cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs

Journal of Neuroscience

Volumn 22, Issue 8, 2002, Pages 3262-3268

  Conti, Alana C ^a   Cryan, John F ^a,c   Dalvi, Ashutosh ^a,b   Lucki, Irwin ^a   Blendy, Julie A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Pharmacology ^*  (Denmark)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antidepressant; BDNF; CREB; Desipramine; Fluoxetine; Forced swimming test; Gene expression; Tail suspension test

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN MONOAMINE; CORTICOSTERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DESIPRAMINE; FLUOXETINE; NEUROTRANSMITTER RECEPTOR;

ADAPTATION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DEPRESSION; DRUG MECHANISM; FORCED SWIMMING TEST; GENE EXPRESSION REGULATION; HORMONE RELEASE; LONG TERM EXPOSURE; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MONOAMINE RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRESS; TAIL SUSPENSION TEST; TRANSCRIPTION REGULATION;

EID: 0037092432     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-08-03262.2002     Document Type: Article

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