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Volumn 285, Issue 2, 2003, Pages 236-242

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21WAF1 expression

Author keywords

Cdk2; Cell cycle; P21; P53; Replicative senescence

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; M PROTEIN; MUTANT PROTEIN; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 0037403348     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00050-8     Document Type: Article
Times cited : (15)

References (35)
  • 1
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 2
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
    • Wright W.E., Pereira-Smith O.M., Shay J.W. Reversible cellular senescence implications for immortalization of normal human diploid fibroblasts . Mol. Cell Biol. 9:1989;3088-3092.
    • (1989) Mol. Cell Biol. , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 3
    • 0028322713 scopus 로고
    • SV40-induced immortalization of human cells
    • Bryan T.M., Reddel R.R. SV40-induced immortalization of human cells. Crit. Rev. Oncol. 5:1994;331-357.
    • (1994) Crit. Rev. Oncol. , vol.5 , pp. 331-357
    • Bryan, T.M.1    Reddel, R.R.2
  • 4
    • 0027263711 scopus 로고
    • E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts
    • Shay J.W., Wright W.E., Brasiskyte D., Van der Haegen B.A. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene. 8:1993;1407-1413.
    • (1993) Oncogene , vol.8 , pp. 1407-1413
    • Shay, J.W.1    Wright, W.E.2    Brasiskyte, D.3    Van der Haegen, B.A.4
  • 5
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 6
    • 0025150387 scopus 로고    scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein G.H., Beeson M., Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science. 249:1998;666-669.
    • (1998) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 7
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta D.A., Xiong Y., Phelps D., Hannon G., Beach D., Barrett J.C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA. 93:1996;13742-13747.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 8
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
    • Hara E., Smith R., Parry D., Tahara H., Stone S., Peters G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell Biol. 16:1996;859-867.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3    Tahara, H.4    Stone, S.5    Peters, G.6
  • 9
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 10
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • Brown J.P., Wei W., Sedivy J.M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:1999;831-834.
    • (1999) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 13
    • 0002888471 scopus 로고    scopus 로고
    • Telomere dynamics and telomerase activity in cell senescence and cancer
    • Bacchetti S. Telomere dynamics and telomerase activity in cell senescence and cancer. Cell Dev. Biol. 7:1996;31-39.
    • (1996) Cell Dev. Biol. , vol.7 , pp. 31-39
    • Bacchetti, S.1
  • 14
    • 0032912802 scopus 로고    scopus 로고
    • Control of replicative life span in human cells: Barriers to clonal expansion intermediate between M1 senescence and M2 crisis
    • Bond J.A., Haughton M.F., Rowson J.M., Smith P.J., Gire V., Wynford-Thomas D., Wyllie F.S. Control of replicative life span in human cells barriers to clonal expansion intermediate between M1 senescence and M2 crisis . Mol. Cell Biol. 19:1999;3103-3114.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 3103-3114
    • Bond, J.A.1    Haughton, M.F.2    Rowson, J.M.3    Smith, P.J.4    Gire, V.5    Wynford-Thomas, D.6    Wyllie, F.S.7
  • 15
    • 0031935827 scopus 로고    scopus 로고
    • Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
    • Gire V., Wynford-Thomas D. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell Biol. 18:1998;1611-1621.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 1611-1621
    • Gire, V.1    Wynford-Thomas, D.2
  • 16
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • Bond J.A., Wyllie F.S., Wynford-Thomas D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene. 9:1994;1885-1889.
    • (1994) Oncogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 18
    • 0028340020 scopus 로고
    • SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence
    • Rubelj I., Pereira-Smith O.M. SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence. Exp. Cell Res. 211:1994;82-89.
    • (1994) Exp. Cell Res. , vol.211 , pp. 82-89
    • Rubelj, I.1    Pereira-Smith, O.M.2
  • 19
    • 0028946009 scopus 로고
    • Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal, and SV40-transformed human fibroblasts
    • Tahara H., Sato E., Noda A., Ide T. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal, and SV40-transformed human fibroblasts. Oncogene. 10:1995;835-840.
    • (1995) Oncogene , vol.10 , pp. 835-840
    • Tahara, H.1    Sato, E.2    Noda, A.3    Ide, T.4
  • 20
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander P., Haupt Y., Prives C., Oren M. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell Biol. 16:1996;4961-4971.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 21
    • 0029742781 scopus 로고    scopus 로고
    • Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
    • Ludwig R.L., Bates S., Vousden K.H. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol. Cell Biol. 16:1996;4952-4960.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4952-4960
    • Ludwig, R.L.1    Bates, S.2    Vousden, K.H.3
  • 23
    • 0027958344 scopus 로고
    • Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
    • Lukas J., Pagano M., Staskova Z., Draetta G., Bartek J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene. 9:1994;707-718.
    • (1994) Oncogene , vol.9 , pp. 707-718
    • Lukas, J.1    Pagano, M.2    Staskova, Z.3    Draetta, G.4    Bartek, J.5
  • 25
    • 0031742097 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity
    • Alessi F., Quarta S., Savio M., Riva F., Rossi L., Stivala L.A., Scovassi A.I., Meijer L., Prosperi E. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp. Cell Res. 245:1998;8-18.
    • (1998) Exp. Cell Res. , vol.245 , pp. 8-18
    • Alessi, F.1    Quarta, S.2    Savio, M.3    Riva, F.4    Rossi, L.5    Stivala, L.A.6    Scovassi, A.I.7    Meijer, L.8    Prosperi, E.9
  • 26
    • 0033013980 scopus 로고    scopus 로고
    • Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
    • [in process citation]
    • Stein G.H., Drullinger L.F., Soulard A., Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell Biol. 19:1999;2109-2117. [in process citation].
    • (1999) Mol. Cell Biol. , vol.19 , pp. 2109-2117
    • Stein, G.H.1    Drullinger, L.F.2    Soulard, A.3    Dulic, V.4
  • 27
    • 0029811984 scopus 로고    scopus 로고
    • Genetic determinants of p53-induced apoptosis and growth arrest
    • Polyak K., Waldman T., He T.C., Kinzler K.W., Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10:1996;1945-1952.
    • (1996) Genes Dev. , vol.10 , pp. 1945-1952
    • Polyak, K.1    Waldman, T.2    He, T.C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 28
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
    • Slingerland J.M., Hengst L., Pan C.H., Alexander D., Stampfer M.R., Reed S.I. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol. Cell Biol. 14:1994;3683-3694.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 29
    • 0032981481 scopus 로고    scopus 로고
    • Induced expression of p16(INK4a) inhibits both CDK4- and CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
    • [in process citation]
    • McConnell B.B., Gregory F.J., Stott F.J., Hara E., Peters G. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell Biol. 19:1999;1981-1989. [in process citation].
    • (1999) Mol. Cell Biol. , vol.19 , pp. 1981-1989
    • McConnell, B.B.1    Gregory, F.J.2    Stott, F.J.3    Hara, E.4    Peters, G.5
  • 30
    • 0027269711 scopus 로고
    • Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
    • Lucibello F.C., Sewing A., Brusselbach S., Burger C., Muller R. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 105:1993;123-133.
    • (1993) J. Cell Sci. , vol.105 , pp. 123-133
    • Lucibello, F.C.1    Sewing, A.2    Brusselbach, S.3    Burger, C.4    Muller, R.5
  • 31
    • 0033573113 scopus 로고    scopus 로고
    • Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: Roles of p16, p21, and cyclin D1
    • Morisaki H., Ando A., Nagata Y., Pereira-Smith O., Smith J.R., Ikeda K., Nakanishi M. Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence roles of p16, p21, and cyclin D1 . Exp. Cell Res. 253:1999;503-510.
    • (1999) Exp. Cell Res. , vol.253 , pp. 503-510
    • Morisaki, H.1    Ando, A.2    Nagata, Y.3    Pereira-Smith, O.4    Smith, J.R.5    Ikeda, K.6    Nakanishi, M.7
  • 32
    • 0027532449 scopus 로고
    • Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro
    • Connell-Crowley L., Solomon M.J., Wei N., Harper J.W. Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. Mol. Biol. Cell. 4:1993;79-92.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 79-92
    • Connell-Crowley, L.1    Solomon, M.J.2    Wei, N.3    Harper, J.W.4
  • 33
    • 0029767016 scopus 로고    scopus 로고
    • Structural basis of cyclin-dependent kinase activation by phosphorylation
    • Russo A.A., Jeffrey P.D., Pavletich N.P. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3:1996;696-700.
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 696-700
    • Russo, A.A.1    Jeffrey, P.D.2    Pavletich, N.P.3
  • 34
    • 0028950016 scopus 로고
    • Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2, Mol
    • Desai D., Wessling H.C., Fisher R.P., Morgan D.O. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2, Mol. Cell Biol. 15:1995;345-350.
    • (1995) Cell Biol. , vol.15 , pp. 345-350
    • Desai, D.1    Wessling, H.C.2    Fisher, R.P.3    Morgan, D.O.4
  • 35
    • 0026713875 scopus 로고
    • Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
    • Gu Y., Rosenblatt J., Morgan D.O. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11:1992;3995-4005.
    • (1992) EMBO J. , vol.11 , pp. 3995-4005
    • Gu, Y.1    Rosenblatt, J.2    Morgan, D.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.