The Highly Selective 5-Hydroxytryptamine (5-HT)2A Receptor Antagonist, EMD 281014, Significantly Increases Swimming and Decreases Immobility in Male Congenital Learned Helpless Rats in the Forced Swim Test

Synapse

Volumn 52, Issue 1, 2004, Pages 73-75

  Patel, Jignesh G ^a,d   Bartoszyk, Gerd D ^b   Edwards, Emmeline ^c   Ashby Jr , Charles R ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b MERCK KGAA   (Germany)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d LUNDBECK RESEARCH USA   (United States)

Author keywords

EMD 281014; Forced swim test; Serotonin2A antagonist

Indexed keywords

7 [4 [2 (4 FLUOROPHENYL)ETHYL]PIPERAZINE 1 CARBONYL] 1H INDOLE 3 CARBONITRILE; ANTIDEPRESSANT AGENT; DIMETHYL SULFOXIDE; EMD 281014; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CLIMBING; CONTROLLED STUDY; DEPRESSION; DIVING; DOSE RESPONSE; FORCED SWIMMING TEST; IMMOBILIZATION; LEARNED HELPLESSNESS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR, ANIMAL; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELPLESSNESS, LEARNED; INDOLES; MALE; PIPERAZINES; RATS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; SWIMMING;

EID: 1542373715     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10308     Document Type: Article

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