Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF)

Neurochemistry International

Volumn 36, Issue 3, 2000, Pages 197-202

  Mössner, Rainald ^a   Daniel, Silke ^a   Albert, Dietmar ^a   Heils, Armin ^a   Okladnova, Olga ^a   Schmitt, Angelika ^a   Lesch, Klaus Peter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; SEROTONIN TRANSPORTER;

ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; DNA POLYMORPHISM; HUMAN; HUMAN CELL; NERVE CELL; NEUROTRANSMISSION; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM;

ALLELES; B-LYMPHOCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARRIER PROTEINS; CELL LINE, TRANSFORMED; GENE EXPRESSION; GENOTYPE; HERPESVIRUS 4, HUMAN; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEUROBLASTOMA; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RECEPTOR, TRKA; RECEPTOR, TRKB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TUMOR CELLS, CULTURED;

EID: 17544385905     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00122-9     Document Type: Article

References (19)

1. Altar C.A., Criden M.R., Lindsay R.M., DiStefano P.S. Characterization and topography of high-affinity 125I-neurotrophin-3 binding to mammalian brain. Journal of Neuroscience. 13:1993;733-743.
2. Anderson K.D., Alderson R.F., Altar C.A., DiStefano P.S., Lindsay R.M., Wiegand S.J. Distribution of exogenous BDNF and NGF delivered into the brain. Journal of Comparative Neurology. 357:1995;296-317.
3. Azmitia E.C., Dolan K., Whitaker-Azmitia P.M. S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor. Brain Research. 516:1990;354-356.
4. Chomczynski P., Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry. 162:1987;156-159.
5. Jayanthi L.D., Ramamoorthy S., Mahesh V.B., Leibach F.H., Ganapathy V. Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. Journal of Biological Chemistry. 269:1994;14,424-14,429.
6. Kawaja M.D., Gage F.H. Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron. 7:1991;1019-1030.
7. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Müller C.R., Hamer D.H., Murphy D. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
8. Lesch K.P., Meyer J., Glatz K., Flugge G., Hinney A., Hebebrand J., Klauck S.M., Poustka A., Poustka F., Bengel D., Mössner R., Riederer P., Heils A. The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Journal of Neural Transmission. 104:1997;1259-1266.
9. Lesch K.P., Mössner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biological Psychiatry. 44:1998;179-192.
10. Little K.Y., McLaughlin D.P., Zhang L., Livermore C.S., Dalack G.W., McFinton P.R., Delproposto Z.S., Hill E., Cassin B.J., Watson S.J., Cook E.H. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. American Journal of Psychiatry. 155:1998;207-213.
11. Mamounas L.A., Blue M.E., Siuciak J.A., Altar C.A. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. Journal of Neuroscience. 15:1995;7929-7939.
12. Merlio J.-P., Ernfors P., Jaber M., Persson H. Molecular cloning of rat trkC and distribution of cells expressing messenger mRNAs for members of the trk family in the rat central nervous system. Neuroscience. 51:1992;513-532.
13. Mössner R., Lesch K.P. Role of serotonin in the immune system and in neuroimmune interactions. Brain, Behavior, and Immunity. 12:1998;249-271.
14. Schenone A., Gill J.S., Zacharias D.A., Windebank A.J. Expression of high- and low-affinity neurotrophin receptors on human transformed B lymphocytes. Journal of Neuroimmunology. 64:1996;141-149.
15. Siuciak J.A., Altar C.A., Wiegand S.J., Lindsay R.M. Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Research. 633:1994;326-330.
16. Siuciak J.A., Lewis D., Wiegand S.J., Lindsay R.M. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behavior. 56:1997;131-137.
17. Siuciak J.A., Clark M.S., Rind H.B., Whittemore S.R., Russo A.F. BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain. Journal of Neuroscience Research. 52:1998;149-158.
18. Smeyne R.J., Klein R., Schnapp A., Long L.K., Bryant S., Lewin A., Lira S.A., Barbacid M. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature. 368:1994;246-249.
19. White L.A., Eaton M.J., Castro M.C., Klose K.J., Globus M., Shaw G., Whittemore S.R. Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons. Journal of Neuroscience. 14:1994;6744-6753.