-
3
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003;426:194-8.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
-
4
-
-
3342929538
-
DNA damage checkpoint kinase Chk2 triggers replicative senescence
-
Gire V, Roux P, Wynford-Thomas D, Brondello J-M, Dulic V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 2004;3:2554-63.
-
(2004)
EMBO J
, vol.3
, pp. 2554-2563
-
-
Gire, V.1
Roux, P.2
Wynford-Thomas, D.3
Brondello, J.-M.4
Dulic, V.5
-
5
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004;23:2919-33.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
6
-
-
0037042177
-
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: Association with cell senescence and tumour-promoting activities in stromal fibroblasts
-
Roninson IB. Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities in stromal fibroblasts. Cancer Lett 2002;179:1-14.
-
(2002)
Cancer Lett
, vol.179
, pp. 1-14
-
-
Roninson, I.B.1
-
7
-
-
85047694328
-
Cellular senescence in cancer treatment, friend or foe?
-
Kahlem P, Dorken B, Schmitt CA. Cellular senescence in cancer treatment, friend or foe? J Clin Invest 2004;113:169-74.
-
(2004)
J Clin Invest
, vol.113
, pp. 169-174
-
-
Kahlem, P.1
Dorken, B.2
Schmitt, C.A.3
-
8
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res 2003;63: 2705-15.
-
(2003)
Cancer Res
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
9
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003;3:155-68.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
10
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003;3:421-9.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
11
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004;432: 316-23.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
12
-
-
0141757504
-
P53 and radiation responses
-
Fei P, El Deiry WS. P53 and radiation responses. Oncogene 2003;22:5774-83.
-
(2003)
Oncogene
, vol.22
, pp. 5774-5783
-
-
Fei, P.1
El Deiry, W.S.2
-
13
-
-
1542353401
-
Control of apoptosis by p53
-
Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003;22: 9030-40.
-
(2003)
Oncogene
, vol.22
, pp. 9030-9040
-
-
Fridman, J.S.1
Lowe, S.W.2
-
14
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res 2000;60:5934-6.
-
(2000)
Cancer Res
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
15
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998;282:1893-7.
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
16
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000;14:289-300.
-
(2000)
Genes Dev
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
17
-
-
0035393594
-
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
-
Lukas C, Bartkova J, Latella L, et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res 2001;61:4990-3.
-
(2001)
Cancer Res
, vol.61
, pp. 4990-4993
-
-
Lukas, C.1
Bartkova, J.2
Latella, L.3
-
18
-
-
0033615647
-
Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
-
Tominaga K, Morisaki H, Kaneko Y, et al. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J Biol Chem 1999;274:31463-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 31463-31467
-
-
Tominaga, K.1
Morisaki, H.2
Kaneko, Y.3
-
19
-
-
0037795780
-
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation
-
Schwarz JK, Lovly CM, Piwnica-Worms H. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Mol Cancer Res 2003;1:598-609.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 598-609
-
-
Schwarz, J.K.1
Lovly, C.M.2
Piwnica-Worms, H.3
-
20
-
-
0036258583
-
Chk2 activation and phosphorylation-dependent oligomerization
-
Xu X, Tsvetkov LM, Stern DF. Chk2 activation and phosphorylation- dependent oligomerization. Mol Cell Biol 2002;22:4419-32.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4419-4432
-
-
Xu, X.1
Tsvetkov, L.M.2
Stern, D.F.3
-
21
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-7.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
22
-
-
3242883729
-
The p53 response to DNA damage
-
Meek DW. The p53 response to DNA damage. DNA Repair 2004;3:1049-56.
-
(2004)
DNA Repair
, vol.3
, pp. 1049-1056
-
-
Meek, D.W.1
-
23
-
-
0035815627
-
DNA damage induces p53-dependent down-regulation of hCHK1
-
Damia G, Sanchez Y, Erba E, Broggini M. DNA damage induces p53-dependent down-regulation of hCHK1. J Biol Chem 2001;276:10641-5.
-
(2001)
J Biol Chem
, vol.276
, pp. 10641-10645
-
-
Damia, G.1
Sanchez, Y.2
Erba, E.3
Broggini, M.4
-
25
-
-
0036479115
-
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
-
Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 2002;277:3247-57.
-
(2002)
J Biol Chem
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
26
-
-
18344369169
-
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
-
Mirza A, McGuirk M, Hockenberry TN, et al. Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway. Oncogene 2002;21:2613-22.
-
(2002)
Oncogene
, vol.21
, pp. 2613-2622
-
-
Mirza, A.1
McGuirk, M.2
Hockenberry, T.N.3
-
27
-
-
0036785525
-
DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells
-
Zhou M, Gu L, Li F, Zhu Y, Woods WG, Findley HW. DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells. J Pharmacol Exp Ther 2002;303:124-31.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 124-131
-
-
Zhou, M.1
Gu, L.2
Li, F.3
Zhu, Y.4
Woods, W.G.5
Findley, H.W.6
-
28
-
-
0029073142
-
Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
-
Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A 1995;92:5545-9.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5545-5549
-
-
Datto, M.B.1
Li, Y.2
Panus, J.F.3
Howe, D.J.4
Xiong, Y.5
Wang, X.F.6
-
29
-
-
0031450362
-
Activated cell cycle checkpoints in epirubicin-treated breast cancer cells studied by BrdUrd-flow cytometry
-
Hedenfalk IA, Baldetorp B, Borg A, Oredsson SM. Activated cell cycle checkpoints in epirubicin-treated breast cancer cells studied by BrdUrd-flow cytometry. Cytometry 1997;29:321-7.
-
(1997)
Cytometry
, vol.29
, pp. 321-327
-
-
Hedenfalk, I.A.1
Baldetorp, B.2
Borg, A.3
Oredsson, S.M.4
-
30
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao A, Kong YY, Matsuoka S, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 2000;287:1824-7.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
-
31
-
-
0033080402
-
Transcriptional regulation of the p21(WAF1/CIP1) gene
-
Gartel AL, Tyner AL. Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp Cell Res 1999;246:280-9.
-
(1999)
Exp Cell Res
, vol.246
, pp. 280-289
-
-
Gartel, A.L.1
Tyner, A.L.2
-
32
-
-
22244486020
-
Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: Checkpoint activation as a strategy against cancer
-
Chen CR, Wang W, Rogoff HA, Li X, Mang W, Li CJ. Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res 2005;65:6017-21.
-
(2005)
Cancer Res
, vol.65
, pp. 6017-6021
-
-
Chen, C.R.1
Wang, W.2
Rogoff, H.A.3
Li, X.4
Mang, W.5
Li, C.J.6
-
33
-
-
0038013875
-
Senescence, apoptosis and therapy-cutting the lifelines of cancer
-
Schmitt CA. Senescence, apoptosis and therapy-cutting the lifelines of cancer. Nat Rev Cancer 2003;3:286-95.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 286-295
-
-
Schmitt, C.A.1
-
34
-
-
0037013154
-
INK4a contributes to the outcome of cancer therapy
-
INK4a contributes to the outcome of cancer therapy. Cell 2002;109: 335-46.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
-
35
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002;62: 1876-83.
-
(2002)
Cancer Res
, vol.62
, pp. 1876-1883
-
-
Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
36
-
-
0034183694
-
Retroviral delivery of peptide modulators of cellular functions
-
Lorens JB, Bennett MK, Pearsall DM, et al. Retroviral delivery of peptide modulators of cellular functions. Mol Ther 2000;1:438-47.
-
(2000)
Mol Ther
, vol.1
, pp. 438-447
-
-
Lorens, J.B.1
Bennett, M.K.2
Pearsall, D.M.3
-
37
-
-
0003059314
-
-
Coligan RCJE, Kruisbeek A, Margulies DH, Shevach EM, Strober W, editors. Vol. 10.17C. New York: Wiley
-
Swift SE, Lorens JB, Achacoso P, Nolan GP. Current protocols in immunology. In: Coligan RCJE, Kruisbeek A, Margulies DH, Shevach EM, Strober W, editors. Vol. 10.17C. New York: Wiley; 1999. p. 1-17.
-
(1999)
Current Protocols in Immunology
, pp. 1-17
-
-
Swift, S.E.1
Lorens, J.B.2
Achacoso, P.3
Nolan, G.P.4
-
38
-
-
0021833387
-
Flow cytometric DNA analysis
-
Vindelov LL. Flow cytometric DNA analysis. Eur J Respir Dis 1985;66:313-4.
-
(1985)
Eur J Respir Dis
, vol.66
, pp. 313-314
-
-
Vindelov, L.L.1
-
39
-
-
0037310955
-
Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin
-
De Schepper S, Bruwiere H, Verhulst T, et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther 2003;304:881-8.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 881-888
-
-
De Schepper, S.1
Bruwiere, H.2
Verhulst, T.3
-
40
-
-
0031922432
-
RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis
-
Kockx MM, Muhring J, Knaapen MW, De Meyer GR. RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis. Am J Pathol 1998;152:885-8.
-
(1998)
Am J Pathol
, vol.152
, pp. 885-888
-
-
Kockx, M.M.1
Muhring, J.2
Knaapen, M.W.3
De Meyer, G.R.4
|