메뉴 건너뛰기




Volumn 6, Issue 1, 2006, Pages 55-61

Adenovirus p53 gene therapy

Author keywords

Adenovirus; Apoptosis; Gene therapy; p53; Tumour suppression

Indexed keywords

ADENOVIRUS VECTOR; ADVEXIN; CARBOPLATIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLIN DEPENDENT KINASE; CYCLINE; DEATH RECEPTOR; DNA; DOCETAXEL; DOXORUBICIN; FAS ANTIGEN; GENE PRODUCT; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; NAVELBINE; PACLITAXEL; PLATINUM; PROTEIN BAK; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; RETROVIRUS VECTOR;

EID: 30044439886     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.1.55     Document Type: Review
Times cited : (107)

References (57)
  • 1
    • 0032876814 scopus 로고    scopus 로고
    • The p53 pathway and apoptosis
    • BURNS T, EL-DEIRY W: The p53 pathway and apoptosis. J. Cell. Physiol. (1999) 181(15):231-239.
    • (1999) J. Cell. Physiol. , vol.181 , Issue.15 , pp. 231-239
    • Burns, T.1    El-Deiry, W.2
  • 2
    • 0027818396 scopus 로고
    • A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis
    • FUJIWARA T, GRIMM EA, MUKHOPADHYAY T et al.: A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. (1993) 53(15):4129-4133.
    • (1993) Cancer Res. , vol.53 , Issue.15 , pp. 4129-4133
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3
  • 3
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    • RAYCROFT L, WU H, LOZANO G: Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science (1990) 249(15):1049-1051.
    • (1990) Science , vol.249 , Issue.15 , pp. 1049-1051
    • Raycroft, L.1    Wu, H.2    Lozano, G.3
  • 4
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • ADAMS JM, CORY S: The Bcl-2 protein family: arbiters of cell survival. Science (1998) 281(15):1322-1326.
    • (1998) Science , vol.281 , Issue.15 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 5
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • KAMIJO T, ZINDY F, ROUSSEL MF et al.: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 91(15):649-659.
    • (1997) Cell , vol.91 , Issue.15 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3
  • 6
    • 0028574883 scopus 로고
    • Prognostic significance of p53 and ras gene abnormalities in lung adenocarcinoma patients with stage I disease after curative resection
    • ISOBE T, HIYAMA K, YOSHIDA Y, FUJIWARA Y, YAMAKIDO M: Prognostic significance of p53 and ras gene abnormalities in lung adenocarcinoma patients with stage I disease after curative resection. Jpn. J. Cancer Res. (1994) 85(15):1240-1246.
    • (1994) Jpn. J. Cancer Res. , vol.85 , Issue.15 , pp. 1240-1246
    • Isobe, T.1    Hiyama, K.2    Yoshida, Y.3    Fujiwara, Y.4    Yamakido, M.5
  • 7
    • 0026737950 scopus 로고
    • Accumulation of p53 protein correlates with a poor prognosis in human lung cancer
    • QUINLAN DC, DAVIDSON AG, SUMMERS CL, WARDEN HE, DOSHI HM: Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res. (1992) 52(15):4828-4831.
    • (1992) Cancer Res. , vol.52 , Issue.15 , pp. 4828-4831
    • Quinlan, D.C.1    Davidson, A.G.2    Summers, C.L.3    Warden, H.E.4    Doshi, H.M.5
  • 9
    • 0029364471 scopus 로고
    • Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA
    • CAI DW, MUKHOPADHYAY T, ROTH JA: Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther. (1995) 2(15):199-205.
    • (1995) Cancer Gene Ther. , vol.2 , Issue.15 , pp. 199-205
    • Cai, D.W.1    Mukhopadhyay, T.2    Roth, J.A.3
  • 10
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
    • FUJIWARA T, CAI DW, GEORGES RN et al.: Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model (Commentary). J. Natl. Cancer Inst. (1994) 86(15):1437-1438.
    • (1994) J. Natl. Cancer Inst. , vol.86 , Issue.15 , pp. 1437-1438
    • Fujiwara, T.1    Cai, D.W.2    Georges, R.N.3
  • 11
    • 0028403234 scopus 로고
    • High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus
    • ZHANG WW, FANG X, MAZUR W et al.: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther. (1994) 1(15):5-13.
    • (1994) Cancer Gene Ther. , vol.1 , Issue.15 , pp. 5-13
    • Zhang, W.W.1    Fang, X.2    Mazur, W.3
  • 12
    • 0029261994 scopus 로고
    • Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53
    • WANG JX, BUCANA CD, ROTH JA, ZHANG WW: Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. Cancer Gene Ther. (1995) 2(15):9-17.
    • (1995) Cancer Gene Ther. , vol.2 , Issue.15 , pp. 9-17
    • Wang, J.X.1    Bucana, C.D.2    Roth, J.A.3    Zhang, W.W.4
  • 13
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct
    • GEORGES RN, MUKHOPADHYAY T, ZHANG Y, YEN N, ROTH JA: Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res. (1993) 53(15):1743-1746.
    • (1993) Cancer Res. , vol.53 , Issue.15 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 14
    • 0029856574 scopus 로고    scopus 로고
    • Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation
    • SPITZ FR, NGUYEN D, SKIBBER JM et al.: Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation. Clin. Cancer Res. (1996) 2(15):1665-1671.
    • (1996) Clin. Cancer Res. , vol.2 , Issue.15 , pp. 1665-1671
    • Spitz, F.R.1    Nguyen, D.2    Skibber, J.M.3
  • 15
    • 0031084922 scopus 로고    scopus 로고
    • Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts
    • NIELSEN LL, DELL J, MAXWELL E et al.: Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts. Cancer Gene Ther. (1997) 4(15):129-138.
    • (1997) Cancer Gene Ther. , vol.4 , Issue.15 , pp. 129-138
    • Nielsen, L.L.1    Dell, J.2    Maxwell, E.3
  • 16
    • 0031911004 scopus 로고    scopus 로고
    • Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide
    • BOUVET M, FANG B, EKMEKCIOGLU S et al.: Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide. Gene Ther. (1998) 5(15):189-195.
    • (1998) Gene Ther. , vol.5 , Issue.15 , pp. 189-195
    • Bouvet, M.1    Fang, B.2    Ekmekcioglu, S.3
  • 17
    • 0031038841 scopus 로고    scopus 로고
    • Patenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity
    • XU M, KUMAR D, SRINIVAS S et al.: Patenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity. Hum. Gene Ther. (1997) 8(15):177-185.
    • (1997) Hum. Gene Ther. , vol.8 , Issue.15 , pp. 177-185
    • Xu, M.1    Kumar, D.2    Srinivas, S.3
  • 18
    • 0030178932 scopus 로고    scopus 로고
    • High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus
    • CUSACK JC, SPITZ FR, NGUYEN D et al.: High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus. Cancer Gene Ther. (1996) 3(15):245-249.
    • (1996) Cancer Gene Ther. , vol.3 , Issue.15 , pp. 245-249
    • Cusack, J.C.1    Spitz, F.R.2    Nguyen, D.3
  • 19
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of human bax gene
    • MIYASHITA T, REED JC: Tumor suppressor p53 is a direct transcriptional activator of human bax gene. Cell (1995) 80(15):293-299.
    • (1995) Cell , vol.80 , Issue.15 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 20
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • DAMERON KM, VOLPERT OV, TAINSKY MA, BOUCK N: Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (1994) 265(15):1582-1584.
    • (1994) Science , vol.265 , Issue.15 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 21
    • 0034284450 scopus 로고    scopus 로고
    • Longitudinal follow-up of cellular and humoral immunity induced by recombinant adenovirus-mediated gene therapy in cancer patients
    • MOLINIER-FRENKEL V, LE BOULAIRE C, LE GAL FA et al.: Longitudinal follow-up of cellular and humoral immunity induced by recombinant adenovirus-mediated gene therapy in cancer patients. Hum. Gene Ther. (2000) 11(15):1911-1920.
    • (2000) Hum. Gene Ther. , vol.11 , Issue.15 , pp. 1911-1920
    • Molinier-Frenkel, V.1    Le Boulaire, C.2    Le Gal, F.A.3
  • 22
    • 0034085041 scopus 로고    scopus 로고
    • Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumor injection of an adenovirus vector expressing wild-type p53 (Ad-p53)
    • YEN N, IOANNIDES CG, XU K et al.: Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumor injection of an adenovirus vector expressing wild-type p53 (Ad-p53). Cancer Gene Ther. (2000) 7(15):530-536.
    • (2000) Cancer Gene Ther. , vol.7 , Issue.15 , pp. 530-536
    • Yen, N.1    Ioannides, C.G.2    Xu, K.3
  • 23
    • 0035524591 scopus 로고    scopus 로고
    • The role of natural killer cells in adenovirus-mediated p53 gene therapy
    • CARROLL JL, NIELSEN LL, PRUETT SB, MATHIS JM: The role of natural killer cells in adenovirus-mediated p53 gene therapy. Mol. Cancer Ther. (2001) 1(15):49-60.
    • (2001) Mol. Cancer Ther. , vol.1 , Issue.15 , pp. 49-60
    • Carroll, J.L.1    Nielsen, L.L.2    Pruett, S.B.3    Mathis, J.M.4
  • 24
    • 0029003501 scopus 로고
    • Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
    • OWEN-SCHAUB LB, ZHANG W, CUSACK JC et al.: Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol. (1995) 15(15):3032-3040.
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.15 , pp. 3032-3040
    • Owen-Schaub, L.B.1    Zhang, W.2    Cusack, J.C.3
  • 25
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • ROTH JA, NGUYEN D, LAWRENCE DD et al.: Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat. Med. (1996) 2(15):985-991.
    • (1996) Nat. Med. , vol.2 , Issue.15 , pp. 985-991
    • Roth, J.A.1    Nguyen, D.2    Lawrence, D.D.3
  • 26
    • 0029984307 scopus 로고    scopus 로고
    • Clinical protocol: Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC)
    • ROTH JA: Clinical protocol: modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC). Hum. Gene Ther. (1996) 7(15):875-889.
    • (1996) Hum. Gene Ther. , vol.7 , Issue.15 , pp. 875-889
    • Roth, J.A.1
  • 27
    • 0029890861 scopus 로고    scopus 로고
    • Clinical protocol: Modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wildtype p53 and cisplatin
    • ROTH JA: Clinical protocol: modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wildtype p53 and cisplatin. Hum. Gene Ther. (1996) 7(15):1013-1030.
    • (1996) Hum. Gene Ther. , vol.7 , Issue.15 , pp. 1013-1030
    • Roth, J.A.1
  • 28
    • 0033526357 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in advanced non-small cell lung cancer
    • SWISHER SG, ROTH JA, NEMUNAITIS J et al.: Adenovirus-mediated p53 gene transfer in advanced non-small cell lung cancer. J. Natl. Cancer Inst. (1999) 91(15):763-771.
    • (1999) J. Natl. Cancer Inst. , vol.91 , Issue.15 , pp. 763-771
    • Swisher, S.G.1    Roth, J.A.2    Nemunaitis, J.3
  • 29
    • 0031750168 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
    • CLAYMAN GL, EL-NAGGAR AK, LIPPMAN SM et al.: Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J. Clin. Oncol. (1998) 16(15):2221-2232.
    • (1998) J. Clin. Oncol. , vol.16 , Issue.15 , pp. 2221-2232
    • Clayman, G.L.1    El-Naggar, A.K.2    Lippman, S.M.3
  • 30
    • 0006596907 scopus 로고    scopus 로고
    • Randomized Phase II study of intratumoral injection of two dosing schedules using a replication-deficient adenovirus carrying the p53 gene (AD5CMV-P53) in patients with recurrent/refractory head and neck cancer
    • GOODWIN WJ, ESSER D, CLAYMAN GL et al.: Randomized Phase II study of intratumoral injection of two dosing schedules using a replication-deficient adenovirus carrying the p53 gene (AD5CMV-P53) in patients with recurrent/refractory head and neck cancer. Proc. Am. Soc. Clin. Oncol. (1999) 19(15):445a.
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.19 , Issue.15
    • Goodwin, W.J.1    Esser, D.2    Clayman, G.L.3
  • 31
    • 25344469401 scopus 로고    scopus 로고
    • A Phase II multi-center study of AD5CMV-P53 administered intratumorally to patients with recurrent head and neck cancer
    • BIER-LANING CM, VANECHO D, YVERA, DREILING LK: A Phase II multi-center study of AD5CMV-P53 administered intratumorally to patients with recurrent head and neck cancer. Proc. Am. Soc. Clin. Oncol. (1999) 18(15):444a.
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18 , Issue.15
    • Bier-Laning, C.M.1    Vanecho, D.2    Yver, A.3    Dreiling, L.K.4
  • 32
    • 0003079179 scopus 로고    scopus 로고
    • Tolerance and safety of RPR/INGN 201, an adeno-viral vector containing a p53 gene, administered intratumorally in 309 patients with advanced cancer enrolled in Phase I and II studies world-wide
    • YVER A, DREILING LK, MOHANTY S et al.: Tolerance and safety of RPR/INGN 201, an adeno-viral vector containing a p53 gene, administered intratumorally in 309 patients with advanced cancer enrolled in Phase I and II studies world-wide. Proc. Am. Soc. Clin. Oncol. (1999) 19(15):460a.
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.19 , Issue.15
    • Yver, A.1    Dreiling, L.K.2    Mohanty, S.3
  • 33
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
    • YONISH-ROUACH E, RESNITZKY D, LOTEM J et al.: Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature (1991) 352(15):345-347.
    • (1991) Nature , vol.352 , Issue.15 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3
  • 34
    • 0027318202 scopus 로고
    • Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53
    • RAMQVIST T, MAGNUSSON KP, WANG Y, SZEKELEY L, KLEIN G: Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53. Oncogene (1993) 8(15):1495-1500.
    • (1993) Oncogene , vol.8 , Issue.15 , pp. 1495-1500
    • Ramqvist, T.1    Magnusson, K.P.2    Wang, Y.3    Szekeley, L.4    Klein, G.5
  • 35
    • 0026523778 scopus 로고
    • Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
    • SHAW P, BOVEY R, TARDY S et al.: Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA (1992) 89(15):4495-4499.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.15 , pp. 4495-4499
    • Shaw, P.1    Bovey, R.2    Tardy, S.3
  • 37
    • 0343686533 scopus 로고
    • Review: Clinical protocol for modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wildtype p53 and cisplatin
    • ROTH JA: Review: Clinical protocol for modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wildtype p53 and cisplatin. Hum. Gene Ther. (1995) 6(15):252-255.
    • (1995) Hum. Gene Ther. , vol.6 , Issue.15 , pp. 252-255
    • Roth, J.A.1
  • 38
    • 0029032579 scopus 로고
    • Apoptosis in murine tumors treated with chemotherapy agents
    • MEYN RE, STEPHENS LC, HUNTER NR, MILAS L: Apoptosis in murine tumors treated with chemotherapy agents. Anticancer Drugs (1995) 6(3):443-450.
    • (1995) Anticancer Drugs , vol.6 , Issue.3 , pp. 443-450
    • Meyn, R.E.1    Stephens, L.C.2    Hunter, N.R.3    Milas, L.4
  • 39
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene
    • FUJIWARA T, GRIMM EA, MUKHOPADHYAY T et al.: Induction of chemosensitivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene. Cancer Res. (1994) 54(15):2287-2291.
    • (1994) Cancer Res. , vol.54 , Issue.15 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3
  • 40
    • 0029835487 scopus 로고    scopus 로고
    • Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer
    • NGUYEN DM, SPITZ FR, YEN N, CRISTIANO RJ, ROTH JA: Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J. Thorac. Cardiovasc. Surg. (1996) 112(15):1372-1377.
    • (1996) J. Thorac. Cardiovasc. Surg. , vol.112 , Issue.15 , pp. 1372-1377
    • Nguyen, D.M.1    Spitz, F.R.2    Yen, N.3    Cristiano, R.J.4    Roth, J.A.5
  • 41
    • 9344266882 scopus 로고    scopus 로고
    • The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers
    • HAMADA M, FUJIWARA T, HIZUTA A et al.: The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers. J. Cancer Res. Clin. Oncol. (1996) 122(15):360-365.
    • (1996) J. Cancer Res. Clin. Oncol. , vol.122 , Issue.15 , pp. 360-365
    • Hamada, M.1    Fujiwara, T.2    Hizuta, A.3
  • 42
    • 0031133029 scopus 로고    scopus 로고
    • Delivery of the p53 tumor suppressor gene into lung cancer cells by an adenovirus/DNA complex
    • NGUYEN DM, WIEHLE SA, KOCH PE et al.: Delivery of the p53 tumor suppressor gene into lung cancer cells by an adenovirus/DNA complex. Cancer Gene Ther. (1997) 4(15):191-198.
    • (1997) Cancer Gene Ther. , vol.4 , Issue.15 , pp. 191-198
    • Nguyen, D.M.1    Wiehle, S.A.2    Koch, P.E.3
  • 43
    • 0032191052 scopus 로고    scopus 로고
    • Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells
    • JASTY R, LU J, IRWIN T et al.: Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells. Mol. Genet. Metab. (1998) 65(15):155-164.
    • (1998) Mol. Genet. Metab. , vol.65 , Issue.15 , pp. 155-164
    • Jasty, R.1    Lu, J.2    Irwin, T.3
  • 44
    • 0032719534 scopus 로고    scopus 로고
    • Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas
    • AKIMOTO T, HUNTER NR, BUCHMILLER L et al.: Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clin. Cancer Res. (1999) 5(15):2884-2890.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.15 , pp. 2884-2890
    • Akimoto, T.1    Hunter, N.R.2    Buchmiller, L.3
  • 45
    • 0032745541 scopus 로고
    • Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?
    • FEINMESSER M, HALPERN M, FENIG E et al.: Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: can they predict treatment response and clinical outcome? Hum. Pathol. (1994) 30(15):1367-1372.
    • (1994) Hum. Pathol. , vol.30 , Issue.15 , pp. 1367-1372
    • Feinmesser, M.1    Halpern, M.2    Fenig, E.3
  • 46
    • 0032759016 scopus 로고    scopus 로고
    • Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction
    • BROADDUS WC, LIU Y, STEELE LL et al.: Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction. J. Neurosurg. (1999) 91(15):997-1004.
    • (1999) J. Neurosurg. , vol.91 , Issue.15 , pp. 997-1004
    • Broaddus, W.C.1    Liu, Y.2    Steele, L.L.3
  • 47
    • 8944244998 scopus 로고    scopus 로고
    • Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
    • SAKAKURA C, SWEENEY EA, SHIRAHAMA T et al.: Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int. J. Cancer (1996) 67(15):101-105.
    • (1996) Int. J. Cancer , vol.67 , Issue.15 , pp. 101-105
    • Sakakura, C.1    Sweeney, E.A.2    Shirahama, T.3
  • 48
    • 0027176479 scopus 로고
    • P53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cells lines
    • BRACHMAN DG, BECKET M, GRAVES D et al.: p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cells lines. Cancer Res. (1993) 53(15):3667-3669.
    • (1993) Cancer Res. , vol.53 , Issue.15 , pp. 3667-3669
    • Brachman, D.G.1    Becket, M.2    Graves, D.3
  • 49
    • 0027893001 scopus 로고
    • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage
    • SLICHENMYER WJ, NELSON WG, SLEBOS RJ, KASTAN MB: Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. (1993) 53(15):4164-4168.
    • (1993) Cancer Res. , vol.53 , Issue.15 , pp. 4164-4168
    • Slichenmyer, W.J.1    Nelson, W.G.2    Slebos, R.J.3    Kastan, M.B.4
  • 50
    • 0032852871 scopus 로고
    • No association between radiosensitivity and TP53 status, G(1) arrest or protein levels of p53, myc, ras or raf in human melanoma lines
    • DANIELSEN T, SMITH-SORENSEN B, GRONLUND HA et al.: No association between radiosensitivity and TP53 status, G(1) arrest or protein levels of p53, myc, ras or raf in human melanoma lines. Int. J. Radiat. Biol. (1994) 75(15):1149-1160.
    • (1994) Int. J. Radiat. Biol. , vol.75 , Issue.15 , pp. 1149-1160
    • Danielsen, T.1    Smith-Sorensen, B.2    Gronlund, H.A.3
  • 51
    • 0033950285 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer
    • NEMUNAITIS J, SWISHER SG, TIMMONS T et al.: Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J. Clin. Oncol. (2000) 18(15):609-622.
    • (2000) J. Clin. Oncol. , vol.18 , Issue.15 , pp. 609-622
    • Nemunaitis, J.1    Swisher, S.G.2    Timmons, T.3
  • 52
    • 0035868848 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter Phase II study
    • SCHULER M, HERRMANN R, DE GREVE JL et al.: Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter Phase II study. J. Clin. Oncol. (2001) 19(15):1750-1758.
    • (2001) J. Clin. Oncol. , vol.19 , Issue.15 , pp. 1750-1758
    • Schuler, M.1    Herrmann, R.2    De Greve, J.L.3
  • 53
    • 0036019371 scopus 로고    scopus 로고
    • A Phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer
    • BULLER RE, RUNNEBAUM IB, KARLAN BY et al.: A Phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer. Cancer Gene Ther. (2002) 9(15):553-566.
    • (2002) Cancer Gene Ther. , vol.9 , Issue.15 , pp. 553-566
    • Buller, R.E.1    Runnebaum, I.B.2    Karlan, B.Y.3
  • 54
    • 0036019372 scopus 로고    scopus 로고
    • Long term follow-up of patients with recurrent ovarian cancer after Ad p53 gene replacement with SCH 58500
    • BULLER RE, SHAHIN MS, HOROWITZ JA et al.: Long term follow-up of patients with recurrent ovarian cancer after Ad p53 gene replacement with SCH 58500. Cancer Gene Ther. (2002) 9(15):567-572.
    • (2002) Cancer Gene Ther. , vol.9 , Issue.15 , pp. 567-572
    • Buller, R.E.1    Shahin, M.S.2    Horowitz, J.A.3
  • 55
    • 12244298187 scopus 로고    scopus 로고
    • Induction of p53 regulated genes and tumor regression in lung cancer following intratumoral delivery of adenoviral p53 (RPR/INGN 201) and radiation therapy
    • SWISHER SG, ROTH JA, KOMAKI R et al.: Induction of p53 regulated genes and tumor regression in lung cancer following intratumoral delivery of adenoviral p53 (RPR/INGN 201) and radiation therapy. Clin. Cancer Res. (2003) 9(15):93-101.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.15 , pp. 93-101
    • Swisher, S.G.1    Roth, J.A.2    Komaki, R.3
  • 56
    • 1042295976 scopus 로고    scopus 로고
    • Clinical evaluation of safety and efficacy of intratumoral administration of a recombinant adenoviral-p53 anticancer agent (Genkaxin®)
    • PENG Z, HAN D, ZHANG S et al.: Clinical evaluation of safety and efficacy of intratumoral administration of a recombinant adenoviral-p53 anticancer agent (Genkaxin®). Mol. Ther. (2003) 7(15):422-423.
    • (2003) Mol. Ther. , vol.7 , Issue.15 , pp. 422-423
    • Peng, Z.1    Han, D.2    Zhang, S.3
  • 57
    • 0034981225 scopus 로고    scopus 로고
    • Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector
    • RAMESH R, SAEKI T, TEMPLETON NS et al.: Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol. Ther. (2001) 3(15):337-350.
    • (2001) Mol. Ther. , vol.3 , Issue.15 , pp. 337-350
    • Ramesh, R.1    Saeki, T.2    Templeton, N.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.