Eukaryotic mismatch repair: An update

Mutation Research - DNA Repair

Volumn 409, Issue 3, 1998, Pages 107-121

  Jiricny, Josef ^a  

^a Institute of Medical Radiobiology   (Switzerland)

Author keywords

Drug resistance; Hereditary nonpolyposis colon cancer; Mismatch repair; Mutator phenotype; Replication error

Indexed keywords

ALKYLATING AGENT;

ARTICLE; COLON CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DRUG RESISTANCE; GENE MUTATION; HUMAN; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DRUG RESISTANCE; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; HUMANS; MUTAGENESIS;

EUKARYOTA; MAMMALIA;

EID: 0031743804     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(98)00056-1     Document Type: Article

References (117)

1. Kolodner R.D. Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci. 20:1995;397-401.
2. Modrich P., Lahue R. Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem. 65:1996;101-133.
3. P. Schär, J. Jiricny, Eukaryotic mismatch repair, in: F. Eckstein, D.M.J. Lilley (Eds.), Nucleic Acids and Molecular Biology, Vol. 12, Springer Verlag, Berlin, 1998.
4. Modrich P. Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet. 25:1991;229-253.
5. Modrich P. Strand-specific mismatch repair in mammalian cells. J. Biol. Chem. 272:1997;24727-24730.
6. J. Jiricny, Replication errors: cha(lle)nging the genome, EMBO J., 1998, in press.
7. G. Crouse, Mismatch repair systems in Saccharomyces cerevisiae, in: J.A. Nickoloff, M.F. Hoekstra (Eds.), DNA Damage and Repair, Vol. 1, DNA Repair in Prokaryotes and Lower Eukaryotes, Humana Press, Totowa, NJ, 1997, pp. 411-448.
8. Karran P., Hampson R. Genomic instability and tolerance to alkylating agents. Cancer Surv. 28:1996;69-85.
9. Karran P., Bignami M. Drug-related killings: a case of mistaken identity. Chem. Biol. 3:1996;875-879.
10. Fink D., Aebi S., Howell S.B. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res. 4:1998;1-6.
11. Fishel R., Kolodner R.D. Identification of mismatch repair genes and their role in the development of cancer. Curr. Opin. Genet. Dev. 5:1995;382-395.
12. Modrich P. Mismatch repair, genetic stability and cancer. Science. 266:1994;1959-1960.
13. Jiricny J. Mismatch repair and cancer. Cancer Surv. 28:1996;47-68.
14. Lahue R.S., Au K.G., Modrich P. DNA mismatch correction in a defined system. Science. 245:1989;160-164.
15. Allen D.J., Makhov A., Grilley M., Taylor J., Thresher R., Modrich P., Griffith J.D. MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J. 16:1997;4467-4476.
16. Lahue R.S., Su S.S., Modrich P. Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction. Proc. Natl. Acad. Sci. USA. 84:1987;1482-1486.
17. Barras F., Marinus M.G. The great GATC: DNA methylation in E. coli. Trends Genet. 5:1989;139-143.
18. Dao V., Modrich P. Mismatch-, MutS-, MutL- and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. J. Biol. Chem. 273:1998;9202-9207.
19. Yamaguchi M., Dao V., Modrich P. MutS and MutL activate DNA helicase II in a mismatch-dependent manner. J. Biol. Chem. 273:1998;9197-9201.
20. Hall M.C., Jordan J.R., Matson S.W. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17:1998;1535-1541.
21. Cooper D.L., Lahue R.S., Modrich P. Methyl-directed mismatch repair is bidirectional. J. Biol. Chem. 268:1993;11823-11829.
22. Grenert J.P., Sullivan W.P., Fadden P., Haystead T.A.J., Clark J., Mimnaugh E., Krutzsch H., Ochel H.J., Schulte T.W., Sausville E., Neckers L.M., Toft D.O. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J. Biol. Chem. 272:1997;23843-23850.
23. Grilley M., Griffith J., Modrich P. Bidirectional excision in methyl-directed mismatch repair. J. Biol. Chem. 268:1993;11830-11837.
24. Su S.S., Grilley M., Thresher R., Griffith J., Modrich P. Gap formation is associated with methyl-directed mismatch correction under conditions of restricted DNA synthesis. Genome. 31:1989;104-111.
25. Claverys J.P., Lacks S.A. Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria. Microbiol. Rev. 50:1986;133-165.
26. Hare J.T., Taylor J.H. One role for DNA methylation in vertebrate cells is strand discrimination in mismatch repair. Proc. Natl. Acad. Sci. USA. 82:1985;7350-7354.
27. Umar A., Buermeyer A.B., Simon J.A., Thomas D.C., Clark A.B., Liskay R.M., Kunkel T.A. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell. 87:1996;65-73.
28. Gu L., Hong Y., McCulloch S., Watanabe H., Li G.M. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair. Nucleic Acids Res. 26:1998;1173-1178.
29. Longley M.J., Pierce A.J., Modrich P. DNA polymerase delta is required for human mismatch repair in vitro. J. Biol. Chem. 272:1997;10917-10921.
30. Fang W.H., Modrich P. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J. Biol. Chem. 268:1993;11838-11844.
31. Drummond J.T., Li G.M., Longley M.J., Modrich P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science. 268:1995;1909-1912.
32. Li G.M., Modrich P. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl. Acad. Sci. USA. 92:1995;1950-1954.
33. Jiricny J., Hughes M., Corman N., Rudkin B.B. A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches. Proc. Natl. Acad. Sci. USA. 85:1988;8860-8864.
34. Palombo F., Gallinari P., Iaccarino I., Lettieri T., Hughes M., D'Arrigo A., Truong O., Hsuan J.J., Jiricny J. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science. 268:1995;1912-1914.
35. Hughes M.J., Jiricny J. The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities. J. Biol. Chem. 267:1992;23876-23882.
36. F. Palombo, I. Iaccarino, E. Nakajima, M. Ikejima, T. Shimada, J. Jiricny, hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA, Sept. 1, 6, 9, 1996, 1181-1184.
37. Genschel J., Littman S.J., Drummond J.T., Modrich P. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of mutSbeta and MutSalpha. J. Biol. Chem. 273:1998;19895-19901.
38. Macpherson P., Humbert O., Karran P. Frameshift mismatch recognition by the human MutS alpha complex. Mut. Res. 408:1998;55-66.
39. Su S.S., Lahue R.S., Au K.G., Modrich P. Mispair specificity of methyl-directed DNA mismatch correction in vitro. J. Biol. Chem. 263:1988;6829-6835. published erratum appears in J. Biol. Chem. 263 (22) (August 5, 1988) 11015.
40. Kramer B., Kramer W., Fritz H.J. Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli. Cell. 38:1984;879-887.
41. Gasc A.M., Sicard A.M., Claverys J.P. Repair of single- and multiple-substitution mismatches during recombination in Streptococcus pneumoniae. Genetics. 121:1989;29-36.
42. Bishop D.K., Andersen J., Kolodner R.D. Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA. Proc. Natl. Acad. Sci. USA. 86:1989;3713-3717.
43. Kramer B., Kramer W., Williamson M.S., Fogel S. Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes. Mol. Cell. Biol. 9:1989;4432-4440.
44. Brown T.C., Jiricny J. Different base/base mismatches are corrected with different efficiencies and specificities in monkey kidney cells. Cell. 54:1989;705-711.
45. Genschel J., Littman S.J., Drummond J.T., Modrich P. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J. Biol. Chem. 273:1998;19895-19901.
46. Papadopoulos N., Nicolaides N.C., Liu B., Parsons R., Lengauer C., Palombo F., D'Arrigo A., Markowitz S., Willson J.K., Kinzler K.W., Jiricny J., Vogelstein B. Mutations of GTBP in genetically unstable cells. Science. 268:1995;1915-1917.
47. Marra G., Iaccarino I., Lettieri T., Roscilli G., Delmastro P., Jiricny J. Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc. Natl. Acad. Sci. USA. 95:1998;8568-8573.
48. Drummond J.T., Genschel J., Wolf E., Modrich P. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. Proc. Natl. Acad. Sci. USA. 94:1997;10144-10149.
49. Bhattacharyya N.P., Ganesh A., Phear G., Richards B., Skandalis A., Meuth M. Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet. 4:1995;2057-2064.
50. Umar A., Risinger J.I., Glaab W.E., Tindall K.R., Barrett J.C., Kunkel T.A. Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics. 148:1998;1637-1646.
51. Gradia S., Acharya S., Fishel R. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell. 91:1997;995-1005.
52. Haber L.T., Walker G.C. Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. EMBO J. 10:1991;2707-2715.
53. Iaccarino I., Marra G., Palombo F., Jiricny J. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha. EMBO J. 17:1998;2677-2686.
54. Alani E., Sokolsky T., Studamire B., Miret J.J., Lahue R.S. Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition. Mol. Cell. Biol. 17:1997;2436-2447.
55. B. Studamire, T. Quach, E. Alani, The S. cerevisiae Msh2p and Msh6p ATPase activities are coordinated during mismatch repair, Mol. Cell Biol., 1998, in press.
56. Alani E., Chi N.W., Kolodner R. The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions. Genes Dev. 9:1995;234-247.
57. Fishel R., Ewel A., Lee S., Lescoe M.K., Griffith J. Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science. 266:1994;1403-1405.
58. Fishel R., Ewel A., Lescoe M.K. Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54:1994;5539-5542.
59. Mello J.A., Acharya S., Fishel R., Essigmann J.M. The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chem. Biol. 3:1996;579-589.
60. Alani E., Lee S., Kane M.F., Griffith J., Kolodner R.D. Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA. J. Mol. Biol. 265:1997;289-301.
61. Acharya S., Wilson T., Gradia S., Kane M.F., Guerrette S., Marsischky G.T., Kolodner R., Fishel R. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. USA. 93:1996;13629-13634.
62. G.T. Marsischky, S. Lee, J. Griffith, R.D. Kolodner, Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes, 1998, in press.
63. Kolodner R. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev. 10:1996;1433-1442.
64. Pang Q., Prolla T.A., Liskay R.M. Functional domains of the Saccharomyces cerevisiae Mlh 1p and Pms 1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol. Cell. Biol. 17:1997;4465-4473.
65. Prolla T.A., Pang Q., Alani E., Kolodner R.D., Liskay R.M. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science. 265:1994;1091-1093.
66. White J.H., Lusnak K., Fogel S. Mismatch-specific post-meiotic segregation frequency in yeast suggests a heteroduplex recombination intermediate. Nature. 315:1985;350-352.
67. Tishkoff D.X., Boerger A.L., Bertrand P., Filosi N., Gaida G.M., Kane M.F., Kolodner R.D. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. Proc. Natl. Acad. Sci. USA. 94:1997;7487-7492.
68. Drummond J.T., Anthoney A., Brown R., Modrich P. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem. 271:1996;19645-19648.
69. Nicolaides N.C., Littman S.J., Modrich P., Kinzler K.W., Vogelstein B. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype. Mol. Cell. Biol. 18:1998;1635-1641.
70. Umezu K., Sugawara N., Chen C., Haber J.E., Kolodner R.D. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics. 148:1998;989-1005.
71. Fink D., Nebel S., Aebi S., Zheng H., Cenni B., Nehme A., Christen R.D., Howell S.B. The role of DNA mismatch repair in platinum drug resistance. Cancer Res. 56:1996;4881-4886.
72. Fritzell J.A., Narayanan L., Baker S.M., Bronner C.E., Andrew S.E., Prolla T.A., Bradley A., Jirik F.R., Liskay R.M., Glazer P.M. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res. 57:1997;5143-5147.
73. Karran P., Marinus M.G. Mismatch correction at O6-methylguanine residues in E. coli DNA. Nature. 296:1982;868-869.
74. Branch P., Aquilina G., Bignami M., Karran P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature. 362:1993;652-654.
75. Karran P., Bignami M. DNA damage tolerance, mismatch repair and genome instability. Bioessays. 16:1994;833-839.
76. Duckett D.R., Drummond J.T., Murchie A.I., Reardon J.T., Sancar A., Lilley D.M., Modrich P. Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl. Acad. Sci. USA. 93:1996;6443-6447.
77. Griffin S., Branch P., Xu Y.Z., Karran P. DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. Biochemistry. 33:1994;4787-4793.
78. D'Atri S., Tentori L., Lacal P.M., Graziani G., Pagani E., Benincasa E., Zambruno G., Bonmassar E., Jiricny J. Involvement of the mismatch repair system in temozolomide-induced apoptosis. Mol. Pharmacol. 54:1998;334-341.
79. Hawn M.T., Umar A., Carethers J.M., Marra G., Kunkel T.A., Boland C.R., Koi M. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 55:1995;3721-3725.
80. Kaina B., Ziouta A., Ochs K., Coquerelle T. Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. Mut. Res. 381:1997;227-241.
81. Anthoney D.A., McIlwrath A.J., Gallagher W.M., Edlin A.R., Brown R. Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells. Cancer Res. 56:1996;1374-1381.
82. Fink D., Zheng H., Nebel S., Norris P.S., Aebi S., Lin T.P., Nehme A., Christen R.D., Haas M., MacLeod C.L., Howell S.B. In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res. 57:1997;1841-1845.
83. Moggs J.G., Szymkowski D.E., Yamada M., Karran P., Wood R.D. Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts. Nucleic Acids Res. 25:1997;480-491.
84. Yamada M., O'Regan E., Brown R., Karran P. Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins. Nucleic Acids Res. 25:1997;491-496.
85. Davis T.W., Wilson-Van Patten C., Meyers M., Kunugi K.A., Cuthill S., Reznikoff C., Garces C., Boland C.R., Kinsella T.J., Fishel R., Boothman D.A. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 58:1998;767-778.
86. Mellon I., Rajpal D.K., Koi M., Boland C.R., Champe G.N. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science. 272:1996;557-560.
87. Leadon S.A., Avrutskaya A.V. Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae. Mut. Res. 407:1998;177-187.
88. Koi M., Umar A., Chauhan D.P., Cherian S.P., Carethers J.M., Kunkel T.A., Boland C.R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:1994;4308-4312. published erratum appears in Cancer Res. 55 (1) (January 1, 1995) 201.
89. Umar A., Koi M., Risinger J.I., Glaab W.E., Tindall K.R., Kolodner R.D., Boland C.R., Barrett J.C., Kunkel T.A. Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 57:1997;3949-3955.
90. Risinger J.I., Umar A., Boyd J., Berchuck A., Kunkel T.A., Barrett J.C. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14:1996;102-105.
91. Risinger J.I., Umar A., Glaab W.E., Tindall K.R., Kunkel T.A., Barrett J.C. Single gene complementation of the hPMS2 defect in HEC-1-A endometrial carcinoma cells. Cancer Res. 58:1998;2978-2981.
92. Shin K.H., Han H.J., Park J.G. Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein. Int. J. Oncol. 12:1998;609-615.
93. Peltomaki P., Aaltonen L.A., Sistonen P., Pylkkanen L., Mecklin J.P., Jarvinen H., Green J.S., Jass J.R., Weber J.L., Leach F.S. Genetic mapping of a locus predisposing to human colorectal cancer. Science. 260:1993;810-812.
94. Kunkel T.A. Nucleotide repeats. Slippery DNA and diseases. Nature. 365:1993;207-208.
95. Fishel R., Lescoe M.K., Rao M.R., Copeland N.G., Jenkins N.A., Garber J., Kane M., Kolodner R. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 75:1993;1027-1038. published erratum appears in Cell 77 (1) (April 8, 1994) 167.
96. Leach F.S., Nicolaides N.C., Papadopoulos N., Liu B., Jen J., Parsons R., Peltomaki P., Sistonen P., Aaltonen L.A., Nystrom-Lahti M. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 75:1993;1215-1225.
97. Parsons R., Li G.M., Longley M.J., Fang W.H., Papadopoulos N., Jen J., de la Chapelle A., Kinzler K.W., Vogelstein B., Modrich P. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell. 75:1993;1227-1236.
98. Nicolaides N.C., Papadopoulos N., Liu B., Wei Y.F., Carter K.C., Ruben S.M., Rosen C.A., Haseltine W.A., Fleischmann R.D., Fraser C.M. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature. 371:1994;75-80.
99. Prolla T.A., Baker S.M., Harris A.C., Tsao J.L., Yao X., Bronner C.E., Zheng B., Gordon M., Reneker J., Arnheim N., Shibata D., Bradley A., Liskay R.M. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh 1, Pms 1 and Pms2 DNA mismatch repair. Nat. Genet. 18:1998;276-279.
100. Akiyama Y., Sato H., Yamada T., Nagasaki H., Tsuchiya A., Abe R., Yuasa Y. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 57:1997;3920-3923.
101. Edelmann W., Yang K., Umar A., Heyer J., Lau K., Fan K., Liedtke W., Cohen P.E., Kane M.F., Lipford J.R., Yu N., Crouse G.F., Pollard J.W., Kunkel T., Lipkin M., Kolodner R., Kucherlapati R. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 91:1997;467-477.
102. Yamamoto H., Sawai H., Weber T.K., Rodriguez-Bigas M.A., Perucho M. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res. 58:1998;997-1003.
103. Baker S.M., Harris A.C., Tsao J.L., Flath T.J., Bronner C.E., Gordon M., Shibata D., Liskay R.M. Enhanced intestinal adenomatous polyp formation in Pms2-/-:Min mice. Cancer Res. 58:1998;1087-1089.
104. de Wind N., Dekker M., van Rossum A., van der Valk M., te Riele H. Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res. 58:1998;248-255.
105. Yamamoto H., Sawai H., Perucho M. Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res. 57:1997;4420-4426.
106. Baylin S.B., Herman J.G., Graff J.R., Vertino P.M., Issa J.P. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res. 72:1998;141-196.
107. Kane M.F., Loda M., Gaida G.M., Lipman J., Mishra R., Goldman H., Jessup J.M., Kolodner R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57:1997;808-811.
108. Veigl M.L., Kasturi L., Olechnowicz J., Ma A., Lutterbaugh J.D., Periyasamy S., Li G.M., Drummond J., Modrich P.L., Sedwick W.D., Markowitz S.D. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc. Natl. Acad. Sci. USA. 95:1998;8698-8702.
109. Hollingsworth N.M., Ponte L., Halsey C. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev. 9:1995;1728-1739.
110. Ross Macdonald P., Roeder G.S. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell. 79:1994;1069-1080.
111. Ciotta C., Ceccotti S., Aquilina G., Humbert O., Palombo F., Jiricny J., Bignami M. Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. J. Mol. Biol. 276:1998;705-719.
112. Rayssiguier C., Thaler D.S., Radman M. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature. 342:1989;396-401.
113. Worth L.J., Clark S., Radman M., Modrich P. Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. Proc. Natl. Acad. Sci. USA. 91:1994;3238-3241.
114. Worth L.J., Bader T., Yang J., Clark S. Role of MutS ATPase activity in MutS, L-dependent block of in vitro strand transfer. J. Biol. Chem. 273:1998;23176-23182.
115. Alani E., Reenan R.A., Kolodner R.D. Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics. 137:1994;19-39.
116. Datta A., Adjiri A., New L., Crouse G.F., Jinks Robertson S. Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:1996;1085-1093.
117. Selva E.M., New L., Crouse G.F., Lahue R.S. Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae. Genetics. 139:1995;1175-1188.