High Thermostability and Lack of Cooperative DNA Binding Distinguish the p63 Core Domain from the Homologous Tumor Suppressor p53

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37390-37401

  Klein, Christian ^a,b   Georges, Guy ^a   Künkele, Klaus Peter ^a   Huber, Robert ^b   Engh, Richard A ^a,b   Hansen, Silke ^a  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ELECTROSTATICS; HYDROPHOBICITY; INTERFACES (MATERIALS); TUMORS;

MAMMALS; TUMOR SUPPRESSORS;

BIOCHEMISTRY;

CORE PROTEIN; GLUTATHIONE TRANSFERASE; ISOPROTEIN; PROTEIN P53; PROTEIN P63; PROTEIN P63 DELTA; PROTEIN P73; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CKAP4 PROTEIN, HUMAN; DNA; DNA BINDING PROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; TP73L PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; UREA; ZINC;

ARTICLE; BAX GENE; BINDING AFFINITY; CANCER INHIBITION; CIRCULAR DICHROISM; CONSENSUS SEQUENCE; CORE DNA BINDING DOMAIN; CYCLIN G GENE; DEVELOPMENT; DIFFERENTIAL SCANNING CALORIMETRY; DIFFERENTIATION; DIMERIZATION; ELECTRICITY; FLUORESCENCE SPECTROSCOPY; GADD45 GENE; GENE; HYDROPHOBICITY; MOLECULAR CLONING; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; P21 GENE; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STABILITY; SEQUENCE HOMOLOGY; THERMODYNAMICS; THERMOSTABILITY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SPECTROFLUOROMETRY; TEMPERATURE; TUMOR SUPPRESSOR GENE;

MAMMALIA;

AMINO ACID SEQUENCE; CIRCULAR DICHROISM; CLONING, MOLECULAR; DNA; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; THERMODYNAMICS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UREA; ZINC;

EID: 0035813165     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103801200     Document Type: Article

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