WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization

Journal of Biological Chemistry

Volumn 281, Issue 13, 2006, Pages 8600-8606

  Tomita, York ^b   Marchenko, Natasha ^a   Erster, Susan ^a   Nemajerova, Alice ^a   Dehner, Alexander ^d   Klein, Christian ^c   Pan, Hongguang ^b   Kessler, Horst ^d   Pancoska, Petr ^a   Moll, Ute M ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DNA; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS; PROTEINS; TUMORS;

MITOCHONDRIA; OLIGOMERIZATION; OUTER MITOCHONDRIAL MEMBRANE PERMEABILIZATION (OMMP);

MUTAGENESIS;

CYTOCHROME C; PROTEIN BCL 2; PROTEIN P53; CAMPTOTHECIN; DNA BINDING PROTEIN; ENZYME INHIBITOR;

ARTICLE; BIOPHYSICS; CANCER CELL; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DENSITY GRADIENT CENTRIFUGATION; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; PERMEABILITY; PROTEIN TERTIARY STRUCTURE; SECRETION; SERODIAGNOSIS; STRUCTURE ACTIVITY RELATION; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CAMPTOTHECIN; CELL LINE, TUMOR; CENTRIFUGATION, DENSITY GRADIENT; CYTOCHROMES C; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PERMEABILITY; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33646826684     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507611200     Document Type: Article

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