Distribution of 5-HT7 receptors in the human brain: A preliminary autoradiographic study using [3H]SB-269970

Neuroscience Letters

Volumn 367, Issue 3, 2004, Pages 313-316

  Varnäs, Katarina ^a   Thomas, David R ^b   Tupala, Erkki ^c   Tiihonen, Jari ^c   Hall, Håkan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Niuvanniemen sairaala   (Finland)

Author keywords

5 HT7 receptor; 3H SB 269970; Human brain whole hemisphere autoradiography

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL H3; RADIOLIGAND; RECEPTOR SUBTYPE; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; PHENOL DERIVATIVE; SEROTONIN RECEPTOR; SULFONAMIDE; TRITIUM;

AMYGDALOID NUCLEUS; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; BRAIN NUCLEUS; BRAIN RADIOGRAPHY; BRAIN REGION; BRAIN STEM; CAUDATE NUCLEUS; CINGULATE GYRUS; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; DENTATE GYRUS; DIENCEPHALON; FRONTAL CORTEX; HEMISPHERE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; INSULA; LIGAND BINDING; LIMBIC CORTEX; OCCIPITAL CORTEX; OLFACTORY CORTEX; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PULVINAR; PUTAMEN; RECEPTOR BINDING; RECEPTOR UPREGULATION; TEMPORAL CORTEX; THALAMUS ANTERIOR NUCLEUS; THALAMUS DORSOMEDIAL NUCLEUS; TISSUE DISTRIBUTION; ADULT; BRAIN; COMPARATIVE STUDY; FEMALE; HISTOLOGY; MALE; METABOLISM; METHODOLOGY; RADIOASSAY;

ADULT; AUTORADIOGRAPHY; BRAIN; FEMALE; HUMANS; MALE; PHENOLS; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONAMIDES; TRITIUM;

EID: 4444323618     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.06.025     Document Type: Article

References (20)

1. 1A/1B double-knockout mice J. Pharmacol. Exp. Ther. 302:2002;240-248
2. 5A receptor. Neuron. 22:1999;581-591
3. 7 receptor in rat brain. Br. J. Pharmacol. 117:1996;657-666
4. 7 receptor antagonist. Br. J. Pharmacol. 130:2000;539-548
5. Hall H., Halldin C., Farde L., Sedvall G. Whole hemisphere autoradiography of the postmortem human brain. Nucl. Med. Biol. 25:1998;715-719
6. Hall H., Hurd Y., Pauli S., Halldin C., Sedvall G. Human brain imaging post-mortem-whole hemisphere technologies. Int. Rev. Psychiatry. 13:2001;12-17
7. Heimer L. A new anatomical framework for neuropsychiatric disorders and drug abuse. Am. J. Psychiatry. 160:2003;1726-1739
8. Hoyer D., Hannon J.P., Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71:2002;533-554
9. 7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl) pyrrolidine-1-sulfonyl)phenol (SB-269970). J. Med. Chem. 43:2000;342-345
10. Mantere T., Tupala E., Hall H., Särkioja T., Räsänen P., Bergström K., Callaway J., Tiihonen J. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study. Am. J. Psychiatry. 159:2002;599-606
11. 3H ]mesulergine: comparison to other mammalian species Br. J. Pharmacol. 141:2004;92-104
12. 7 receptors in the facilitatory response induced by 8-OH-DPAT on learning consolidation. Behav. Brain Res. 121:2001;21-28
13. 7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol. Pharmacol. 47:1995;99-103
14. 7 receptors in rodent, pig and primate brain tissues Neuropharmacology. 42:2002;74-81
15. 7 receptors Br. J. Pharmacol. 130:2000;409-417
16. 7 receptors. Curr. Drug Target. CNS Neurol. Disord. 3:2004;81-90
17. 7 receptors in guinea-pig brain. Br. J. Pharmacol. 115:1995;107-116
18. 7 receptors: current knowledge and future prospects. Trends Pharmacol. Sci. 21:2000;70-77
19. Varnäs K., Halldin C., Hall H. Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum. Brain Mapp. 22:2004;246-260
20. B.A. Vogt, L.J. Vogt, E.A. Nimchinsky, P.R. Hof, Primate cingulate cortex chemoarchitecture and its disruption in Alzheimer's disease, in: F.E. Bloom, A. Björklund, T. Hökfelt (Eds.), Handbook of Chemical Neuroanatomy, Vol. 13: The Primate Nervous System, Part I, Elsevier Science B.V., Amsterdam, 1997, pp. 455-528.