Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

Genes and Development

Volumn 17, Issue 24, 2003, Pages 3112-3126

  Aguirre, Andrew J ^a   Bardeesy, Nabeel ^a   Sinha, Manisha ^a   Lopez, Lyle ^a   Tuveson, David A ^c   Horner, James ^a   Redston, Mark S ^b   DePinho, Ronald A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ink4a Arf; Metastasis; Mouse model; Pancreatic cancer; PanIN

Indexed keywords

ARF PROTEIN;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CONTROLLED STUDY; DEATH; DELETION MUTANT; DISEASE COURSE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; MEDICAL ASSESSMENT; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREATIC INTRAEPITHELIAL NEOPLASIA; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STROMA; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FIBROBLASTS; GENES, RAS; HUMANS; INTEGRASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIRAL PROTEINS;

ANIMALIA;

EID: 0346455774     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1158703     Document Type: Article

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