The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 29, 2005, Pages 10188-10193

  Krummel, Kurt A ^a   Lee, Crystal J ^a   Toledo, Franck ^a,b   Wahl, Geoffrey M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

Mdm2; p53; Trp 53; Tumor suppressor; Ubiquitination

Indexed keywords

ARGININE; E1A PROTEIN; LYSINE; MUTANT PROTEIN; PROTEIN P53; RAS PROTEIN; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOASSAY; CANCER; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE ARREST; CELL IMMORTALIZATION; CELL STRAIN 3T3; DNA DAMAGE; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HALF LIFE TIME; HOMEOSTASIS; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STABILITY; STOICHIOMETRY; STRESS; THYMOCYTE; TRANSACTIVATION; TUMOR SUPPRESSION ASSAY; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; DNA DAMAGE; DNA PRIMERS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENOTYPE; LYSINE; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; REGULATORY SEQUENCES, NUCLEIC ACID; THYMUS GLAND; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 22544484456     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503068102     Document Type: Article

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