Dietary lycopene: Its properties and anticarcinogenic effects

Comprehensive Reviews in Food Science and Food Safety

Volumn 7, Issue 3, 2008, Pages 255-270

  Singh, Preeti ^a   Goyal, G K ^a  

^a NATIONAL DAIRY RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CITRUS RETICULATA; LYCOPERSICON ESCULENTUM; TETRA;

EID: 48249090070     PISSN: 15414337     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1541-4337.2008.00044.x     Document Type: Review

References (252)

1. Abushita AA, Daood HG, Biacs PA. 2000. Change in carotenoids and antioxidant vitamin in tomato as a function of varietal and technological factors. J Agric Food Chem 48 : 2075 81.
2. Agarwal A, Shen H, Agarwal S, Rao AV. 2001. Lycopene content of tomato products: its stability, bioavailability and in vivo antioxidant properties. J Med Food 4 (1 9 15.
3. Agarwal S, Rao AV. 1998. Tomato lycopene and low-density lipoprotein oxidation: a human dietary intervention study. Lipids 33 (10 981 4.
4. Allen CM. 2000. Effects of the consumption of fresh and processed tomato products on blood and tissue lycopene concentrations PhD thesis]. Columbus, Ohio : The Ohio State Univ.
5. Allen CM, Smith AM, Clinton SK, Schwartz SJ. 2002. Tomato consumption increases lycopene isomer concentrations in breast milk and plasma of lactating women. J Am Diet Assoc 102 : 1257 62.
6. Ames BN, Gold LS, Willett WC. 1995. Causes and prevention of cancer. Proc Nat Acad Sci USA 92 (12 5258 65.
7. Anderson PA, Hein GL, Forshee RA, Storey ML. 2007. A case study in implementing the FDA's interim guidance for qualified health claims for consumption of tomatoes, tomato products, and/or lycopene and risk of prostate cancer. A Ceres white paper. College Park, Md. : Center for Food, Nutrition, and Agriculture Policy.
8. Anjos Ferreira AL, Yeum KJ, Russell RM, Krinsky NI, Tang G. 2003. Enzymatic and oxidative metabolites of lycopene. J Nutr Biochem 14 : 531 40.
9. Anonymous. 2001. Health watch: a pizza - just what the Doctor ordered! Belfast Newsl 5 : 1 3.
10. Anonymous. 2004. FDA reviews expanded claims on health benefits of certain foods. J Natl Cancer Inst 96 (16 1198 9.
11. Balestrieri ML, Prisco RD, Nicolaus B, Pari P, Schiano Moriello V, Strazzullo G, Iorio EL, Servillo L, Balestrieri C. 2004. Lycopene in association with α-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. Free Radical Biol Med 36 (8 1058 67.
12. Bankson DD, Countryman CJ, Collins SJ. 1991. Potentiation of the retinoic acid-induced differentiation of HL-60 cells by lycopene. Am J Clin Nutr 53 (Suppl 13 7.
13. Barber NJ, Barber J. 2002. Lycopene and prostate cancer. Prostate Cancer Prostatic Diseases 5 : 6 12.
14. Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW. 1993. Serum micronutrients and subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidermiological Biomarkers Prev 2 (4 335 9.
15. Beatty S, Boulton M, Koh HH, Murray IJ. 1999. Macular pigment and age-related macular degeneration. Br J Opthalmol 83 (4 867 77.
16. Ben-Shaul Y, Naftali Y. 1969. The development and ultrastructure of lycopene bodies in chromoplasts of lycopersicum esculentum. Protoplasma 67 (7 333 44.
17. Bertram JS, Pung A, Churley M, Kappock TJ, Wilkins LR, Cooney RV. 1991. Diverse carotenoids protect against chemically induced neoplastic transformation. Carcinogenesis 12 (4 671 8.
18. Bertram JS, King T, Fukishima L, Khachik F. 2000. Enhanced activity of an oxidation product of lycopene found in tomato products and human serum relevant to cancer prevention. In : Sen CK, Sies H, Baeuerle PA, editors. Antioxidant and redox regulation of genes. New York : Academic Press. p 409 24.
19. Bjelke F. 1974. Case-control study in Norway. Scand J Gastroenterol 9 (Suppl 31 42 8.
20. Block G. 1992. The data support a role for antioxidants in reducing cancer risk. Nutr Rev 50 (4 207 13.
21. Block G, Patterson B, Subar A. 1992. Fruits, vegetables and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18 (1 1 29.
22. Bohm V. 2002. Intestinal absorption of lycopene from different types of oleoresin capsules. J Food Sci 67 (5 1910 3.
23. Bohm V, Bitsch R. 1999. Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipids status and the antioxidant capacity of human plasma. Eur J Nutr 38 : 118 25.
24. Bohm F, Tinkler JH, Truscott TG. 1995. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nature Med 1 : 98 9.
25. Bohm F, Edge R, Burke M, Truscott TG. 2001. Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide-ROS components from cigarette smoke. J Photochem Photobiol B: Biol 64 (2-3 176 8.
26. Boileau TW, Boileau AC, Erdman JW Jr. 2002. Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med 227 (10 914 9.
27. Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW Jr., Clinton SK. 2003. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Instt 95 (21 1578 86.
28. Borel P, Tyssandier V, Mekki N, Grolier P, Rochette Y, Alexandre-Gouabau MC, Lairon D, Azais-Braesco V. 1998. Chylomicron β-carotene and retinyl palmitate responses are dramatically diminished when men ingest β-carotene with medium-chain rather than long-chain triglycerides. J Nutr 128 : 1361 7.
29. Brown MJ, Ferruzzi MG, Nguyen ML, Cooper DA, Eldridge AL, Schwartz SJ, White WS. 2004. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am J Clin Nutr 80 : 396 403.
30. Bushway RJ. 1985. Separation of carotenoids in fruits and vegetables by high performance liquid chromatography. J Liq Chromatogr 8 (2 1527 47.
31. Campbell JK, Canene-Adams K, Lindshield BL, Boileau TW, Clinton SK, Erdman JW Jr. 2004. Tomato phytochemicals and prostate cancer risk. J Nutr 134 : 3486S 92S.
32. Cano MP, Ancos B, Lobo G, Monreal M, De Ancos B. 1996. Effects of freezing and canning of papaya slices on their carotenoid composition. Zeits Lebensm Forsch 202 (5 279 84.
33. Castenmiller JJ, West CE, Linssen JP, van het Hof KH, Voragen AG. 1999. The food matrix of spinach is a limiting factor in determining the bioavailability of β-carotene and to a lesser extent of lutein in humans. J Nutr 129 (1 349 55.
34. Chandler LA, Schwartz SJ. 1988. Isomerization and losses of trans-β-carotene in sweet potatoes as affected by processing treatments. J Agric Food Chem 36 (1 129 33.
35. Chasse GA, Chasse KP, Kucsman A, Torday LL, Papp JG. 2001. Conformational potential energy surfaces of a lycopene model. J Mol Struct (Theochem) 571 (1 7 26.
36. Clinton SK. 1998. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56 (2 35 51.
37. Clinton SK. 1999. The dietary antioxidant network and prostate carcinoma. Cancer 86 (1, 9 1629 30.
38. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW. 1996. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidermiol Biomarkers Prev 5 (10 823 33.
39. Colditz GA, Branch LG, Lipnick RJ. 1985. Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr 41 (1 32 6.
40. Cole ER, Kapur NS. 1957a. The stability of lycopene. I. Degradation by oxygen. J Sci Food Agric 8 (1 360 5.
41. Cole ER, Kapur NS. 1957b. The stability of lycopene. II. Oxidation during heating of tomato pulps. J Sci Food Agric 8 (1 366 8.
42. Cook-Mozaffari PJ, Azordegan F, Day NE. 1979. Esophageal cancer studies in the Caspian litoral of Iran: results of a case-control study. Br J Cancer 39 (5 292 309.
43. Craft NE. 1992. Carotenoid reverse-phase high-performance liquid chromatography methods: reference compendium. Methods Enzymol 213 : 185 205.
44. Crouzet J, Kanasawud P. 1992. Formation of volatile compounds by thermal degradation of carotenoids. Methods Enzymol 213 : 54 62.
45. Crozier A, Lean MEJ, McDonald MS, Black C. 1997. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J Agric Food Chem 45 : 590 5.
46. Dachtler M, Glaser T, Kohler K, Albert K. 2001. Combined HPLC-MS and HPLC-NMR on-line coupling for the separation and determination of lutein and zeaxanthin stereoisomers in spinach and in retina. Anal Chem 73 (3 667 4.
47. Davies BH. 1976. Carotenoids. In : Goodwin TW, editors. Chemistry and biochemistry of plant pigments, Vol. 2. 2nd ed. New York : Academic Press. p 38 65.
48. Davis AR, Fish WW, Veazie PP. 2003. A rapid spectrometric method for analysing lycopene content in tomato and tomato products. Postharvest Biol Technol 28 (3 425 30.
49. Deming DM, Boileau AC, Lee CM, Erdman JW Jr. 2000. Amount of dietary fat and type of soluble fiber independently modulate postabsorptive conversion of β-carotene to vitamin A in Mongolian gerbils. J Nutr 130 (45 2789 96.
50. Derby BM, Levy AS. 2005. Effects of strength of science disclaimers on the communication impacts of health claims. College Park, Md. : Center for Food Safety and Applied Nutrition.
51. Di Mascio P, Kaiser S, Sies H. 1989. Lycopene as the most effective biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274 (2 532 8.
52. Diaz MN, Frei B, Vita JA, Keaney JF. 1997. Antioxidants and atherosclerotic heart disease. New Eng J Med 337 (12 408 16.
53. Duggar BM. 1913. Lycopersicon: the red pigment of the tomato and the effects of conditions on its development. Washington Univ. Studies 1 : 22 45.
54. Elinder LS, Hadell K, Johansson J, Holme JM, Olsson AG, Walldius G. 1995. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arteriosclerosis Thrombosis Vascular Biol 15 : 1057 63.
55. Emenhiser C, Simunovic N, Sander LC, Schwartz SJ. 1996. Separation of geometric isomers in biological extracts using a polymeric C30 column in reversed-phase liquid chromatography. J Agric Food Chem 44 (12 3887 93.
56. Epler KS, Sander LC, Ziegler RG, Wise SA, Craft NE. 1992. Evaluation of reversed-phase liquid chromatographic columns for recovery and selectivity of selected carotenoids. J Chromatogr 595 (2 89 101.
57. Erdman JW. 2005. How do nutritional and hormonal status modify the bioavailability, uptake, and distribution of different isomers of lycopene? J Nutr 135 : 2046S 47S.
58. Erdman JW, Poor CL, Dietz JM. 1988. Factors affecting the bioavailability of vitamin A, carotenoids, and vitamin E. Food Technol 42 (8 214 21.
59. Erdman JW, Bierer TL, Gugger ET. 1993. Absorption and transport of carotenoids. Ann New York Acad Sci 691 (12 76 85.
60. Erdman JW Jr., Fahey GC Jr., White CB. 1986. Effects of purified dietary fiber sources on b-carotene utilization by the chick. J Nutr 116 (19 2415 23.
61. Erhardt JG, Meisner C, Bode JC, Bode C. 2003. Lycopene, β-carotene, and colorectal adenomas. Am J Clin Nutr 78 (6 1219 24.
62. Etminan M, Takkouche B, Caamano-Isorna F. 2004. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev 13 (3 340 5.
63. Fantin G, Fogagnolo M, Medici A, Daniela P. 2007. Isolation of lycopene from crude tomato extract via selective inclusion in deoxycholic acid. Tetrahedron Lett 48 : 9148 50.
64. Ferruzi MG, Sander LC, Rock CL, Schwartz SJ. 1998. Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector. Anal Biochem 256 (1 74 81.
65. Fish WW, Veazie PP, Collins JK. 2002. A quantitative assay for lycopene that utilizes reduced volumes of organic solvents. J Food Comp Anal 15 (3 309 17.
66. Franceschi S, Bidoli E, La Vecchia G, Talamini R, D'Avanzo B, Negri E. 1994. Tomatoes and risk of digestive-tract cancers. Int J Cancer 59 (3 181 4.
67. Fraser P, Truesdale MR, Bird CR, Wolfgang S, Bramley PM. 1994. Carotenoid biosynthesis during tomato fruit development. Plant Physiol 105 : 405 13.
68. Freeman VL, Meydani M, Yong S, Pyle J, Wan Y, Arvizu-Durazo R. 2000. Prostatic levels of tocopherols, carotenoids, and retinol in relation to plasma levels and self-reported usual dietary intake. Am J Epidemiol 151 (2 109 18.
69. Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ. 1999. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 59 (6 1225 30.
70. Gärtner C, Stahl W, Sies H. 1997. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 66 (1 116 22.
71. Gester H. 1997. The potential role of lycopene for human health. J Am Coll Nutr 16 (2 109 26.
72. Giovannucci E. 2002. A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med 227 (56 852 9.
73. Giovannucci EL, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. 1995. Intake of carotenoids and retinol in relationship to risk of prostate cancer. J Natl Cancer Inst 87 (23 1767 76.
74. Glaser T, Lienau A, Zeeb D, Krucker M, Dachtler M, Albert K. 2003. Qualitative and quantitative determination of carotenoid stereoisomers in a variety of spinach samples by use of MSPD before HPLC-APCI-MS, and HPLC-NMR on-line coupling. Chromatographia 57 (Suppl 1 S19 25.
75. Goula AM, Adampoulos KG, Chatzitakis PC, Nikas VA. 2006. Prediction of lycopene degradation during a drying process of tomato pulp. J Food Eng 74 (1 37 46.
76. Gugget ET, Erdman JW Jr. 1996. Intracellular β-carotene transport in bovine liver and intestine is not mediated by cytosolic proteins. J Nutr 126 : 1470 4.
77. Gustin DM, Rodvold KA, Sosman JA, Diwadkar-Navsariwala V, Stacewicz-Sapuntzakis M, Viana M, Crowell JA, Murray J, Tiller P, Bowen PE. 2004. Single-dose pharmacokinetic study of lycopene delivered in a well-defined food based lycopene delivery system (tomato paste-oil mixture) in healthy adult male subjects. Cancer Epidemiol Biomarkers Prev 13 : 850 60.
78. Hadley CW, Elizabeth CM, Steven JS, Steven KC. 2002. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med 227 (10 869 80.
79. Hadley CW, Clinton SK, Schwartz SJ. 2003. The consumption of processed tomato products enhances plasma lycopene concentrations in association with reduced lipoprotein sensitivity to oxidative damage. J Nutr 133 : 727 32.
80. Hagiwara T, Yasuno T, Funayama K, Suzuki S. 1998. Determination of lycopene, α-carotene and β-carotene in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectroscopy with selected-ion monitoring. J Chromatogr B Biomedical Sci Appl 708 (1-2 67 73.
81. Halliwell B. 1994. Free radicals, antioxidants and human disease: curiosity, cause or consequence? Lancet 344 (8924 721 4.
82. Halliwell B, Murcia MA, Chirico S, Aruoma OI. 1995. Free radicals and antioxidants in food and in vivo: what they do and how they work. Crit Rev Food Sci Nutr 35 (1-2 7 20.
83. Handelman GJ, Parker L, Cross CE. 1996. Destruction of tocopherols, carotenoids and retinol in human plasma by cigarette smoke. Am J Clin Nutr 63 (4 559 65.
84. Hart DJ, Scott KJ. 1995. Development and evaluation of an HPLC method for the analysis of carotenoids in food, and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem 54 : 101 11.
85. Hartsen. 1873. Chemistry Centre 204.
86. Helzlsouer KJ, Comstock GW, Morris JS. 1989. Selenium, lycopene, α-tocopherol, β-carotene, retinol, and subsequent bladder cancer. Cancer Res 49 : 6144 8.
87. Herring T, Albrecht J. 2005. Functional foods. Lincoln, Neb. : The Board of Regents of the Univ. of Nebraska.
88. Ibanez E, Sebastian SL, Tabera J, Reglero G. 1998. Separation of carotenoids by supercritical fluid chromatography with coated, packed capillary columns and neat carbon dioxide. J Chromatogr A 823 (4 313 9.
89. Ignarro LJ, Balestrieri ML, Napoli C. 2007. Nutrition, physical activity, and cardiovascular disease: an update. Cardiovasc Res 73 : 326 40.
90. Isaacson T, Ronen G, Zamir D, Hirschberg J. 2002. Cloning of tangerine tomatoes reveals a carotenoid isomerase essential for the production of β-carotene and xanthophylls in plants. Plant Cell 14 : 333 42.
91. Ishida BK, Burri BJ, Chapman MH. 2005. Effects of processing on lycopene-isomer content of tangerine tomato. Abstr Pap Am Chem Soc 229 : U46 7.
92. Isler O. 1973. Introduction. In : Isler O, editor. Carotenoids. Basel, Switzerland : Birkhauser. p 11 27.
93. Johnson EJ. 1998. Human studies on bioavailability and plasma response of lycopene. Proc Soc Exp Biol Med 218 (5 115 20.
94. Johnson EJ, Qin J, Krinsky NI, Russell RM. 1997. Ingestion by men of a combined dose of β-carotene and lycopene does not affect the absorption of β-carotene but improves that of lycopene. J Nutr 127 (9 1833 7.
95. Johnson-Down L, Saudny-Unterberger H, Gray-Donald K. 2002. Food habits of Canadians: lutein and lycopene intake in the Canadian population. J Am Diet Assoc 102 : 988 91.
96. Jorge P. 2001. Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am J Cardiol 88 (Suppl 11K 5K.
97. Kaplan LA, Lau JM, Stein EA. 1990. Carotenoid composition, concentrations and relationships in various human organs. Clin Physiol Biochem 8 (3 1 10.
98. Karrer P, Helfenstein A, Widmer R. 1928. Pflanzenfarbstoffe IX. Zur kenntnis des crocetins und lycopins. Helvetica Chim Acta 11 (8 1201 9.
99. Karrer P, Helfenstein A, Wenrli H, Wettstein A. 1930. Ueber die konstitution des lycopins und carotins. Acta Pflanzenfarbstoffe XXV 14 (2 154 62.
100. Kaufmann R, Wingerath T, Kirsch D, Stahl W, Sies H. 1996. Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectroscopy. Anal Biochem 238 (2 117 28.
101. Khachik F, Beecher GR, Lusby WR, Smith JC. 1992a. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal Chem 64 (4 2111 22.
102. Khachik F, Goli MB, Beecher GR, Holden J, Lusby WR, Tenorio MD, Barrera MR. 1992b. Effect of food preparation on qualitative and quantitative distribution of major carotenoid of tomatoes and several green vegetables. J Agric Food Chem 40 (3 390 8.
103. Khachik F, Beecher GR, Smith JC Jr. 1995. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem 22 (4 236 46.
104. Khachik F, Spangler CJ, Smith C. 1997. Identification, quantification and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal Chem 69 (13 1873 81.
105. Kim H. 1995. Carotenoid protects cultured rat hepatocytes from injury caused by carbon tetrachloride. Int J Biochem Cell Biol 2 : 1303 9.
106. Kimura M, Rodriguez-Amaya DB, Godoy HT. 1990. Assessments of the saponification step in the quantitative determination of carotenoids and provitamins A. Food Chem 35 (3 187 95.
107. King TJ, Khachik F, Bortkiewicz H, Fukushima LH, Morioka S, Bertram JS. 1997. Metabolites of dietary carotenoids as potential cancer preventive agents. Pure Appl Chem 69 (10 2135 40.
108. Kirk JTO, Tilney-Basset RAE. 1978. The plastids: their chemistry, structure, growth, and inheritance. 2nd ed. Amsterdam, The Netherlands : Elsevier.
109. Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB. 2006. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15 (1 92 8.
110. Kohlmeier L, Clarke JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ. 1997. Lycopene and myocardial infarction risk in the EURAMIC study. Am J Epidemiol 146 (2 618 26.
111. Krinsky NI. 1992. Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 20 : 248 54.
112. Krinsky NI, Russett MD, Handelman GJ, Snodderly DM. 1990. Structural and geometrical isomers of carotenoids in human plasma. J Nutr 120 (12 1654 62.
113. Krinsky NI, Wang XD, Tang G, Russell RM. 1993. Conversion of carotenoids to retinoids. In : Livrea MA, Packer L, editors. Retinoids: progress in research and clinical applications. New York : Marcel Dekker. p 1 16.
114. Kristenson M, Zieden B, Kucinskiene Z, Elinder LS, Bergdahl B, Elwing B. 1997. Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross-sectional study of men aged 50. Br Med J 314 (11 629 33.
115. Kritchevsky SB, Tell GS, Shimakawa T, Dennis B, Li R, Kohlmeier L, Steere E, Heiss G. 1998. Provitamin A carotenoids intake and carotid artery plaques: the atherosclerosis risk in communities study. Am J Clin Nutr 68 (9 726 33.
116. Kucuk O, Sarkar FH, Djuric Z, Sakr W, Pollak MN, Khachik F, Banerjee M, Bertram JS, Wood DP Jr. 2002. Effects of lycopene supplementation in patients with localized prostate cancer. Exp Biol Med 227 : 881 5.
117. Kuhn R, Grundmann C. 1932. Die konstitution des lycopins. Berichte Deutsche Chemische Gesellschaft 65 : 1880 9.
118. Kun Y, Lule US, Xiao-Lin D. 2006. Lycopene: its properties and relationship to human health. Food Rev Int 22 : 309 33.
119. Labrador A, Ruiz RM, Latorre A. 1999. Effect of processing techniques on the colour and lycopene content of tomato sauces for pizza during frozen storage. Acta Hort (ISHS) 487 : 453 6.
120. Landers GM, Olson JA. 1986. Absence of isomerization of retinyl palmitate, retinal, and retinal in chlorinated and unchlorinated solvents under gold light. JAOAC 69 (1 50 5.
121. Laval-Martin D. 1974. La maturation du fruit de tomate "cerise": Mise en evidence, par cryodecapage de I'evolution des chloroplasts en deux types de chromoplates. Protoplasma 82 (1 33 59.
122. Lazarus SA, Bowen K, Garg ML. 2004. Tomato juice and platelet aggregation in type 2 diabetes. J Am Med Assoc 292 (7 805 6.
123. Lee MT, Chen BH. 2002. Stability of lycopene during heating and illumination in a model system. Food Chem 78 (4 425 32.
124. Lessin WJ, Catigani GL, Schwartz SJ. 1997. Quantification of cis-trans isomers of provitamin A carotenoids in fresh and processed fruits and vegetables. J Agric Food Chem 45 (10 3728 32.
125. Levy J, Bosh E, Feldman B, Giat Y, Munster A, Danilenko M, Sharoni Y. 1995. Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutr Cancer 24 (5 257 66.
126. Lin CH, Chen BH. 2003. Determination of carotenoids in tomato juice by liquid chromatography. J Chromatogr A 1012 : 103 9.
127. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. 2004. Polyphenols: food sources and bioavailability. Am J Clin Nutr 79 : 727 47.
128. Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E. 1993. Carotenoid content of fruits and vegetables and evaluation of analytic data. J Am Diet Assoc 93 : 284 96.
129. Matsushima-Nishiwaki. 1995. Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids 30 (4 1029 34.
130. Mayer-Miebach E, Spieβ WEL. 2003. Influence of cold storage and blanching on the carotenoid content of Kintoki carrots. J Food Eng 56 : 211 3.
131. Michaud DS, Giovannucci EL, Ascherio A, Rimm EB, Forman MR, Sampson L. 1998. Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database. Cancer Epidemiol Biomarkers Prev 7 (4 283 90.
132. Millardet PMA. 1875. Bull Soc Sci Nancy 2 (1 21 5.
133. Miller EC, Hadley CW, Schwartz SJ, Erdman JW Jr., Boileau TW, Clinton SK. 2002. Lycopene, tomato products, and prostate cancer prevention. Have we established causality? Pure Appl Chem 74 (8 1435 41.
134. Miller NJ, Diplock AT, Rice-Evans CA. 1995. Evaluation of the total antioxidant activity as a marker of the deterioration of apple juice on storage. J Agric Food Chem 43 : 1794 801.
135. Miller NJ, Sampson J, Candeiar LP, Bramley PM, Rice-Evans CA. 1996. Antioxidant activities of carotenes and xanthophylls. Federation Europe Biochemical Sci Lett 384 (3 240 6.
136. Mohr WP. 1979. Pigment bodies in fruit of crimson high pigment lines of tomato. Ann Botany 44 (2 427 47.
137. Monselise JJ, Berk Z. 1954. Oxidative destruction of lycopene during the manufacturing of tomato puree. Bull Res Council Israel 4 (2 188 91.
138. Mortensen A, Skibsted LH. 1997. Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. A real time kinetic study of antioxidant hierarchy. Fed Europ Biochemical Sci Lett 417 (3 261 6.
139. Moss GP, Weedon BCL. 1976. Chemistry of the carotenoids. In : Goodwin TW, editors. Chemistry and biochemistry of plant pigments, Vol. 1. 2nd ed. New York : Academic Press. p 149 224.
140. Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K. 1997. Effects of lycopene on spontaneous mammary tumor development in SHN virgin mice. Anticancer Res 15 (1 118 23.
141. Narisawa T, Fukaura Y, Terada K, Sekiguchi H. 1998. Prevention of N-methylnitrosourea-induced colon carcinogenesis in F344 rats by lycopene and tomato juice rich in lycopene. Jpn J Cancer Res 89 (10 1009 13.
142. [NCI] Natl. Cancer Inst. 1987. Diet, nutrition and cancer prevention: a guide to food choices. Washington, D.C. : U.S. Govt. Printing Office.
143. Nguyen ML, Schwartz SJ. 1998. Lycopene stability during food processing. Exp Biol Med 218 (2 101 5.
144. Nguyen ML, Schwartz SJ. 1999. Lycopene: chemical and biological properties. Food Technol 53 (1 38 45.
145. Nicoli MC, Anese M, Parpinel M. 1999. Influence of processing on the antioxidant properties of fruit and vegetables. Trends Food Sci Technol 10 : 94 100.
146. Nierenberg DW, Nann SL. 1992. A method for determining concentrations of retinol, tocopherol, and five carotenoids in human plasma and tissue samples. Am J Clin Nutr 56 (2 417 26.
147. Nkondjock A, Ghadirian P, Johnson KC, Krewski D. 2005. Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J Nutr 135 (3 592 7.
148. Ojima F, Sakamoto H, Ishiguro Y, Terao J. 1993. Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low-density lipoprotein. Free Radical Biol Med 15 (4 377 84.
149. Okajima E, Tsutsumi M, Ozono S, Akai H, Denda A, Nishino H, Oshima S, Sakamoto H, Konishi Y. 1998. Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4-hydroxybutyl) nitrosamine initiation. Jpn J Cancer Res 89 (1 22 6.
150. Olson JA. 1961. The conversion of radioactive β-carotene into vitamin A by rat small intestine in-vivo. J Biol Chem 236 : 349 56.
151. Olson JA. 1989. Provitamin A function of carotenoids: the conversion of β-carotene into vitamin A. J Nutr 119 : 105 8.
152. Otteneder H. 1986. Authenticity of tomato products. Deutsch Lebensm Rundsch 82 (1 14 8.
153. Panalaks T, Murray TK. 1970. The effect of processing on the content of carotene isomers in vegetables and peaches. Can Inst Food Sci Technol J 3 (2 145 51.
154. Parker RS. 1988. Carotenoid and tocopherol composition in human adipose tissue. Am J Clin Nutr 47 (1 33 6.
155. Parker RS. 1996. Absorption, metabolism, and transport of carotenoids. FASEB J 10 (1 542 51.
156. Pastori M, Pfander H, Boscoboinik D, Azzi A. 1998. Lycopene in association with α-tocopherol inhibits at physiological concentrations proliferation of prostate cancer cells. Biochem Biophys Res Comm 250 (4 582 5.
157. Peng YS, Peng YM. 1992. Simultaneous liquid chromatographic determination of carotenoids, retinoids, and tocopherols in human buccal mucosal cells. Cancer Epidemiol Biomarkers Prev 1 (5 375 82.
158. Pincemail J. 1995. Free radicals and antioxidants in human disease. In : Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre JL, editors. Analysis of free radicals in biological systems. Basel, Switzerland : Birkhäuser Verlag. p 83 98.
159. Pol J, Hyotylainen T, Aho OR, Riekkola ML. 2004. Determination of lycopene in food by online SFE coupled to HPLC using a single monolithic column for trapping and separation. J Chromatogr A 1052 (1 25 31.
160. Pool-Zobel BL, Bub A, Muller H, Wollowski I, Rechkemmer G. 1997. Consumption of vegetables reduces genetic damage in humans: first result of a human intervention trial with carotenoid-rich foods. Carcinogenesis 18 (9 1847 50.
161. Porrini M, Riso P, Testolin G. 1998. Absorption of lycopene from single or daily portions of raw and processed tomato. Br J Nutr 80 (3 353 61.
162. Porter JW, Lincoln RE. 1950. Lycopersicon selections containing a high content of carotenes and colorless polyenes. II. The mechanism of carotene biosynthesis. Arch Biochem Biophys 27 (2 390 5.
163. Potischman N, Hoover RN, Brinton LA, Swanson CA, Herrero R, Tenorio F, de Britton RC, Gartan E, Reeves WC. 1994. The relations between cervical cancer and serological markers of nutritional status. Nutr Cancer 21 (2 193 201.
164. Price SF, Breen PJ, Valladao M, Watson BT. 1995. Cluster sun exposure and quercetin in Pinot noir grapes and wine. Am J Enol Vitic 46 : 187 94.
165. Quackenbush FW. 1987. Reversed-phase HPLC separation of cis and trans-carotenoids and its application to food materials. J Liq Chromatogr 10 (3 643 53.
166. Ramon JM, Serra L, Como C, Oromi J. 1993. Dietary factors and gastric cancer risk. Cancer 71 (6 1731 5.
167. Rao AV, Agarwal S. 1998. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 31 (3 199 203.
168. Rao AV, Agarwal S. 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr Res 19 (2 305 23.
169. Rao AV, Waseem Z, Agarwal S. 1998. Lycopene contents of tomatoes and tomato products and their contribution to dietary lycopene. Food Res Int 31 (10 737 41.
170. Rao LG, Guns E, Rao AV. 2003. Lycopene: its role in human health and disease. Agro Food 7-8 : 25 30.
171. Re R, Bramley PM, Rice-Evans C. 2002. Effects of food processing on flavonoids and lycopene status in a Mediterranean tomato variety. Free Rad Res 36 : 803 10.
172. Re R, Mishra GD, Thane CW, Bates CJ. 2003. Tomato consumption and plasma lycopene concentration in people aged 65 year and over in a British national survey. Eur J Clin Nutr 57 : 1545 54.
173. Reboul E, Borel P, Mikail C, Abou L, Charbonnier M, Caris-Veyrat C, Goupy P, Portugal H, Lairon D, Amiot MJ. 2005. Enrichment of tomato paste with 6% tomato peel increases lycopene β-carotene bioavailability in men. J Nutr 135 : 790 4.
174. Reddy V. 1995. Vitamin A status and dark green leafy vegetables. Lancet 346 : 1634 6.
175. Rentel C, Srohschein S, Albert K, Bayer E. 1998. Silver-plated vitamins: a method of detecting tocopherols and carotenoids in LC/ESI-MS coupling. Anal Chem 70 (20 4394 400.
176. Ribayo-Mercado JD, Garmyn M, Gilchrest BA, Russel RM. 1995. Skin lycopene is destroyed preferentially over β-carotene during ultraviolet irradiation in humans. J Nutr 125 (7 1854 9.
177. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. 1993. Vitamin E consumption and the risk of coronary heart disease in men. New Eng J Med 328 (20 1450 6.
178. Rock CL, Swenseid ME. 1992. Plasma β-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr 55 (1 96 9.
179. Rouseff R, Raley L, Hofsommer HJ. 1996. Application of diode array detection with a C30 reversed-phase column for the separation and identification of saponified orange juice carotenoids. J Agric Food Chem 44 (8 2176 81.
180. Sanchez-Moreno C, Cano MP, de Ancos B, Plaza L, Olmedilla B, Granado F, Martin A. 2004. Consumption of high-pressurized vegetable soup increases plasma vitamin C and decreases oxidative stress and inflammatory biomarkers in healthy humans. J Nutr 134 (11 3021 5.
181. Sander LC, Wise SA. 1987. Effect of phase length on column selectivity for the separation of polycyclic aromatic hydrocarbons by reversed-phase liquid chromatography. Anal Chem 59 (11 2309 13.
182. Sander LC, Sharpless KE, Craft NE, Wise SA. 1994. Development of engineered stationary phases for the separation of carotenoid isomers. Anal Chem 66 (9 1667 74.
183. Scalfi L, Fogliano V, Pentangelo A, Graziani G, Giordano I, Ritieni A. 2000. Antioxidant activity and general fruit characteristics in different ecotypes of Corbarini small tomatoes. J Agric Food Chem 48 : 1363 6.
184. Schieber A, Carle R. 2005. Occurrence of carotenoid cis-isomers in food: technological, analytical, and nutritional implications. Trends Food Sci Technol 16 : 416 22.
185. Schierle J, Bretzel W, Buhler I, Faccin N, Hess D, Steiner K, Schuep W. 1997. Content and isomeric ratio of lycopene in food and blood plasma. Food Chem 96 (4 459 65.
186. Schmitz HH, Poor CL, Wellman RB, Erdman JW Jr. 1991. Concentrations of
187. Schunck CA. 1903. The xanthophyll group of yellow coloring matters. Proc Royal Soc London 72 (2 165 76.
188. Scita G. 1992. Stability of β-carotene under different laboratory conditions. Methods Enzymol 213 (1 175 85.
189. Scolastici C, Alves de Lima RO, Barbisan LF, Ferreira AL, Ribeiro DA, Salvadori DMF. 2007. Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells. Toxicol Vitro 21 : 840 5.
190. Sesso HD, Liu S, Gaziano JM, Buring JE. 2004. Dietary lycopene, tomato-based food products and cardiovascular disease in women. J Nutr 134 (9 2336 41.
191. Sharoni Y, Giron E, Rise M, Levy J. 1997. Effects of lycopene-enriched oleoresin on 7,12-dimetheyl-benz[a]anthracene-induced rat mammary tumors. Cancer Detect Prev 21 (2 118 23.
192. Shi J, Le Maguer M. 2000. Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Food Sci Nutr 40 (1 1 42.
193. Shi J, Dai Y, Kakuda Y, Mittal G, Xue SJ. 2008. Effect of heating and exposure to light on the stability of lycopene in tomato puree. Food Control 19 : 514 20.
194. Sies H, Stahl W. 1995. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 62 (6 1315S 21S.
195. Silvano G, Renato T, Cristina B, Eva N, Maurizio M, Silvia F, Attilio G, Carlo LV. 2006. Pizza consumption and the risk of breast, ovarian and prostate cancer. Eur J Cancer Prev 15 (1 74 6.
196. Simpson KL, Lee TC, Rodriguez DB, Chichester CO. 1976. Metabolism in senescent and stored tissues. In : Goodwin TW, editors. Chemistry and biotechnology of plant pigments, Vol. 1. 2nd ed. New York : Academic Press. p 779 842.
197. Spanos GA, Wrolstad RE, Heatherbell DA. 1990. Influence of processing and storage on the phenolic composition of apple juice. J Agric Food Chem 38 : 1572 9.
198. Stahl W, Sies H. 1992. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122 (11 2161 6.
199. Stahl W, Sies H. 1996. Lycopene: a biologically important carotenoid for human. Arch Physiol Biochem 336 (1 1 9.
200. Stahl W, Schwarz W, Sundquist AR, Sies H. 1992. Cis-trans isomers of lycopene and β-carotene in human serum and tissues. Arch Physiol Biochem 294 (2 173 7.
201. Steinmetz KA, Potter JD. 1996. Vegetables, fruits, and cancer prevention: a review. J Am Dietetic Assoc 96 (10 1027 39.
202. 30 stationary phase. J Pharm Biomed Anal 21 (2 669 77.
203. Sweeney JP, Marsh AC. 1971. Effect of processing on provitamin A in vegetables. J Am Dietetic Assoc 59 (2 238 43.
204. Tajima K, Tominaga S. 1985. Dietary habits and gastrointestinal cancers: a comparative case-control study of stomach and large intestinal cancer in Nagoya, Japan. Jpn J Cancer Res 76 (3 705 16.
205. Tang G, Wang XD, Russell RM, Krinsky NI. 1991. Characterization of β-apo-13-carotenone and β-apo-14′-carotenal as enzymatic products of the excentric cleavage of β-carotene. Biochem 30 : 9829 34.
206. Tinkler JH, Boehm F, Schalch W, Truscott TG. 1994. Dietary carotenoids protect human cells from damage. J Photochem Photobiol 26 : 283 5.
207. Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis CS, Mulokozi G. 1995. Carotenoid content of thermally processed tomato-based food products. J Agric Food Chem 43 : 579 86.
208. Trichopoulos D, Willett WC. 1996. Nutrition and cancer. Cancer Causes Control 7 (1 3 4.
209. Tsukida K, Saiki K, Takii T, Koyama Y. 1981. Structural elucidation of the main cis-β-carotenes. J Nutr Sci Vitaminol 27 (3 552 61.
210. Tsushima M, Maoka T, Katsuyama M, Kozuka M, Matsuno T, Tokuda H, Nishino H, Iwashima A. 1995. Inhibitory effect of natural carotenoids on Epstein-Barr virus activation activity of a tumor promoter in Raji cells. A screening study for anti-tumor promoters. Biol Pharm Bull 18 (2 227 33.
211. [UKDoH] U.K. Dept. of Health. 1999. Committee on medical aspects of food and nutrition policy (COMA) annual report, U.K.
212. Unlu NZ, Bohn T, Clinton SK, Schwartz SJ. 2005. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutr 135 : 431 6.
213. Unlu NZ, Bohn T, Francis DM, Nagaraja HN, Clinton SK. 2007a. Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. Br J Nutr 98 (1 140 6.
214. Unlu NZ, Bohn T, Francis D, Clinton SK, Schwartz SJ. 2007b. Carotenoid absorption in humans consuming tomato sauces obtained from tangerine or high-β-carotene varieties of tomatoes. J Agric Food Chem 55 (4 1597 603.
215. [USDA/USHHS] U.S. Dept. of Agriculture, U.S. Dept. of Health and Human Services. 2000. Dietary guidelines for Americans, 5th ed. Home and Garden Bull nr 232. Washington, D.C. Available from : http://www.nal.usda.gov/fnic/dga. Accessed April 15 2007.
216. [USFDA] U.S. Food and Drug Administration. 1993. Health claims: general requirements (21 CFR 101.14). Washington, D.C. : U.S. Government Printing Office.
217. [USFDA] U.S. Food and Drug Administration. 2005. Qualified health claims: letter of partial denial - tomatoes and prostate cancer (lycopene health claim coalition). College Park, Md. : Center for Food Safety and Applied Nutrition.
218. U.S. Natl Research Council. 1989. Committee on diet and health: implications for reducing chronic disease risk. Washington, D.C. : Natl. Academy Press.
219. van Breemen R, Schmitz H, Schwartz S. 1993. Continuous-flow fast atom bombardment liquid chromatography/mass spectrometry of carotenoids. Anal Chem 65 (8 965 9.
220. van het Hof KH, de Boer BCJ, Tijburg LBM, Lucius BRHM, Zijp I, West CE, Hautvast JGAJ, Weststarte JA. 2000. Carotenoid bioavailability in humans from tomatoes processed in different ways determined from the carotenoid response in the triglyceride-rich lipoprotein fraction of plasma after a single consumption and in plasma after four days of consumption. J Nutr 130 : 1189 96.
221. 2 extraction of lycopene from tomato in the presence of vegetable oil as co-solvent. J Supercrit Fluids 29 (1 87 96.
222. Visioli F, Riso P, Grande S, Galli C, Porrini M. 2003. Protective activity of tomato products on in vivo markers of lipid oxidation. Eur J Nutr 42 (1 201 6.
223. Walfisch S, Walfisch Y, Kirilov E, Linde N, Mintentag H, Agbaria R, Sharoni Y, Levy J. 2007. Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev 16 (4 298 303.
224. Wang XD, Krinsky NI, Tang G, Russell RM. 1992. Retinoic acid can be produced from excentric cleavage of β-carotene in human intestinal mucosa. Arch Biochem Biophys 293 : 293 304.
225. Weisburger JH. 1998. Evaluation of the evidence on the role of tomato products in disease prevention. Proc Soc Exp Biol Med 218 (2 140 3.
226. Weststarte J, Meifer G. 1998. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 52 (4 334 43.
227. [WHO] World Health Organization. 1990. Diet, nutrition and the prevention of chronic disease. Technical report series 797. Geneva: World Health Organization.
228. Weststarte J, van het Hof KH. 1995. Sucrose polyester and plasma carotenoid concentrations in healthy subjects. Am J Clin Nutr 55 (1 96 9.
229. Williams AW, Boileau TWM, Erdman JW Jr. 1998. Factors influencing the uptake and absorption of carotenoids. Proc Soc Exp Biol Med 218 (2 106 8.
230. Williams GM, Williams CL, Weisburger JH. 1999. Diet and cancer prevention: the fiber first diet. Toxicological Sci 52 (1 72 86.
231. Willstatter R, Escher HH. 1910. Über den farbstoff der tomate. Zeitsch Physikalische Chem 64 (1 47 51.
232. Witztum JL. 1994. The oxidation hypothesis of atherosclerosis. Lancet 344 (8925 793 5.
233. Woodall AA, Lee SWM, Weesie RJ, Jackson MJ, Britton G. 1997. Oxidation of carotenoids by free radicals: relationship between structure and reactivity. Biochim Biophys Acta 1336 (1 33 42.
234. World Cancer Research Fund, American Inst. for Cancer Research. 1997. Food, nutrition and the prevention of cancer: a global prospective. Washington, D.C. : American Inst. for Cancer Research.
235. Xianquan S, Shi J, Kakuda Y, Yueming J. 2005. Stability of lycopene during food processing and storage. J Med Food 8 (4 413 22.
236. Yamamoto J, Taka T, Yamada K, Ijiri Y, Murakami M, Hirata Y, Naemura A, Hashimoto M, Yamashita T, Oiwa K, Seki J, Suganuma H, Inakuma T, Yoshida T. 2003. Tomatoes have natural anti-thrombotic effects. Br J Nutr 90 (6 1031 8.
237. Yaping Z, Wenli YU, Weile HU, Ying Y. 2003. Anti-inflammatory and anti-coagulant activities of lycopene in mice. Nutr Res 23 : 1591 5.
238. Yeum KJ, Lee-Kim YC, Yoon S, Lee KY, Park IS, Lee KS, Kim BS, Tang G, Russell RM, Krinsky NI. 1995. Similar metabolites formed from β-carotene by either human gastric mucosal homogenates, lipoxygenase or linoleic acid hydroperoxide. Arch Biochem Biophys 321 (1 167 74.
239. Yeum KJ, Ferreira ALA, Smith D, Krinsky NI, Russell RM. 2000. The effect of α-tocopherol on the oxidative cleavage of β-carotene. Free Rad Biol Med 29 : 105 14.
240. Zechmeister L. 1962. Cis-trans isomeric carotenoids, vitamins A and arylpolyenes. New York : Academic Press.
241. Zechmeister L, Cholnoky L. 1936. Lycoxanthin und lycophyll, zwei natürliche derivative des lycopins. Berichte Deutsch Chemische Gesellschaft 69 (4 422 9.
242. Zechmeister L, Polgar A. 1944. Cis-trans isomerization and cis-peak effect in the α-carotene set and in some other stereoisomeric sets. JAOCS 66 (1 137 44.
243. Zechmeister L, Tuzson P. 1938a. Spontaneous isomerization of lycopene. Nature 141 (2 249 50.
244. Zechmeister L, Tuzson P. 1938b. Isomerization of carotenoids. Biochem J 32 (11 1305 11.
245. Zechmeister L, Le Rosen AL, Went FW, Pauling L. 1941. Prolycopene, a naturally occurring stereoisomer of lycopene. Proc Natl Acad Sci USA 27 (10 468 74.
246. Zechmeister L, Le Rosen AL, Schroeder WA, Polgar A, Pauling L. 1943. Spectral characteristics and configuration of some stereoisomeric carotenoids including prolycopene and pro-γ-carotene. JAOCS 65 (11 1940 51.
247. Zhang LX, Cooney RV, Bertram JS. 1991. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenisis 12 : 2109 14.
248. Zhang LX, Cooney RV, Bertram JS. 1992. Carotenoids upregulate conexin 43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 52 : 5707 12.
249. Zhang S, Tang G, Russell RM, Mayzel KA, Stampfer MJ, Willett WC, Hunter DJ. 1997. Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects. Am J Clin Nutr 66 : 626 32.
250. Ziegler RG. 1991. Vegetables, fruits and carotenoids and the risk of cancer. Am J Clin Nutr 53 (8 251S 9S.
251. Zimmermann J, Herrlinger S, Metzger T, Wanner C. 1999. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 55 : 648 58.
252. Zimmerman M. 2002. Antioxidant powerhouse. Taste for Life 8 : 1 3.