-
1
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
-
(1965)
Exp. Cell Res.
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
2
-
-
0024366596
-
Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
-
Wright W.E., Pereira-Smith O.M., Shay J.W. Reversible cellular senescence implications for immortalization of normal human diploid fibroblasts . Mol. Cell Biol. 9:1989;3088-3092.
-
(1989)
Mol. Cell Biol.
, vol.9
, pp. 3088-3092
-
-
Wright, W.E.1
Pereira-Smith, O.M.2
Shay, J.W.3
-
3
-
-
0028322713
-
SV40-induced immortalization of human cells
-
Bryan T.M., Reddel R.R. SV40-induced immortalization of human cells. Crit. Rev. Oncol. 5:1994;331-357.
-
(1994)
Crit. Rev. Oncol.
, vol.5
, pp. 331-357
-
-
Bryan, T.M.1
Reddel, R.R.2
-
4
-
-
0027263711
-
E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
-
Shay J.W., Wright W.E., Brasiskyte D., Van der Haegen B.A. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene. 8:1993;1407-1413.
-
(1993)
Oncogene
, vol.8
, pp. 1407-1413
-
-
Shay, J.W.1
Wright, W.E.2
Brasiskyte, D.3
Van der Haegen, B.A.4
-
5
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
6
-
-
0025150387
-
Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
-
Stein G.H., Beeson M., Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science. 249:1998;666-669.
-
(1998)
Science
, vol.249
, pp. 666-669
-
-
Stein, G.H.1
Beeson, M.2
Gordon, L.3
-
7
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta D.A., Xiong Y., Phelps D., Hannon G., Beach D., Barrett J.C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA. 93:1996;13742-13747.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
8
-
-
0029670840
-
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
-
Hara E., Smith R., Parry D., Tahara H., Stone S., Peters G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell Biol. 16:1996;859-867.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 859-867
-
-
Hara, E.1
Smith, R.2
Parry, D.3
Tahara, H.4
Stone, S.5
Peters, G.6
-
9
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
-
(1994)
Exp. Cell Res.
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
Pereira-Smith, O.M.4
Smith, J.R.5
-
10
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
-
Brown J.P., Wei W., Sedivy J.M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:1999;831-834.
-
(1999)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
11
-
-
0028294605
-
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
-
el-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., Jackman J., Pietenpol J.A., Burrell M., Hill D.E., Wang Y., et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1994;1169-1174.
-
(1994)
Cancer Res.
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrell, M.8
Hill, D.E.9
Wang, Y.10
-
12
-
-
0028177401
-
P53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
-
Slebos R.J., Lee M.H., Plunkett B.S., Kessis T.D., Williams B.O., Jacks T., Hedrick L., Kastan M.B., Cho K.R. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA. 91:1994;5320-5324.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5320-5324
-
-
Slebos, R.J.1
Lee, M.H.2
Plunkett, B.S.3
Kessis, T.D.4
Williams, B.O.5
Jacks, T.6
Hedrick, L.7
Kastan, M.B.8
Cho, K.R.9
-
13
-
-
0002888471
-
Telomere dynamics and telomerase activity in cell senescence and cancer
-
Bacchetti S. Telomere dynamics and telomerase activity in cell senescence and cancer. Cell Dev. Biol. 7:1996;31-39.
-
(1996)
Cell Dev. Biol.
, vol.7
, pp. 31-39
-
-
Bacchetti, S.1
-
14
-
-
0032912802
-
Control of replicative life span in human cells: Barriers to clonal expansion intermediate between M1 senescence and M2 crisis
-
Bond J.A., Haughton M.F., Rowson J.M., Smith P.J., Gire V., Wynford-Thomas D., Wyllie F.S. Control of replicative life span in human cells barriers to clonal expansion intermediate between M1 senescence and M2 crisis . Mol. Cell Biol. 19:1999;3103-3114.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 3103-3114
-
-
Bond, J.A.1
Haughton, M.F.2
Rowson, J.M.3
Smith, P.J.4
Gire, V.5
Wynford-Thomas, D.6
Wyllie, F.S.7
-
15
-
-
0031935827
-
Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
-
Gire V., Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell Biol. 18:1998;1611-1621.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 1611-1621
-
-
Gire, V.1
Wynford-Thomas, D.2
-
16
-
-
0028261160
-
Escape from senescence in human diploid fibroblasts induced directly by mutant p53
-
Bond J.A., Wyllie F.S., Wynford-Thomas D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene. 9:1994;1885-1889.
-
(1994)
Oncogene
, vol.9
, pp. 1885-1889
-
-
Bond, J.A.1
Wyllie, F.S.2
Wynford-Thomas, D.3
-
17
-
-
0029024691
-
Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
-
Bond J.A., Blaydes J.P., Rowson J., Haughton M.F., Smith J.R., Wynford-Thomas D., Wyllie F.S. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1. Cancer Res. 55:1995;2404-2409.
-
(1995)
Cancer Res.
, vol.55
, pp. 2404-2409
-
-
Bond, J.A.1
Blaydes, J.P.2
Rowson, J.3
Haughton, M.F.4
Smith, J.R.5
Wynford-Thomas, D.6
Wyllie, F.S.7
-
18
-
-
0028340020
-
SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence
-
Rubelj I., Pereira-Smith O.M. SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence. Exp. Cell Res. 211:1994;82-89.
-
(1994)
Exp. Cell Res.
, vol.211
, pp. 82-89
-
-
Rubelj, I.1
Pereira-Smith, O.M.2
-
19
-
-
0028946009
-
Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal, and SV40-transformed human fibroblasts
-
Tahara H., Sato E., Noda A., Ide T. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal, and SV40-transformed human fibroblasts. Oncogene. 10:1995;835-840.
-
(1995)
Oncogene
, vol.10
, pp. 835-840
-
-
Tahara, H.1
Sato, E.2
Noda, A.3
Ide, T.4
-
20
-
-
0029783722
-
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
-
Friedlander P., Haupt Y., Prives C., Oren M. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell Biol. 16:1996;4961-4971.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 4961-4971
-
-
Friedlander, P.1
Haupt, Y.2
Prives, C.3
Oren, M.4
-
21
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
Ludwig R.L., Bates S., Vousden K.H. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol. Cell Biol. 16:1996;4952-4960.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 4952-4960
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
22
-
-
0027450860
-
Direct growth stimulation of normal human epithelial cells by mutant p53
-
Wyllie F.S., Lemoine N.R., Barton C.M., Dawson T., Bond J.A., Wynford-Thomas D. Direct growth stimulation of normal human epithelial cells by mutant p53. Mol. Carcinogen. 7:1993;83-88.
-
(1993)
Mol. Carcinogen
, vol.7
, pp. 83-88
-
-
Wyllie, F.S.1
Lemoine, N.R.2
Barton, C.M.3
Dawson, T.4
Bond, J.A.5
Wynford-Thomas, D.6
-
23
-
-
0027958344
-
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
-
Lukas J., Pagano M., Staskova Z., Draetta G., Bartek J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene. 9:1994;707-718.
-
(1994)
Oncogene
, vol.9
, pp. 707-718
-
-
Lukas, J.1
Pagano, M.2
Staskova, Z.3
Draetta, G.4
Bartek, J.5
-
24
-
-
12644284504
-
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
-
Kitagawa M., Higashi H., Jung H.K., Suzuki-Takahashi I., Ikeda M., Tamai K., Kato J., Segawa K., Yoshida E., Nishimura S., Taya Y. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15:1996;7060-7069.
-
(1996)
EMBO J.
, vol.15
, pp. 7060-7069
-
-
Kitagawa, M.1
Higashi, H.2
Jung, H.K.3
Suzuki-Takahashi, I.4
Ikeda, M.5
Tamai, K.6
Kato, J.7
Segawa, K.8
Yoshida, E.9
Nishimura, S.10
Taya, Y.11
-
25
-
-
0031742097
-
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity
-
Alessi F., Quarta S., Savio M., Riva F., Rossi L., Stivala L.A., Scovassi A.I., Meijer L., Prosperi E. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp. Cell Res. 245:1998;8-18.
-
(1998)
Exp. Cell Res.
, vol.245
, pp. 8-18
-
-
Alessi, F.1
Quarta, S.2
Savio, M.3
Riva, F.4
Rossi, L.5
Stivala, L.A.6
Scovassi, A.I.7
Meijer, L.8
Prosperi, E.9
-
26
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
[in process citation]
-
Stein G.H., Drullinger L.F., Soulard A., Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell Biol. 19:1999;2109-2117. [in process citation].
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
27
-
-
0029811984
-
Genetic determinants of p53-induced apoptosis and growth arrest
-
Polyak K., Waldman T., He T.C., Kinzler K.W., Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10:1996;1945-1952.
-
(1996)
Genes Dev.
, vol.10
, pp. 1945-1952
-
-
Polyak, K.1
Waldman, T.2
He, T.C.3
Kinzler, K.W.4
Vogelstein, B.5
-
28
-
-
0028227197
-
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
-
Slingerland J.M., Hengst L., Pan C.H., Alexander D., Stampfer M.R., Reed S.I. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol. Cell Biol. 14:1994;3683-3694.
-
(1994)
Mol. Cell Biol.
, vol.14
, pp. 3683-3694
-
-
Slingerland, J.M.1
Hengst, L.2
Pan, C.H.3
Alexander, D.4
Stampfer, M.R.5
Reed, S.I.6
-
29
-
-
0032981481
-
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
-
[in process citation]
-
McConnell B.B., Gregory F.J., Stott F.J., Hara E., Peters G. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell Biol. 19:1999;1981-1989. [in process citation].
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 1981-1989
-
-
McConnell, B.B.1
Gregory, F.J.2
Stott, F.J.3
Hara, E.4
Peters, G.5
-
30
-
-
0027269711
-
Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
-
Lucibello F.C., Sewing A., Brusselbach S., Burger C., Muller R. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 105:1993;123-133.
-
(1993)
J. Cell Sci.
, vol.105
, pp. 123-133
-
-
Lucibello, F.C.1
Sewing, A.2
Brusselbach, S.3
Burger, C.4
Muller, R.5
-
31
-
-
0033573113
-
Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: Roles of p16, p21, and cyclin D1
-
Morisaki H., Ando A., Nagata Y., Pereira-Smith O., Smith J.R., Ikeda K., Nakanishi M. Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence roles of p16, p21, and cyclin D1 . Exp. Cell Res. 253:1999;503-510.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 503-510
-
-
Morisaki, H.1
Ando, A.2
Nagata, Y.3
Pereira-Smith, O.4
Smith, J.R.5
Ikeda, K.6
Nakanishi, M.7
-
32
-
-
0027532449
-
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro
-
Connell-Crowley L., Solomon M.J., Wei N., Harper J.W. Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. Mol. Biol. Cell. 4:1993;79-92.
-
(1993)
Mol. Biol. Cell
, vol.4
, pp. 79-92
-
-
Connell-Crowley, L.1
Solomon, M.J.2
Wei, N.3
Harper, J.W.4
-
33
-
-
0029767016
-
Structural basis of cyclin-dependent kinase activation by phosphorylation
-
Russo A.A., Jeffrey P.D., Pavletich N.P. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3:1996;696-700.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 696-700
-
-
Russo, A.A.1
Jeffrey, P.D.2
Pavletich, N.P.3
-
34
-
-
0028950016
-
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2, Mol
-
Desai D., Wessling H.C., Fisher R.P., Morgan D.O. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2, Mol. Cell Biol. 15:1995;345-350.
-
(1995)
Cell Biol.
, vol.15
, pp. 345-350
-
-
Desai, D.1
Wessling, H.C.2
Fisher, R.P.3
Morgan, D.O.4
-
35
-
-
0026713875
-
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
-
Gu Y., Rosenblatt J., Morgan D.O. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11:1992;3995-4005.
-
(1992)
EMBO J.
, vol.11
, pp. 3995-4005
-
-
Gu, Y.1
Rosenblatt, J.2
Morgan, D.O.3
|