Solution structure of p53 core domain: Structural basis for its instability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 7, 2006, Pages 2109-2114

  Pérez Cañadillas, José Manuel ^a,b   Tidow, Henning ^a   Freund, Stefan M V ^a   Rutherford, Trevor J ^a   Ang, Hwee Ching ^a   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

Dynamics; Isotope labeling; NMR; Protein; Stability

Indexed keywords

AMINO ACID; CARBON 13; HYDROXYL GROUP; ISOLEUCINE; ISOTOPE; NITROGEN 15; PHENYLALANINE; PROTEIN P53; PROTON; THIOL GROUP; THREONINE; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; DYNAMICS; HYDROGEN BOND; ISOTOPE LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

CRYSTALLOGRAPHY; HUMANS; HYDROPHOBICITY; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53; WATER;

EID: 33144474649     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510941103     Document Type: Article

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