The illusion of cell immortality

British Journal of Cancer

Volumn 83, Issue 7, 2000, Pages 841-846

  Hayflick, L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b School of Medicine   (United States)

Author keywords

Ageing; Cell senescence; Immortality; Longevity determination; Mortality; Telomerase; Telomeres

Indexed keywords

TELOMERASE;

CANCER CELL; CELL AGING; CELL CULTURE; CELL DIVISION; CELL IMMORTALIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SHORT SURVEY; SOMATIC CELL; TELOMERE;

EID: 0033834612     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2000.1296     Document Type: Short Survey

References (59)

1. Telomere length predicts replicative capacity of human fibroblasts
2. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
3. Extension of life span by introduction of telomerase into normal human cells
4. Replicative senescence and cell immortality: The role of telomeres and telomemse
5. Variability of the telomeres of the X/Y pseudoautosomal region
6. Growth and development in clonal plant populations
7. Telomere shortening associated with chromosome instability is arrested in immortal Cells which express telomerase activity
8. For better or worse? Telomerase inhibition and cancer
9. Structure and variability of human chromosome ends
10. Production of malignancy in vitro
11. The RNA component of human telomerase
12. Telomeres and senescence: The history, the experiment, the future
13. Identification of a specific telomere terminal transferase enzyme with two kinds of primer specificity
14. Telomeres shorten during ageing of human fibrobtasts
15. Telomere reduction in human colorectal carcinoma and with ageing
16. The limited in vitro lifetime of human diploid cell strains
17. Cell Aging
18. Mortality and immortalily at the cellular level: A review
19. How and why we age
20. A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy
21. The serial cultivation of human diploid cell strains
22. Telomere DNA structure
23. Teloraerase in 'immortal' fish
24. Continuous cultures of fused cells secreting antibody of predefined specificity
25. Spontaneous immortalization rate of cultured Chinese hamster cells
26. Telomere end-replication problem and cellular aging
27. Instability and decay of the primary structure of DNA
28. A comparative biology of cell immortalization
29. How clonal are bacteria?
30. The stability of broken ends of chromosomes in Zea mays
31. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
32. A highly conserved repetitive DNA sequence (TTAGGG)n, present at the telomeres of human chromosomes
33. Cellular aging studied by the reconstruction of replicating cells from nuclei and cytoplasms isolated from normal human diploid cells
34. The remakiug of chromosomes
35. Telomerase catalytic subunit homologs from fission yeast and humans
36. The correlation between the size of Finnish bracken (Pteridium aquilinum [L.] Kuhn.) Clones and certain periods of site history
37. Principles of marginotomy in template synthesis of polynucleotides
38. A theory of marginotomy: The incomplete copying of template margin in enzyme synthesis of polynucleotides and biological significance of the problem
39. Telomeres, telomerase and aging: Origin of the theory
40. Genetic diseases and gene knockouts reveal diverse connexin functions
41. Genetic approaches to the study of replicative senescence
42. Human cell transformation by simian vires 40. A review
43. Functional evidence for an RNA template in telomerase
44. Creosote bush: Long-lived clones in the Mohave Desert
45. Origin of concatemeric T7 DNA
46. Alexis Carrel and the mysticism of tissue culture
47. Dr. Carrel's immortal cells
48. The myth of cell immortality
49. Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblasts
50. Telomere positional effect and the regulation of cellular senescence
51. Telomere Shortening and apoptosis in telomerase-inhibited human tumor cells