Inhibition of p53-dependent transcription by BOX-I phospo-peptide mimetics that bind to p300

EMBO Reports

Volumn 2, Issue 2, 2001, Pages 139-144

  Dornan, D ^a   Hupp, T R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; DOCKING PROTEIN; GREEN FLUORESCENT PROTEIN; LIGAND; PHOSPHOPEPTIDE; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P300; PROTEIN P53; REGULATOR PROTEIN; SERINE; THREONINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOCHEMISTRY; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; IRRADIATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

AMINO ACID SUBSTITUTION; BINDING SITES; HUMANS; LIGANDS; MOLECULAR MIMICRY; MUTATION; NUCLEAR PROTEINS; PHOSPHOPEPTIDES; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035092598     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve025     Document Type: Article

References (19)

1. Regulation of p53 function and stability by phosphorylation
2. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
3. Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA
4. Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation
5. Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
6. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
7. CBP/p300 in cell growth, transformation, and development
8. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
9. Mdm2 promotes the rapid degradation of p53
10. Phosphorylation of p53 serine 15 increases interaction with CBP
11. Regulation and function of the p53-related proteins: Same family, different rules
12. Protein interaction methods-toward an endgame
13. Regulation of the p53 tumor suppressor protein
14. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
15. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
16. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
17. A novel cofactor for p300 that regulates the p53 response
18. Critical role for ser20 of human p53 in the negative regulation of p53 by mdm2
19. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage