Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

Science

Volumn 274, Issue 5289, 1996, Pages 1001-1005

  Gorina, Svetlana ^a   Pavletich, Nikola P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CRYSTAL STRUCTURE; DISEASES; DNA; ENZYME INHIBITION; GENES; ONCOLOGY; PROTEINS;

ANKYRIN; DNA BINDING; DNA DAMAGE; ENZYME INHIBITOR; MUTATIONS; PEPTIDE; TUMOR SUPPRESSION; TUMOR SUPPRESSOR;

CELLS;

ANKYRIN; BINDING PROTEIN; PROTEIN P53;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANKYRINS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030575866     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5289.1001     Document Type: Article

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41. 2,-terminal sequence analyses; W. Farley for help with the surface plasmon resonance experiments; M. Mayhew for helpful discussions; and R. Kenny for administrative assistance. Supported by the NIH (CA65698), the Pew Charitable Trusts, the Arnold and Mabel Beckman Foundation, the Dewitt Wallace Foundation, and the Samuel and May Rudin Foundation. Coordinates have been deposited with the Brookhaven Protein Data Bank (code 1YCS).