Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect

Journal of Neuroscience

Volumn 22, Issue 24, 2002, Pages 10883-10890

  Newton, Samuel S ^a   Thome, Johannes ^a   Wallace, Tanya L ^a   Shirayama, Yukihikko ^a   Schlesinger, Lee ^a   Sakai, Norio ^a   Chen, Jingshan ^a   Neve, Rachael ^b   Nestler, Eric J ^c   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Behavior; Depression; Dysphoria; Learned helplessness; Prodynorphin; opiate receptors

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DYNORPHIN; KAPPA OPIATE RECEPTOR; PRODYNORPHIN; TRANSCRIPTION FACTOR; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; DEPRESSION; DISEASE MODEL; DOPAMINERGIC SYSTEM; DYSPHORIA; FOREBRAIN; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSFER; LEARNED HELPLESSNESS; LIMBIC CORTEX; MOTIVATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REWARD; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; VIRAL GENE DELIVERY SYSTEM;

EID: 0037115028     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-24-10883.2002     Document Type: Article

References (43)

1. Baamonde A, Dauge V, Ruiz-Gayo M, Fulga IG, Turcaud S, FournieZaluski M-C, Roques BP (1992) Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid δ and dopamine D1 receptor stimulation. Eur J Pharmacol 216:157-166.
2. Blom J, Tascedda F, Carra S, Ferraguti C, Barden N, Brunello N (2002) Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function. Neuropsychopharmacology 26:605-614.
3. Borsok D, Konradi C, Falkowski O, Comb M, Hyman S (1994) Molecular mechanisms of stress-induced proenkephalin gen regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Endocrinol 8:240-248.
4. Caldarone B, George TP, Zachariou V, Picciotto M (2000) Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacol Biochem Behav 66:811-817.
5. Carlezon JW, Thome J, Olson V, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ (1998) Regulation of cocaine reward by CREB. Science 282:2272-2275.
6. Chen A-H, Shirayama Y, Shin K-H, Neve RL, Duman RS (2001) Expression of the cAMP response element binding protein (CREB) in hippocampus produces antidepressant effect. Biol Psychiatry 49:753-762.
7. Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PD, Picciotto M, Lazova R, Duman RS, Nestler EJ (1998) Transgenic animal models for inducible, targeted gene expression in brain. Mol Pharmacol 54:495-503.
8. Cole R, Konradi C, Douglass J, Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
9. Collins-Hicok J, Lin L, Spiro C, Laybourn PJ, Tschumper R, Rapacz B, McMurray CT (1994) Induction of the rat prodynorphin gene through Gs-coupled receptors may involve phosphorylation-dependent derepression and activation. Mol Cell Biol 14:2837-2848.
10. Conti A, Cryan JF, Dalvi A, Lucki L, Blendy JA (2002) CREB is essential for the upregulation of BDNF transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci 3262-3268.
11. Curran E, Watson SJ (1995) Dopamine receptor mRNA expression patterns by opioid peptide cells in the nucleus accumbens of the rat: A double in situ hybridization study. J Comp Neurol 361:57-76.
12. Dowlatshahi D, MacQueen GM, Wang JF, Young LT (1998) Increased temporal cortex CREB concentrations and antidepressant treatment in major depression. Lancet 352:1754-1755.
13. Duman R, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606.
14. Duman R, Malberg J, Nakagawa S, D'Sa C (2000) Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48:732-739.
15. Furth P, Onge LS, Böger H, Gruss P, Gossen M, Kistner A, Bujard H, Hennighausen L (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA 91:9302-9306.
16. Gerfen C, Young WS (1988) Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: An in situ hybridization histochemistry and fluorescent retrograde tracing study. Brain Res 460:161-167.
17. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at Serine 133. Cell 59:675-680.
18. Kelz M, Chen J, Carlezon WA, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang Y-J, Marotti L, Self DW, Tkatch T, Baranauskas T, Surmeier G, Neve RJ, Duman RS, Picciotto MR, Nestler EJ (1999) Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401:272-276.
19. Manier D, Shelton RC, Sulser F (2002) Noradrenergic antidepressants: Does chronic treatment increase or decrease nuclear CREB-P? J Neural Transm 109:91-99.
20. Manji H, Drevets WC, Charney DS (2001b) The cellular neurobiology of depression. Nat Med 7:541-547.
21. Milner B, Squire LR, Kandel ER (1998) Cognitive neuroscience and the study of memory. Neuron 20:445-468.
22. Nakagawa S, Kim J-E, Lee R, Malberg JE, Chen J, Steffen C, Zhang Y-J, Nestler EJ, Duman RS (2002) Regulation of neurogenesis in adult mouse hippocampus by cAMP and cAMP response element-binding protein. J Neurosci 22:3673-3682.
23. Nestler E, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58-63.
24. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobioloy of depression. Neuron 34:13-25.
25. Newton S, Dow A, Terwilliger R, Duman RS (2002) A simplified method for combined immunohistochemistry and in situ hybridization in fresh frozen, cryocut mouse brain sections. Brain Res Brain Res Protoc 9:214-219.
26. Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16:2365-2372.
27. Paxinos G, Watson C (1997) The Rat Brain in Stereotaxic Coordinates. New York: Academic.
28. Pliakas A, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in the nucleus accumbens. J Neurosci 21:7397-7403.
29. Rossby S, Manier DH, Liang S, Nalepa I, Sulser F (1999) Venlafaxine: Pharmacological actions beyond aminergic receptors. Int J Neuropsychopharmacol 2:1-8.
30. Sakai N, Thome J, Chen J, Kelz M, Nestler EJ, Duman RS (2002) Inducible and brain-region specific expression of CREB. Mol Pharmacol 61:1453-1464.
31. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
32. Seligman M, Beagley G (1975) Learned helplessness in the rat. J Comp Physiol Psychol 88:534-541.
33. Shanks N, Anisman H (1989) Strain-specific effects of antidepressants on escape deficits induced by inescapable shock. Psychopharmacology 99:122-128.
34. Shaywitz A, Greenberg ME (1999) CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
35. Shirayama Y, Chen AC-H, Nakagawa S, Russell RS, Duman RS (2002) Brain derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251-3261.
36. Shockett P, Difilippantonio M, Hellman N, Schatz DG (1995) A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA 92:6522-6526.
37. Silva A, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127-148.
38. Spanagel R, Shippenberg TS (1993) Modulation of morphine-induced sensitization by endogenous κ opioid systems in the rat. Neurosci Lett 153:232-236.
39. Spanagel R, Herz A, Shippenberg TS (1990) The effects of opioid peptides on dopamine release in the nucleus accumbens: An in vivo microdialysis study. J Neurochem 55:1734-1740.
40. Tejedor-Real P, Mico JA, Smadja C, Maldonado R, Roques BP, Gibert Rahola (1998) Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model. Eur J Pharmacol 354:1-7.
41. Thiébot M-H, Martin P, Puech AJ (1992) Animal behavioural studies in the evaluation of antidepressant drugs. Br J Psychiatry Suppl 160:44-50.
42. Thome J, Sakai N, Shin KH, Steffen C, Zhang Y-J, Impey S, Storm DR, Duman RS (2000) cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20:4030-4036.
43. Willner P (1984) The validity of animal models of depression. Psychopharmacology 83:1-16.