Structural biology of the tumor suppressor p53

Annual Review of Biochemistry

Volumn 77, Issue , 2008, Pages 557-582

  Joerger, Andreas C ^a   Fersht, Alan R ^a  

^a MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

Drug design; Intrinsic disorder; Multidomain protein; Oncogenic mutation; Transcription factor

Indexed keywords

PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; TRANSCRIPTION FACTOR;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; CELL CYCLE ARREST; CRYSTAL STRUCTURE; DNA BINDING; DNA DAMAGE; DNA REPAIR; DRUG DESIGN; DRUG TARGETING; FAMILIAL CANCER; GENE MUTATION; HYPOXIA; MISSENSE MUTATION; NEOPLASM; ORTHOLOGY; PARALOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; REVIEW; SENESCENCE; TUMOR SUPPRESSOR GENE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; CHEMISTRY; DOMINANT GENE; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE; DRUG DESIGN; GENES, DOMINANT; GENES, P53; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 47649096991     PISSN: 00664154     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.77.060806.091238     Document Type: Review

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