Structural and energetic responses to cavity-creating mutations in hydrophobic cores: Observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities

Biochemistry

Volumn 35, Issue 14, 1996, Pages 4298-4305

  Buckle, Ashley M ^a   Cramer, Patrick ^a,b   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

WATER;

AMINO ACID SUBSTITUTION; ARTICLE; CROSS LINKING; CRYSTAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BACILLUS; BACTERIOPHAGE T4; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; ENZYME STABILITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MURAMIDASE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; RIBONUCLEASES; THERMODYNAMICS; WATER;

EID: 0029882171     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9524676     Document Type: Article

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