메뉴 건너뛰기




Volumn 16, Issue 3, 1998, Pages 1197-1206

Role of the p16 tumor suppressor gene in cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 0344301900     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.3.1197     Document Type: Article
Times cited : (614)

References (133)
  • 1
    • 0027967944 scopus 로고
    • Rules to replicate by
    • Heichman KA, Roberts JM: Rules to replicate by. Cell 79:557-560, 1994
    • (1994) Cell , vol.79 , pp. 557-560
    • Heichman, K.A.1    Roberts, J.M.2
  • 2
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter T, Pines J: Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 79:573-576, 1994
    • (1994) Cell , vol.79 , pp. 573-576
    • Hunter, T.1    Pines, J.2
  • 3
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and CDK inhibitors in human cancer
    • Hall M, Peters G: Genetic alterations of cyclins, cyclin-dependent kinases, and CDK inhibitors in human cancer. Adv Cancer Res 68:67-108, 1996
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 4
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, et al: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756, 1994
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3
  • 5
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in the genesis of many tumor types
    • Kamb A, Gruis NA, Weaver-Feldhaus J, et al: A cell cycle regulator potentially involved in the genesis of many tumor types. Science 264:436-437, 1994
    • (1994) Science , vol.264 , pp. 436-437
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3
  • 6
    • 0028033422 scopus 로고
    • Rates of p16 (MTS1) mutations in primary tumors with 9p loss
    • Cairns P, Mao L, Merlo A, et al: Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science 265:415-417, 1994
    • (1994) Science , vol.265 , pp. 415-417
    • Cairns, P.1    Mao, L.2    Merlo, A.3
  • 7
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-707, 1993
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 9
    • 0028013327 scopus 로고
    • Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p and evidence for genetic heterogeneity
    • Goldstein AM, Dracopoli NC, Engelstein M, et al: Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p and evidence for genetic heterogeneity. Am J Hum Genet 54:489-496, 1994
    • (1994) Am J Hum Genet , vol.54 , pp. 489-496
    • Goldstein, A.M.1    Dracopoli, N.C.2    Engelstein, M.3
  • 10
    • 0028566386 scopus 로고
    • Genetic heterogeneity in familial malignant melanoma
    • MacGeoch C, Bishop JA, Bataille V, et al: Genetic heterogeneity in familial malignant melanoma. Hum Mol Genet 3:2195-2200, 1994
    • (1994) Hum Mol Genet , vol.3 , pp. 2195-2200
    • MacGeoch, C.1    Bishop, J.A.2    Bataille, V.3
  • 12
    • 0029009926 scopus 로고
    • Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
    • Gruis NA, van der Velden PA, Sandkuijl LA, et al: Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nature Genet 10:351-353, 1995
    • (1995) Nature Genet , vol.10 , pp. 351-353
    • Gruis, N.A.1    Van Der Velden, P.A.2    Sandkuijl, L.A.3
  • 14
    • 0028197612 scopus 로고
    • Homozygous deletion of 9p21 in primary human bladder tumors detected by comparative multiple polymerase chain reaction
    • Cairns P, Tokino K, Eby Y, et al: Homozygous deletion of 9p21 in primary human bladder tumors detected by comparative multiple polymerase chain reaction. Cancer Res 54:1422-1424, 1994
    • (1994) Cancer Res , vol.54 , pp. 1422-1424
    • Cairns, P.1    Tokino, K.2    Eby, Y.3
  • 15
    • 0029091503 scopus 로고
    • Frequency of homozygous deletion at p16/CDKN2 in primary human tumors
    • Cairns P, Poladcik TJ, Eby Y, et al: Frequency of homozygous deletion at p16/CDKN2 in primary human tumors. Nature Genet 11:210-212, 1995
    • (1995) Nature Genet , vol.11 , pp. 210-212
    • Cairns, P.1    Poladcik, T.J.2    Eby, Y.3
  • 16
    • 0028641184 scopus 로고
    • Mutation rate of the CDKN2 gene in malignant gliomas
    • Giani C, Finocchiaro G: Mutation rate of the CDKN2 gene in malignant gliomas. Cancer Res 54:6338-6339, 1994
    • (1994) Cancer Res , vol.54 , pp. 6338-6339
    • Giani, C.1    Finocchiaro, G.2
  • 17
    • 0028618304 scopus 로고
    • Deletion of p16 and p15 genes in brain tumors
    • Jen J, Harper JW, Bigner SH, et al: Deletion of p16 and p15 genes in brain tumors. Cancer Res 54:6353-6358, 1994
    • (1994) Cancer Res , vol.54 , pp. 6353-6358
    • Jen, J.1    Harper, J.W.2    Bigner, S.H.3
  • 18
    • 0028018501 scopus 로고
    • MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p
    • Ueki K, Rubio M-P, Ramesh V, et al: MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p. Hum Mol Genetics 10:1841-1845, 1994
    • (1994) Hum Mol Genetics , vol.10 , pp. 1841-1845
    • Ueki, K.1    Rubio, M.-P.2    Ramesh, V.3
  • 19
    • 0028935143 scopus 로고
    • Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization
    • Dreyling MH, Bohlander SK, Adeyanju MO, et al: Detection of CDKN2 deletions in tumor cell lines and primary glioma by interphase fluorescence in situ hybridization. Cancer Res 55:984-988, 1995
    • (1995) Cancer Res , vol.55 , pp. 984-988
    • Dreyling, M.H.1    Bohlander, S.K.2    Adeyanju, M.O.3
  • 20
    • 0030032928 scopus 로고    scopus 로고
    • Mutations of the p16 gene in gliomas
    • Kyritsis AP, Zhang B, Zhang W, et al: Mutations of the p16 gene in gliomas. Oncogene 12:63-67, 1996
    • (1996) Oncogene , vol.12 , pp. 63-67
    • Kyritsis, A.P.1    Zhang, B.2    Zhang, W.3
  • 21
    • 0029156810 scopus 로고
    • Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas
    • Li Y-J, Hoang-Xuan K, Delattre J-Y, et al: Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas. Oncogene 11:597-600, 1995
    • (1995) Oncogene , vol.11 , pp. 597-600
    • Li, Y.-J.1    Hoang-Xuan, K.2    Delattre, J.-Y.3
  • 22
    • 0028930619 scopus 로고
    • MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme
    • Moulton T, Samara G, Chung W-Y, et al: MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme. Am J Path 146:613-619, 1995
    • (1995) Am J Path , vol.146 , pp. 613-619
    • Moulton, T.1    Samara, G.2    Chung, W.-Y.3
  • 23
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, et al: CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56:150-153, 1996
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3
  • 24
    • 0028897307 scopus 로고
    • Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas
    • Walker DG, Duan W, Popovic EA, et al: Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas. Cancer Res 55:20-23, 1995
    • (1995) Cancer Res , vol.55 , pp. 20-23
    • Walker, D.G.1    Duan, W.2    Popovic, E.A.3
  • 25
    • 0029967152 scopus 로고    scopus 로고
    • Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
    • Costello JF, Berger MS, Huang H-JS, et al: Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56:2405-2410, 1996
    • (1996) Cancer Res , vol.56 , pp. 2405-2410
    • Costello, J.F.1    Berger, M.S.2    Huang, H.-J.S.3
  • 26
    • 0029836267 scopus 로고    scopus 로고
    • Abnormalities of p16, p15 and CDK4 genes in recurrent malignant astrocytomas
    • Saxena A, Robertson JT, Ali IU: Abnormalities of p16, p15 and CDK4 genes in recurrent malignant astrocytomas. Oncogene 13:661-664, 1996
    • (1996) Oncogene , vol.13 , pp. 661-664
    • Saxena, A.1    Robertson, J.T.2    Ali, I.U.3
  • 27
    • 0030056824 scopus 로고    scopus 로고
    • Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas
    • Tsuzuki T, Tsunoda S, Sakaki T, et al: Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas. Cancer 78:287-293, 1996
    • (1996) Cancer , vol.78 , pp. 287-293
    • Tsuzuki, T.1    Tsunoda, S.2    Sakaki, T.3
  • 28
    • 0028138707 scopus 로고
    • Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
    • Zhang S-Y, Klein-Szanto AJP, Saute ER, et al: Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res 54:5050-5053, 1994
    • (1994) Cancer Res , vol.54 , pp. 5050-5053
    • Zhang, S.-Y.1    Klein-Szanto, A.J.P.2    Saute, E.R.3
  • 29
    • 0029034268 scopus 로고
    • Homozygous deletions and loss of expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors
    • Lydiatt WM, Murty VVVS, Davidson BJ, et al: Homozygous deletions and loss of expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors. Genes Chromosom Cancer 13:94-98, 1995
    • (1995) Genes Chromosom Cancer , vol.13 , pp. 94-98
    • Lydiatt, W.M.1    Murty, V.V.V.S.2    Davidson, B.J.3
  • 30
    • 9444255067 scopus 로고    scopus 로고
    • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma
    • Reed A, Califano J, Cairns P, et al: High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56:3630-3633, 1996
    • (1996) Cancer Res , vol.56 , pp. 3630-3633
    • Reed, A.1    Califano, J.2    Cairns, P.3
  • 31
    • 0029851041 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the p53, p21, and p16 genes in oral carcinomas of Indian betel quid chewers
    • Heinzel PA, Balaram P, Bernard H-U: Mutations and polymorphisms in the p53, p21, and p16 genes in oral carcinomas of Indian betel quid chewers. Int J Cancer 68:420-423, 1996
    • (1996) Int J Cancer , vol.68 , pp. 420-423
    • Heinzel, P.A.1    Balaram, P.2    Bernard, H.-U.3
  • 32
    • 0028338514 scopus 로고
    • Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinomas
    • Mori T, Miura K, Aoki T, et al: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinomas. Cancer Res 54:3396-3397, 1994
    • (1994) Cancer Res , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3
  • 33
    • 0028033270 scopus 로고
    • Mutations and altered expression of p16INK4 in human cancer
    • Okamoto A, Demetrick DJ, Spillane EA, et al: Mutations and altered expression of p16INK4 in human cancer. Proc Natl Acad Sci USA 91:11045-11049, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11045-11049
    • Okamoto, A.1    Demetrick, D.J.2    Spillane, E.A.3
  • 34
    • 0029938115 scopus 로고    scopus 로고
    • Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas
    • Esteve A, Martel-Planche G, Sylla BS, et al: Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas. Int J Cancer 66:301-304, 1996
    • (1996) Int J Cancer , vol.66 , pp. 301-304
    • Esteve, A.1    Martel-Planche, G.2    Sylla, B.S.3
  • 35
    • 9444268107 scopus 로고    scopus 로고
    • Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma
    • Maesawa C, Tamura G, Nishizuka S, et al: Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma. Cancer Res 56:3875-3878, 1996
    • (1996) Cancer Res , vol.56 , pp. 3875-3878
    • Maesawa, C.1    Tamura, G.2    Nishizuka, S.3
  • 36
    • 0028113974 scopus 로고
    • The MTS1 gene is frequently mutated in primary human esophageal tumors
    • Zhou X, Tarmin L, Yin J, et al: The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene 9:3737-3741, 1994
    • (1994) Oncogene , vol.9 , pp. 3737-3741
    • Zhou, X.1    Tarmin, L.2    Yin, J.3
  • 37
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS-1) gene in pancreatic adenocarcinoma
    • Caldas C, Hahn SA, da Costa LT, et al: Frequent somatic mutations and homozygous deletions of the p16 (MTS-1) gene in pancreatic adenocarcinoma. Nature Genet 8:27-32, 1994
    • (1994) Nature Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 38
    • 0028809606 scopus 로고
    • Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas
    • Bartsch D, Shevlin DW, Tung WS, et al: Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. Genes Chromosom Cancer 14:189-195, 1995
    • (1995) Genes Chromosom Cancer , vol.14 , pp. 189-195
    • Bartsch, D.1    Shevlin, D.W.2    Tung, W.S.3
  • 39
    • 0030043385 scopus 로고    scopus 로고
    • Deletion and mutation analyses of the p16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas
    • Huang L, Goodrow TL, Zhang S-Y, et al: Deletion and mutation analyses of the p16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res 56:1137-1141, 1996
    • (1996) Cancer Res , vol.56 , pp. 1137-1141
    • Huang, L.1    Goodrow, T.L.2    Zhang, S.-Y.3
  • 40
    • 0028853608 scopus 로고
    • Deletion of the p16 and p15 genes in human bladder tumors
    • Orlow I, Lacombe L, Hannon GJ, et al: Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst 87:1524-1529, 1995
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1524-1529
    • Orlow, I.1    Lacombe, L.2    Hannon, G.J.3
  • 41
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDNKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzales-Zulueta M, Bender CM, Yang AS, et al: Methylation of the 5′ CpG island of the p16/CDNKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531-4535, 1995
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzales-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3
  • 42
    • 0028879681 scopus 로고
    • Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors
    • Packenham JP, Taylor JA, Anna CH, et al: Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors. Mol Carcinog 14:147-151, 1995
    • (1995) Mol Carcinog , vol.14 , pp. 147-151
    • Packenham, J.P.1    Taylor, J.A.2    Anna, C.H.3
  • 43
    • 0029146575 scopus 로고
    • p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer
    • Williamson MP, Elder PA, Shaw ME, et al: p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer. Hum Mol Genet 4:1569-1577, 1995
    • (1995) Hum Mol Genet , vol.4 , pp. 1569-1577
    • Williamson, M.P.1    Elder, P.A.2    Shaw, M.E.3
  • 44
    • 0027960580 scopus 로고
    • p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma
    • Cheng JQ, Jhanwar SC, Klein WM, et al: p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res 54:5547-5551, 1994
    • (1994) Cancer Res , vol.54 , pp. 5547-5551
    • Cheng, J.Q.1    Jhanwar, S.C.2    Klein, W.M.3
  • 45
    • 0029155471 scopus 로고
    • Codeletion of p15 and p16 in primary malignant mesothelioma
    • Xiao S, Li D, Vijg J, et al: Codeletion of p15 and p16 in primary malignant mesothelioma. Oncogene 11:511-515, 1995
    • (1995) Oncogene , vol.11 , pp. 511-515
    • Xiao, S.1    Li, D.2    Vijg, J.3
  • 46
    • 0027938776 scopus 로고
    • INK4B) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphocytic leukemias
    • INK4B) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphocytic leukemias. Blood 84:4038-4044, 1994
    • (1994) Blood , vol.84 , pp. 4038-4044
    • Herbert, J.1    Cayuela, J.M.2    Berkeley, J.3
  • 47
    • 0027943835 scopus 로고
    • Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias
    • Ogawa S, Hirano N, Sato N, et al: Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood 84:2431-2435, 1994
    • (1994) Blood , vol.84 , pp. 2431-2435
    • Ogawa, S.1    Hirano, N.2    Sato, N.3
  • 48
    • 0029132295 scopus 로고
    • INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias
    • INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia 9:1240-1245, 1995
    • (1995) Leukemia , vol.9 , pp. 1240-1245
    • Delmer, A.1    Tang, R.2    Senamaud-Beaufort, C.3
  • 50
    • 0028985436 scopus 로고
    • p16 gene homozygous deletions in acute lymphoblastic leukemia
    • Quesnel B, Preudhomme C, Philippe N, et al: p16 gene homozygous deletions in acute lymphoblastic leukemia. Blood 85:657-663, 1995
    • (1995) Blood , vol.85 , pp. 657-663
    • Quesnel, B.1    Preudhomme, C.2    Philippe, N.3
  • 51
    • 0028900889 scopus 로고
    • Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • Sill H, Goldman JM, Cross NCP: Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 85:2013-2016, 1995
    • (1995) Blood , vol.85 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.P.3
  • 52
    • 0028967263 scopus 로고
    • Deletions and rearrangement of CDKN2 in lymphoid malignancy
    • Stranks G, Height SE, Mitchell D, et al: Deletions and rearrangement of CDKN2 in lymphoid malignancy. Blood 85:893-901, 1995
    • (1995) Blood , vol.85 , pp. 893-901
    • Stranks, G.1    Height, S.E.2    Mitchell, D.3
  • 53
    • 0029915461 scopus 로고    scopus 로고
    • Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia
    • Cayuela J-M, Madani A, Sanhes L, et al: Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Blood 85:2180-2186, 1996
    • (1996) Blood , vol.85 , pp. 2180-2186
    • Cayuela, J.-M.1    Madani, A.2    Sanhes, L.3
  • 54
    • 0030031325 scopus 로고    scopus 로고
    • Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic leukaemias
    • Guidal-Giroux C, Gerard B, Cave H, et al: Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic leukaemias. Br J Haematol 92:410-419, 1996
    • (1996) Br J Haematol , vol.92 , pp. 410-419
    • Guidal-Giroux, C.1    Gerard, B.2    Cave, H.3
  • 56
    • 0029881994 scopus 로고    scopus 로고
    • INK4A and p18, in childhood T-cell lineage acute lymphoblastic leukemias
    • INK4A and p18, in childhood T-cell lineage acute lymphoblastic leukemias. Leukemia 10:255-260, 1996
    • (1996) Leukemia , vol.10 , pp. 255-260
    • Iolascon, A.1    Faienza, M.F.2    Coppola, B.3
  • 57
    • 0029994588 scopus 로고    scopus 로고
    • Alterations of CDKN2 gene structure in childhood acute lymphoblastic leukemia: Mutations of CDKN2 are observed preferentially in T-lineage
    • Nakao M, Yokota S, Kaneko H, et al: Alterations of CDKN2 gene structure in childhood acute lymphoblastic leukemia: Mutations of CDKN2 are observed preferentially in T-lineage. Leukemia 10:249-254, 1996
    • (1996) Leukemia , vol.10 , pp. 249-254
    • Nakao, M.1    Yokota, S.2    Kaneko, H.3
  • 58
    • 0029869772 scopus 로고    scopus 로고
    • Mutational analysis of the p15 and p16 genes in acute leukaemias
    • Sill H, Aguiar RCT, Schmidt H, et al: Mutational analysis of the p15 and p16 genes in acute leukaemias. Br J Haematol 92:681-683, 1996
    • (1996) Br J Haematol , vol.92 , pp. 681-683
    • Sill, H.1    Aguiar, R.C.T.2    Schmidt, H.3
  • 59
    • 0029666314 scopus 로고    scopus 로고
    • Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood
    • Ohnishi H, Hanada R, Horibe K, et al: Homozygous deletions of p16/MTS1 and p15/MTS2 genes are frequent in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood. Leukemia 10:1104-1110, 1996
    • (1996) Leukemia , vol.10 , pp. 1104-1110
    • Ohnishi, H.1    Hanada, R.2    Horibe, K.3
  • 60
    • 0029758396 scopus 로고    scopus 로고
    • The CDKN2 gene alterations in various types of adult T-cell leukaemia
    • Uchida T, Kinoshita T, Watanabe T, et al: The CDKN2 gene alterations in various types of adult T-cell leukaemia. Br J Haematol 94:665-670, 1996
    • (1996) Br J Haematol , vol.94 , pp. 665-670
    • Uchida, T.1    Kinoshita, T.2    Watanabe, T.3
  • 61
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, et al: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525-4530, 1995
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3
  • 62
    • 0028024945 scopus 로고
    • Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4I (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small-cell lung carcinomas
    • Hayashi N, Sugimoto Y, Tsuchiya E, et al: Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4I (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small-cell lung carcinomas. Biochem Biophys Res Comm 202:1426-1430, 1994
    • (1994) Biochem Biophys Res Comm , vol.202 , pp. 1426-1430
    • Hayashi, N.1    Sugimoto, Y.2    Tsuchiya, E.3
  • 63
    • 0028987265 scopus 로고
    • INK4B/MTS2, and p18 genes in primary and metastatic lung cancer
    • INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 55:1448-1451, 1995
    • (1995) Cancer Res , vol.55 , pp. 1448-1451
    • Okamoto, A.1    Hussain, S.P.2    Hagiwara, K.3
  • 65
    • 0028955673 scopus 로고
    • In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small-cell lung cancers
    • Washimi O, Nagatake M, Osada H, et al: In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small-cell lung cancers. Cancer Res 55:514-517, 1995
    • (1995) Cancer Res , vol.55 , pp. 514-517
    • Washimi, O.1    Nagatake, M.2    Osada, H.3
  • 66
    • 0029032228 scopus 로고
    • Codeletion of p15 and p16 genes in primary non-small-cell lung carcinoma
    • Xiao S, Li D, Corson JM, et al: Codeletion of p15 and p16 genes in primary non-small-cell lung carcinoma. Cancer Res 55:2968-2971, 1995
    • (1995) Cancer Res , vol.55 , pp. 2968-2971
    • Xiao, S.1    Li, D.2    Corson, J.M.3
  • 67
    • 84871468059 scopus 로고    scopus 로고
    • Detailed deletion mapping at chromosome 9p21 in non-small-cell lung cancer by microsatellite analysis and fluorescence in situ hybridization
    • submitted
    • Okami K, Cairns P, Westra W, et al: Detailed deletion mapping at chromosome 9p21 in non-small-cell lung cancer by microsatellite analysis and fluorescence in situ hybridization. Int J Cancer (submitted).
    • Int J Cancer
    • Okami, K.1    Cairns, P.2    Westra, W.3
  • 68
    • 0027946010 scopus 로고
    • Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma
    • Ohta M, Nagai H, Shimizu M, et al: Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma. Cancer Res 54:5269-5272, 1994
    • (1994) Cancer Res , vol.54 , pp. 5269-5272
    • Ohta, M.1    Nagai, H.2    Shimizu, M.3
  • 69
    • 0029658666 scopus 로고    scopus 로고
    • INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
    • INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res 56:5023-5032, 1996
    • (1996) Cancer Res , vol.56 , pp. 5023-5032
    • Flores, J.F.1    Walker, G.J.2    Glendening, M.3
  • 70
    • 0029024708 scopus 로고
    • Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance of 9q and rare alterations involving 9p including CDKN2
    • Schultz DC, Vanderveer L, Buetow KH, et al: Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance of 9q and rare alterations involving 9p including CDKN2. Cancer Res 55:2150-2157, 1995
    • (1995) Cancer Res , vol.55 , pp. 2150-2157
    • Schultz, D.C.1    Vanderveer, L.2    Buetow, K.H.3
  • 71
    • 8044224019 scopus 로고    scopus 로고
    • Inactivation of p16/CDKN2 and p15/MTS2 genes in different histological types and clinical stages of primary ovarian tumors
    • Ichikawa Y, Yoshida S, Koyama Y, et al: Inactivation of p16/CDKN2 and p15/MTS2 genes in different histological types and clinical stages of primary ovarian tumors. Int J Cancer 69:466-470, 1996
    • (1996) Int J Cancer , vol.69 , pp. 466-470
    • Ichikawa, Y.1    Yoshida, S.2    Koyama, Y.3
  • 72
    • 0029763773 scopus 로고    scopus 로고
    • Sporadic CDKN2 (MTS1/p16INK4) gene alterations in human ovarian tumors
    • Schuyer M, van Staveren IL, Klijn JGM, et al: Sporadic CDKN2 (MTS1/p16INK4) gene alterations in human ovarian tumors. Brit J Cancer 74:1069-1073, 1996
    • (1996) Brit J Cancer , vol.74 , pp. 1069-1073
    • Schuyer, M.1    Van Staveren, I.L.2    Klijn, J.G.M.3
  • 73
    • 0030922573 scopus 로고    scopus 로고
    • Alteration of p16 and p15 genes in common epithelial ovarian tumors
    • Fujita M, Enomoto T, Haba T, et al: Alteration of p16 and p15 genes in common epithelial ovarian tumors. Int J Cancer 74:148-155, 1997
    • (1997) Int J Cancer , vol.74 , pp. 148-155
    • Fujita, M.1    Enomoto, T.2    Haba, T.3
  • 74
    • 0029664548 scopus 로고    scopus 로고
    • INK4a gene product in human pituitary tumors
    • INK4a gene product in human pituitary tumors. Cancer Res 56:2493-2496, 1996
    • (1996) Cancer Res , vol.56 , pp. 2493-2496
    • Woloschak, M.1    Yu, A.2    Xiao, J.3
  • 75
    • 0029118134 scopus 로고
    • Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - Relationship to amplification and mRNA levels of CDK4 and CCND1
    • Maelandsmo GM, Berner J-M, Florenes VA, et al: Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - Relationship to amplification and mRNA levels of CDK4 and CCND1. Br J Cancer 72:393-398, 1995
    • (1995) Br J Cancer , vol.72 , pp. 393-398
    • Maelandsmo, G.M.1    Berner, J.-M.2    Florenes, V.A.3
  • 76
    • 0029929274 scopus 로고    scopus 로고
    • Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma
    • Iolascon A, Faienza MF, Coppola B, et al: Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma. Genes Chromosom Cancer 15:217-222, 1996
    • (1996) Genes Chromosom Cancer , vol.15 , pp. 217-222
    • Iolascon, A.1    Faienza, M.F.2    Coppola, B.3
  • 77
    • 0029918497 scopus 로고    scopus 로고
    • Alterations of the p15, p16, and p18 genes in osteosarcoma
    • Miller CW, Aslo A, Campbell MJ, et al: Alterations of the p15, p16, and p18 genes in osteosarcoma. Cancer Genet Cytogenet 86:136-142, 1996
    • (1996) Cancer Genet Cytogenet , vol.86 , pp. 136-142
    • Miller, C.W.1    Aslo, A.2    Campbell, M.J.3
  • 78
    • 0029826439 scopus 로고    scopus 로고
    • Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan
    • Wu M-S, Lin Y-W, Sheu J-C, et al: Intragenic homozygous deletions of MTS1 gene in gastric cancer in Taiwan. Jpn J Cancer Res 87:1052-1055, 1996
    • (1996) Jpn J Cancer Res , vol.87 , pp. 1052-1055
    • Wu, M.-S.1    Lin, Y.-W.2    Sheu, J.-C.3
  • 80
    • 0028108985 scopus 로고
    • Data base of p53 gene somatic mutations in human tumors and cell lines
    • Hollstein M, Rice K, Greenblatt MS, et al: Data base of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res 22:3551-3555, 1994
    • (1994) Nucleic Acids Res , vol.22 , pp. 3551-3555
    • Hollstein, M.1    Rice, K.2    Greenblatt, M.S.3
  • 82
    • 0029060657 scopus 로고
    • Complex structure and regulation of the p16 (MTS1) locus
    • Stone S, Jiang P, Dayananth P, et al: Complex structure and regulation of the p16 (MTS1) locus. Cancer Res 55:2988-2994, 1995
    • (1995) Cancer Res , vol.55 , pp. 2988-2994
    • Stone, S.1    Jiang, P.2    Dayananth, P.3
  • 83
    • 0028158010 scopus 로고
    • Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia
    • Coleman A, Fountain JW, Nobori T, et al: Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia. Cancer Res 54:344-348, 1994
    • (1994) Cancer Res , vol.54 , pp. 344-348
    • Coleman, A.1    Fountain, J.W.2    Nobori, T.3
  • 84
  • 87
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird A: The essentials of DNA methylation. Cell 70:5-8, 1992
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird, A.1
  • 88
    • 0025223284 scopus 로고
    • Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa
    • Migeon BR: Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa. Genet Res 56:91-98, 1990
    • (1990) Genet Res , vol.56 , pp. 91-98
    • Migeon, B.R.1
  • 89
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li E, Beard C, Jaenisch R: Role for DNA methylation in genomic imprinting. Nature 366:362-365, 1993
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 90
    • 0028072991 scopus 로고
    • Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma
    • Herman JG, Latif F, Weng Y, et al: Silencing of the VHL tumor suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700-9704, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9700-9704
    • Herman, J.G.1    Latif, F.2    Weng, Y.3
  • 91
    • 0025891856 scopus 로고
    • Allele-specific hypermethylation of the retinoblastoma tumor suppressor gene
    • Sakai T, Toguchida J, Ohtani N, et al: Allele-specific hypermethylation of the retinoblastoma tumor suppressor gene. Am J Hum Genet 48:880-888, 1991
    • (1991) Am J Hum Genet , vol.48 , pp. 880-888
    • Sakai, T.1    Toguchida, J.2    Ohtani, N.3
  • 92
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor CDKN2/p16 in human cancers
    • Merlo A, Herman JG, Mao L, et al: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor CDKN2/p16 in human cancers. Nature Med 7:686-692, 1995
    • (1995) Nature Med , vol.7 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3
  • 93
    • 0029664606 scopus 로고    scopus 로고
    • INK4/MTS1 gene by a chromosome translocation t(9;14)(p21-22;q11) in an acute lymphoblastic leukemia of B-cell type
    • INK4/MTS1 gene by a chromosome translocation t(9;14)(p21-22;q11) in an acute lymphoblastic leukemia of B-cell type. Cancer Res 56:848-854, 1996
    • (1996) Cancer Res , vol.56 , pp. 848-854
    • Duro, D.1    Bernard, O.2    Valle, V.D.3
  • 94
    • 0025734356 scopus 로고
    • Human cyclin E: A new cyclin that interacts with two members of the CDC2 gene family
    • Koff A, Cross F, Fisher J, et al: Human cyclin E: A new cyclin that interacts with two members of the CDC2 gene family. Cell 66:1217-1228, 1991
    • (1991) Cell , vol.66 , pp. 1217-1228
    • Koff, A.1    Cross, F.2    Fisher, J.3
  • 95
    • 0025850767 scopus 로고
    • Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
    • Lew DJ, Dulic V, Reed SI: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66:1197-1206, 1991
    • (1991) Cell , vol.66 , pp. 1197-1206
    • Lew, D.J.1    Dulic, V.2    Reed, S.I.3
  • 96
    • 0027193034 scopus 로고
    • Cyclin-dependent regulation of G1 in mammalian fibroblasts
    • Ohtsubo M, Roberts JM: Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259:1908-1912, 1993
    • (1993) Science , vol.259 , pp. 1908-1912
    • Ohtsubo, M.1    Roberts, J.M.2
  • 97
    • 0027293137 scopus 로고
    • Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
    • Quelle DE, Ashman RA, Shurtleff SA, et al: Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev 7:1559-1571, 1993
    • (1993) Genes Dev , vol.7 , pp. 1559-1571
    • Quelle, D.E.1    Ashman, R.A.2    Shurtleff, S.A.3
  • 98
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ, Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163, 1995
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 99
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ: Cancer cell cycles. Science 274:1672-1677, 1996
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 100
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR: E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429, 1992
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 101
    • 0027301324 scopus 로고
    • Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation
    • Xiong Y, Zhang H, Beach D: Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7:1572-1583, 1993
    • (1993) Genes Dev , vol.7 , pp. 1572-1583
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 102
    • 0028869884 scopus 로고
    • Lack of cyclin D-CDK complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product
    • Parry D, Bates S, Mann DJ, et al: Lack of cyclin D-CDK complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product. EMBO J 14:503-511, 1995
    • (1995) EMBO J , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3
  • 103
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18 are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H, Roussei MF, Kato J-Y, et al: Novel INK4 proteins, p19 and p18 are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-2681, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussei, M.F.2    Kato, J.-Y.3
  • 104
    • 0028929988 scopus 로고
    • Replacement of the p16/CDKN2 gene suppresses human glioma cell growth
    • Arap W, Nishikawa R, Furnari FB, et al: Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res 55:1351-1354, 1995
    • (1995) Cancer Res , vol.55 , pp. 1351-1354
    • Arap, W.1    Nishikawa, R.2    Furnari, F.B.3
  • 105
    • 0029094704 scopus 로고
    • INK4 gene mediated by an adenovirus vector
    • INK4 gene mediated by an adenovirus vector. Cancer Res 55:3250-3253, 1995
    • (1995) Cancer Res , vol.55 , pp. 3250-3253
    • Jin, X.1    Nguyen, D.2    Zhang, W.-W.3
  • 106
    • 0029052951 scopus 로고
    • Tumor-derived p16 alleles encoding proteins defective in cell cycle inhibition
    • Koh J, Enders GH, Dynlacht BD, et al: Tumor-derived p16 alleles encoding proteins defective in cell cycle inhibition. Nature 375:506-510, 1995
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3
  • 108
    • 0028971961 scopus 로고
    • INK4A inactivation in non-small-cell lung cancer cell lines
    • INK4A inactivation in non-small-cell lung cancer cell lines. Cancer Res 55:6200-6209, 1995
    • (1995) Cancer Res , vol.55 , pp. 6200-6209
    • Shapiro, G.I.1    Park, J.E.2    Edwards, C.D.3
  • 109
    • 0029587551 scopus 로고    scopus 로고
    • Alternative reading frames of the INK4A tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle DE, Zindy F, Ashman RA, et al: Alternative reading frames of the INK4A tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000, 1996
    • (1996) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashman, R.A.3
  • 110
    • 9544251503 scopus 로고    scopus 로고
    • p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro
    • Liggett WH Jr, Sewell DA, Rocco J, et al: p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res 56:4119-4123, 1996
    • (1996) Cancer Res , vol.56 , pp. 4119-4123
    • Liggett W.H., Jr.1    Sewell, D.A.2    Rocco, J.3
  • 111
    • 0028582034 scopus 로고
    • INK/MTS2- related CDK6 inhibitor, correlates with wild-type pRb function
    • INK/MTS2- related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 8:2939-2952, 1994
    • (1994) Genes Dev , vol.8 , pp. 2939-2952
    • Guan, K.1    Jenkins, C.W.2    Li, Y.3
  • 112
    • 0028983491 scopus 로고
    • Growth suppression by p16/Ink4 requires functional retinoblastoma protein
    • Medema RH, Herrera RE, Lam F, et al: Growth suppression by p16/Ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci USA 92:6289-6293, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6289-6293
    • Medema, R.H.1    Herrera, R.E.2    Lam, F.3
  • 113
    • 0027985749 scopus 로고
    • E2F-4, a new member of the E2F gene family has oncogenic activity and associates with p107 in vivo
    • Beijersbergen RL, Kerkhoven RM, Zhu L, et al: E2F-4, a new member of the E2F gene family has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690, 1994
    • (1994) Genes Dev , vol.8 , pp. 2680-2690
    • Beijersbergen, R.L.1    Kerkhoven, R.M.2    Zhu, L.3
  • 114
    • 0027140404 scopus 로고
    • Cell cycle-specific association of E2F with the p130 E1A-binding protein
    • Cobrink D, Whyte P, Peeper DS, et al: Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404, 1993
    • (1993) Genes Dev , vol.7 , pp. 2392-2404
    • Cobrink, D.1    Whyte, P.2    Peeper, D.S.3
  • 115
    • 0027362625 scopus 로고
    • The retinoblastoma protein binds to a family of E2F transcription factors
    • Lees JA, Sito M, Vidal M, et al: The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol 13:7813-7825, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 7813-7825
    • Lees, J.A.1    Sito, M.2    Vidal, M.3
  • 116
    • 0009573792 scopus 로고    scopus 로고
    • Human p16β encodes a novel 14 kd protein and suppresses growth in vitro independently from pRB
    • abstr
    • Sewell DA, Liggett WH Jr, Yarborough WG, et al: Human p16β encodes a novel 14 kd protein and suppresses growth in vitro independently from pRB. Proc Am Assoc Can Res 38:80, 1997 (abstr)
    • (1997) Proc Am Assoc Can Res , vol.38 , pp. 80
    • Sewell, D.A.1    Liggett W.H., Jr.2    Yarborough, W.G.3
  • 117
    • 0015043748 scopus 로고
    • Mutation and cancer. Statistical study of retinoblastoma
    • Knudson AG Jr: Mutation and cancer. Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823, 1971
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson A.G., Jr.1
  • 118
    • 0028243879 scopus 로고
    • Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    • Wang TC, Cardiff RD, Zukerberg L, et al: Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369:699-671, 1994
    • (1994) Nature , vol.369 , pp. 699-1671
    • Wang, T.C.1    Cardiff, R.D.2    Zukerberg, L.3
  • 119
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    • Sicinski P, Donaher JL, Parker SB, et al: Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82:621-630, 1995
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1    Donaher, J.L.2    Parker, S.B.3
  • 120
    • 0030982897 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
    • Costello JF, Plass C, Arap W, et al: Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res 57:1250-1254, 1997
    • (1997) Cancer Res , vol.57 , pp. 1250-1254
    • Costello, J.F.1    Plass, C.2    Arap, W.3
  • 121
    • 0029664339 scopus 로고    scopus 로고
    • INK4a binging domain of CDK4 in familial melanoma
    • INK4a binging domain of CDK4 in familial melanoma. Nature Genet 12:97-99, 1996
    • (1996) Nature Genet , vol.12 , pp. 97-99
    • Zuo, L.1    Weger, J.2    Yang, Q.3
  • 122
    • 0027454445 scopus 로고
    • Coamplification of the CDK4 gene with MDM2, and GLI in human sarcomas
    • Khatib ZA, Matsushime H, Valentine M, et al: Coamplification of the CDK4 gene with MDM2, and GLI in human sarcomas. Cancer Res 53:5535-5541, 1993
    • (1993) Cancer Res , vol.53 , pp. 5535-5541
    • Khatib, Z.A.1    Matsushime, H.2    Valentine, M.3
  • 123
    • 0027978368 scopus 로고
    • Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2
    • Reifenberger G, Reifenberger J, Ichimura K, et al: Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res 54:4299-4303, 1994
    • (1994) Cancer Res , vol.54 , pp. 4299-4303
    • Reifenberger, G.1    Reifenberger, J.2    Ichimura, K.3
  • 124
    • 0030614944 scopus 로고    scopus 로고
    • INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
    • INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nature Med 3:313-319, 1997
    • (1997) Nature Med , vol.3 , pp. 313-319
    • Sandig, V.1    Brand, K.2    Herwig, S.3
  • 125
    • 0028226679 scopus 로고
    • Induction versus progression of brain tumor development: Differential functions for the pRB- and p53- targeting domains of simian virus 40 T antigen
    • Robles MTS, Symonds H, Chen J, et al: Induction versus progression of brain tumor development: Differential functions for the pRB- and p53- targeting domains of simian virus 40 T antigen. Mol Cell Biol 14:2686-2698, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 2686-2698
    • Robles, M.T.S.1    Symonds, H.2    Chen, J.3
  • 126
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 127
    • 9344247476 scopus 로고    scopus 로고
    • Genetic progression model for head and neck cancer: Implications for field cancerization
    • Califano J, van der Riet P, Westra W, et al: Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Res 56:2488-2492, 1996
    • (1996) Cancer Res , vol.56 , pp. 2488-2492
    • Califano, J.1    Van Der Riet, P.2    Westra, W.3
  • 128
    • 0029890863 scopus 로고    scopus 로고
    • Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6. but not E7, transformed human uroepithelial cells
    • Reznikoff CA, Yeager TR, Belair CD, et al: Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6. but not E7, transformed human uroepithelial cells. Cancer Res 56:2886-2890, 1996
    • (1996) Cancer Res , vol.56 , pp. 2886-2890
    • Reznikoff, C.A.1    Yeager, T.R.2    Belair, C.D.3
  • 129
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta DA, Xiong Y, Phelps D, et al: Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93:13742-13747, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3
  • 130
    • 0029670840 scopus 로고    scopus 로고
    • Regulation of p16 CDKN2 expression and its implication for cell immortalization and senescence
    • Hara E, Smith R, Parry D, et al: Regulation of p16 CDKN2 expression and its implication for cell immortalization and senescence. Mol Cell Biol 16:859-867, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 859-867
    • Hara, E.1    Smith, R.2    Parry, D.3
  • 133
    • 0029993450 scopus 로고    scopus 로고
    • Role of the Ink4a locus in tumor suppression and cell mortality
    • Serrano M, Lee H-W, Chin L, et al: Role of the Ink4a locus in tumor suppression and cell mortality. Cell 85:27-37, 1996
    • (1996) Cell , vol.85 , pp. 27-37
    • Serrano, M.1    Lee, H.-W.2    Chin, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.