Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Journal of Neuroscience

Volumn 16, Issue 7, 1996, Pages 2365-2372

  Nibuya, Masashi ^a   Nestler, Eric J ^a   Duman, Ronald S ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale University School of Medicine and the Connecticut Mental Health Center   (United States)

Author keywords

brain derived neurotrophic factor; cAMP; desipramine; ECS; fluoxetine; imipramine; rolipra m; sertraline; tranylcypromine

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DESIPRAMINE; FLUOXETINE; HALOPERIDOL; IMIPRAMINE; MESSENGER RNA; MORPHINE; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR; PSYCHOTROPIC AGENT; ROLIPRAM; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRANYLCYPROMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; LONG TERM EXPOSURE; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ANALYSIS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029992189     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-07-02365.1996     Document Type: Article

References (44)

1. Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB (1995) MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 152:973-981.
2. Cole RL, Konradi C, Douglass J, Hyman SE (1995) Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 14:813-823.
3. Condorelli DF, Dell'Albani P, Mudo G, Timmusk T, Belluardo N (1994) Expression of neurotrophins and their receptors in primary astroglial cultures:induction by cAMP elevating agents. J Neurochem 63:509-516.
4. Duman RS, Heninger GR, Nestler EJ (1994) Adaptations of receptor-coupled signal transduction pathways underlying stress- and drug-induced neural plasticity. J Nervous Mental Dis 182:692-700.
5. Duman RS, Vaidya VA, Nibuya M, Morinobu S, Rydelek Fitzgerald L (1995) Stress, antidepressant treatments, and neurotrophic factors: molecular and cellular mechanisms. The Neuroscientist 1:351-360.
6. Fitzgerald RL, Vaidya VA, Terwilliger RZ, Duman RS (1995) Electroconvulsive seizure increases the expression of CREM (cAMP response element modulator) and ICER (inducible cAMP early repressor) in rat brain. J Neurochem 66:429-432.
7. Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268:239-247.
8. Ghosh A, Carnahan J, Greenberg ME (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263:1618-1623.
9. Heninger GR, Charney DS (1987) Mechanisms of action of antidepressant treatments: Implications for the etiology and treatment of depressive disorders. In: Psychopharmacology: the third generation of progress (Meltzer HY, ed), pp 535-544. New York: Raven.
10. Hudson CJ, Young LT, Li PP, Warsh JJ (1993) CNS signal transduction in the patho-physiology and pharmacotherapy of affective disorders and schizophrenia. Synapse 13:278-293.
11. Jacobson L, Sapolsky R (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocrine Rev 12:18-134.
12. Konradi C, Cole RL, Heckers S, Hyman SE (1994) Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14:5623-5634.
13. Lindsay RM, Wiegand SJ, Anthony Altar CA, DiStefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190.
14. Lindvali O, Kokaia Z, Bengzon J, Elmer E, Kokaia M (1994) Neurotrophins and brain insults. Trends Neurosci 17:490-496.
15. Maes M, Meltzer HY (1995) The serotonin hypothesis of depression. In: Psychopharmacology: the fourth generation of progress (Bloom FE, Kupfer DJ, eds), pp 933-944. New York: Raven.
16. Mamounas LA, Blue ME, Siuciak JA, Anthony Altar C (1995) BDNF promotes the survival and sprouting of serotonergic axons in the rat brain. J Neurosci 15:7929-7939.
17. McEwen BS, Gould E (1990) Adrenal steroid influences on the survival of hippocampal neurons. Biochem Pharmacol 40:2393-2402.
18. Melia KR, Rasmussen K, Haycock J, Terwilliger RZ, Nestler EJ, Duman RS (1992) Coordinate regulation of firing rate, tyrosine hydroxylase, and the cyclic AMP system in rat locus coeruleus: effects of chronic stress and norepinephrine depleting agents. J Neurochem 58:494-502.
19. Menkes DB, Rasenick MM, Wheeler MA, Bitensky MW (1983) Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment. Science 129:65-67.
20. Meyer TE, Habener JF (1993) Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocrine Rev 14:269-290.
21. Meyer TE, Waeber G, Lin J, Beckman W, Haebner JF (1993) The promoter of the gene encoding 3′,5′-cyclic monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence of positive autoregulation of gene transcription. Endocrinology 132:770-780.
22. Nestler EJ, Terwilliger RZ, Duman RS (1989) Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem 53:1644-1647.
23. Nibuya M, Rydelek Fitzgerald L, Russell DS, Nestler EJ, Duman RS (1994) Induction of BDNF and trkB by electroconvulsive seizure: regional regulation and role of CREB. Soc Neurosci Abstr 24:1312.
24. Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539-7547.
25. Ozawa H, Rasenick MM (1991) Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J Neurochem 56:330-338.
26. Perez J, Tinelli D, Brunello N, Racagni G (1989) cAMP-dependent phosphorylation of soluble and crude microtubule fractions of rat cerebral cortex after prolonged desmethylimipramine treatment. Eur J Pharmacol 172:305-316.
27. Ruppert S, Cole TJ, Boshart M, Schmid W, Schutz G (1992) Multiple mRNA isoforms of the transcription factor CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J 11:1503-1512.
28. Sapolsky RM, Krey LC, McEwen BS (1985) Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J Neurosci 5:1222-1227.
29. Sapolsky RM, Uno H, Robert CS, Finsh CE (1990) Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 10:2897-2902.
30. Schatzberg AF, Schildkraut JJ (1995) Recent studies on norepinephrine systems in mood disorders. In: Psychopharmacology: the fourth generation of progress (Bloom FE, Kupfer DJ, eds), pp 911-920. New York: Raven.
31. Schwaninger M, Schoel C, Blume R, Rossig L, Knepel W (1995) Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription. Mol Pharmacol 47:1112-1118.
32. Siuciak JA, Lewis D, Wiegand SJ, Lindsay RM (1994a) Brain derived neurotrophic factor (BDNF) produces an anti-depressant like effect in two animal models of depression. Soc Neurosci Abstr 20:1106.
33. Siuciak JA, Anthony Altar CA, Wiegand SJ, Lindsay RM (1994b) Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Res 633:326-330.
34. Sklair-Tavron L, Nestler EJ (1995) Opposing effects of morphine and the neurotrophins, NT-3, NT-4, and BDNF, on locus coeruleus neurons in vitro. Brain Res 702:117-125.
35. Sleight AJ, Carolo C, Petit N, Zwingelstein C, Bourson A (1995) Identification of 5-hydroxytryptamines 7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatments. Mol Pharmacol 47:99-103.
36. Smith MA, Makino S, Kvetnansky R, Post RM (1995) Stress alters the express of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15:1768-1777.
37. Stein-Behrens B, Mattson MP, Chang I, Yeh M, Sapolsky R (1994) Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus. J Neurosci 14:5373-5380.
38. Sulser F (1989) New perspectives on the molecular pharmacology of affective disorders. Psychol Sci 238:231-239.
39. Uno H, Tarara R, Else JG, Suleman MA, Sapolsky RM (1989) Hippocampal damage associated with prolonged and fatal stress in primates. J Neurosci 9:1705-1711.
40. Waeber G, Meyer TE, LeSieur M, Hermann HL, Gerard N, Haebner JF (1991) Developmental stage-specific expression of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol 5:1418-1430.
41. Watanabe Y, Gould E, McEwen BS (1992) Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588:341-345.
42. Widnell KL, Russell DS, Nestler EJ (1994) Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proc Natl Acad Sci USA 91:10947-10951.
43. Widnell KL, Self DW, Lane SB, Russell DS, Vaidya VA, Miserendino MJD, Rubin CR, Duman RS, Nestler EJ (1996) Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J Pharmacol Exp Ther 276:306-315.
44. Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H (1991) Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 48:693-699.