Human skin reconstruct models: A new application for studies of melanocyte and melanoma biology

Histology and Histopathology

Volumn 16, Issue 2, 2001, Pages 669-674

  Berking, C ^a   Herlyn, M ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

Grafting; Melanocyte; Melanoma; Organotypic culture; Skin reconstruct

Indexed keywords

ARTIFACT; CANCER INVASION; CANCER RESEARCH; CELL CULTURE; CELL GROWTH; CELL MIGRATION; CELL NUCLEUS MATRIX; DISEASE MODEL; EXPERIMENTAL ANIMAL; GENE EXPRESSION; HUMAN; IN VIVO STUDY; MELANOCYTE; MELANOGENESIS; MELANOMA; METASTASIS; MORPHOLOGY; PHENOTYPE; PIGMENT CELL; REVIEW; SKIN; SKIN GRAFT; THREE DIMENSIONAL IMAGING;

ANIMALS; HUMANS; MELANOCYTES; MELANOMA; MICE; MICE, SCID; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; SKIN NEOPLASMS; SKIN TRANSPLANTATION;

ANIMALIA;

EID: 0035071889     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Keratinocytes and fibroblasts in a human skin equivalent model enhance melanocyte survival and melanin synthesis after ultraviolet irradiation
2. Penetration of human metastatic melanoma cells through an authentic dermal-epidermal junction is associated with dissolution of native collagen types IV and VII
3. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickeness
4. Ex vivo study of skin phototypes
5. Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal karatinocytes
6. Studies on epidermis reconstructed with and without melanocytes: Melanocytes prevent sunburn cell formation but not appearance of DNA damaged cells in fair-skinned caucasians
7. In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh
8. Skin equivalent: An attractive model to evaluate early melanoma metastasis
9. Characterization of an in vitro model of human melanoma invasionn based on reconstructed human skin
10. A comparison of methodologies for the preparation of human epidermal-dermal composites
11. Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: A novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma
12. Biology of tumor progression in human melanocytes
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14. E-cadherin expression in melanoma cells restores keratinocyte-mediated grown control and down-regulates expression of invasion-related adhesion receptors
15. Normal keratinocytes supress early stages of neoplastic progression in stratified epithelium
16. Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
17. The use of Apligraf in acute wounds
18. A new skin equivalent model: Dermal substrate that combines de-epidermized dermis with firoblast-populated collagen matrix
19. Human melanoma progression in skin reconstructs: Biological significance of bFGF
20. Expression of high molecular weight (67K) keratin in human keratinocytes cultured on dead de-epidermized dermis
21. Integration of Langerhans cells into a pigmented reconstructed human epidermis
22. Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture
23. Phenocytes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model
24. Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact