Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 909-912

  Grasberger, Bruce L ^a   Lu, Tianbao ^a   Schubert, Carsten ^a   Parks, Daniel J ^a   Carver, Theodore E ^a   Koblish, Holly K ^a   Cummings, Maxwell D ^a   LaFrance, Louis V ^a,b   Milkiewicz, Karen L ^a,c   Calvo, Raul R ^a   Maguire, Diane ^a   Lattanze, Jennifer ^a   Franks, Carol F ^a   Zhao, Shuyuan ^a   Ramachandren, Kannan ^a   Bylebyl, Gwendolyn R ^a,d   Zhang, Marie ^a,e   Manthey, Carl L ^a   Petrella, Eugene C ^a,f   Pantoliano, Michael W ^a,g   Deckman, Ingrid C ^a   Spurlino, John C ^a   Maroney, Anna C ^a   Tomczuk, Bruce E ^a   Molloy, Christopher J ^a   Bone, Roger F ^a   more..

^a J/J Pharmaceut Res/Devmt   (United States)

^b GLAXOSMITHKLINE   (United States)

^c CEPHALON INC   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e Stratagene   (United States)

^f SUNTORY LTD   (Japan)

^g MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINEDIONE DERIVATIVE; BENZODIAZEPINEDIONE HDM2 ANTAGONIST; PROTEIN; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CANCER INHIBITION; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; THERMAL DENATURATION ASSAY;

BENZODIAZEPINES; BINDING SITES; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 13944274061     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049137g     Document Type: Article

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