Antidepressant-like effects of CRF 1 receptor antagonist SSR125543 in an animal model of depression

European Journal of Pharmacology

Volumn 497, Issue 1, 2004, Pages 49-53

  Overstreet, David H ^a   Griebel, Guy ^b  

^a Center for Alcohol Studies   (United States)

^b SANOFI   (France)

Author keywords

CRF 1 receptor antagonist SSR125543; Depression; Desipramine; Flinders Sensitive Line rat model; Fluoxetine; Forced swim test; Social interaction test

Indexed keywords

4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 2 THIAZOLAMINE; ANTIDEPRESSANT AGENT; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; DESIPRAMINE; FLUOXETINE; UNCLASSIFIED DRUG; ANXIOLYTIC AGENT; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CRF RECEPTOR TYPE 1; HALOGENATED HYDROCARBON; SEROTONIN ANTAGONIST; THIAZINE DERIVATIVE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE CALCULATION; DRUG EFFECT; MAJOR DEPRESSION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SOCIAL INTERACTION; SWIMMING; TASK PERFORMANCE; TRANQUILIZING ACTIVITY; ANIMAL; COMPARATIVE STUDY; DEPRESSION; DRUG ANTAGONISM; GENETICS; INTRAPERITONEAL DRUG ADMINISTRATION; SOCIAL BEHAVIOR;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DEPRESSION; DESIPRAMINE; FLUOXETINE; HYDROCARBONS, HALOGENATED; INJECTIONS, INTRAPERITONEAL; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; SWIMMING; THIAZINES;

EID: 4143089517     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.06.035     Document Type: Article

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