메뉴 건너뛰기




Volumn 25, Issue 13, 2005, Pages 5389-5395

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; LYSINE; PROTEIN P53;

EID: 20744448187     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.13.5389-5395.2005     Document Type: Article
Times cited : (200)

References (44)
  • 1
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Appella, E., and C. W. Anderson. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2764-2772.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 2
    • 0034031250 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the posttranslational modification code
    • Appella, E., and C. W. Anderson. 2000. Signaling to p53: breaking the posttranslational modification code. Pathol. Biol. (Paris) 48:227-245.
    • (2000) Pathol. Biol. (Paris) , vol.48 , pp. 227-245
    • Appella, E.1    Anderson, C.W.2
  • 3
    • 0035694469 scopus 로고    scopus 로고
    • Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    • Barlev, N. A., L. Liu, N. H. Chehab, K. Mansfield, K. G. Harris, T. D. Halazonetis, and S. L. Berger. 2001. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell. 8:1243-1254.
    • (2001) Mol. Cell , vol.8 , pp. 1243-1254
    • Barlev, N.A.1    Liu, L.2    Chehab, N.H.3    Mansfield, K.4    Harris, K.G.5    Halazonetis, T.D.6    Berger, S.L.7
  • 4
    • 0036211857 scopus 로고    scopus 로고
    • p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene
    • Boley, S. E., V. A. Wong, J. E. French, and L. Recio. 2002. p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene. Toxicol. Sci. 66:209-215.
    • (2002) Toxicol. Sci. , vol.66 , pp. 209-215
    • Boley, S.E.1    Wong, V.A.2    French, J.E.3    Recio, L.4
  • 5
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • Brooks, C. L., and W. Gu. 2003. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15:164-171.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 6
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi, J. 2005. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 8
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao, C., S. Saito, C. W. Anderson, E. Appella, and Y. Xu. 2000. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl. Acad. Sci. USA 97:11936-11941.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 9
    • 0034665461 scopus 로고    scopus 로고
    • p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
    • Chao, C., S. Saito, J. Kang, C. W. Anderson, E. Appella, and Y. Xu. 2000. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 19:4967-4975.
    • (2000) EMBO J. , vol.19 , pp. 4967-4975
    • Chao, C.1    Saito, S.2    Kang, J.3    Anderson, C.W.4    Appella, E.5    Xu, Y.6
  • 12
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa, J. M., and B. M. Emerson. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8:57-69.
    • (2001) Mol. Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 14
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu, W., and R. G. Roeder. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 15
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 17
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., H. Tanaka, and H. Yasuda. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 18
    • 0036097492 scopus 로고    scopus 로고
    • Essential roles of the kappa light chain intronic enhancer and 3′ enhancer in kappa rearrangement and demethylation
    • Inlay, M., F. W. Alt, D. Baltimore, and Y. Xu. 2002. Essential roles of the kappa light chain intronic enhancer and 3′ enhancer in kappa rearrangement and demethylation. Nat. Immunol. 3:463-468.
    • (2002) Nat. Immunol. , vol.3 , pp. 463-468
    • Inlay, M.1    Alt, F.W.2    Baltimore, D.3    Xu, Y.4
  • 19
    • 0035868964 scopus 로고    scopus 로고
    • p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
    • Ito, A., C.-H. Lai, X. Zhao, S. I. Saito, M. H. Hamilton, E. Appella, and T.-P. Yao. 2001. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 20:1331-1340.
    • (2001) EMBO J. , vol.20 , pp. 1331-1340
    • Ito, A.1    Lai, C.-H.2    Zhao, X.3    Saito, S.I.4    Hamilton, M.H.5    Appella, E.6    Yao, T.-P.7
  • 20
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • Kaeser, M. D., and R. D. Iggo. 2002. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. USA 99:95-100.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2
  • 21
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 22
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M. H., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 23
    • 0031702817 scopus 로고    scopus 로고
    • Regulation of Mdm2-directed degradation by the C terminus of p53
    • Kubbutat, M. H. G., R. L. Ludwig, M. Ashcroft, and K. H. Vousden. 1998. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol. Cell. Biol. 18:5690-5698.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5690-5698
    • Kubbutat, M.H.G.1    Ludwig, R.L.2    Ashcroft, M.3    Vousden, K.H.4
  • 25
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 26
    • 0037061508 scopus 로고    scopus 로고
    • Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
    • Li, M., D. Chen, A. Shiloh, J. Luo, A. Y. Nikolaev, J. Qin, and W. Gu. 2002. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416:648-653.
    • (2002) Nature , vol.416 , pp. 648-653
    • Li, M.1    Chen, D.2    Shiloh, A.3    Luo, J.4    Nikolaev, A.Y.5    Qin, J.6    Gu, W.7
  • 27
    • 0037184969 scopus 로고    scopus 로고
    • Acetylation of p53 inhibits its ubiquitination by Mdm2
    • Li, M., J. Luo, C. L. Brooks, and W. Gu. 2002. Acetylation of p53 inhibits its ubiquitination by Mdm2. J. Biol. Chem. 277:50607-50611.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50607-50611
    • Li, M.1    Luo, J.2    Brooks, C.L.3    Gu, W.4
  • 28
    • 13944273471 scopus 로고    scopus 로고
    • p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • Lin, T., C. Chao, S. Saito, S. J. Mazur, M. E. Murphy, E. Appella, and Y. Xu. 2004. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 7:165-171.
    • (2004) Nat. Cell Biol. , vol.7 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3    Mazur, S.J.4    Murphy, M.E.5    Appella, E.6    Xu, Y.7
  • 30
    • 1442330508 scopus 로고    scopus 로고
    • Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
    • Luo, J., M. Li, Y. Tang, M. Laszkowska, R. G. Roeder, and W. Gu. 2004. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc. Natl. Acad. Sci. USA 101:2259-2264.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2259-2264
    • Luo, J.1    Li, M.2    Tang, Y.3    Laszkowska, M.4    Roeder, R.G.5    Gu, W.6
  • 31
    • 8644241631 scopus 로고    scopus 로고
    • p53 linear diffusion along DNA requires its C terminus
    • McKinney, K., M. Mattia, V. Gottifredi, and C. Prives. 2004. p53 linear diffusion along DNA requires its C terminus. Mol. Cell 16:413-424.
    • (2004) Mol. Cell , vol.16 , pp. 413-424
    • McKinney, K.1    Mattia, M.2    Gottifredi, V.3    Prives, C.4
  • 32
    • 3242883729 scopus 로고    scopus 로고
    • The p53 response to DNA damage
    • Meek, D. W. 2004. The p53 response to DNA damage. DNA Repair (Amsterdam). 3:1049-1056.
    • (2004) DNA Repair (Amsterdam) , vol.3 , pp. 1049-1056
    • Meek, D.W.1
  • 33
    • 0034458966 scopus 로고    scopus 로고
    • Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
    • Nakamura, S., J. A. Roth, and T. Mukhopadhyay. 2000. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol. Cell. Biol. 20:9391-9398.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9391-9398
    • Nakamura, S.1    Roth, J.A.2    Mukhopadhyay, T.3
  • 34
    • 0033767235 scopus 로고    scopus 로고
    • Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome- mediated degradation
    • Rodriguez, M. S., J. M. Desterro, S. Lain, D. P. Lane, and R. T. Hay. 2000. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome- mediated degradation. Mol. Cell. Biol. 20:8458-8467.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8458-8467
    • Rodriguez, M.S.1    Desterro, J.M.2    Lain, S.3    Lane, D.P.4    Hay, R.T.5
  • 37
  • 39
  • 40
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden, K. H., and X. Lu. 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2:594-604.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 41
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman, M. J., E. S. Stavridi, J. L. Waterman, and T. D. Halazonetis. 1998. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19:175-178.
    • (1998) Nat. Genet. , vol.19 , pp. 175-178
    • Waterman, M.J.1    Stavridi, E.S.2    Waterman, J.L.3    Halazonetis, T.D.4
  • 43
    • 3142570737 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    • Xirodimas, D. P., M. K. Saville, J. C. Bourdon, R. T. Hay, and D. P. Lane. 2004. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118:83-97.
    • (2004) Cell , vol.118 , pp. 83-97
    • Xirodimas, D.P.1    Saville, M.K.2    Bourdon, J.C.3    Hay, R.T.4    Lane, D.P.5
  • 44
    • 0037737758 scopus 로고    scopus 로고
    • Regulation of p53 responses by post-translational modifications
    • Xu, Y. 2003. Regulation of p53 responses by post-translational modifications. Cell Death Differ. 10:400-403.
    • (2003) Cell Death Differ. , vol.10 , pp. 400-403
    • Xu, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.