메뉴 건너뛰기




Volumn 444, Issue 2, 2004, Pages 108-118

Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib

Author keywords

GIST; Imatinib; KIT; PDGF R ; RTK inhibitor; Targeted therapy

Indexed keywords

ABELSON KINASE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; CYTOSTATIC AGENT; IMATINIB; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; TRASTUZUMAB;

EID: 1542315370     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-003-0945-5     Document Type: Review
Times cited : (22)

References (71)
  • 4
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Nature 411:355-365
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 5
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, Lydon NB (1995) Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci U S A 92:2558-2562
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2558-2562
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Druker, B.J.6    Lydon, N.B.7
  • 6
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylamonipyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, Lydon NB (1996) Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylamonipyrimidine derivative. Cancer Res 56:100-104
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Druker, B.J.6    Lydon, N.B.7
  • 7
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, Lydon NB (2000) Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295:139-145
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3    Stover, D.4    Ohno-Jones, S.5    Druker, B.J.6    Lydon, N.B.7
  • 10
    • 0036784162 scopus 로고    scopus 로고
    • Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate)
    • Chen MYM, Bechtold RE, Savage PD (2002) Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate). AJR 179:1059-1062
    • (2002) AJR , vol.179 , pp. 1059-1062
    • Chen, M.Y.M.1    Bechtold, R.E.2    Savage, P.D.3
  • 11
    • 0036092268 scopus 로고    scopus 로고
    • KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
    • Corless CL, McGreevey L, Haley A, Town A, Heinrich MC (2002) KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol 160:1567-1572
    • (2002) Am J Pathol , vol.160 , pp. 1567-1572
    • Corless, C.L.1    McGreevey, L.2    Haley, A.3    Town, A.4    Heinrich, M.C.5
  • 12
    • 0035397627 scopus 로고    scopus 로고
    • Chromosomal aberrations in malignant gastrointestinal stromal tumors: Correlation with c-KIT gene mutation
    • Debiec-Rychter M, Lasota J, Sarlomo-Rikala M, Kordek R, Miettinen M (2001) Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation. Cancer Genet Cytogenet 128:24-30
    • (2001) Cancer Genet Cytogenet , vol.128 , pp. 24-30
    • Debiec-Rychter, M.1    Lasota, J.2    Sarlomo-Rikala, M.3    Kordek, R.4    Miettinen, M.5
  • 13
    • 0041466445 scopus 로고    scopus 로고
    • Specific targeted therapy of chronic myelogenous leukemia with imatinib
    • Deininger MWN, Druker BJ (2003) Specific targeted therapy of chronic myelogenous leukemia with imatinib. Pharmacol Rev 55:401-423
    • (2003) Pharmacol Rev , vol.55 , pp. 401-423
    • Deininger, M.W.N.1    Druker, B.J.2
  • 14
    • 0036841799 scopus 로고    scopus 로고
    • The GIST of targeted cancer therapy: A tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571)
    • DeMatteo RP (2002) The GIST of targeted cancer therapy: a tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571). Ann Surg Oncol 9:831-839
    • (2002) Ann Surg Oncol , vol.9 , pp. 831-839
    • DeMatteo, R.P.1
  • 15
    • 0036305274 scopus 로고    scopus 로고
    • Clinical management of gastrointestinal stromal tumors: Before and after STI-571
    • DeMatteo RP, Heinrich MC, El-Rifai WM, Demetri G (2002) Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol 33:466-477
    • (2002) Hum Pathol , vol.33 , pp. 466-477
    • DeMatteo, R.P.1    Heinrich, M.C.2    El-Rifai, W.M.3    Demetri, G.4
  • 19
    • 0026793260 scopus 로고
    • Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
    • Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU (1992) Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52:4550-4553
    • (1992) Cancer Res , vol.52 , pp. 4550-4553
    • Fleming, T.P.1    Saxena, A.2    Clark, W.C.3    Robertson, J.T.4    Oldfield, E.H.5    Aaronson, S.A.6    Ali, I.U.7
  • 23
    • 0035207172 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptors: A therapeutic target in solid tumors
    • George D (2001) Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin Oncol 28[Suppl 17]:27-33
    • (2001) Semin Oncol , vol.28 , Issue.17 SUPPL. , pp. 27-33
    • George, D.1
  • 24
    • 0036134201 scopus 로고    scopus 로고
    • CD117 (KIT): A diverse protein with selective applications in surgical pathology
    • Gibson PC, Cooper K (2002) CD117 (KIT): a diverse protein with selective applications in surgical pathology. Adv Anat Pathol 9:65-69
    • (2002) Adv Anat Pathol , vol.9 , pp. 65-69
    • Gibson, P.C.1    Cooper, K.2
  • 25
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Ziegler AJ (2000) Inhibition of c-kit receptor tyrosine kinase activity by STI571, a selective tyrosine kinase inhibitor. Blood 96:925-932
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Ziegler, A.J.6
  • 26
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich MC, Blanke CD, Druker BJ, Corless CL (2002) Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 20:1692-1703
    • (2002) J Clin Oncol , vol.20 , pp. 1692-1703
    • Heinrich, M.C.1    Blanke, C.D.2    Druker, B.J.3    Corless, C.L.4
  • 31
  • 33
    • 0041971080 scopus 로고    scopus 로고
    • Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
    • Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y (2003) Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors. Gastroenterology 125:660-667
    • (2003) Gastroenterology , vol.125 , pp. 660-667
    • Hirota, S.1    Ohashi, A.2    Nishida, T.3    Isozaki, K.4    Kinoshita, K.5    Shinomura, Y.6    Kitamura, Y.7
  • 36
    • 0033786922 scopus 로고    scopus 로고
    • Protein tyrosine kinase structure and function
    • Hubbard SR, Till JH (2000) Protein tyrosine kinase structure and function. Annu Rev Biochem 69:373-398
    • (2000) Annu Rev Biochem , vol.69 , pp. 373-398
    • Hubbard, S.R.1    Till, J.H.2
  • 38
    • 0034665138 scopus 로고    scopus 로고
    • Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylamino-pyrimidine class
    • Kilic T, Alberta JA, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, Buchdunger E, Black PM, Stiles CD (2000) Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylamino-pyrimidine class. Cancer Res 60:5143-5150
    • (2000) Cancer Res , vol.60 , pp. 5143-5150
    • Kilic, T.1    Alberta, J.A.2    Zdunek, P.R.3    Acar, M.4    Iannarelli, P.5    O'Reilly, T.6    Buchdunger, E.7    Black, P.M.8    Stiles, C.D.9
  • 39
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM (1998) Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 152:1259-1269
    • (1998) Am J Pathol , vol.152 , pp. 1259-1269
    • Kindblom, L.G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 40
    • 0033883653 scopus 로고    scopus 로고
    • The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
    • Krystal GW, Honsawek S, Litz J, Buchdunger E (2000) The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth. Clin Cancer Res 6:3319-3326
    • (2000) Clin Cancer Res , vol.6 , pp. 3319-3326
    • Krystal, G.W.1    Honsawek, S.2    Litz, J.3    Buchdunger, E.4
  • 42
  • 43
    • 0037365824 scopus 로고    scopus 로고
    • Kit expression in desmoid fibromatosis. Comparative immunohistochrnical evaluation of two commercial antibodies
    • Lucas DR, Al-Abbadi M, Tabaczka P, Hamre MR, Weaver DW, Mott MJ (2003) c-Kit expression in desmoid fibromatosis. Comparative immunohistochrnical evaluation of two commercial antibodies. Am J Clin Pathol 119:339-345
    • (2003) Am J Clin Pathol , vol.119 , pp. 339-345
    • Lucas, D.R.1    Al-Abbadi, M.2    Tabaczka, P.3    Hamre, M.R.4    Weaver, D.W.5    Mott, M.J.6
  • 44
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y, Zeng S, Metcalfe DD, Akin C, Dimitrijevic S, Butterfield JH, McMahon G, Longley BJ (2002) The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 99:1741-1744
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3    Akin, C.4    Dimitrijevic, S.5    Butterfield, J.H.6    McMahon, G.7    Longley, B.J.8
  • 46
    • 0037143794 scopus 로고    scopus 로고
    • Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
    • Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR (2002) Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 100:623-626
    • (2002) Int J Cancer , vol.100 , pp. 623-626
    • Maki, R.G.1    Awan, R.A.2    Dixon, R.H.3    Jhanwar, S.4    Antonescu, C.R.5
  • 48
    • 0037146220 scopus 로고    scopus 로고
    • Potential use of imatinib in Ewing's sarcoma: Evidence for in vitro and in vivo activity
    • Merchant MS, Woo C-W, Mackall CL, Thiele CJ (2002) Potential use of imatinib in Ewing's sarcoma: evidence for in vitro and in vivo activity. J Natl Cancer Inst 94:1673-1679
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1673-1679
    • Merchant, M.S.1    Woo, C.-W.2    Mackall, C.L.3    Thiele, C.J.4
  • 49
    • 0033763567 scopus 로고    scopus 로고
    • Involvement of platelet-derived growth factor in disease: Development of specific antagonists
    • Östman A, Heldin C-H (2001) Involvement of platelet-derived growth factor in disease: development of specific antagonists. Adv Cancer Res 80:1-38
    • (2001) Adv Cancer Res , vol.80 , pp. 1-38
    • Östman, A.1    Heldin, C.-H.2
  • 50
    • 0036124762 scopus 로고    scopus 로고
    • Class III receptor tyrosine kinases: Role in leukaemogenesis
    • Reilly JT (2002) Class III receptor tyrosine kinases: role in leukaemogenesis. Br J Haematol 116:744-757
    • (2002) Br J Haematol , vol.116 , pp. 744-757
    • Reilly, J.T.1
  • 52
    • 0036727124 scopus 로고    scopus 로고
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    • Rubin BP, Schuetze SM, Eary JF, Norwood TH, Mirza S, Conrad EU, Bruckner JD (2002) Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 20:3586-3591
    • (2002) J Clin Oncol , vol.20 , pp. 3586-3591
    • Rubin, B.P.1    Schuetze, S.M.2    Eary, J.F.3    Norwood, T.H.4    Mirza, S.5    Conrad, E.U.6    Bruckner, J.D.7
  • 53
    • 0038640974 scopus 로고    scopus 로고
    • Alterations of the c-kit gene in testicular germ cell tumors
    • Sakuma Y, Sakurai S, Oguni S, Hironaka M, Saito K (2003) Alterations of the c-kit gene in testicular germ cell tumors. Cancer Sci 94:486-491
    • (2003) Cancer Sci , vol.94 , pp. 486-491
    • Sakuma, Y.1    Sakurai, S.2    Oguni, S.3    Hironaka, M.4    Saito, K.5
  • 54
    • 0034981645 scopus 로고    scopus 로고
    • Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese
    • Sakurai S, Oguni S, Hironaka M, Fukayama M, Morinaga S, Saito K (2001) Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese. Jpn J Cancer Res 92:494-498
    • (2001) Jpn J Cancer Res , vol.92 , pp. 494-498
    • Sakurai, S.1    Oguni, S.2    Hironaka, M.3    Fukayama, M.4    Morinaga, S.5    Saito, K.6
  • 56
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlesinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-225
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlesinger, J.1
  • 58
    • 0037106370 scopus 로고    scopus 로고
    • Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    • Singer S, Rubin BP, Lux ML, Chen C-J, Demetri GD, Fletcher CDM, Fletcher JA (2002) Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol 20:3898-3905
    • (2002) J Clin Oncol , vol.20 , pp. 3898-3905
    • Singer, S.1    Rubin, B.P.2    Lux, M.L.3    Chen, C.-J.4    Demetri, G.D.5    Fletcher, C.D.M.6    Fletcher, J.A.7
  • 59
    • 0037402488 scopus 로고    scopus 로고
    • Genetics of dermatofibrosarcoma protuberans family of tumors: From ring chromosomes to tyrosine kinase inhibitor treatment
    • Sirvent N, Maire G, Pedeutour F (2003) Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 37:1-19
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 1-19
    • Sirvent, N.1    Maire, G.2    Pedeutour, F.3
  • 60
    • 0035421175 scopus 로고    scopus 로고
    • Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis
    • Sjöblom T, Shimizu A, O'Brian KP, Pietras K, Dal Cin P, Buchdunger E, Dumanski JP, Östman A, Heldin C-H (2001) Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res 61:5778-5783
    • (2001) Cancer Res , vol.61 , pp. 5778-5783
    • Sjöblom, T.1    Shimizu, A.2    O'Brian, K.P.3    Pietras, K.4    Dal Cin, P.5    Buchdunger, E.6    Dumanski, J.P.7    Östman, A.8    Heldin, C.-H.9
  • 62
    • 0032983371 scopus 로고    scopus 로고
    • Activating c-kit gene mutations in human germ cell tumors
    • Tian Q, Frierson HF, Krystal GW, Moskaluk CA (1999) Activating c-kit gene mutations in human germ cell tumors. Am J Pathol 154:1643-1647
    • (1999) Am J Pathol , vol.154 , pp. 1643-1647
    • Tian, Q.1    Frierson, H.F.2    Krystal, G.W.3    Moskaluk, C.A.4
  • 63
    • 0347659463 scopus 로고    scopus 로고
    • Advances in molecular therapies in patients with brain tumors
    • Tremont-Lukats IW, Gilbert MR (2003) Advances in molecular therapies in patients with brain tumors. Cancer Control 10:125-137
    • (2003) Cancer Control , vol.10 , pp. 125-137
    • Tremont-Lukats, I.W.1    Gilbert, M.R.2
  • 65
    • 0036769690 scopus 로고    scopus 로고
    • Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs)
    • Van den Abbeele AD, Badawi RD (2002) Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs). Eur J Cancer 38[Suppl 5]S60-S65
    • (2002) Eur J Cancer , vol.38 , Issue.5 SUPPL.
    • Van Den Abbeele, A.D.1    Badawi, R.D.2
  • 67
    • 0242522370 scopus 로고    scopus 로고
    • Early efficacy comparison of two doses of imatinib for the treatment of advanced gastro-intestinal stromal tumors (GIST): Interim results of a randomized phase in trial from the EORTC-STBSG, ISG and AGITG
    • abstract 3272
    • Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichard P, Blay J-Y, Issels M, van Glabbeke M, Donato Di Paola E, Judson IR (2003) Early efficacy comparison of two doses of imatinib for the treatment of advanced gastro-intestinal stromal tumors (GIST): interim results of a randomized phase in trial from the EORTC-STBSG, ISG and AGITG (abstract 3272). Proc Am Soc Clin Oncol 22:814
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 814
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3    LeCesne, A.4    Reichard, P.5    Blay, J.-Y.6    Issels, M.7    Van Glabbeke, M.8    Donato Di Paola, E.9    Judson, I.R.10
  • 68
    • 0036175997 scopus 로고    scopus 로고
    • c-kit mutations in gastrointestinal stromal tumors occur preferentially in the spindle rather than in the epithelioid variant
    • Wardelmann E, Neidt I, Bierhoff E, Speidel N, Manegold C, Fischer H-P, Pfeifer U, Pietsch T (2002) C-kit mutations in gastrointestinal stromal tumors occur preferentially in the spindle rather than in the epithelioid variant. Mod Pathol 15:125-136
    • (2002) Mod Pathol , vol.15 , pp. 125-136
    • Wardelmann, E.1    Neidt, I.2    Bierhoff, E.3    Speidel, N.4    Manegold, C.5    Fischer, H.-P.6    Pfeifer, U.7    Pietsch, T.8
  • 69
    • 0042338788 scopus 로고    scopus 로고
    • Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behaviour of gastrointestinal stromal tumors
    • Wardelmann E, Losen I, Hans V, Neidt I, Speidel N, Bierhoff E, Heinicke T, Pietsch T, Büttner R, Merkelbach-Bruse S (2003) Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behaviour of gastrointestinal stromal tumors. Int J Cancer 106:887-895
    • (2003) Int J Cancer , vol.106 , pp. 887-895
    • Wardelmann, E.1    Losen, I.2    Hans, V.3    Neidt, I.4    Speidel, N.5    Bierhoff, E.6    Heinicke, T.7    Pietsch, T.8    Büttner, R.9    Merkelbach-Bruse, S.10
  • 71
    • 0036139884 scopus 로고    scopus 로고
    • Receptor tyrosine kinases as targets for anticancer drugs
    • Zwick E, Bange J, Ullrich A (2002) Receptor tyrosine kinases as targets for anticancer drugs. Trends Mol Med 8:17-23
    • (2002) Trends Mol Med , vol.8 , pp. 17-23
    • Zwick, E.1    Bange, J.2    Ullrich, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.