Non-targeted bystander effects induced by ionizing radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 616, Issue 1-2, 2007, Pages 159-164

  Morgan, William F ^a   Sowa, Marianne B ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Bystander effects; Genomic instability; Ionizing radiation; Non targeted effects

Indexed keywords

DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DOUBLE STRANDED DNA; HELIUM; HISTONE H2AX; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; RAD51 PROTEIN; RAD51C PROTEIN; REPLICATION PROTEIN A; UNCLASSIFIED DRUG;

ALPHA RADIATION; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CELL COMMUNICATION; CELL PROLIFERATION; CHROMOSOME REARRANGEMENT; CYTOTOXICITY; DNA CLEAVAGE; DNA STRAND BREAKAGE; FIBROBLAST; GAP JUNCTION; GENE MUTATION; GENOMIC INSTABILITY; GLIOMA; HELIUM ION RADIATION; HOMOLOGOUS RECOMBINATION; HUMAN; IONIZING RADIATION; LOW ENERGY RADIATION; MICRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION CARCINOGENESIS; SISTER CHROMATID EXCHANGE; WILD TYPE;

ANIMALS; BYSTANDER EFFECT; CHROMOSOME ABERRATIONS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENOMIC INSTABILITY; HUMANS; MICE; RADIATION, IONIZING; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

EID: 33846834182     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2006.11.009     Document Type: Article

References (63)

1. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation. I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159 (2003) 567-580
2. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation. II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159 (2003) 581-596
3. Wright E.G., and Coates P.J. Untargeted effects of ionizing radiation: implications for radiation pathology. Mutat. Res. 597 (2006) 119-132
4. Gerashchenko B.I., and Howell R.W. Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with gamma-rays. Cytometry 56A (2003) 71-80
5. Azzam E.I., de Toledo S.M., Gooding T., and Little J.B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150 (1998) 497-504
6. Folkard M., Vojnovic B., Prise K.M., Bowey A.G., Locke R.J., Schettino G., and Michael B.D. A charged-particle microbeam. I. Development of an experimental system for targeting cells individually with counted particles. Int. J. Radiat. Biol. 72 (1997) 375-385
7. Randers-Pehrson G., Geard C.R., Johnson G., Elliston C.D., and Brenner D.J. The Columbia University single-ion microbeam. Radiat. Res. 156 (2001) 210-214
8. Sowa Resat M., and Morgan W.F. Microbeam developments and applications: a low linear energy transfer perspective. Cancer Metastasis Rev. 23 (2004) 323-331
9. Mothersill C., and Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71 (1997) 421-427
10. Komarova E.A., Diatchenko L., Rokhlin O.W., Hill J.E., Wang Z.J., Krivokrysenko V.I., Feinstein E., and Gudkov A.V. Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. Oncogene 17 (1998) 1089-1096
11. Gerashchenko B.I., and Howell R.W. Proliferative response of bystander cells adjacent to cells with incorporated radioactivity. Cytometry A 60 (2004) 155-164
12. Gerashchenko B.I., and Howell R.W. Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation. Cytometry A 66 (2005) 62-70
13. Iyer R., and Lehnert B.E. Factors underlying the cell growth-related bystander response to α-particles. Cancer Res. 60 (2000) 1290-1298
14. Iyer R., and Lehnert B.E. Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiat. Res. 157 (2002) 3-7
15. Iyer R., and Lehnert B.E. Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutat. Res. 503 (2002) 1-9
16. Sowa Resat M.B., and Morgan W.F. Radiation-induced genomic instability: a role for secreted soluble factors in communicating the radiation response to non-irradiated cells. J. Cell Biochem. 92 (2004) 1013-1019
17. Azzam E.I., de Toledo S.M., and Little J.B. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 473-478
18. Azzam E.I., de Toledo S.M., and Little J.B. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res. 63 (2003) 7128-7135
19. Glover D., Little J.B., Lavin M.F., and Gueven N. Low dose ionizing radiation-induced activation of connexin 43 expression. Int. J. Radiat. Biol. 79 (2003) 955-964
20. Little J.B. Cellular radiation effects and the bystander response. Mutat. Res. 597 (2006) 113-118
21. Mitchell S.A., Randers-Pehrson G., Brenner D.J., and Hall E.J. The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contact. Radiat. Res. 161 (2004) 397-401
22. Azzam E.I., de Toledo S.M., and Little J.B. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22 (2003) 7050-7057
23. Lehnert B.E., and Goodwin E.H. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 57 (1997) 2164-2171
24. Mothersill C., Stamato T.D., Perez M.L., Cummins R., Mooney R., and Seymour C.B. Involvement of energy metabolism in the production of 'bystander effects' by radiation. Br. J. Cancer 82 (2000) 1740-1746
25. Narayanan P.K., Goodwin E.H., and Lehnert B.E. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57 (1997) 3963-3971
26. Narayanan P.K., LaRue K.E., Goodwin E.H., and Lehnert B.E. Alpha particles induce the production of interleukin-8 by human cells. Radiat. Res. 152 (1999) 57-63
27. Shao C., Furusawa Y., Aoki M., Matsumoto H., and Ando K. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int. J. Radiat. Biol. 78 (2002) 837-844
28. Shao C., Stewart V., Folkard M., Michael B.D., and Prise K.M. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63 (2003) 8437-8442
29. Nagar S., Smith L.E., and Morgan W.F. Characterization of a novel epigenetic effect of ionizing radiation: the death inducing effect. Cancer Res. 63 (2003) 324-328
30. Mothersill C., Rea D., Wright E.G., Lorimore S.A., Murphy D., Seymour C.B., and O'Malley K. Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium. Carcinogenesis 22 (2001) 1465-1471
31. Johnson J.D., and Fleshner M. Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72. J. Leukoc. Biol. 79 (2006) 425-434
32. Ingber D.E. Cellular mechanotransduction: putting all the pieces together again. FASEB J. 20 (2006) 811-827
33. Nagasawa H., Cremesti A., Kolesnick R., Fuks Z., and Little J.B. Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res. 62 (2002) 2531-2534
34. King J.S., Phillips J.W., and Morgan W.F. The role of DNA double strand break rejoining in chromosome damage and repair. In: Obe G., and Natarajan A.T. (Eds). Chromosomal Alterations: Origin and Significance (1994), Springer-Verlag, Berlin 64-75
35. Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G., Bonner W.M., and Sedelnikova O.A. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24 (2005) 7257-7265
36. Yang H., Asaad N., and Held K.D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24 (2005) 2096-2103
37. Nagasawa H., Huo L., and Little J.B. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79 (2003) 35-41
38. Huo L., Nagasawa H., and Little J.B. HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156 (2001) 521-525
39. Nagasawa H., and Little J. Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutat. Res. 508 (2002) 121
40. Nagasawa H., Peng Y., Wilson P.F., Lio Y.C., Chen D.J., Bedford J.S., and Little J.B. Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiat. Res. 164 (2005) 141-147
41. Mothersill C., Seymour R.J., and Seymour C.B. Bystander effects in repair-deficient cell lines. Radiat. Res. 161 (2004) 256-263
42. Balajee A.S., Ponnaiya B., Baskar R., and Geard C.R. Induction of replication protein a in bystander cells. Radiat. Res. 162 (2004) 677-686
43. Morgan W.F. Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation. Oncogene 22 (2003) 7094-7099
44. Lorimore S.A., Coates P.J., and Wright E.G. Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 22 (2003) 7058-7069
45. Little J.B. Genomic instability and bystander effects: a historical perspective. Oncogene 22 (2003) 6978-6987
46. Lorimore S.A., Kadhim M.A., Pocock D.A., Papworth D., Stevens D.L., Goodhead D.T., and Wright E.G. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5730-5733
47. Kadhim M.A., Lorimore S.A., Hepburn M.D., Goodhead D.T., Buckle V.J., and Wright E.G. Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet 344 (1994) 987-988
48. Rees G.J., and Ross C.M. Abscopal regression following radiotherapy for adenocarcinoma. Br. J. Radiol. 56 (1983) 63-66
49. Ohba K., Omagari K., Nakamura T., Ikuno N., Saeki S., Matsuo I., Kinoshita H., Masuda J., Hazama H., Sakamoto I., and Kohno S. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 43 (1998) 575-577
50. Demaria S., Ng B., Devitt M.L., Babb J.S., Kawashima N., Liebes L., and Formenti S.C. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int. J. Radiat. Oncol. Biol. Phys. 58 (2004) 862-870
51. Khan M.A., Hill R.P., and Van Dyk J. Partial volume rat lung irradiation: an evaluation of early DNA damage. Int. J. Radiat. Oncol. Biol. Phys. 40 (1998) 467-476
52. Camphausen K., Moses M.A., Menard C., Sproull M., Beecken W.D., Folkman J., and O'Reilly M.S. Radiation abscopal antitumor effect is mediated through p53. Cancer Res. 63 (2003) 1990-1993
53. Lloyd D.C., and Moquet J.E. The clastogenic effect of irradiated human plasma. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 47 (1985) 433-444
54. Gemignani F., Ballardin M., Maggiani F., Rossi A.M., Antonelli A., and Barale R. Chromosome aberrations in lymphocytes and clastogenic factors in plasma detected in Belarus children 10 years after Chernobyl accident. Mutat. Res. 446 (1999) 245-253
55. Emerit I., Levy A., Cernjavski L., Arutyunyan R., Oganesyan N., Pogosian A., Mejlumian H., Sarkisian T., Gulkandanian M., Quastel M., et al. Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J. Cancer Res. Clin. Oncol. 120 (1994) 558-561
56. Pant G.S., and Kamada N. Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals. Hiroshima J. Med. Sci. 26 (1977) 149-154
57. Freeman S.M., Aboud C.N., Whartenby K.A., Packman C.H., Koeplin D.S., Moolten F.L., and Abraham G.N. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53 (1993) 5274-5283
58. Assefa Z., Van Laethem A., Garmyn M., and Agostinis P. Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors. Biochim. Biophys. Acta 1755 (2005) 90-106
59. Seymour C.B., and Mothersill C. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153 (2000) 508-511
60. Sawant S.G., Zheng W., Hopkins K.M., Randers-Pehrson G., Lieberman H.B., and Hall E.J. The radiation-induced bystander effect for clonogenic survival. Radiat. Res. 157 (2002) 361-364
61. Wu L.J., Randers-Pehrson G., Xu A., Waldren C.A., Geard C.R., Yu Z., and Hei T.K. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 4959-4964
62. Shao C., Folkard M., Michael B.D., and Prise K.M. Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 13495-13500
63. Lorimore S.A., Coates P.J., Scobie G.E., Milne G., and Wright E.G. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?. Oncogene 20 (2001) 7085-7095