NMR Solution Structure of a Peptide from the mdm-2 Binding Domain of the p53 Protein that Is Selectively Cytotoxic to Cancer Cells

Biochemistry

Volumn 43, Issue 7, 2004, Pages 1854-1861

  Rosal, Ramon ^a   Pincus, Matthew R ^b,c   Brandt Rauf, Paul W ^a   Fine, Robert L ^d   Michl, Josef ^c   Wang, Hsin ^e  

^a Mailman Sch Pub Hlth Columbia U ^*  (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SUNY Downstate Medical Center   (United States)

^d Columbia Univ Coll Phys/Surgs ^*  (United States)

^e CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; NUCLEAR MAGNETIC RESONANCE; PROTEINS; TUMORS;

AMPHIPATHIC STRUCTURES; HELICAL STRUCTURES;

BIOCHEMISTRY;

PROTEIN MDM2; PROTEIN P53;

ALPHA HELIX; ARTICLE; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SOLVENTS; TUMOR SUPPRESSOR PROTEIN P53; WATER;

EID: 1242330299     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035718g     Document Type: Article

References (21)

1. Levine, A. J. (1997) Cell 88, 323-331.
2. Prives, C., and Hall, P. A. (1999) J. Pathol. 187, 112-126.
3. Kanovsky, M., Raffo, A., Drew, L., Rosal, R., Do, T., Friedman, F. K., Rubinstein, P., Visser, J., Robinson, R., Brandt-Rauf, P. W., Michl, J., Fine, R. L., and Pincus, M. R. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 12438-12443.
4. Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. (1996) Science 274, 948-953.
5. Do, T. N., Rosal, R. V., Drew, L., Raffo, A. J., Michl, J., Pincus, M. R., Friedman, F. K., Petrylak, D. P., Cassai, N., Szmulewicz, J., Sidhu, G., Fine, R. L., and Brandt-Rauf, P. W. (2003) Oncogene 22, 1431-1444.
6. Girvin, M. E., Rastogi, V. K., Abildgaard, F., Markley, J. L., and Fillingame, R. H. (1998) Biochemistry 37, 8817-8824.
7. Girvin, M. E., and Fillingame, R. H. (1993) Biochemistry 32, 12167-12177.
8. Wuthrich, K. (1986) NMR of proteins and nucleic acids, Wiley, New York.
9. Smallcombe, S. H., Patt, S. L., and Keifer, P. A. (1995) J. Magn. Reson., Ser. A 117, 295-303.
10. Cavanagh, J., Fairbrother, W. J., Palmer, A. G., and Skelton, N. J. (1996) Protein NMR Spectroscopy: Principle and Practice, Academic Press, San Diego.
11. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293.
12. Johnson, B. A., and Blevins, R. A. (1994) J. Biomol. NMR 4, 603-614.
13. Guntert, P., Mumenthaler, C., and Wutrich, K. J. (1997) J. Mol. Biol. 273, 283-298.
14. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graphics 14, 51-55.
15. Wishart, D. S., Bigam, C. G., Holm, A., Hodges, R. S., and Sykes, B. D. (1995) J. Biomol. NMR 5, 67-81.
16. Richarz, R., and Wüthrich, K. (1978) Biopolymers 17, 2133-2141.
17. Cho, Y., Gorina, S., Jeffrey, P. D., and Pavletich, N. P. (1994) Science 265, 346-355.
18. Pincus, M. R. (2001) The Physiological Structure and Function of Proteins, 3rd ed., Academic Press, New York.
19. Dathe, M., and Wieprecht, T. (1999) Biochim. Biophys. Acta 1462, 71-87.
20. Hallock, K. J., Lee, D.-K., and Ramamoorthy, A. (2003) Biophys. J. 84, 3052-3060.
21. Naito, A., Nagao, T., Norisada, K., Mizuno, T., Tuzi, S., and Saito, H. (2000) Biophys. J. 78, 2405-2417.