Genetic knockout and pharmacological blockade studies of the 5-HT 7 receptor suggest therapeutic potential in depression

Neuropharmacology

Volumn 48, Issue 4, 2005, Pages 492-502

  Guscott, M ^a   Bristow, L J ^b   Hadingham, K ^a   Rosahl, T W ^a   Beer, M S ^a   Stanton, J A ^a   Bromidge, F ^a   Owens, A P ^a   Huscroft, I ^a   Myers, J ^a   Rupniak, N M ^a   Patel, S ^a   Whiting, P J ^a   Hutson, P H ^a   Fone, K C ^c   Biello, S M ^d   Kulagowski, J J ^a   McAllister, G ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 HT7 receptor; 5 HT7 receptor antagonist; 5 HT7 receptor knockout mouse; Circadian rhythms; Depression; Forced swim test

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL] BENZENESULFONAMIDE; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; ANTIDEPRESSANT AGENT; SEROTONIN 7 RECEPTOR ANTAGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; IMMOBILIZATION STRESS; KNOCKOUT GENE; KNOCKOUT MOUSE; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PHARMACODYNAMICS; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR GENE; RECEPTOR INTRINSIC ACTIVITY; WILD TYPE;

EID: 20044383561     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.11.015     Document Type: Article

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