메뉴 건너뛰기




Volumn 24, Issue 8, 2004, Pages 3536-3551

How Many Mutant p53 Molecules Are Needed to Inactivate a Tetramer?

Author keywords

[No Author keywords available]

Indexed keywords

MONOMER; PROTEIN P53; PROTEIN P63; PROTEIN P73; PROTEIN SUBUNIT; TETRAMER; TRANSCRIPTION FACTOR;

EID: 1842609721     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.8.3536-3551.2004     Document Type: Article
Times cited : (144)

References (54)
  • 1
    • 0033965487 scopus 로고    scopus 로고
    • p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines
    • Aurelio, O. N., X. T. Kong, S. Gupta, and E. J. Stanbridge. 2000. p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines. Mol. Cell. Biol. 20:770-778.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 770-778
    • Aurelio, O.N.1    Kong, X.T.2    Gupta, S.3    Stanbridge, E.J.4
  • 4
    • 0027983669 scopus 로고
    • Crystal structure of a P53 mmor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho, Y., S. Gorina, P. D. Jeffrey, and N. P. Pavletich. 1994. Crystal structure of a P53 mmor suppressor-DNA complex: understanding tumorigenic mutations. Science 265:346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 5
    • 0141541760 scopus 로고    scopus 로고
    • DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase
    • Chow, J. P. H., W. I. Siu, T. K. Fung, W. M. Chan, A. Lau, T. Arooz, C.-P. Ng, K. Yamashita, and R. Y. C. Poon. 2003. DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase. Mol. Biol. Cell 14:3189-4002.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3189-4002
    • Chow, J.P.H.1    Siu, W.I.2    Fung, T.K.3    Chan, W.M.4    Lau, A.5    Arooz, T.6    Ng, C.-P.7    Yamashita, K.8    Poon, R.Y.C.9
  • 6
    • 0033603494 scopus 로고    scopus 로고
    • p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    • Davison, T. S., C. Vagner, M. Kaghad, A. Ayed, D. Caput, and C. H. Arrowsmith. 1999. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274:18709-18714.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18709-18714
    • Davison, T.S.1    Vagner, C.2    Kaghad, M.3    Ayed, A.4    Caput, D.5    Arrowsmith, C.H.6
  • 7
    • 0029806936 scopus 로고    scopus 로고
    • Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
    • Denissenko, M. F., A. Pao, M. Tang, and G. P. Pfeifer. 1996. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274:430-432.
    • (1996) Science , vol.274 , pp. 430-432
    • Denissenko, M.F.1    Pao, A.2    Tang, M.3    Pfeifer, G.P.4
  • 10
    • 0024382760 scopus 로고
    • The p53 proto-oncogene can act as a suppressor of transformation
    • Finlay, C. A., P. W. Hinds, and A. J. Levine. 1989. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083-1093.
    • (1989) Cell , vol.57 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 11
    • 0029027667 scopus 로고
    • Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent
    • Forrester, K., S. E. Lupold, V. L. Ott, C. H. Chay, V. Band, X. W. Wang, and C. C. Harris. 1995. Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent. Oncogene 10:2103-2111.
    • (1995) Oncogene , vol.10 , pp. 2103-2111
    • Forrester, K.1    Lupold, S.E.2    Ott, V.L.3    Chay, C.H.4    Band, V.5    Wang, X.W.6    Harris, C.C.7
  • 12
    • 0028354495 scopus 로고
    • Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype
    • Frebourg, T., M. Sadelain, Y. S. Ng, J. Kassel, and S. H. Friend. 1994. Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype. Cancer Res. 54:878-881.
    • (1994) Cancer Res. , vol.54 , pp. 878-881
    • Frebourg, T.1    Sadelain, M.2    Ng, Y.S.3    Kassel, J.4    Friend, S.H.5
  • 13
    • 0030889245 scopus 로고    scopus 로고
    • In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP
    • Fujita, M., T. Kiyono, Y. Hayashi, and M. Ishibashi. 1997. In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J. Biol. Chem. 272:10928-10935.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10928-10935
    • Fujita, M.1    Kiyono, T.2    Hayashi, Y.3    Ishibashi, M.4
  • 14
    • 0037144583 scopus 로고    scopus 로고
    • Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins
    • Fung, T. K., W. Y. Siu, C. H. Yam, A. Lau, and R. Y. C. Poon. 2002. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. J. Biol. Chem. 277:35140-35149.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35140-35149
    • Fung, T.K.1    Siu, W.Y.2    Yam, C.H.3    Lau, A.4    Poon, R.Y.C.5
  • 15
    • 0035866340 scopus 로고    scopus 로고
    • Mechanism of functional inactivation of a Li-Fraumem syndrome p53 that has a mutation outside of the DNA-binding domain
    • Gu, J., H. Kawai, D. Wiederschain, and Z. M. Yuan. 2001. Mechanism of functional inactivation of a Li-Fraumem syndrome p53 that has a mutation outside of the DNA-binding domain. Cancer Res. 61:1741-1746.
    • (2001) Cancer Res. , vol.61 , pp. 1741-1746
    • Gu, J.1    Kawai, H.2    Wiederschain, D.3    Yuan, Z.M.4
  • 17
    • 0027756186 scopus 로고
    • p53: At the crossroads of molecular carcinogenesis and risk assessment
    • Harris, C. C. 1993. p53: at the crossroads of molecular carcinogenesis and risk assessment. Science 262:1980-1981.
    • (1993) Science , vol.262 , pp. 1980-1981
    • Harris, C.C.1
  • 19
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu, I. C., R. A. Metcalf, T. Sun, J. A. Welsh, N. J. Wang, and C. C. Harris. 1991. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350:427-428.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 20
    • 0034927749 scopus 로고    scopus 로고
    • p53 family update: p73 and p63 develop their own identities
    • Irwin, M. S., and W. G. Kaelin. 2001. p53 family update: p73 and p63 develop their own identities. Cell Growth Differ. 12:337-349.
    • (2001) Cell Growth Differ. , vol.12 , pp. 337-349
    • Irwin, M.S.1    Kaelin, W.G.2
  • 21
    • 0036468249 scopus 로고    scopus 로고
    • Possible oncogenic potential of DeltaNp73: A newly identified isoform of human p73
    • Ishimoto, O., C. Kawahara, K. Enjo, M. Obinata, T. Nukiwa, and S. Ikawa. 2002. Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73. Cancer Res. 62:636-641.
    • (2002) Cancer Res. , vol.62 , pp. 636-641
    • Ishimoto, O.1    Kawahara, C.2    Enjo, K.3    Obinata, M.4    Nukiwa, T.5    Ikawa, S.6
  • 22
    • 0028952841 scopus 로고
    • Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
    • Jeffrey, P. D., S. Gorina, and N. P. Pavletich. 1995. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science 267:1498-1502.
    • (1995) Science , vol.267 , pp. 1498-1502
    • Jeffrey, P.D.1    Gorina, S.2    Pavletich, N.P.3
  • 24
    • 0036733697 scopus 로고    scopus 로고
    • The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2
    • Leung, K. M., L. S. Po, F. C. Tsang, W. Y. Siu, A. Lau, H. T. Ho, and R. Y. C. Poon. 2002. The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. Cancer Res. 62:4890-4893.
    • (2002) Cancer Res. , vol.62 , pp. 4890-4893
    • Leung, K.M.1    Po, L.S.2    Tsang, F.C.3    Siu, W.Y.4    Lau, A.5    Ho, H.T.6    Poon, R.Y.C.7
  • 25
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 26
    • 0032526426 scopus 로고    scopus 로고
    • How p53 binds DNA as a tetramer
    • McLure, K. G., and P. W. Lee. 1998. How p53 binds DNA as a tetramer. EMBO J. 17:3342-3350.
    • (1998) EMBO J. , vol.17 , pp. 3342-3350
    • McLure, K.G.1    Lee, P.W.2
  • 27
    • 0025731379 scopus 로고
    • Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
    • Milner, J., and E. A. Medcalf. 1991. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 65:765-774.
    • (1991) Cell , vol.65 , pp. 765-774
    • Milner, J.1    Medcalf, E.A.2
  • 28
    • 0036203514 scopus 로고    scopus 로고
    • Autoinhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter
    • Nakagawa, T., M. Takahashi, T. Ozaki, K. Watanabe Ki, S. Todo, H. Mizuguchi, T. Hayakawa, and A. Nakagawara. 2002. Autoinhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter. Mol. Cell. Biol. 22:2575-2585.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2575-2585
    • Nakagawa, T.1    Takahashi, M.2    Ozaki, T.3    Watanabe Ki, K.4    Todo, S.5    Mizuguchi, H.6    Hayakawa, T.7    Nakagawara, A.8
  • 29
    • 0037066755 scopus 로고    scopus 로고
    • Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect
    • Nicholls, C. D., K. G. McLure, M. A. Shields, and P. W. Lee. 2002. Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect. J. Biol. Chem. 277:12937-12945.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12937-12945
    • Nicholls, C.D.1    McLure, K.G.2    Shields, M.A.3    Lee, P.W.4
  • 31
    • 0029145975 scopus 로고
    • Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
    • Poon, R. Y. C., H. Toyoshima, and T. Hunter. 1995. Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6:1197-1213.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1197-1213
    • Poon, R.Y.C.1    Toyoshima, H.2    Hunter, T.3
  • 32
    • 0034647718 scopus 로고    scopus 로고
    • An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    • Pozniak, C. D., S. Radinovic, A. Yang, F. McKeon, D. R. Kaplan, and F. D. Miller. 2000. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289:304-306.
    • (2000) Science , vol.289 , pp. 304-306
    • Pozniak, C.D.1    Radinovic, S.2    Yang, A.3    McKeon, F.4    Kaplan, D.R.5    Miller, F.D.6
  • 33
    • 0023931972 scopus 로고
    • Immortalization of rat embryo fibroblasts by the cellular p53 oncogene
    • Rovinski, B., and S. Benchimol. 1988. Immortalization of rat embryo fibroblasts by the cellular p53 oncogene. Oncogene 2:445-452.
    • (1988) Oncogene , vol.2 , pp. 445-452
    • Rovinski, B.1    Benchimol, S.2
  • 34
    • 0035939788 scopus 로고    scopus 로고
    • Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells
    • Sayan, A. E., B. S. Sayan, N. Findikli, and M. Ozturk. 2001. Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells. Oncogene 20:5111-5117.
    • (2001) Oncogene , vol.20 , pp. 5111-5117
    • Sayan, A.E.1    Sayan, B.S.2    Findikli, N.3    Ozturk, M.4
  • 35
    • 0027327989 scopus 로고
    • Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53
    • Srivastava, S., S. Wang, Y. A. Tong, K. Pirollo, and E. H. Chang. 1993. Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53. Oncogene 8:2449-2456.
    • (1993) Oncogene , vol.8 , pp. 2449-2456
    • Srivastava, S.1    Wang, S.2    Tong, Y.A.3    Pirollo, K.4    Chang, E.H.5
  • 36
    • 0037134475 scopus 로고    scopus 로고
    • Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: Implications for tumorigenesis
    • Stiewe, T., C. C. Theseling, and B. M. Putzer. 2002. Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. J. Biol. Chem. 277:14177-14185.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14177-14185
    • Stiewe, T.1    Theseling, C.C.2    Putzer, B.M.3
  • 37
    • 0037222381 scopus 로고    scopus 로고
    • Germline TP53 mutations and Li-Fraumeni syndrome
    • Varley, J. M. 2003. Germline TP53 mutations and Li-Fraumeni syndrome. Hum. Mutat. 21:313-320.
    • (2003) Hum. Mutat. , vol.21 , pp. 313-320
    • Varley, J.M.1
  • 38
    • 0034650611 scopus 로고    scopus 로고
    • p73 competes with p53 and attenuates its response in a human ovarian cancer cell line
    • Vikhanskaya, F., M. D'Incalci, and M. Broggini. 2000. p73 competes with p53 and attenuates its response in a human ovarian cancer cell line. Nucleic Acids Res. 28:513-519.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 513-519
    • Vikhanskaya, F.1    D'Incalci, M.2    Broggini, M.3
  • 39
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B., and K. W. Kinzler. 1992. p53 function and dysfunction. Cell 70:523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 40
    • 0027956867 scopus 로고
    • Tumour-suppressor genes. X-rays strike p53 again
    • Vogelstein, B., and K. W. Kinzler. 1994. Tumour-suppressor genes. X-rays strike p53 again. Nature 370:174-175.
    • (1994) Nature , vol.370 , pp. 174-175
    • Vogelstein, B.1    Kinzler, K.W.2
  • 41
  • 42
    • 0035895602 scopus 로고    scopus 로고
    • MDM2 and MDMX can interact differently with ARF and members of the p53 family
    • Wang, X., T. Arooz, W. Y. Siu, C. H. Chiu, A. Lau, K. Yamashita, and R. Y. C. Poon. 2001. MDM2 and MDMX can interact differently with ARF and members of the p53 family. FEBS Lett. 490:202-208.
    • (2001) FEBS Lett. , vol.490 , pp. 202-208
    • Wang, X.1    Arooz, T.2    Siu, W.Y.3    Chiu, C.H.4    Lau, A.5    Yamashita, K.6    Poon, R.Y.C.7
  • 43
    • 0035866337 scopus 로고    scopus 로고
    • A possible role of p73 on the modulation of p53 level through MDM2
    • Wang, X. Q., W. M. Ongkeko, A. W. Lau, K. M. Leung, and R. Y. C. Poon. 2001. A possible role of p73 on the modulation of p53 level through MDM2. Cancer Res. 61:1598-1603.
    • (2001) Cancer Res. , vol.61 , pp. 1598-1603
    • Wang, X.Q.1    Ongkeko, W.M.2    Lau, A.W.3    Leung, K.M.4    Poon, R.Y.C.5
  • 45
    • 0032954205 scopus 로고    scopus 로고
    • Regulation of cychn A-Cdk2 by SCF component Skp1 and F-box protein Skp2
    • Yam, C. H., R. W. Ng, W. Y. Siu, A. W. Lau, and R. Y. C. Poon. 1999. Regulation of cychn A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Mod. Cell. Biol. 19:635-645.
    • (1999) Mod. Cell. Biol. , vol.19 , pp. 635-645
    • Yam, C.H.1    Ng, R.W.2    Siu, W.Y.3    Lau, A.W.4    Poon, R.Y.C.5
  • 46
    • 0344995254 scopus 로고    scopus 로고
    • MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins
    • Yam, C. H., W. Y. Siu, T. Arooz, C. H. Chiu, A. Lau, X. Q. Wang, and R. Y. C. Poon. 1999. MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Cancer Res. 59:5075-5078.
    • (1999) Cancer Res. , vol.59 , pp. 5075-5078
    • Yam, C.H.1    Siu, W.Y.2    Arooz, T.3    Chiu, C.H.4    Lau, A.5    Wang, X.Q.6    Poon, R.Y.C.7
  • 47
    • 0039596852 scopus 로고    scopus 로고
    • Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2
    • Yam, C. H., W. Y. Siu, A. Lau, and R. Y. C. Poon. 2000. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. J. Biol. Chem. 278:3158-3167.
    • (2000) J. Biol. Chem. , vol.278 , pp. 3158-3167
    • Yam, C.H.1    Siu, W.Y.2    Lau, A.3    Poon, R.Y.C.4
  • 48
    • 0036468523 scopus 로고    scopus 로고
    • On the shoulders of giants: p63, p73 and the rise of p53
    • Yang, A., M. Kaghad, D. Caput, and F. McKeon. 2002. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 18:90-95.
    • (2002) Trends Genet. , vol.18 , pp. 90-95
    • Yang, A.1    Kaghad, M.2    Caput, D.3    McKeon, F.4
  • 49
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang, A., M. Kaghad, Y. Wang, E. Gillett, M. D. Fleming, V. Dotsch, N. C. Andrews, D. Caput, and F. McKeon. 1998. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2:305-316.
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 50
    • 0034576495 scopus 로고    scopus 로고
    • P63 and P73: P53 mimics, menaces and more
    • Yang, A., and F. McKeon. 2000. P63 and P73: P53 mimics, menaces and more. Nat. Rev. Mol. Cell Biol. 1:199-207.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 199-207
    • Yang, A.1    McKeon, F.2
  • 52
    • 0036307307 scopus 로고    scopus 로고
    • p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products
    • Yin, Y., C. W. Stephen, M. G. Luciani, and R. Fahraeus. 2002. p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat. Cell Biol. 4:462-467.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 462-467
    • Yin, Y.1    Stephen, C.W.2    Luciani, M.G.3    Fahraeus, R.4
  • 53
    • 0032926306 scopus 로고    scopus 로고
    • Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAF1/Cip1 and Bax genes in the lung cancer environment. WAF1/Cip1 = WAF1/Cip1
    • Zacharatos, P. V., V. G. Gorgoulis, A. Kotsinas, E. N. Manolis, T. Liloglou, A. N. Rassidakis, P. Kanavaros, J. D. Field, T. Halazonetis, and C. Kittas. 1999. Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAF1/Cip1 and Bax genes in the lung cancer environment. WAF1/Cip1 = WAF1/Cip1. Anticancer Res. 19:579-587.
    • (1999) Anticancer Res. , vol.19 , pp. 579-587
    • Zacharatos, P.V.1    Gorgoulis, V.G.2    Kotsinas, A.3    Manolis, E.N.4    Liloglou, T.5    Rassidakis, A.N.6    Kanavaros, P.7    Field, J.D.8    Halazonetis, T.9    Kittas, C.10
  • 54
    • 0032557649 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for mediating apoptosis
    • Zhu, J., W. Zhou, J. Jiang, and X. Chen. 1998. Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J. Biol. Chem. 273:13030-13036.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13030-13036
    • Zhu, J.1    Zhou, W.2    Jiang, J.3    Chen, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.