Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 21934-21941

  Ang, Hwee Ching ^a   Joerger, Andreas C ^a   Mayer, Sebastian ^a   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; DNA; DRUG PRODUCTS; GENETIC ENGINEERING; MOLECULAR BIOLOGY; MUTAGENESIS; PROTEINS; THERMODYNAMIC STABILITY;

ANTICANCER DRUGS; BIOPHYSICAL MEASUREMENTS; DNA BINDING AFFINITY; MELTING TEMPERATURES;

TUMORS;

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN P53;

ARTICLE; BINDING AFFINITY; CANCER; DIFFERENTIAL SCANNING CALORIMETRY; DNA BINDING; GENE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY; WILD TYPE;

CELL CYCLE PROTEINS; DNA; DNA-BINDING PROTEINS; HUMANS; MUTATION; NEOPLASMS; NUCLEAR PROTEINS; PROTEIN CONFORMATION; PROTEIN DENATURATION; TEMPERATURE; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33746790624     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604209200     Document Type: Article

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