Comparison of the phenotype of NK1R - / - mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs

Behavioural Pharmacology

Volumn 12, Issue 6-7, 2001, Pages 497-508

  Rupniak, N M J ^a   Carlson, E J ^a   Webb, J K ^a   Harrison, T ^a   Porsolt, R D ^b   Roux, S ^b   De Felipe, C ^c   Hunt, S P ^d   Oates, B ^e   Wheeldon, A ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b Porsolt and Partners 9 bis   (France)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anxiety; Depression; Gerbil; GR205171; Guinea pig; Hamster; L 760735; Mouse; NK1 receptor; Rat

Indexed keywords

5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; 5 [[2 [1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY] 3 (4 FLUOROPHENYL) 4 MORPHOLINYL]METHYL] N,N DIMETHYL 1H 1,2,3 TRIAZOLE 4 METHANAMINE; DIAZEPAM; FLUOXETINE; GR 226206; IMIPRAMINE; NEUROKININ 1 RECEPTOR; SUBSTANCE P; SUBSTANCE P ANTAGONIST; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG; VOFOPITANT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ANXIETY NEUROSIS; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; ENANTIOMER; GERBIL; GROOMING; HAMSTER; KNOCKOUT MOUSE; MAZE TEST; MOUSE; NONHUMAN; PHENOTYPE; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; RECEPTOR OCCUPANCY; SCRATCHING; SENSORIMOTOR FUNCTION; STEREOCHEMISTRY; STRAIN DIFFERENCE;

EID: 0035218323     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200111000-00011     Document Type: Article

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