Computerized video time lapse study of cell cycle delay and arrest, mitotic catastrophe, apoptosis and clonogenic survival in irradiated 14-3-3σ and CDKN1A (p21) knockout cell lines

Radiation Research

Volumn 162, Issue 3, 2004, Pages 270-286

  Chu, Kenneth ^a   Teele, Noella ^a   Dewey, Michael W ^a   Albright, Norman ^a   Dewey, William C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL DEATH; CELL DIVISION; CELL SURVIVAL; CLONOGENIC ASSAY; COLORECTAL CARCINOMA; COMPUTER; CONTROLLED STUDY; DIPLOIDY; DNA CONTENT; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; MITOSIS; POLYPLOIDY; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RADIATION DOSE; VIDEORECORDING;

APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; EXONUCLEASES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICROSCOPY, VIDEO; MITOSIS; NEOPLASM PROTEINS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR STEM CELL ASSAY;

EID: 4644304152     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3221     Document Type: Article

References (46)

1. H. B. Forrester, N. Albright, C. C. Ling and W. C. Dewey, Computerized video time lapse (CVTL) analysis of apoptosis of REC:Myc cells X-irradiated in different phases of the cell cycle. Radiat. Res. 154, 625-639 (2000).
2. K. Chu, E. A. Leonhardt, M. Trinh, G. Prieur-Carrillo, J. Lindqvist, N. Albright, C. C. Ling and W. C. Dewey, Computerized video time lapse (CVTL) analysis of cell death kinetics in human bladder carcinoma cells (EJ30) X-irradiated in different phases of the cell cycle. Radiat. Res. 158, 667-677 (2002).
3. 2/M progression. Mol. Cell. 1, 3-11 (1997).
4. 1 arrest in human cancer cells. Cancer Res. 55, 5187-5190 (1995).
5. T. A. Chan, H. Hermeking, C. Lengauer, K. W. Kinsler and B. Vogelstein, 14-3-3σ is required to prevent mitotic catastrophe after DNA damage. Nature 401, 616-620 (1999).
6. 2/M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22, 1049-1059 (2002).
7. 2 checkpoint response to ionizing radiation. Cancer Res. 55, 2500-2502 (1995).
8. S. Okada, Cells. In Radiation Biochemistry, Vol. I (K. I. Altman, G. B. Gerber and S. Okada, Eds.), pp. 218-230 and 239-241. Academic Press, New York, 1970.
9. 2 arrest after DNA damage. Science 282, 1497-1501 (1998).
10. T Waldman, Y. G. Zhang, L. Dillehay, J. Yu, K. Kinzler, B. Vogelstein and J. Williams, Cell-cycle arrest versus cell death in cancer therapy. Nat. Med. 3, 1034-1036 (1997).
11. Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res. 57, 4703-4706 (1997).
12. H. B. Forrester, C. A. Vidair, N. Albright, C. C. Ling and W. C. Dewey, Using computerized video time lapse for quantifying cell death of X-irradiated rat embryo cells transfected with c-myc or c-Ha-ras. Cancer Res. 59, 931-939 (1999).
13. T. Waldman, C. Lengauer, K. W. Kinzler and B. Vogelstein, Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-716 (1996).
14. P. E. Swanson, S. B. Carroll, X. F. Zhang and M. A. Mackey, Spontaneous premature chromosome condensation, micronucleus formation and non-apoptotic cell death in heated HeLa S3 cells. Am. J. Pathol. 146, 963-971 (1995).
15. 1 arrest in resulting tetraploid cells. Cancer Res. 61, 7660-7668 (2001).
16. 2 M checkpoint. Genes Dev. 14, 1594-1598 (2000).
17. F. Bunz, C. Fauth, M. R. Speicher, A. Dutriaux, J. M. Sedivy, K. W. Kinzler, B. Vogelstein and C. Lengauer, Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res. 62, 1129-1133 (2002).
18. W. K. Sinclair, The relative biological effectiveness of 22-Mevp X-rays, cobalt-60 gamma rays and 200-Kvcp X-rays VII. Summary of studies for five criteria of effect. Radiat. Res. 16, 394-398 (1962).
19. M. M. Elkind and G. F. Whitmore, The Radiobiology of Cultured Mammalian Cells. Gordon and Breach, New York, 1967.
20. F. Ianzini and M. A. Mackey, Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells. Mutagenesis 13, 337-344 (1998).
21. D. Alvarez, O. Novac, M. Callejo, M. T. Ruiz, G. B. Price and M. Zannis-Hadjopoulos, 14-3-3σ is a cruciform DNA binding protein and associates in vivo with origins of DNA replication. J. Cell. Biochem. 87, 194-207 (2002).
22. 2/M regulator 14-3-3 sigma prevents apoptosis through sequestration of Bax. J. Biol. Chem. 276, 45201-45206 (2001).
23. 1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res. 54, 5054-5058 (1994).
24. J. S. Lanni and T. Jacks, Characterization of the p53-dependent post-mitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18, 1055-1064 (1998).
25. T. F. Burns, P. Fei, K. A. Scata, D. T. Dicker and W. S. El-Deiry, Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (Taxol)-exposed cells. Mol. Cell. Biol. 23, 5556-5571 (2003).
26. B. D. Chang, Y. Z. Xuan, E. V. Broude, H. M. Zhu, B. Schott, J. Fang and I. B. Roninson, Role of p53 and p21(Waf1/cip1) in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 18, 4808-4818 (1999).
27. 2-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445-3450 (2001).
28. H. M. Hut, W. Lemstra, E. H. Blaauw, G. W. Van Cappellen, H. H. Kampinga and O. C. Sibon, Centrosomes split in the presence of impaired DNA integrity during mitosis. Mol. Biol. Cell. 14, 1993-2004 (2003).
29. N. Sato, K. Mizumoto, M. Nakamura, H. Ueno, Y. A. Minamishima, J. L. Farber and M. Tanaka, A possible role for centrosome over-duplication in radiation-induced cell death. Oncogene 19, 5281-5290 (2000).
30. W. C. Dewey, H. H. Miller and D. P. Leeper, Chromosomal aberrations and mortality of x-irradiated mammalian cells: Emphasis on repair. Proc. Natl. Acad. Sci. USA 68, 667-671 (1971).
31. A. V. Carrano, Chromosome aberrations and radiation induced cell death. II. Predicted and observed cell survival. Mutat. Res. 17, 355-366 (1973).
32. G. P. Joshi, W. J. Nelson, S. H. Revell and C. A. Shaw, X-ray-induced chromosome damage in live mammalian cells and improved measurements of its effects on their colony forming ability. Int. J. Radiat. Biol. 41, 161-181 (1982).
33. M. N. Cornforth and J. S. Bedford, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Radiat. Res. 111, 385-405 (1987).
34. K. Rothkamm, I. Kruger, L. H. Thompson and M. Lobrich, Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 23, 5706-5015 (2003).
35. 1 tetraploidy checkpoint and the suppression of tumorigenesis. J. Cell Biochem. 88, 673-683 (2003).
36. A. Sgura, A. Antoccia, R. Cherubini and C. Tanzarella, Chromosome nondisjunction and loss induced by protons and X rays in primary human fibroblasts: Role of centromeres in aneuploidy. Radiat. Res. 156, 225-231 (2001).
37. J. Pines and C. L. Rieder, Re-staging mitosis: A contemporary view of mitotic progression. Nat. Cell Biol. 3, E3-E6 (2001).
38. S. Hauf, I. C. Waizenegger and J. M. Peters, Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science 293, 1320-1323 (2001).
39. R. H. tePoele, A. L. Okorokov, L. Jardine, J. Cummings and S. P. Joel, DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62, 1876-1883 (2002).
40. -/-) human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. Radiat. Res. 160, 205-209 (2003).
41. C. Y. Guo, J. A. D'Anna, R. Li and J. M. Larner, The radiation-induced S-phase checkpoint is independent of CDKN1A. Radiat. Res. 151, 125-132 (1999).
42. R. G. Lock and L. Stribinskiene, Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res. 56, 4006-4012 (1996).
43. J. B. Brown and B. G. Wouters, Apoptosis, p53 and tumor cell sensitivity to anticancer agents. Cancer Res. 59, 1391-1399 (1999).
44. M. Los, M. Mozoluk, D. Ferrari, A. Stepczynska, C. Stroh, A. Renz, Z. Herceg, Z. Q. Wang and K. Schulze-Osthoff, Activation and caspase-mediated inhibition of PARP: A molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol. Biol. Cell 13, 978-988 (2002).
45. P. V. Jallepalli, C. Lengauer, B. Vogelstein and F. Bunz, The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278, 20475-20479 (2003).
46. M. Zeng, L. Narayanan, X. X. S. Xu, T. A. Prolla, R. M. Liskay and P. M. Glazer, Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Res. 60, 4889-4893 (2000).