Kinetic instability of p53 core domain mutants. Implications for rescue by small molecules

Journal of Biological Chemistry

Volumn 278, Issue 26, 2003, Pages 24108-24112

  Friedler, Assaf ^b   Veprintsev, Dmitry B ^b   Hansson, Lars O ^a   Fersht, Alan R ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BIOSYNTHESIS; DNA; GENETIC ENGINEERING; THERMODYNAMIC STABILITY; TUMORS;

TUMOR SUPPRESSION;

PROTEINS;

CORE BINDING FACTOR; CORE DOMAIN BINDING 3 PEPTIDE; DNA; DNA BINDING PROTEIN; MUTANT PROTEIN; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CARCINOGENESIS; CELL NUCLEUS; DNA BINDING; GENE MUTATION; GENE TARGETING; HALF LIFE TIME; KINETICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN TARGETING; THERMODYNAMICS;

DIMERIZATION; HALF-LIFE; HUMANS; KINETICS; OLIGOPEPTIDES; POINT MUTATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; THERMODYNAMICS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037591875     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302458200     Document Type: Article

References (16)

1. Bargonetti, J., and Manfredi, J. J. (2002) Curr. Opin. Oncol. 14, 86-91
2. Ryan, K. M., Phillips, A. C., and Vousden, K. H. (2001) Curr. Opin. Cell Biol. 13, 332-337
3. Hupp, T. R., Lane, D. P., and Ball, K. L. (2000) Biochem. J. 352, 1-17
4. Lane, D. P., and Lain, S. (2002) Trends Mol. Med. 8, S38-S42
5. Cho, Y., Gorina, S., Jeffrey, P. D., and Pavletich, N. P. (1994) Science 265, 346-355
6. Bullock, A. N., Henckel, J., and Fersht, A. R. (2000) Oncogene 19, 1245-1256
7. Bullock, A. N., and Fersht, A. R. (2001) Nat. Rev. Cancer 1, 68-76
8. Friedler, A., Hansson, L. O., Veprintsev, D. B., Freund, S. M., Rippin, T. M., Nikolova, P. V., Proctor, M. R., Rudiger, S., and Fersht, A. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 937-942
9. Bykov, V. J., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K. G., and Selivanova, G. (2002) Nat. Med. 8, 282-288
10. Foster, B. A., Coffey, H. A., Morin, M. J., and Rastinejad, F. (1999) Science 286, 2507-2510
11. Bullock, A. N., Henckel, J., DeDecker, B. S., Johnson, C. M., Nikolova, P. V., Proctor, M. R., Lane, D. P., and Fersht, A. R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14338-14342
12. Hansson, L. O., Friedler, A., Freund, S., Rudiger, S., and Fersht, A. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 10305-10309
13. Parker, T. G., and Dalgleish, D. G. (1977) Biopolymers 16, 2533-2547
14. Fersht, A. (1999) Structure and Mechanism in Protein Science, 2d. Ed., W. H. Freeman and Co., New York
15. Nikolova, P. V., Wong, K. B., DeDecker, B., Henckel, J., and Fersht, A. R. (2000) EMBO J. 19, 370-378
16. Butler, J. S., and Loh, S. N. (2003) Biochemistry 42, 2396-2403