Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

European Neuropsychopharmacology

Volumn 17, Issue 5, 2007, Pages 328-338

  Gobbi, Gabriella ^a,c   Cassano, Tommaso ^b   Radja, Fatiha ^a,c   Morgese, Maria Grazia ^b   Cuomo, Vincenzo ^d   Santarelli, Luca ^e   Hen, René ^e   Blier, Pierre ^f  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF FOGGIA   (Italy)

^c CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f UNIVERSITY OF OTTAWA   (Canada)

Author keywords

5 HT1A receptor; Antidepressant; Anxiolytic; NK1 receptor; Serotonin; Substance P

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; NEUROKININ 1 RECEPTOR ANTAGONIST; NORADRENALIN; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG ANTAGONISM; ENANTIOMER; IN VIVO STUDY; LOCUS CERULEUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

EID: 33847178396     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2006.07.004     Document Type: Article

References (53)

1. Anderson C.D., Pasquier D.A., Forbes W.B., and Morgane P.J. Locus coeruleus-to-dorsal raphe input examined by electrophysiological and morphological methods. Brain Res. Bull. 2 (1977) 209-221
2. Bert L., Rodier D., Bougault I., Allouard N., Le-Fur G., Soubrie P., and Steinberg R. Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801. Synapse 43 (2002) 62-69
3. Blier P., and de Montigny C. Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors. Neuroscience 16 (1985) 949-955
4. Blier P., and de Montigny C. Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. Eur. J. Pharmacol. 113 (1985) 69-77
5. Blier P., and de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21 (1999) 91S-98S
6. Blier P., Gobbi G., Haddjeri N., Santarelli L., Mathew G., and Hen R. Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. J. Psychiatry Neurosci. 29 (2004) 208-218
7. Bosker F.J., Klompmakers A., and Westenberg H.G. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. Eur. J. Pharmacol. 333 (1997) 147-157
8. Cheetham S.C., Viggers J.A., Butler S.A., Prow M.R., and Heal D.J. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 35 (1996) 63-70
9. Cedarbaum J.M., and Aghajanian G.K. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Res. 112 (1976) 413-419
10. Conley R.K., Cumberbatch M.J., Mason G.S., Williamson D.J., Harrison T., Locker K., Swain C., Maubach K., O'Donnell R., Rigby M., Hewson L., Smith D., and Rupniak N.M. Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity. J. Neurosci. 22 (2002) 7730-7736
11. Cryan J.F., O'Leary O.F., Jin S.H., Friedland J.C., Ouyang M., Hirsch B.R., Page M.E., Dalvi A., Thomas S.A., and Lucki I. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 8186-8191
12. Dong J., and Blier P. Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment. Psychopharmacology 155 (2001) 52-57
13. Dremencov, E., El Mansari, M., Blier, P., in press. Noradrenergic augmentation of escitalopram response by risperidone: Electrophysiological studies in the rat brain. Biological Psychiatry.
14. Ebner K., Rupniak N.M., Saria A., and Singewald N. Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4280-4285
15. Florin-Lechner S.M., Druhan J.P., Aston-Jones G., and Valentino R.J. Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus. Brain Res. 742 (1996) 89-97
16. Fornai F., Bassi L., Torracca M.T., Alessandri M.G., Scalori V., and Corsini G.U. Region- and neurotransmitter-dependent species and strain differences in DSP-4-induced monoamine depletion in rodents. Neurodegeneration 5 (1996) 241-249
17. Franklin K.B.J., and Paxinos G. The Mouse Brain in Stereotaxic Coordinates (1997), Academic Press Inc., San Diego, CA, USA
18. Froger N., Gardier A.M., Moratalla R., Alberti I., Lena I., Boni C., De Felipe C., Rupniak N.M., Hunt S.P., Jacquot C., Hamon M., and Lanfumey L. 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. J. Neurosci. 21 (2001) 8188-8197
19. Garret C., Carruette A., Fardin V., Moussaoui S., Peyronel J.F., Blanchard J.C., and Laduron P.M. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 10208-10212
20. Gartside S.E., Hajos-Korcsok E., Bagdy E., Harsing Jr. L.G., Sharp T., and Hajos M. Neurochemical and electrophysiological studies on the functional significance of burst firing in serotonergic neurons. Neuroscience 98 (2000) 295-300
21. Gobbi G., and Blier P. Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs. Peptides 26 (2005) 1383-1393
22. Gobbi G., Muntoni A., Diana M., and Gessa G.L. Clonidine fails to modify dopaminergic neuronal activity in morphine withdrawal. Psychopharmacology 158 (2001) 1-6
23. Gobbi G., Santarelli L., Hen R., Debonnel G., and Blier P. Understanding the mechanism of action of NK1 receptor antagonist: in vivo electrophysiological studies in mutant mice. Int. J. Neuropsychopharmacol. 5 suppl.1 (2002) S97
24. Gonon F.G. Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience 24 (1988) 19-28
25. Gross C., Zhuang X., Stark K., Ramboz S., Oosting R., Kirby L., Santarelli L., Beck S., and Hen R. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416 6879 (2002) 396-400
26. Guiard B.P., Przybylski C., Guilloux J.P., Seif I., Froger N., De Felipe C., Hunt S.P., Lanfumey L., and Gardier A.M. Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. J. Neurochem. 89 (2004) 54-63
27. Guiard B.P., Froger N., Hamon M., Gardier A.M., and Lanfumey L. Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice. J. Neurochem. 95 (2005) 1713-1723
28. Haddjeri N., and Blier P. Effect of neurokinin-1 receptor antagonists on the function of 5-HT and noradrenaline neurons. Neuroreport 11 (2000) 1323-1327
29. Haddjeri N., and Blier P. Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission. Biol. Psychiatry 50 (2001) 191-199
30. Haddjeri N., and Blier P. Effects of neurokinin 1 antagonists on the firing of locus coeruleus norepinephrine neurons. Soc. Neurosci. Abstr. 27 (2001) (479.19)
31. Haddjeri N., Blier P., and de Montigny C. Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J. Pharmacol. Exp. Ther. 277 (1996) 861-871
32. Haddjeri N., Blier P., and de Montigny C. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. J. Neurosci. 18 (1998) 10150-10156
33. Hutter P., Johansson M., Saria A., and Humpel C. Acute and chronic noradrenergic regulation of neurotrophin messenger RNA expression in rat hippocampus: evidence from lesions and organotypic cultures. Neuroscience 70 (1996) 15-29
34. Keller M., Montgomery S., Ball W., Morrison M., Snavely D., Liu G., Harreaves R., Hietala M., Lines C., Beebe K., and Reines S. Lack of efficacy of the substance p (neurokin-1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol. Psychiatry 59 3 (2006) 216-223
35. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., and Rupniak N.M. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281 (1998) 1640-1645
36. Kramer M.S., Winokur A., Kelsey J., Preskorn S.H., Rothschild A.J., Snavely D., Ghosh K., Ball W.A., Reines S.A., Munjack D., Apter J.T., Cunningham L., Kling M., Bari M., Getson A., and Lee Y. Demonstration of the efficacy and safety of a novel substance P (NK1) receptor antagonist in major depression. Neuropsychopharmacology 29 (2004) 385-392
37. Lejeune F., Gobert A., and Millan M.J. The selective neurokinin (NK)(1) antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study. Brain Res. 935 (2002) 134-139
38. Marchetti C., and Nistri A. Neuronal bursting induced by NK3 receptor activation in the neonatal rat spinal cord in vitro. J. Neurophysiol. 86 (2001) 2939-2950
39. Maubach K.A., Martin K., Chicchi G., Harrison T., Wheeldon A., Swain C.J., Cumberbatch M.J., Rupniak N.M., and Seabrook G.R. Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus. Neuroscience 109 (2002) 609-617
40. Millan M.J., Lejeune F., De Nanteuil G., and Gobert A. Selective blockade of Neurokinin (NK)1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus rats. J. Neurochem. 76 (2001) 1949-1954
41. Mongeau R., Blier P., and de Montigny C. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain Res. Brain Res. Rev. 23 (1997) 145-195
42. Phillips T.J., Hen R., and Crabbe J.C. Complications associated with genetic background effects in research using knockout mice. Psychopharmacology 147 (1999) 5-7
43. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., and Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14476-14481
44. Ranga K., and Krishnan R. Clinical experience with Substance P receptor (NK1) antagonist in depression. J. Clin. Psychiatry 63 suppl. 11 (2002) 25-29
45. 1A receptors. Eur. J. Pharmacol. 435 (2002) 195-203
46. Santarelli L., Gobbi G., Debs P.C., Sibille E., Blier P., Hen R., and Heath M. Genetic and pharmacological disruption of NK1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1912-1917
47. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., and Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 5634 (2003) 805-809
48. Seager M.A., Huff K.D., Barth V.N., Phebus L.A., and Rasmussen K. Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity. Biol. Psychiatry 55 (2004) 1103-1109
49. Szabo S.T., and Blier P. Response of the norepinephrine system to antidepressant drugs. CNS Spectr. 6 (2001) 679-684
50. Szabo S.T., de Montigny C., and Blier P. Progressive attenuation of the firing activity of locus coeruleus noradrenergic neurons by sustained administration of selective serotonin reuptake inhibitors. Int. J. Neuropsychopharmacol. 3 (2000) 1-11
51. Thase M.E., and Rush A.J. When at first you don't succeed: sequential strategies for antidepressant nonresponders. J. Clin. Psychiatry 58 Suppl.13 (1997) 23-29
52. 1B receptors. Neuropsychopharmacology 21 Suppl. 2 (1999) 52S-60S
53. Zocchi A., Varnier G., Arban R., Griffante C., Zanetti L., Bettelini L., Marchi M., Gerrard P.A., and Corsi M. Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse. Neurosci. Lett. 345 (2003) 73-76