986) Behav. Neurosci. , vol.100 , pp. 256-274
    • Jesberger, J.A.1    Richardson, J.S.2
  • 18
    • 0002620727 scopus 로고
    • The comparative pharmacological properties of selective serotonin re-uptake inhibitors in animals
    • In: Feighner, J.P., Boyer, W.F. (Eds.) John Wiley&Sons, Chichester
    • Johnson, A.M., 1991. The comparative pharmacological properties of selective serotonin re-uptake inhibitors in animals. In: Feighner, J.P., Boyer, W.F. (Eds.), Selective Serotonin Re-uptake Inhibitors. John Wiley&Sons, Chichester, pp. 37-70.
    • (1991) Selective Serotonin Re-uptake Inhibitors , pp. 37-70
    • Johnson, A.M.1
  • 19
    • 0021950526 scopus 로고
    • Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus
    • Lakoski J.M., Aghajanian G.K. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24:1985;265-273.
    • (1985) Neuropharmacology , vol.24 , pp. 265-273
    • Lakoski, J.M.1    Aghajanian, G.K.2
  • 20
    • 0029079345 scopus 로고
    • Mechanisms of action of antidepressants
    • Leonard B.E. Mechanisms of action of antidepressants. CNS Drugs. 4:1995;1-12.
    • (1995) CNS Drugs , vol.4 , pp. 1-12
    • Leonard, B.E.1
  • 22
    • 0021336087 scopus 로고
    • Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat
    • Lucki I., Nobler M.S., Frazer A. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. J. Pharmacol. Exp. Ther. 228:1984;133-139.
    • (1984) J. Pharmacol. Exp. Ther. , vol.228 , pp. 133-139
    • Lucki, I.1    Nobler, M.S.2    Frazer, A.3
  • 24
    • 0016760275 scopus 로고
    • Influence of olfactory bulbectomy and the serotonergic system upon intermale aggression and maternal behavior in the mouse
    • Neckers L.M., Zarrow M.X., Myers M.M., Denenberg V.H. Influence of olfactory bulbectomy and the serotonergic system upon intermale aggression and maternal behavior in the mouse. Pharmacol. Biochem. Behav. 3:1975;545-550.
    • (1975) Pharmacol. Biochem. Behav. , vol.3 , pp. 545-550
    • Neckers, L.M.1    Zarrow, M.X.2    Myers, M.M.3    Denenberg, V.H.4
  • 25
    • 0018360480 scopus 로고
    • Comparative effects of trazodone and tricyclic antidepressants on uptake of selected neurotransmitters by isolate rat brain synaptosomes
    • Riblet L.A., Gatewood C.F., Mayol R.F. Comparative effects of trazodone and tricyclic antidepressants on uptake of selected neurotransmitters by isolate rat brain synaptosomes. Psychopharmacology. 63:1979;99-101.
    • (1979) Psychopharmacology , vol.63 , pp. 99-101
    • Riblet, L.A.1    Gatewood, C.F.2    Mayol, R.F.3
  • 26
    • 0021990491 scopus 로고
    • The tail suspension test: A new method for screening antidepressants in mice
    • Steru L., Chermat R., Thierry B., Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology. 85:1985;367-370.
    • (1985) Psychopharmacology , vol.85 , pp. 367-370
    • Steru, L.1    Chermat, R.2    Thierry, B.3    Simon, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.