Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice

Neuroscience

Volumn 140, Issue 1, 2006, Pages 321-334

  Zhao, S ^a   Edwards, J ^a   Carroll, J ^b   Wiedholz, L ^c   Millstein, R A ^c   Jaing, C ^a   Murphy, D L ^b   Lanthorn, T H ^a   Holmes, A ^c  

^a LEXICON PHARMACEUTICALS INC   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

5 HTT; behavior; emotion; knockout; serotonin transporter; SERT

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; MESSENGER RNA; SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; EMOTION; EXON; EXPOSURE; FEMALE; GENE DISRUPTION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; IMMOBILIZATION; MALE; MOUSE; NONHUMAN; NULL ALLELE; OPEN FIELD TEST; PHENOTYPE; PRIORITY JOURNAL; SCREENING; SEROTONIN BRAIN LEVEL; SEROTONIN UPTAKE; THROMBOCYTE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN CHEMISTRY; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; EMOTIONS; EXPLORATORY BEHAVIOR; HINDLIMB SUSPENSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TRITIUM;

EID: 33646379343     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.01.049     Document Type: Article

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