Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines

Cellular and Molecular Neurobiology

Volumn 25, Issue 6, 2005, Pages 973-980

  Koponen, Eija ^a   Rantamäki, Tomi ^b   Voikar, Vootele ^b   Saarelainen, Tommi ^a   MacDonald, Ewen ^a   Castrén, Eero ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

BDNF; Cingulate cortex; Hippocampus; Neurotrophin; Norepinephrine; Serotonin; trkB

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN MONOAMINE; FLUOXETINE; NEUROTROPHIN; SEROTONIN; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR CHANGE; BRAIN LEVEL; BRAIN METABOLISM; CONTROLLED STUDY; DEPRESSION; DRUG RESPONSE; ELECTROENCEPHALOGRAM; FEMALE; FORCED SWIMMING TEST; GENE OVEREXPRESSION; IMMOBILIZATION; LATENT PERIOD; MALE; MOUSE; MOUSE STRAIN; NERVE CELL PLASTICITY; NERVE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTONINERGIC NERVE CELL; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; SWIMMING; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BEHAVIOR, ANIMAL; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; FLUOXETINE; MALE; MICE; MICE, TRANSGENIC; RECEPTOR, TRKB; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; SWIMMING;

ANIMALIA; MUS MUSCULUS;

EID: 31544454715     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-005-8468-z     Document Type: Article

References (33)

1. Castrén, E. (2004). Neurotrophic effects of antidepressant drugs. Curr. Opin. Pharmacol. 4:58-64.
2. Castrén, E. (2005). Is mood chemistry? Nat. Rev. Neurosci. 6:241-246.
3. Chourbaji, S., Hellweg, R., Brandis, D., Zorner, B., Zacher, C., Lang, U. E., Henn, F. A., Hortnagl, H., and Gass, P. (2004). Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain Res. Mol. Brain Res. 121:28-36.
4. Detke, M. J., Johnson, J., and Lucki, I. (1997). Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Exp. Clin. Psychopharmacol. 5:107-112.
5. Drevets, W. C. (2001). Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders. Curr. Opin. Neurobiol. 11:240-249.
6. Duman, R. S., Heninger, G. R., and Nestler, E. J. (1997). A molecular and cellular theory of depression. Arch. Gen. Psychiatry 54:597-606.
7. Galter, D., and Unsicker, K. (2000). Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Mol. Cell Neurosci. 15:446-455.
8. Huang, E. J., and Reichardt, L. F. (2003). Trk receptors: Roles in neuronal signal transduction. Annu. Rev. Biochem. 72:609-642.
9. Koponen, E., Lakso, M., and Castren, E. (2004a). Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain. Brain Res. Mol. Brain Res. 130:81-94.
10. Koponen, E., Voikar, V., Riekki, R., Saarelainen, T., Rauramaa, T., Rauvala, H., Taira, T., and Castrén, E. (2004b). Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLC gamma pathway, reduced anxiety, and facilitated learning. Mol. Cell Neurosci. 26:166-181.
11. Lu, B. (2003). BDNF and activity-dependent synaptic modulation. Learn. Mem. 10:86-98.
12. MacQueen, G. M., Ramakrishnan, K., Croll, S. D., Siuciak, J. A., Yu, G., Young, L. T., and Fahnestock, M. (2001). Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression. Behav. Neurosci. 115:1145-1153.
13. Mamounas, L. A., Altar, C. A., Blue, M. E., Kaplan, D. R., Tessarollo, L., and Lyons, W. E. (2000). BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. J. Neurosci. 20:771-82.
14. Mamounas, L. A., Blue, M. E., Siuciak, J. A., and Altar, C. A. (1995). Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J. Neurosci. 15:7929-39.
15. Manji, H. K., Drevets, W. C., and Charney, D. S. (2001). The cellular neurobiology of depression. Nat. Med. 7:541-547.
16. Mattson, M. P., Maudsley, S., and Martin, B. (2004). BDNF and 5-HT: A dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 27:589-594.
17. McAllister, A. K., Katz, L. C. and Lo, D. C. (1999). Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. 22:295-318.
18. Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., and Nestler, E. J. (2004). Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc. Natl. Acad. Sci. USA 101:10827-10832.
19. Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J. and Monteggia, L. M. (2002). Neurobiology of depression. Neuron 34:13-25.
20. Neves-Pereira, M., Mundo, E., Muglia, P., King, N., Macciardi, F., and Kennedy, J. L. (2002). The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study. Am. J. Hum. Genet. 71:651-655.
21. Nibuya, M., Morinobu, S., and Duman, R. S. (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15:7539-7547.
22. Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T. Sakata, K., Zhen, S., Teng, K. K., Yung, W. H., Hempstead, B. L., and Lu, B. (2004). Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306:487-491.
23. Poo, M. M. (2001). Neurotrophins as synaptic modulators. Nat. Rev. Neurosci. 2:24-32.
24. Porsolt, R. D., Bertin, A., and Jalfre, M. (1977). Behavioral despair in mice: A primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 229:327-336.
25. Russo-Neustadt, A., Beard, R. C., and Cotman, C. W. (1999). Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology 21:679-682.
26. Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., Ernfors, P., and Castrén, E. (2003). Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J. Neurosci. 23:349-357.
27. Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., and Burmeister, M. (2003). A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28:397-401.
28. Shirayama, Y., Chen, A. C., Nakagawa, S., Russell, D. S., and Duman, R. S. (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J. Neurosci. 22:3251-3261.
29. Siuciak, J. A., Boylan, C., Fritsche, M., Altar, C. A., and Lindsay, R. M. (1996). BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res. 710:11-20.
30. Siuciak, J. A., Clark, M. S., Rind, H. B., Whittemore, S. R., and Russo, A. F. (1998). BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain. J. Neurosci. Res. 52:149-158.
31. Siuciak, J. A., Lewis, D. R., Wiegand, S. J., and Lindsay, R. M. (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behav. 56:131-137.
32. Sklar, P., Gabriel, S. B., McInnis, M. G., Bennett, P., Lim, Y. M., Tsan, G., Schaffner, S., Kirov, G., Jones, I., Owen, M., Craddock, N., DePaulo, J. R., and Lander, E. S. (2002). Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol. Psychiatry 7:579-593.
33. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., and Lindholm, D. (1990). Activity-dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J. 9:3545-3550.