메뉴 건너뛰기




Volumn 58, Issue 3, 2004, Pages 991-1002

Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: Focus on NSCLC

Author keywords

EGFR inhibition; Epidermal growth factor receptor (EGFR); Non small cell lung cancer (NSCLC)

Indexed keywords

AMINO ACIDS; CELLS; CHEMOTHERAPY; DRUG THERAPY; ENZYMES; GROWTH KINETICS; MONOCLONAL ANTIBODIES; PLATINUM; RADIOTHERAPY; SKIN; TUMORS;

EID: 1242293090     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2003.09.099     Document Type: Conference Paper
Times cited : (55)

References (55)
  • 2
    • 0003964361 scopus 로고    scopus 로고
    • New York: American Cancer Society
    • Cancer facts and figures 2001. 2001;American Cancer Society, New York.
    • (2001) Cancer facts and figures 2001
  • 3
    • 0003109698 scopus 로고    scopus 로고
    • Treatment strategies for metastatic non-small-cell lung cancer
    • Johnson D.H. Treatment strategies for metastatic non-small-cell lung cancer. Clin Lung Cancer. 1:1999;34-41.
    • (1999) Clin Lung Cancer , vol.1 , pp. 34-41
    • Johnson, D.H.1
  • 4
    • 0034160108 scopus 로고    scopus 로고
    • A multicenter, randomized, phase III study of docetaxel plus best supportive care versus best supportive care in chemotherapy-naive patients with metastatic or non-resectable localized non-small cell lung cancer (NSCLC)
    • Roszkowski K., Pluzanska A., Krazakowski M., et al. A multicenter, randomized, phase III study of docetaxel plus best supportive care versus best supportive care in chemotherapy-naive patients with metastatic or non-resectable localized non-small cell lung cancer (NSCLC). Lung Cancer. 27:2000;145-157.
    • (2000) Lung Cancer , vol.27 , pp. 145-157
    • Roszkowski, K.1    Pluzanska, A.2    Krazakowski, M.3
  • 5
    • 0034608773 scopus 로고    scopus 로고
    • Randomized trial of paclitaxel plus supportive care versus supportive care for patients with advanced non-small-cell lung cancer
    • Ranson M., Davidson N., Nicolson M., et al. Randomized trial of paclitaxel plus supportive care versus supportive care for patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 92:2000;1074-1080.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1074-1080
    • Ranson, M.1    Davidson, N.2    Nicolson, M.3
  • 6
    • 0001913280 scopus 로고    scopus 로고
    • Phase III study of gemcitabine (Gemzar) vs. best supportive care (BSC) in advance non-small-cell lung cancer (NSCLC) [Abstract]
    • Anderson H., Cottier B., Nicolson M., et al. Phase III study of gemcitabine (Gemzar) vs. best supportive care (BSC) in advance non-small-cell lung cancer (NSCLC) [Abstract]. Lung Cancer. 18:1997;9.
    • (1997) Lung Cancer , vol.18 , pp. 9
    • Anderson, H.1    Cottier, B.2    Nicolson, M.3
  • 7
    • 0006453669 scopus 로고    scopus 로고
    • Effects of vinorelbine on quality of life and survival of elderly patients with advance non-small-cell lung cancer
    • Effects of vinorelbine on quality of life and survival of elderly patients with advance non-small-cell lung cancer. J Natl Cancer Inst. 91:1999;66-72.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 66-72
  • 8
    • 17344384668 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patient with locally advanced or metastatic non-small-cell lung cancer
    • Sandler A., Nemunaitis J., Denham C., et al. Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patient with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol. 18:2000;122-130.
    • (2000) J Clin Oncol , vol.18 , pp. 122-130
    • Sandler, A.1    Nemunaitis, J.2    Denham, C.3
  • 9
    • 0031861215 scopus 로고    scopus 로고
    • Randomized trial comparing cisplatin with cisplatin-vinorelbine in the treatment of advanced non-small cell lung cancer: A Southwest Oncology Group study
    • Wozniak A., Crowley J., Balcerzak S.P. Randomized trial comparing cisplatin with cisplatin-vinorelbine in the treatment of advanced non-small cell lung cancer A Southwest Oncology Group study . J Clin Oncol. 16:1998;2459-2465.
    • (1998) J Clin Oncol , vol.16 , pp. 2459-2465
    • Wozniak, A.1    Crowley, J.2    Balcerzak, S.P.3
  • 10
    • 0035397994 scopus 로고    scopus 로고
    • A randomized phase III trial of paclitaxel plus carboplatin (PC) versus vinorelbine plus cisplatin (VC) in untreated advanced non-small cell lung cancer (NSCLC): A Southwest Oncology Group (SWOG) trial [Abstract]
    • Kelly K, Crowley J, Bunn P, et al. A randomized phase III trial of paclitaxel plus carboplatin (PC) versus vinorelbine plus cisplatin (VC) in untreated advanced non-small cell lung cancer (NSCLC): A Southwest Oncology Group (SWOG) trial [Abstract]. J Clin Oncol 2001;19:3210-3218.
    • (2001) J Clin Oncol , vol.19 , pp. 3210-3218
    • Kelly, K.1    Crowley, J.2    Bunn, P.3
  • 11
    • 0037050352 scopus 로고    scopus 로고
    • A comparison of four chemotherapy regimens for advanced non-small cell lung cancer (NSCLC)
    • Schiller J.H., Harrington D., Belani C., et al. A comparison of four chemotherapy regimens for advanced non-small cell lung cancer (NSCLC). N Engl J Med. 346:2002;92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.3
  • 12
    • 0036843105 scopus 로고    scopus 로고
    • Phase III randomized trial comparing three platinum-based doublets in advanced non-small cell lung cancer [Abstract]
    • Scagliotti G.V., De Marinis F., Rinaldi M., et al. Phase III randomized trial comparing three platinum-based doublets in advanced non-small cell lung cancer [Abstract]. Proc Am Soc Clin Oncol. 20:2001;308a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Scagliotti, G.V.1    De Marinis, F.2    Rinaldi, M.3
  • 13
    • 0000828452 scopus 로고    scopus 로고
    • A EORTC randomized phase III trial of three chemotherapy regimens in advanced non-small cell lung cancer (NSCLC) [Abstract]
    • Van Meerbeeck J.P., Smit E.F., Lianes P., et al. A EORTC randomized phase III trial of three chemotherapy regimens in advanced non-small cell lung cancer (NSCLC) [Abstract]. Proc Am Soc Clin Oncol. 20:2001;308a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Van Meerbeeck, J.P.1    Smit, E.F.2    Lianes, P.3
  • 14
    • 4244154628 scopus 로고    scopus 로고
    • Phase II multicenter randomized trial of weekly paclitaxel (P) administered in combination with carboplatin (C) followed by maintenance P vs. observation for patients (pts) with advanced and metastatic non-small cell lung cancer (NSCLC) [Abstract]
    • Belani C., Barstis J., Perry M., et al. Phase II multicenter randomized trial of weekly paclitaxel (P) administered in combination with carboplatin (C) followed by maintenance P vs. observation for patients (pts) with advanced and metastatic non-small cell lung cancer (NSCLC) [Abstract]. Proc Am Soc Clin Oncol. 20:2001;323a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Belani, C.1    Barstis, J.2    Perry, M.3
  • 15
    • 0000012871 scopus 로고    scopus 로고
    • A multicenter, randomized phase III study of docetaxel + cisplatin (DC) and docetaxel + carboplatin (DCB) vs. vinorelbine + cisplatin (VC) in chemotherapy-naive patients with advanced and metastatic non-small cell lung cancer [Abstract]
    • Rodriguez J., Pawel J., Pluzanska A., et al. A multicenter, randomized phase III study of docetaxel + cisplatin (DC) and docetaxel + carboplatin (DCB) vs. vinorelbine + cisplatin (VC) in chemotherapy-naive patients with advanced and metastatic non-small cell lung cancer [Abstract]. Proc Am Soc Clin Oncol. 20:2001;314a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Rodriguez, J.1    Pawel, J.2    Pluzanska, A.3
  • 16
    • 0001834442 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled trial of marimastat in patients with small cell lung cancer (SCLC) following response to first-line chemotherapy: An NIC-CTG and EORTC study
    • Shepherd F., Giaccone G., Debruyne C., et al. Randomized double-blind placebo-controlled trial of marimastat in patients with small cell lung cancer (SCLC) following response to first-line chemotherapy An NIC-CTG and EORTC study . Proc Am Soc Clin Oncol. 20:2001;4a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Shepherd, F.1    Giaccone, G.2    Debruyne, C.3
  • 17
    • 0001185393 scopus 로고    scopus 로고
    • Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC) [Abstract]
    • Smylie M., Mercier R., Aboulafia D., et al. Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC) [Abstract]. Proc Am Soc Clin Oncol. 20:2001;307a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Smylie, M.1    Mercier, R.2    Aboulafia, D.3
  • 18
    • 0034988184 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for cancer therapy
    • Mendelsohn J. The epidermal growth factor receptor as a target for cancer therapy. Endocr Relat Cancer. 8:2001;3-9.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 3-9
    • Mendelsohn, J.1
  • 19
    • 0028937815 scopus 로고
    • Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metabolic involvement of the hilar and mediastinal lymph nodes in squamous subtypes
    • Fontanini G., Vignati S., Bigini D., et al. Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metabolic involvement of the hilar and mediastinal lymph nodes in squamous subtypes. Eur J Cancer. 31A:1995;178-183.
    • (1995) Eur J Cancer , vol.31 , pp. 178-183
    • Fontanini, G.1    Vignati, S.2    Bigini, D.3
  • 20
    • 0000329007 scopus 로고    scopus 로고
    • A phase II trial of the epidermal growth factor receptor (EGFr) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy in patients with advanced EGFr-expressing non-small cell lung cancer (NSCLC) [Abstract]
    • Perez-Soler R., Chachoua A., Huberman M., et al. A phase II trial of the epidermal growth factor receptor (EGFr) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy in patients with advanced EGFr-expressing non-small cell lung cancer (NSCLC) [Abstract]. Proc Am Soc Clin Oncol. 20:2001;310a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Perez-Soler, R.1    Chachoua, A.2    Huberman, M.3
  • 21
    • 1242311459 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene. 196:2000;550-565.
    • (2000) Oncogene , vol.196 , pp. 550-565
    • Mendelsohn, J.1    Baselga, J.2
  • 22
    • 0033763084 scopus 로고    scopus 로고
    • ZD1839 (Iressa) as an anticancer agent
    • Baselga J., Averbuch S.D. ZD1839 (Iressa) as an anticancer agent. Drugs. 60:2000;33-42.
    • (2000) Drugs , vol.60 , pp. 33-42
    • Baselga, J.1    Averbuch, S.D.2
  • 23
    • 0035939330 scopus 로고    scopus 로고
    • Studies leading to the identification of ZD1839 (Iressa): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
    • Barker A.J., Gibson K.H., Grundy W., et al. Studies leading to the identification of ZD1839 (Iressa) An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer . Bioorg Med Chem Lett. 11:2001;1911-1914.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 1911-1914
    • Barker, A.J.1    Gibson, K.H.2    Grundy, W.3
  • 25
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD 1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Sirotnak F.M., Zakowski M.F., Miller V.A., et al. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD 1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res. 6:2000;4885-4892.
    • (2000) Clin Cancer Res , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3
  • 26
    • 0000240853 scopus 로고    scopus 로고
    • Continuous administration of AD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in patients with five selected tumor types: Evidence of activity and good tolerability [Abstract]
    • Baselga J., Herbst R., LoRusso P., et al. Continuous administration of AD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in patients with five selected tumor types evidence of activity and good tolerability [Abstract] . Proc Am Soc Clin Oncol. 19:2000;177a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Baselga, J.1    Herbst, R.2    Lorusso, P.3
  • 27
    • 0000004189 scopus 로고    scopus 로고
    • A phase I intermittent dose-escalation trial of ZD 1839 (Iressa) in Japanese patients with solid malignant tumors [Abstract]
    • Nagakawa K., Yamamoto N., Kudoh S., et al. A phase I intermittent dose-escalation trial of ZD 1839 (Iressa) in Japanese patients with solid malignant tumors [Abstract]. Proc Am Soc Clin Oncol. 19:2000;183a.
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Nagakawa, K.1    Yamamoto, N.2    Kudoh, S.3
  • 28
    • 0034789215 scopus 로고    scopus 로고
    • ZD1839 (Iressa™) in non-small-cell lung cancer
    • Herbst R.S., Khuri F.R., Fossella F.V., et al. ZD1839 (Iressa™) in non-small-cell lung cancer. Clin Lung Cancer. 3:2001;21-32.
    • (2001) Clin Lung Cancer , vol.3 , pp. 21-32
    • Herbst, R.S.1    Khuri, F.R.2    Fossella, F.V.3
  • 29
    • 0001174063 scopus 로고    scopus 로고
    • Objective regressions in non-small cell lung cancer patients treated in phase I trials of oral ZD1839 IRESSA: A selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) [Abstract]
    • Kris M.G., Herbst R., Rischin D., et al. Objective regressions in non-small cell lung cancer patients treated in phase I trials of oral ZD1839 IRESSA A selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR) [Abstract] . Lung Cancer. 29:(Suppl. 1):2000;71.
    • (2000) Lung Cancer , vol.29 , Issue.SUPPL. 1 , pp. 71
    • Kris, M.G.1    Herbst, R.2    Rischin, D.3
  • 30
    • 0001303063 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer who failed platinum- and docetaxel- based regimens
    • Kris MG, Natale RB, Herbst RS, et al. A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer who failed platinum- and docetaxel- based regimens. Proc Am Soc Clin Oncol 2002;21:292a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 31
    • 0000642965 scopus 로고    scopus 로고
    • Improvement in symptoms and quality of life for advanced non-small cell lung cancer patients receiving ZD 1839 (Iressa) in IDEAL 2 [Abstract]
    • Natale RB, Skarin A, Maddox A-M, et al. Improvement in symptoms and quality of life for advanced non-small cell lung cancer patients receiving ZD 1839 (Iressa) in IDEAL 2 [Abstract]. Proc Am Soc Clin Oncol 2002;21:292a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Natale, R.B.1    Skarin, A.2    Maddox, A.-M.3
  • 32
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer.
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer. J Clin Oncol 2003;21:2237-2246.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 33
    • 0000642964 scopus 로고    scopus 로고
    • Improvement in disease-related symptoms and quality of life in patients with advanced non-small-lung cancer (NSCLC) treated with ZD 1839 (Iressa) (IDEAL 1) [Abstract].
    • Douillard J-Y, Giaccone G, Horai T, et al. Improvement in disease-related symptoms and quality of life in patients with advanced non-small-lung cancer (NSCLC) treated with ZD 1839 (Iressa) (IDEAL 1) [Abstract]. Proc Am Soc Clin Oncol 2002;21:299a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Douillard, J.-Y.1    Giaccone, G.2    Horai, T.3    Et Al., I.4
  • 34
    • 0003243810 scopus 로고
    • (Iressa) as a single agent for the treatment of metastatic non-small cell lung cancer [Abstract]
    • Ruckdeschel JC, Simon G, Antonia S, et al. ZD 1839 (Iressa) as a single agent for the treatment of metastatic non-small cell lung cancer [Abstract]. Proc Am Soc Clin Oncol 2002;21:318a.
    • (1839) Proc Am Soc Clin Oncol , vol.21
    • Ruckdeschel, J.C.1    Simon, G.2    Antonia, S.3    Et Al., Z.D.4
  • 35
    • 0013113593 scopus 로고
    • (Iressa) shows antitumor activity in patients with recurrent non-small-cell lung cancer treated on a compassionate use protocol [Abstract].
    • Janne PA, Ostler PA, Lucca J, et al. ZD 1839 (Iressa) shows antitumor activity in patients with recurrent non-small-cell lung cancer treated on a compassionate use protocol [Abstract]. Proc Am Soc Clin Oncol 2002;21:319a.
    • (1839) Proc Am Soc Clin Oncol , vol.21
    • Janne, P.A.1    Ostler, P.A.2    Lucca, J.3    Et Al., Z.D.4
  • 36
    • 0002806626 scopus 로고    scopus 로고
    • A phase III clinical trial of ZD 1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT-1)
    • Giaccone G., Johnson D.H., Manegold C., et al. A phase III clinical trial of ZD 1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT-1). Ann Oncol. 13:(Suppl. 5):2002;2.
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 5 , pp. 2
    • Giaccone, G.1    Johnson, D.H.2    Manegold, C.3
  • 37
    • 0000780450 scopus 로고    scopus 로고
    • ZD 1839 (Iressa) in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (NSCLC): Initial results from a phase III trial (INTACT-2)
    • Johnson D.H., Herbst R., Giaccone G., et al. ZD 1839 (Iressa) in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small cell lung cancer (NSCLC) Initial results from a phase III trial (INTACT-2) . Ann Oncol. 13:(Suppl. 5):2002;127.
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 5 , pp. 127
    • Johnson, D.H.1    Herbst, R.2    Giaccone, G.3
  • 38
    • 0003203826 scopus 로고    scopus 로고
    • Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent: Initial results from Intergroup Trial 0100(SWOG-8814)
    • Albain K.S., Green S.J., Ravdin P.M., et al. Adjuvant chemohormonal therapy for primary breast cancer should be sequential instead of concurrent Initial results from Intergroup Trial 0100(SWOG-8814) . Proc Am Clin Oncol. 21:2002;A143.
    • (2002) Proc Am Clin Oncol , vol.21 , pp. 143
    • Albain, K.S.1    Green, S.J.2    Ravdin, P.M.3
  • 39
    • 0031409362 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy
    • Mendelsohn J. Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy. Clin Cancer Res. 3:1997;2703-2707.
    • (1997) Clin Cancer Res , vol.3 , pp. 2703-2707
    • Mendelsohn, J.1
  • 40
    • 0035409904 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer
    • Herbst R.S., Kim E.S., Harari P.M. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer. Expert Opin Biol Ther. 1:2001;1-14.
    • (2001) Expert Opin Biol Ther , vol.1 , pp. 1-14
    • Herbst, R.S.1    Kim, E.S.2    Harari, P.M.3
  • 41
    • 0027428571 scopus 로고
    • Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
    • Fan Z., Baselga J., Masui H., et al. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res. 53:1993;4637-4642.
    • (1993) Cancer Res , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3
  • 42
    • 0030054907 scopus 로고    scopus 로고
    • Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin
    • Prewett M., Rockwell P., Rose C., et al. Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin. Int J Oncol. 9:1996;217-224.
    • (1996) Int J Oncol , vol.9 , pp. 217-224
    • Prewett, M.1    Rockwell, P.2    Rose, C.3
  • 43
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P., Matsumoto T., Inoue K., et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res. 5:1999;257-265.
    • (1999) Clin Cancer Res , vol.5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 44
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumor radio-response by C225 anti-epidermal growth factor receptor antibody
    • Milas L., Mason K., Hunter N., et al. In vivo enhancement of tumor radio-response by C225 anti-epidermal growth factor receptor antibody. Clin Cancer Res. 6:2000;701-708.
    • (2000) Clin Cancer Res , vol.6 , pp. 701-708
    • Milas, L.1    Mason, K.2    Hunter, N.3
  • 45
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J., Pfister D., Cooper M.R., et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol. 18:2000;904-914.
    • (2000) J Clin Oncol , vol.18 , pp. 904-914
    • Baselga, J.1    Pfister, D.2    Cooper, M.R.3
  • 46
    • 0000229081 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-epidermal growth factor antibody (EGFR) IMC-C225, in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin-containing chemotherapy [Abstract]
    • Hong W.K., Arquette M., Nabell L., et al. Efficacy and safety of the anti-epidermal growth factor antibody (EGFR) IMC-C225, in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin-containing chemotherapy [Abstract]. Proc Am Soc Clin Oncol. 20:2001;224a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Hong, W.K.1    Arquette, M.2    Nabell, L.3
  • 47
    • 0003241755 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin-containing chemotherapy [Abstract]
    • Kies M.S., Arquette M.A., Nabell L., et al. Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin-containing chemotherapy [Abstract]. Proc Am Soc Clin Oncol. 21:2002;232a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kies, M.S.1    Arquette, M.A.2    Nabell, L.3
  • 48
    • 0001413605 scopus 로고    scopus 로고
    • Phase III trial comparing cisplatin and placebo to cisplatin and anti-epidermal growth factor antibody (EGF-R) C225 in patients with metastatic/recurrent head and neck cancer [Abstract].
    • Burtness BA, Li Y, Flood W, et al. Phase III trial comparing cisplatin and placebo to cisplatin and anti-epidermal growth factor antibody (EGF-R) C225 in patients with metastatic/recurrent head and neck cancer [Abstract]. Proc Am Soc Clin Oncol 2002.
    • (2002) Proc Am Soc Clin Oncol
    • Burtness, B.A.1    Li, Y.2    Flood, W.3
  • 49
    • 0033970141 scopus 로고    scopus 로고
    • Modulation of molecular targets to enhance radiation
    • Harari P.M., Huang S.M. Modulation of molecular targets to enhance radiation. Clin Cancer Res. 6:2000;323-325.
    • (2000) Clin Cancer Res , vol.6 , pp. 323-325
    • Harari, P.M.1    Huang, S.M.2
  • 50
    • 0004875404 scopus 로고    scopus 로고
    • The epidermal growth factor receptor (EGFR) as a therapeutic target in squamous cell malignancies.
    • Bonner J, Robert F, Raisch K. The epidermal growth factor receptor (EGFR) as a therapeutic target in squamous cell malignancies. Clin Can Research 2000;6(Suppl.):4481S.
    • (2000) Clin Can Research , vol.6 , Issue.SUPPL.
    • Bonner, J.1    Robert, F.2    Raisch, K.3
  • 51
    • 0011720039 scopus 로고    scopus 로고
    • A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC) [Abstract]
    • Kim E.S., Mauer A.M., Fossella F.V., et al. A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer (NSCLC) [Abstract]. Proc Am Soc Clin Oncol. 21:2002;293a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kim, E.S.1    Mauer, A.M.2    Fossella, F.V.3
  • 52
    • 0003282147 scopus 로고    scopus 로고
    • A phase I clinical and pharmacokinetic study of oral CI-1033, a pan-erbB tyrosinekinase inhibitor in patients with advanced solid tumors [Abstract]
    • Rinehart J.J., Wilding G., Willson J., et al. A phase I clinical and pharmacokinetic study of oral CI-1033, a pan-erbB tyrosinekinase inhibitor in patients with advanced solid tumors [Abstract]. Proc Am Soc Clin Oncol. 21:2002;11A.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Rinehart, J.J.1    Wilding, G.2    Willson, J.3
  • 53
    • 0001100596 scopus 로고    scopus 로고
    • A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI 166, a novel tyrosine kinase inhibitor in patients with advanced cancers [Abstract]
    • Murren JR, Papadimitrakopoulou VA, Sizer KC, et al. A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI 166, a novel tyrosine kinase inhibitor in patients with advanced cancers [Abstract]. Proc Am Soc Clin Oncol 2002;21:95a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Murren, J.R.1    Papadimitrakopoulou, V.A.2    Sizer, K.C.3
  • 54
    • 0003266310 scopus 로고    scopus 로고
    • A phase I study to investigate the safety, tolerability, and pharmacokinetics of single oral escalating doses of GW 572016 in healthy volunteers [Abstract]
    • DeSimone P.A., Bence A.K., Anderson E.B., et al. A phase I study to investigate the safety, tolerability, and pharmacokinetics of single oral escalating doses of GW 572016 in healthy volunteers [Abstract]. Proc Am Soc Clin Oncol. 21:2002;94A.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Desimone, P.A.1    Bence, A.K.2    Anderson, E.B.3
  • 55
    • 0003339017 scopus 로고    scopus 로고
    • A phase I pharmacokinetic/pharmacodynamic study evaluating multiple doses of oral GW 572016 in healthy subjects [Abstract]
    • Adams V.R., Bence A.K., Anderson E.B., et al. A phase I pharmacokinetic/pharmacodynamic study evaluating multiple doses of oral GW 572016 in healthy subjects [Abstract]. Proc Am Soc Clin Oncol. 21:2002;94A.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Adams, V.R.1    Bence, A.K.2    Anderson, E.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.