SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats

British Journal of Pharmacology

Volumn 139, Issue 4, 2003, Pages 705-714

  Thomas, David R ^a   Melotto, Sergio ^b   Massagrande, Mario ^b   Gribble, Andrew D ^a   Jeffrey, Phillip ^a   Stevens, Alexander J ^a   Deeks, Nigel J ^a   Eddershaw, Peter J ^a   Fenwick, Susan H ^a   Riley, Graham ^a   Stean, Tania ^a   Scott, Claire M ^a   Hill, Matthew J ^a   Middlemiss, Derek N ^a   Hagan, Jim J ^a   Price, Gary W ^a   Forbes, Ian T ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE   (Italy)

Author keywords

Body temperature; Guinea pig; Pharmacokinetics; Rat; REM sleep; SB 269970 A; SB 656104 A

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 5 CARBAMOYLTRYPTAMINE; CYCLIC AMP; SB 656104A; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; [2 [2 [4 (4 CHLOROPHENOXY)PIPERIDIN 1 YL]ETHYL]PYRROLIDINE 1 SULFONYL] 1H INDOLE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CELL CLONING; COMPETITIVE INHIBITION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROCARDIOGRAM; ELECTROOCULOGRAM; EMBRYO CELL; HUMAN; HUMAN CELL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; REM SLEEP; SLEEP; STEADY STATE;

EID: 10744231657     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705290     Document Type: Article

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