Substance P: A pioneer amongst neuropeptides

Journal of Internal Medicine

Volumn 249, Issue 1, 2001, Pages 27-40

  Hökfelt, Tomas ^a   Pernow, B ^a   Wahren, J ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antagonists; Depression; Gut; Internalization; Neuropeptides; Receptors; Sensory neurones

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; APREPITANT; FLUOXETINE; GLUTAMIC ACID; MK 868; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROKININ B; NEUROPEPTIDE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SUBSTANCE P; SUBSTANCE P ANTAGONIST; SUBSTANCE P RECEPTOR; TACHYKININ; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG;

DEPRESSION; DRUG RECEPTOR BINDING; GASTROINTESTINAL TRACT; HUMAN; KNOCKOUT MOUSE; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL PLASTICITY; NEUROENDOCRINE SYSTEM; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SENSORY NERVE;

ANIMALS; ANTIDEPRESSIVE AGENTS; GLUTAMIC ACID; GUINEA PIGS; HISTORY, 20TH CENTURY; HUMANS; INTESTINES; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDES; RECEPTORS, NEUROKININ-1; RECEPTORS, TACHYKININ; SUBSTANCE P; TACHYKININS;

EID: 0035137002     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0954-6820.2000.00773.x     Document Type: Review

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15. Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: Immunohisto-chemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase
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43. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat
44. Alterations in neurokinin 1 receptor gene expression in models of pain and inflammation
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46. Injury-induced plasticity of spinal reflex activity: NK-1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in rat spinal cord in vitro
47. The nonpeptide NK1 receptor antagonists LY-303,870 and LY-306,740 block the responses of spinal dorsal horn neurons to substance P and to peripheral noxious stimuli
48. Neurokinin-A like immunoreactivity in rat primary sensory neurons: Coexistence with substance P
49. The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat
50. Intrathecal neurokinin A facilitates the spinal nociceptive flexor reflex evoked by thermal and mechanical stimuli and synergistically interacts with substance P
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53. On the role of the NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat
54. Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurons
55. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
56. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species
57. Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioural responses of the rat
58. Behavioural evidence that substance P may be a spinal cord sensory neurotransmitter
59. Distribution of galanin immunoreactivity in the central nervous system and responses of galanin-containing neuronal pathways to injury
60. Galanin-like immunoreactivity in capsaicin sensitive sensory neurons and ganglia
61. Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy
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63. Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord
64. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurons in the dorsal horn of the rat
65. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states
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83. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation
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91. An interaction of ondansetron and dexamethasone antagonizing cisplatin-induced acute and delayed emesis in the ferret
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