Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells

Clinical Cancer Research

Volumn 5, Issue 8, 1999, Pages 2140-2147

  Kusumoto, Masahiro ^a   Ogawa, Takahiro ^a   Mizumoto, Kazuhiro ^a   Ueno, Hikaru ^a   Niiyama, Hideaki ^a   Sato, Norihiro ^a   Nakamura, Masafumi ^a,b   Tanaka, Masao ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; PROTEIN P53; TELOMERASE; VIRUS VECTOR;

ADENOVIRUS; APOPTOSIS; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TARGETING; GENETIC TRANSDUCTION; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; APOPTOSIS; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; ETOPOSIDE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032792828     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Greider, C. W., and Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43: 405-413, 1985.
2. Morin, G. B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell, 59: 521-529, 1989.
3. Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256: 271-282, 1991.
4. Shay, J. W., Werbin, H., and Wright, W. E. Telomere shortening may contribute to aging and cancer: a perspective. Mol. Cell. Differ., 2: 1-21, 1994.
5. Harley, C. B., Futcher, A. B., and Greider, C. W. Telomere shorten during aging of human fibroblasts. Nature (Lond.), 345: 458-460. 1990.
6. Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., and Harley, C. B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA, 89: 10114-10118, 1992.
7. Kim, N. W., Piatyzek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Conviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
8. Hiyama, K., Hiyama, E., Ishioka, S., Yamakido, M., Inai, K., Gazdar, A. F., Piatyszek, M. A., and Shay, J. W. Telomerase activity in small-cell and non-small-cell lung cancers. J. Natl. Cancer Inst., 87: 895-903, 1995.
9. Suehara, N., Mizumoto, K., Muta, T., Tominaga, Y., Shimura, H., Kitajima, S., Hamasaki, N., Tsuneyoshi, M., and Tanaka, M. Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. Clin. Cancer Res., 3: 993-998, 1997.
10. Suehara, N., Mizumoto, K., Tanaka, M., Niiyama, H., Yokohata, K., Tominaga, Y., Shimura, H., Muta, T., and Hamasaki, N. Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis. Clin. Cancer Res., 3: 2479-2483, 1997.
11. Landberg, G., Nielsen, N. H., Nilsson, P., Emdin, S. O., Cajander, J., and Roos, G. Telomerase activity is associated with cell cycle deregulation in human breast cancer. Cancer Res., 57: 549-554, 1997.
12. Zhu, X., Kumar, R., Mandal, M., Sharma, N., Sharma, H. W., Dhingra, U., Sokoloski, J. A., Hsiao, R., and Narayanan, R. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acid. Sci. USA, 93: 6091-6095, 1996.
13. Holt, S. E., Wright, W. E., and Shay, J. W. Regulation of telomerase activity in immortal cell lines. Mol. Cell. Biol., 16: 2932-2939, 1996.
14. Hande, M. P., Balajee, A. S., and Natarajan, A. T. Induction of telomerase activity by UV-irradiation in Chinese hamster cells. Oncogene, 15: 1747-1752, 1997.
15. Holt, S. E., Aisner, D. L., Shay, J. W., and Wright, W. E. Lack of cell cycle regulation of telomerase activity in human cells. Proc. Natl. Acad. Sci. USA, 94: 10687-10692, 1997.
16. Belair, C. D., Yeager, T. R., Lopez, P. M., and Reznikoff, C. A. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc. Natl. Acad. Sci. USA, 94: 13677-13682, 1997.
17. Faraoni, I., Turriziani, M., Masci, G., De Vecchis, L., Shay, J. W., Bonmassar, E., and Graziani, G. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro. Clin. Cancer Res., 3: 579-585, 1997.
18. Barton, C. M., Staddon, S. L., Hughes, C. M., Hall, P. A., O'Sullivan, C., Kloppel, G., Theis, B., Russell, R. C. G., Neoptolemos, J., Williamson, R. C. N., Lane, D. P., and Lemoine, N. R. Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer. Br. J. Cancer, 64: 1076-1082, 1991.
19. Scarpa, A., Capelli, P., Mukai, K., Zamboni, G., Oda, T., Iacono, C., and Hirohashi, S. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am. J. Pathol., 142: 1534-1543, 1993.
20. Aizawa, S., Sasaki, M., Wada, R., Koyama, M., and Yagihashi, S. p53 protein expression in pancreatic tumors and its relationship to clinicopathological factors and prognosis. J. Surg. Oncol., 62: 279-283, 1996.
21. Dergham, S. T., Dugan, M. C., Joshi, U. S., Chen, Y. C., Du, W., Smith, D. W., Arlauskas, P., Crissman, J. D., Vaitkevicius, V. K., and Sarkar, F. H. The clinical significance of p21(WAF1/CIP-1) and p53 expression in pancreatic adenocarcinoma. Cancer (Phila.), 80: 372-381, 1997.
22. 1 cyclin-dependent kinases. Cell, 75: 817-825, 1993.
23. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
24. Miyashita, T., Krajewska, S., Wang, H. G., Lin, H. K., Liebermann, D. A., Hoffman, B., and Reed, J. C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9: 1799-1805, 1994.
25. Gollahon, L. S., Kraus, E., Wu, T. A., Yim, S. O., Strong, L. C., Shay, J. W., and Tainsky, M. A. Telomerase activity during spontaneous immortalizaton of Li-Fraumeni syndrome skin fibroblasts. Oncogene, 17: 709-717, 1998.
26. Mukhopadhyay, T., Multani, A. S., Roth, J. A., and Pathak, S. Reduced telomeric signals and increased telomeric associations in human lung cancer cell lines undergoing p53-mediated apoptosis. Oncogene, 17: 901-906, 1998.
27. Maxwell, S. A., Capp, D., and Acosta, S. A. Telomerase activity in immortalized endothelial cells undergoing p53-mediated apoptosis. Biochem. Biophys. Res. Commun., 241: 642-645, 1997.
28. Iguchi, H., Morita, D., Yasuda, D., Takayanagi, R., Ikeda, Y., Takada, Y., Shimazoe, T., Nawata, H., and Kono, A. Alterations of the p53 tumor suppressor gene and Ki-ras oncogene in human pancreatic cancer-derived cell lines with different metastatic potential. Oncol. Rep., 1: 1223-1227, 1994.
29. 5 may predict the susceptibility to adenovirus-mediated gene transfer in human lung cancer cells. Gene Ther., 5: 361-368, 1998.
30. Ueno, H., Masuda, S., Nishio, S., Li, J. J., Yamamoto, H., and Takeshita, A. Adenovirus-mediated transfer of cyclin-dependent kinase inhibitor-p21 suppresses neointimal formation in the balloon-injured rat carotid arteries in vivo. Ann. N. Y. Acad. Sci., 811: 401-411, 1997.
31. Ueno, H., Li, J. J., Tomita, H., Yamamoto, H., Pan, Y., Kanegae, Y., Saito, I., and Takeshita, A. Quantitative analysis of repeat adenovirus-mediated gene transfer into injured canine femoral arteries. Arterioscl. Thromb. Vasc. Biol., 15: 2246-2253, 1995.
32. Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., and Saito, I. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA, 93: 1320-1324, 1996.
33. Ueno, H., Yamamoto, H., Ito, S., Li, J. J., and Takeshita, A. Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. Arterioscl. Thromb. Vasc. Biol., 17: 898-904, 1997.
34. Ueno, H., Li, J. J., Masuda, S., Qi, Z., Yamamoto, H., and Takeshita, A. Adenovirus-mediated expression of the secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo. Arterioscl. Thromb. Vasc. Biol., 17: 2453-2460, 1997.
35. Niwa, H., Yamamura, K., and Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene, 108: 193-199, 1991.
36. Nieminen, A. L., Gores, G. J., Bond, J. M., Imberti, R., Herman, B., and Lemasters, J. J. A novel cytotoxicity screening assay using a multiwell fluorescence scanner. Toxicol. Appl. Pharmacol., 115: 147-155, 1992.
37. Chresta, C. M., Masters, J. R. W., and Hickman, J. A. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res., 56: 1834-1841, 1996.
38. Martens, U. M., Zijlmans, J. M. J. M., Poon, S. S. S., Dragowska, W., Yui, J., Chavez, E. A., Ward, R. K., and Lansdorp, P. M. Short telomeres on human chromosome 17p. Nat. Genet., 18: 76-80, 1998.
39. Hiyama, K., Ishioka, S., Shirotani, Y., Inai, K., Hiyama, E., Murakami, I., Isobe, T., Inamizu, T., and Yamakido, M. Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and Rb. Oncogene, 10: 937-944, 1995.
40. his). Oncogene, 12: 715-725, 1996.
41. Frazier, M. W., He, X., Wang, J., Gu, Z., Cleveland, J. L., and Zambetti, G. P. Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain. Mol. Cell. Biol., 18: 3735-3743, 1998.
42. Wang, J., Xie, L. Y., Allan, S., Beach, D., and Hannon, G. J. Myc activates telomerase. Genes Dev., 12: 1769-1774, 1998.
43. WAF1 gene expression. Mol. Carcinog., 21: 26-36, 1998.