-
1
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
Feinberg, A. P. & Vogelstein, B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301, 89-92 (1983).
-
(1983)
Nature
, vol.301
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
2
-
-
0021101229
-
The 5-methylcytosine content of DNA from human tumors
-
Gama-Sosa, M. A. et al. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 11. 6883-6894 (1983).
-
(1983)
Nucleic Acids Res.
, vol.11
, pp. 6883-6894
-
-
Gama-Sosa, M.A.1
-
3
-
-
0021950948
-
Hypomethylation of DNA from benign and malignant human colon neoplasms
-
Goelz, S. E., Vogelstein, B., Hamilton, S. R. & Feinberg, A. P. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-190 (1985).
-
(1985)
Science
, vol.228
, pp. 187-190
-
-
Goelz, S.E.1
Vogelstein, B.2
Hamilton, S.R.3
Feinberg, A.P.4
-
4
-
-
0023848637
-
Reduced genomic 5-methylcytosine content in human colonic neoplasia
-
Feinberg, A. P., Gehrke, C. W., Kuo, K. C. & Ehrlich, M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res. 48, 1159-1161 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 1159-1161
-
-
Feinberg, A.P.1
Gehrke, C.W.2
Kuo, K.C.3
Ehrlich, M.4
-
5
-
-
0036230566
-
A genome-wide screen for normally methylated human CgG islands that can identify novel imprinted genes
-
Strichman-Almashanu, L. Z. et al. A genome-wide screen for normally methylated human CgG islands that can identify novel imprinted genes. Genome Res. 12, 543-554 (2002).
-
(2002)
Genome Res.
, vol.12
, pp. 543-554
-
-
Strichman-Almashanu, L.Z.1
-
6
-
-
0020627846
-
Hypomethylation of ras oncogenes in primary human cancers
-
Feinberg, A. P. & Vogelstein, B. Hypomethylation of ras oncogenes in primary human cancers. Biochem. Biophys. Res. Commun. 111, 47-54 (1983).
-
(1983)
Biochem. Biophys. Res. Commun.
, vol.111
, pp. 47-54
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
7
-
-
0029957792
-
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
-
De Smet, C. et al. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc. Natl Acad. Sci. USA 93, 7149-7153 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7149-7153
-
-
De Smet, C.1
-
8
-
-
0038387946
-
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma
-
Cho, B. et al. Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma, Biochem. Biophys. Res. Commun. 307, 52-63 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.307
, pp. 52-63
-
-
Cho, B.1
-
9
-
-
0011964662
-
Tumour class prediction and discovery by microarray-based DNA methylation analysis
-
Adorjan, P. et al. Tumour class prediction and discovery by microarray-based DNA methylation analysis. Nucleic Acids Res. 30, e21 (2002).
-
(2002)
Nucleic Acids Res.
, vol.30
-
-
Adorjan, P.1
-
10
-
-
0037379406
-
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
-
Iacobuzio-Donahue, C. A. et al. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am. J. Pathol. 162, 1151-1162 (2003).
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 1151-1162
-
-
Iacobuzio-Donahue, C.A.1
-
11
-
-
1042263110
-
Promoter methylation of cyclin D2 gene in gastric carcinoma
-
Oshimo, Y. et al. Promoter methylation of cyclin D2 gene in gastric carcinoma. Int. J. Oncol. 6, 1663-1670 (2003).
-
(2003)
Int. J. Oncol.
, vol.6
, pp. 1663-1670
-
-
Oshimo, Y.1
-
12
-
-
0142182088
-
Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells
-
Akiyama, Y., Maesawa, C., Ogasawara, S., Terashima, M. & Masuda, T. Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells. Am. J. Pathol. 163, 1911-1919 (2003).
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 1911-1919
-
-
Akiyama, Y.1
Maesawa, C.2
Ogasawara, S.3
Terashima, M.4
Masuda, T.5
-
13
-
-
0035902856
-
Hypomethylation of the MN/CA9 promoter and upregulated MN/CA 9 expression in human renal cell carcinoma
-
Cho, M. et al. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br. J. Cancer 85, 563-567 (2001).
-
(2001)
Br. J. Cancer
, vol.85
, pp. 563-567
-
-
Cho, M.1
-
14
-
-
0032468051
-
Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
-
Nakamura, N. & Takenaga, K. Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin. Exp. Metastasis 16, 471-479 (1998).
-
(1998)
Clin. Exp. Metastasis
, vol.16
, pp. 471-479
-
-
Nakamura, N.1
Takenaga, K.2
-
15
-
-
0038365277
-
CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: Genomic hypomethylation correlates with carcinogenic progression
-
Badal, V. et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J. Virol. 77, 6227-6234 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 6227-6234
-
-
Badal, V.1
-
16
-
-
0642345170
-
DNA demethylation is directly related 1o tumour progression: Evidence in normal, pre-malignant and malignant cells from uterine cervix samples
-
De Capoa, A. et al. DNA demethylation is directly related 1o tumour progression: evidence in normal, pre-malignant and malignant cells from uterine cervix samples. Oncol. Rep. 10, 545-549 (2003).
-
(2003)
Oncol. Rep.
, vol.10
, pp. 545-549
-
-
De Capoa, A.1
-
17
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
Sato, N. et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 63, 4158-4166 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 4158-4166
-
-
Sato, N.1
-
18
-
-
0037306633
-
Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)
-
Piyathilake, C. J. et al. Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States). Cancer Causes Control 14, 37-42 (2003).
-
(2003)
Cancer Causes Control
, vol.14
, pp. 37-42
-
-
Piyathilake, C.J.1
-
19
-
-
0030983076
-
DNA methylation and genetic instability in colorectal cancer cells
-
Lengauer, C., Kinzler, K. W. & Vogelstein, B. DNA methylation and genetic instability in colorectal cancer cells. Proc. Natl Acad. Sci. USA 94, 2545-2550 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2545-2550
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
20
-
-
0034677569
-
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines
-
Pao, M. M. et al. DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene 19, 943-952 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 943-952
-
-
Pao, M.M.1
-
21
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane, M. F. et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57, 808-811 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
-
22
-
-
0031761362
-
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
-
Cui, H., Horon, I. L., Ohlsson, R., Hamilton, S. R. & Feinberg, A. P. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nature Med. 4, 1276-1280 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 1276-1280
-
-
Cui, H.1
Horon, I.L.2
Ohlsson, R.3
Hamilton, S.R.4
Feinberg, A.P.5
-
23
-
-
0033081639
-
Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16
-
Qu, G. Z., Grundy, P. E., Narayan, A. & Ehrlich, M. Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16. Cancer Genet. Cytogenet. 109, 34-39 (1999).
-
(1999)
Cancer Genet. Cytogenet.
, vol.109
, pp. 34-39
-
-
Qu, G.Z.1
Grundy, P.E.2
Narayan, A.3
Ehrlich, M.4
-
24
-
-
0036778642
-
Chromosome arm 16q in Wilms tumors: Unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
-
Yeh, A. et al. Chromosome arm 16q in Wilms tumors: unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene. Genes Chromosomes Cancer 35, 156-163 (2002).
-
(2002)
Genes Chromosomes Cancer
, vol.35
, pp. 156-163
-
-
Yeh, A.1
-
25
-
-
0033435205
-
The DNMT 3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
-
Hansen, R. S. et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc. Natl Acad. Sci. USA 96, 14412-14417 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14412-14417
-
-
Hansen, R.S.1
-
26
-
-
0033547330
-
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
-
Xu, G. L. et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402, 187-191 (1999).
-
(1999)
Nature
, vol.402
, pp. 187-191
-
-
Xu, G.L.1
-
27
-
-
0033615717
-
DNA methyltransferases Dnmt 3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
28
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden, A., Gaudet, F., Waghmare, A. & Jaenisch, R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300, 455 (2003).
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
29
-
-
1242285594
-
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
-
8 Oct (doi: 10.1007/s00384-003-0539-3)
-
Suter, C. M., Martin, D. I. & Ward, R. L. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int. J. Colorectal Dis. 8 Oct 2003 (doi: 10.1007/s00384-003-0539-3).
-
(2003)
Int. J. Colorectal Dis.
-
-
Suter, C.M.1
Martin, D.I.2
Ward, R.L.3
-
30
-
-
0032403478
-
Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
-
Nakayama, M. et al. Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood 92, 4296-4307 (1998).
-
(1998)
Blood
, vol.92
, pp. 4296-4307
-
-
Nakayama, M.1
-
31
-
-
0037960155
-
Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
-
Takaguchi, M., Achanzar, W. E., Qu, W., Li G. & Waalkes, M. P. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp. Cell Res. 286, 355-365 (2003).
-
(2003)
Exp Cell Res.
, vol.286
, pp. 355-365
-
-
Takaguchi, M.1
Achanzar, W.E.2
Qu, W.3
Li, G.4
Waalkes, M.P.5
-
32
-
-
0036262265
-
Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice
-
Okoji, R. S., Yu, R. C., Maronpot, R. R. & Froines, J. R. Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis 23, 777-785 (2002).
-
(2002)
Carcinogenesis
, vol.23
, pp. 777-785
-
-
Okoji, R.S.1
Yu, R.C.2
Maronpot, R.R.3
Froines, J.R.4
-
33
-
-
0642276399
-
Host cell-dependent expression of latent Epstein-Barr virus genomes: Regulation by DNA methylation
-
Li, H. & Minarovits, J. Host cell-dependent expression of latent Epstein-Barr virus genomes: regulation by DNA methylation. Adv. Cancer Res. 89, 133-156 (2003).
-
(2003)
Adv. Cancer Res.
, vol.89
, pp. 133-156
-
-
Li, H.1
Minarovits, J.2
-
34
-
-
0037444389
-
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer
-
Heijmans, B. T. et al. A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. Cancer Res. 63, 1249-1253 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1249-1253
-
-
Heijmans, B.T.1
-
35
-
-
0029855024
-
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
-
Chen, J. et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res. 56, 4862-4864 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 4862-4864
-
-
Chen, J.1
-
36
-
-
0038523843
-
Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: A case control study
-
Pufulete, M. et al. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124, 1240-1248 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 1240-1248
-
-
Pufulete, M.1
-
37
-
-
0015904654
-
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma
-
Poiner, L. A. Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma. Cancer Res. 33, 2109-2113 (1973).
-
(1973)
Cancer Res.
, vol.33
, pp. 2109-2113
-
-
Poiner, L.A.1
-
38
-
-
0034069652
-
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation
-
Gibbons, R. J. et al. Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nature Genet. 24, 368-371 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 368-371
-
-
Gibbons, R.J.1
-
39
-
-
2642647094
-
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
-
Versteege, I. et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394, 203-206 (1998).
-
(1998)
Nature
, vol.394
, pp. 203-206
-
-
Versteege, I.1
-
40
-
-
0043136702
-
Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis
-
Fan, T. et al. Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Res. 63, 4677-4683 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 4677-4683
-
-
Fan, T.1
-
41
-
-
0037162542
-
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b 4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
-
Saito, Y. et al. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc. Natl Acad. Sci. USA 99, 10060-10065 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10060-10065
-
-
Saito, Y.1
-
42
-
-
0022495317
-
DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas
-
Baylin, S. B. et al. DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas. Cancer Res. 46, 2917-2922 (1986).
-
(1986)
Cancer Res.
, vol.46
, pp. 2917-2922
-
-
Baylin, S.B.1
-
43
-
-
0024365892
-
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
-
Greger, V., Passarge, E., Hopping, W., Messmer, E. & Horsthemke, B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Genet. 83, 155-158 (1989).
-
(1989)
Hum. Genet.
, vol.83
, pp. 155-158
-
-
Greger, V.1
Passarge, E.2
Hopping, W.3
Messmer, E.4
Horsthemke, B.5
-
44
-
-
0025891856
-
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene
-
Sakai, T. et al. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am. J. Hum. Genet. 48, 880-888 (1991).
-
(1991)
Am. J. Hum. Genet.
, vol.48
, pp. 880-888
-
-
Sakai, T.1
-
45
-
-
0027537296
-
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene
-
Ohtani-Fujita, N. et al. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8, 1083-1067 (1993).
-
(1993)
Oncogene
, vol.8
, pp. 1083-1067
-
-
Ohtani-Fujita, N.1
-
46
-
-
0027962591
-
Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma
-
Greger, V. et al. Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Hum. Genet. 94, 491-496 (1994).
-
(1994)
Hum. Genet.
, vol.94
, pp. 491-496
-
-
Greger, V.1
-
47
-
-
0028875205
-
Methylation of the 5′ Cpg island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
-
Gonzalez-Zulueta, M. et al. Methylation of the 5′ Cpg island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 55, 4531-4535 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4531-4535
-
-
Gonzalez-Zulueta, M.1
-
48
-
-
0028849277
-
E-Cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
-
Graff, J. R. et al. E-Cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res. 55, 5195-5199 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 5195-5199
-
-
Graff, J.R.1
-
49
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman, J. G. et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl Acad. Sci. USA 91, 9700-9704 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
-
50
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo, A. et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Med. 1, 686-692 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 686-692
-
-
Merlo, A.1
-
51
-
-
0032146118
-
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
-
Cunningham, J. M. et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res. 58, 3455-3460 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 3455-3460
-
-
Cunningham, J.M.1
-
52
-
-
13144307115
-
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
-
Veigl, M. L. et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc. Natl Acad. Sci. USA 95, 8698-8702 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8698-8702
-
-
Veigl, M.L.1
-
53
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
Toyota, M. et al. CpG island methylator phenotype in colorectal cancer. Proc. Natl Acad. Sci. USA 96, 8681-8686 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 8681-8686
-
-
Toyota, M.1
-
54
-
-
0027285696
-
Inactivation of a tumor suppressor function in immortal Syrian hamster cells by N-methyl-N′-nitro-N-nitrosoguanidine and by 5-aza-2′ -deoxycytidine
-
West, R. W. & Barrett, J. C. Inactivation of a tumor suppressor function in immortal Syrian hamster cells by N-methyl-N′ -nitro-N-nitrosoguanidine and by 5-aza-2′-deoxycytidine. Carcinogenesis 14, 285-289 (1993).
-
(1993)
Carcinogenesis
, vol.14
, pp. 285-289
-
-
West, R.W.1
Barrett, J.C.2
-
55
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee, I. et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416, 552-556 (2002).
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
-
56
-
-
0037224722
-
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
-
Robert, M. F. et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nature Genet. 33, 61-65 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 61-65
-
-
Robert, M.F.1
-
57
-
-
0037355506
-
Unanswered questions about the role of promoter methylation in carcinogenesis
-
Bestor, T. H. Unanswered questions about the role of promoter methylation in carcinogenesis. Ann. NY Acad. Sci. 983, 22-27 (2003).
-
(2003)
Ann. NY Acad. Sci.
, vol.983
, pp. 22-27
-
-
Bestor, T.H.1
-
58
-
-
0033518130
-
Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements
-
Hajra, K. M., Ji, X. & Fearon, E. R. Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18, 7274-7279 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7274-7279
-
-
Hajra, K.M.1
Ji, X.2
Fearon, E.R.3
-
59
-
-
0037924433
-
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
-
Bachman, K. E. et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3, 89-95 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 89-95
-
-
Bachman, K.E.1
-
60
-
-
0037068393
-
DNA methylation and gene silencing in cancer: Which is the guilty party?
-
Clark, S. J. & Melki, J. DNA methylation and gene silencing in cancer: which is the guilty party? Oncogene 21, 5380-5387 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 5380-5387
-
-
Clark, S.J.1
Melki, J.2
-
61
-
-
0037179870
-
Hypomethylation and hypermethylation of DNA in Wilms tumors
-
Ehrlich, M. et al. Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene 21, 6694-6702 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 6694-6702
-
-
Ehrlich, M.1
-
62
-
-
0032575010
-
INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue
-
INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue. Oncogene 16, 2723-2727 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 2723-2727
-
-
Van Zee, K.J.1
Calvano, J.E.2
Bisogna, M.3
-
63
-
-
0021237658
-
Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
-
Surani, M. A., Barton, S. C. & Norris, M. L. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature 308, 548-550 (1984).
-
(1984)
Nature
, vol.308
, pp. 548-550
-
-
Surani, M.A.1
Barton, S.C.2
Norris, M.L.3
-
64
-
-
0021139084
-
Completion of mouse embryogenesis requires both the maternal and paternal genomes
-
McGrath, J. & Solter, D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37, 179-183 (1984).
-
(1984)
Cell
, vol.37
, pp. 179-183
-
-
McGrath, J.1
Solter, D.2
-
65
-
-
0017696835
-
Androgenetic origin of hydatidiform mole
-
Kajii, T. & Ohama, K. Androgenetic origin of hydatidiform mole. Nature 268, 633 (1977).
-
(1977)
Nature
, vol.268
, pp. 633
-
-
Kajii, T.1
Ohama, K.2
-
66
-
-
0016426316
-
Parthenogenetic origin of benign ovarian teratomas
-
Under, D., McCaw, B., Kaiser, X. & Hecht, F. Parthenogenetic origin of benign ovarian teratomas. N. Engl. J. Med. 292, 63-66 (1975).
-
(1975)
N. Engl. J. Med.
, vol.292
, pp. 63-66
-
-
Under, D.1
McCaw, B.2
Kaiser, X.3
Hecht, F.4
-
67
-
-
0025227901
-
Preferential loss of maternal alleles in sporadic Wilms' tumor
-
Pal, N. et al. Preferential loss of maternal alleles in sporadic Wilms' tumor. Oncogene 5, 1665-1668 (1990).
-
(1990)
Oncogene
, vol.5
, pp. 1665-1668
-
-
Pal, N.1
-
68
-
-
0023256838
-
Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors
-
Schroeder, W. T. et al. Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors. Am. J. Hum. Genet. 40, 413-420 (1987).
-
(1987)
Am. J. Hum. Genet.
, vol.40
, pp. 413-420
-
-
Schroeder, W.T.1
-
69
-
-
0009615132
-
A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting
-
Scrable, H. et al. A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proc. Natl Acad. Sci. USA 86, 7480-7484 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7480-7484
-
-
Scrable, H.1
-
70
-
-
0024543131
-
Maternal allele loss in Wilms' tumor
-
Williams, J. C., Brown, K. W., Mott, M. G. & Maitland, N. J. Maternal allele loss in Wilms' tumor. Lancet 1, 283-284 (1989).
-
(1989)
Lancet
, vol.1
, pp. 283-284
-
-
Williams, J.C.1
Brown, K.W.2
Mott, M.G.3
Maitland, N.J.4
-
71
-
-
0025309895
-
Genomic imprinting and the Beckwith-Wiedemann syndrome
-
Brown, K. W., Williams, J. C., Maitland, N.J. & Mott, M. G. Genomic imprinting and the Beckwith-Wiedemann syndrome. Am. J. Hum. Genet. 46, 1000-1001 (1990).
-
(1990)
Am. J. Hum. Genet.
, vol.46
, pp. 1000-1001
-
-
Brown, K.W.1
Williams, J.C.2
Maitland, N.J.3
Mott, M.G.4
-
72
-
-
0024517062
-
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5
-
Koufos, A. et al. Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am. J. Hum. Genet. 44, 711-719 (1989).
-
(1989)
Am. J. Hum. Genet.
, vol.44
, pp. 711-719
-
-
Koufos, A.1
-
73
-
-
0024518392
-
Genetic linkage of Beckwith-Wiedemann syndrome to 11p15
-
Ping, A. J. et al. Genetic linkage of Beckwith-Wiedemann syndrome to 11p15. Am. J. Hum. Genet. 44, 720-723 (1989).
-
(1989)
Am. J. Hum. Genet.
, vol.44
, pp. 720-723
-
-
Ping, A.J.1
-
74
-
-
0028316620
-
Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia
-
Mannens, M. et al. Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia. Eur. J. Hum. Genet. 2, 3-23 (1994).
-
(1994)
Eur. J. Hum. Genet.
, vol.2
, pp. 3-23
-
-
Mannens, M.1
-
75
-
-
0026849544
-
Monoallelic expression of the human H19 gene
-
Zhang, Y. & Tycko, B. Monoallelic expression of the human H19 gene. Nature Genet. 1, 40-44 (1992).
-
(1992)
Nature Genet.
, vol.1
, pp. 40-44
-
-
Zhang, Y.1
Tycko, B.2
-
76
-
-
0027158855
-
Parental genomic imprinting of the human IGF2 gene
-
Giannoukakis, N., Deal, C., Paquette, J., Goodyer, C. G. & Polychronakos, C. Parental genomic imprinting of the human IGF2 gene. Nature Genet. 4, 98-101 (1993).
-
(1993)
Nature Genet.
, vol.4
, pp. 98-101
-
-
Giannoukakis, N.1
Deal, C.2
Paquette, J.3
Goodyer, C.G.4
Polychronakos, C.5
-
77
-
-
0027322519
-
IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome
-
Ohlsson, R. et al. IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome. Nature Genet. 4, 94-97 (1993).
-
(1993)
Nature Genet.
, vol.4
, pp. 94-97
-
-
Ohlsson, R.1
-
78
-
-
0027172683
-
Relaxation of imprinted genes in human cancer
-
Rainier, S. et al. Relaxation of imprinted genes in human cancer. Nature 362, 747-749 (1993).
-
(1993)
Nature
, vol.362
, pp. 747-749
-
-
Rainier, S.1
-
79
-
-
0027285258
-
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
-
Ogawa, O. et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature 362, 749-751 (1993).
-
(1993)
Nature
, vol.362
, pp. 749-751
-
-
Ogawa, O.1
-
80
-
-
0026098090
-
The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus
-
Barlow, D. P., Stoger, R., Herrmann, B. G., Saito, K. & Schweifer, N. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349, 84-87 (1991).
-
(1991)
Nature
, vol.349
, pp. 84-87
-
-
Barlow, D.P.1
Stoger, R.2
Herrmann, B.G.3
Saito, K.4
Schweifer, N.5
-
81
-
-
0025809321
-
Parental imprinting of the mouse H19 gene
-
Bartolomei, M., Zemel, S. & Tilghman, S. M. Parental imprinting of the mouse H19 gene. Nature 351, 153-155 (1991).
-
(1991)
Nature
, vol.351
, pp. 153-155
-
-
Bartolomei, M.1
Zemel, S.2
Tilghman, S.M.3
-
82
-
-
0025967857
-
Parental imprinting of the mouse insulin-like growth factor-2 gene
-
DeChiara, T. M., Robertson, E. J. & Efstratiadis, A. Parental imprinting of the mouse insulin-like growth factor-2 gene. Cell 64, 849-859 (1991).
-
(1991)
Cell
, vol.64
, pp. 849-859
-
-
DeChiara, T.M.1
Robertson, E.J.2
Efstratiadis, A.3
-
83
-
-
0027730805
-
Functional imprinting and epigenetic modification of the human SNRPN gene
-
Glenn, C. C., Porter, K. A., Jong, M. T., Nicholls, R. D. & Driscoll, D. J. Functional imprinting and epigenetic modification of the human SNRPN gene. Hum Mol. Genet. 2, 2001-2005 (1993).
-
(1993)
Hum Mol. Genet.
, vol.2
, pp. 2001-2005
-
-
Glenn, C.C.1
Porter, K.A.2
Jong, M.T.3
Nicholls, R.D.4
Driscoll, D.J.5
-
84
-
-
0027018063
-
Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region
-
Leff, S. E. et al. Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region. Nature Genet. 2, 259-264 (1992).
-
(1992)
Nature Genet.
, vol.2
, pp. 259-264
-
-
Leff, S.E.1
-
85
-
-
0027378582
-
Role for DNA methylation in genomic imprinting
-
Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362-365 (1993).
-
(1993)
Nature
, vol.366
, pp. 362-365
-
-
Li, E.1
Beard, C.2
Jaenisch, R.3
-
86
-
-
0033665147
-
Sequence and comparative analysis of the mouse 1 megabase region orthologous to the human 11p15 imprinted domain
-
Onyango, P. et al. Sequence and comparative analysis of the mouse 1 megabase region orthologous to the human 11p15 imprinted domain. Genome Res. 10, 1697-1710 (2000).
-
(2000)
Genome Res.
, vol.10
, pp. 1697-1710
-
-
Onyango, P.1
-
87
-
-
0031750223
-
Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5
-
Paulsen, M. et al. Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Hum. Mol. Genet. 7, 1149-1159 (1998).
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1149-1159
-
-
Paulsen, M.1
-
88
-
-
9844265406
-
The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG 51, implicated in Fas expression and apoptosis
-
Qian, N. et al. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Hum. Mol Genet. 6, 2021-2029 (1997).
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2021-2029
-
-
Qian, N.1
-
89
-
-
0031924628
-
IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes
-
Dao, D. et al. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. Hum. Mol. Genet. 7,597-608 (1998).
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 597-608
-
-
Dao, D.1
-
90
-
-
0028227938
-
Epigenetic lesions at the H19 locus in Wilms' tumour patients
-
Moulton, T. et al. Epigenetic lesions at the H19 locus in Wilms' tumour patients. Nature Genet. 7, 440-447 (1994).
-
(1994)
Nature Genet.
, vol.7
, pp. 440-447
-
-
Moulton, T.1
-
91
-
-
0028356544
-
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour
-
Steenman, M. J. et al. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour. Nature Genet 7, 433-439 (1994).
-
(1994)
Nature Genet
, vol.7
, pp. 433-439
-
-
Steenman, M.J.1
-
92
-
-
0030973543
-
Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorgenesis
-
Okamoto, K., Morison, I. M., Taniguchi, T. & Reeve, A. E. Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorgenesis. Proc. Natl Acad. Sci. USA 94, 5367-5371 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5367-5371
-
-
Okamoto, K.1
Morison, I.M.2
Taniguchi, T.3
Reeve, A.E.4
-
93
-
-
0027442239
-
Tumor-suppressor activity of H 19 RNA
-
Hao, Y., Crenshaw, T., Moulton, T., Newcomb, E. & Tycko, B. Tumor-suppressor activity of H19 RNA. Nature 365, 764-767 (1993).
-
(1993)
Nature
, vol.365
, pp. 764-767
-
-
Hao, Y.1
Crenshaw, T.2
Moulton, T.3
Newcomb, E.4
Tycko, B.5
-
94
-
-
0029006470
-
Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during β-cell tumorigenesis
-
Christofori, G., Naik, P. & Hanahan, D. Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during β-cell tumorigenesis. Nature Genet. 10, 196-201 (1995).
-
(1995)
Nature Genet.
, vol.10
, pp. 196-201
-
-
Christofori, G.1
Naik, P.2
Hanahan, D.3
-
95
-
-
0028356419
-
A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis
-
Christofori, G., Naik, P. & Hanahan, D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369, 414-418 (1994).
-
(1994)
Nature
, vol.369
, pp. 414-418
-
-
Christofori, G.1
Naik, P.2
Hanahan, D.3
-
96
-
-
0035930134
-
Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
-
Ravenel, J. D. et al. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J. Natl Cancer Inst. 93, 1698-1703 (2001).
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1698-1703
-
-
Ravenel, J.D.1
-
97
-
-
0036292260
-
Preferential loss of paternal 19q, but not 1p, alleles in oligodendrogliomas
-
Sanson, M., Leuraud, P., Marie, Y., Delattre, J. Y. & Hoang-Xuan, K. Preferential loss of paternal 19q, but not 1p, alleles in oligodendrogliomas. Ann. Neurol. 52, 105-107 (2002).
-
(2002)
Ann. Neurol.
, vol.52
, pp. 105-107
-
-
Sanson, M.1
Leuraud, P.2
Marie, Y.3
Delattre, J.Y.4
Hoang-Xuan, K.5
-
98
-
-
0034994067
-
Epigentic silencing of PEG3 gene expression in human glioma cell lines
-
Maegawa, S. et al. Epigentic silencing of PEG3 gene expression in human glioma cell lines. Mol. Carcinogen. 31, 1-9 (2001).
-
(2001)
Mol. Carcinogen.
, vol.31
, pp. 1-9
-
-
Maegawa, S.1
-
99
-
-
0034791736
-
Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group
-
Jenkins, R. B., Curran, W., Scott, C. B. & Cairncross, G. Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group. Am. J. Clin. Oncol. 24, 506-508 (2001).
-
(2001)
Am. J. Clin. Oncol.
, vol.24
, pp. 506-508
-
-
Jenkins, R.B.1
Curran, W.2
Scott, C.B.3
Cairncross, G.4
-
100
-
-
0033537716
-
Regulation of maternal behavior and offspring growth by paternally expressed Peg3
-
Li, L. et al. Regulation of maternal behavior and offspring growth by paternally expressed Peg3. Science 284, 330-333 (1999).
-
(1999)
Science
, vol.284
, pp. 330-333
-
-
Li, L.1
-
101
-
-
0035061907
-
Tumour suppressor activity of human imprinted gene PEG 3 in a glioma cell line
-
Kohda, T. et al. Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. Genes Cells 6, 237-247 (2001).
-
(2001)
Genes Cells
, vol.6
, pp. 237-247
-
-
Kohda, T.1
-
102
-
-
0034994067
-
Epigenetic silencing of PEG3 gene expression in human glioma cell lines
-
Maegawa, S. et al. Epigenetic silencing of PEG3 gene expression in human glioma cell lines. Mol. Carcinogen. 31, 1-9 (2001).
-
(2001)
Mol. Carcinogen.
, vol.31
, pp. 1-9
-
-
Maegawa, S.1
-
103
-
-
0035158966
-
Chromosome bands 1p35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted
-
Caron, H. et al. Chromosome bands 1p35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted. Genes Chromosomes Cancer 30, 168-174 (2001).
-
(2001)
Genes Chromosomes Cancer
, vol.30
, pp. 168-174
-
-
Caron, H.1
-
104
-
-
0036090234
-
Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia
-
Morison, I. M., Ellis, L. M., Teague, L. R. & Reeve, A. E. Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia. Blood 99, 375-377 (2002).
-
(2002)
Blood
, vol.99
, pp. 375-377
-
-
Morison, I.M.1
Ellis, L.M.2
Teague, L.R.3
Reeve, A.E.4
-
105
-
-
0041672342
-
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers
-
Yuan, J. et al. Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. Cancer Res. 63, 4174-4180 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 4174-4180
-
-
Yuan, J.1
-
106
-
-
0033609117
-
Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting
-
Lee, M. P. et al. Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting. Proc. Natl Acad. Sci. USA 98, 5203-5208 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5203-5208
-
-
Lee, M.P.1
-
107
-
-
0033529207
-
A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome
-
Smilinch, N. J. et al. A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. Proc. Natl Sci. USA 96, 8064-8069 (1999).
-
(1999)
Proc. Natl. Sci. USA
, vol.96
, pp. 8064-8069
-
-
Smilinch, N.J.1
-
108
-
-
0344630574
-
Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene
-
Buschhausen, G., Wittig, B., Graessmann, M. & Graessmann, A. Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. Proc. Natl Acad. Sci. USA 84, 1177-1181 (1987).
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 1177-1181
-
-
Buschhausen, G.1
Wittig, B.2
Graessmann, M.3
Graessmann, A.4
-
109
-
-
0022545498
-
DNA methylation affects the formation of active chromatin
-
Keshet, I., Lieman-Hurwitz, J. & Cedar, H. DNA methylation affects the formation of active chromatin. Cell 44, 535-543 (1986).
-
(1986)
Cell
, vol.44
, pp. 535-543
-
-
Keshet, I.1
Lieman-Hurwitz, J.2
Cedar, H.3
-
110
-
-
0026747761
-
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
-
Lewis, J. D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905-914 (1992).
-
(1992)
Cell
, vol.69
, pp. 905-914
-
-
Lewis, J.D.1
-
111
-
-
0026658662
-
Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
-
Meehan, R. R., Lewis, J. D. & Bird, A. P. Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA. Nucleic Acids Res. 20, 5085-5092 (1992).
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 5085-5092
-
-
Meehan, R.R.1
Lewis, J.D.2
Bird, A.P.3
-
112
-
-
0031837109
-
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
-
Jones, P. L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187-191 (1998).
-
(1998)
Nature Genet.
, vol.19
, pp. 187-191
-
-
Jones, P.L.1
-
113
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
-
(1998)
Nature
, vol.393
, pp. 386-389
-
-
Nan, X.1
-
114
-
-
0033945861
-
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
-
Rountree, M. R., Bachman, K. E. & Baylin, S. B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genet. 25, 269-277 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 269-277
-
-
Rountree, M.R.1
Bachman, K.E.2
Baylin, S.B.3
-
115
-
-
0032845039
-
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
-
Wade, P. A. et al. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nature Genet. 23, 62-66 (1999).
-
(1999)
Nature Genet.
, vol.23
, pp. 62-66
-
-
Wade, P.A.1
-
116
-
-
0033826338
-
Transcriptional repression by Drosophila methyl-CpG-binding proteins
-
Roder, K. et al. Transcriptional repression by Drosophila methyl-CpG-binding proteins. Mol. Cell Biol. 20, 7401-7409 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 7401-7409
-
-
Roder, K.1
-
117
-
-
0034632829
-
Regulation of chromatin structure by site-specific histone H 3 methyltransferases
-
Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599 (2000).
-
(2000)
Nature
, vol.406
, pp. 593-599
-
-
Rea, S.1
-
118
-
-
0033592999
-
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena
-
Strahl, B. D., Ohba, R., Cook, R. G. & Allis, C. D. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc. Natl Acad. Sci. USA 96, 14967-14972 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14967-14972
-
-
Strahl, B.D.1
Ohba, R.2
Cook, R.G.3
Allis, C.D.4
-
119
-
-
0037112369
-
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′ -deoxycytidine
-
Nguyen, C. T. et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res. 62, 6456-6461 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6456-6461
-
-
Nguyen, C.T.1
-
120
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
Yoder, J. A., Walsh, C. P. & Bestor, T. H. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13, 335-340 (1997).
-
(1997)
Trends Genet.
, vol.13
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
121
-
-
0037058948
-
Histone H3 variants specify modes of chromatin assembly
-
Ahmad, K. & Henikoff, S. Histone H3 variants specify modes of chromatin assembly. Proc. Natl Acad Sci. USA 99, S16477-S16484 (2002).
-
(2002)
Proc. Natl. Acad Sci. USA
, vol.99
-
-
Ahmad, K.1
Henikoff, S.2
-
122
-
-
0037188911
-
Histone methylation: Dynamic or static?
-
Bannister, A. J., Schneider, R. & Kouzarides, T. Histone methylation: dynamic or static? Cell 109, 801-806 (2002).
-
(2002)
Cell
, vol.109
, pp. 801-806
-
-
Bannister, A.J.1
Schneider, R.2
Kouzarides, T.3
-
123
-
-
0022533573
-
Sequence-specific DNA-binding proteins which interact with (G + C)-rich sequences flanking the chicken c-myc gene
-
Lobanenkov, V. V., Nicolas, R. H., Plumb, M. A., Wright, C. A. & Goodwin, G. H. Sequence-specific DNA-binding proteins which interact with (G + C)-rich sequences flanking the chicken c-myc gene. Eur. J. Biochem. 159, 181-188 (1986).
-
(1986)
Eur. J. Biochem.
, vol.159
, pp. 181-188
-
-
Lobanenkov, V.V.1
Nicolas, R.H.2
Plumb, M.A.3
Wright, C.A.4
Goodwin, G.H.5
-
124
-
-
0035943045
-
CpG methylation regulates the Igf2/H19 insulator
-
Holmgren, C. et al. CpG methylation regulates the Igf2/H19 insulator. Curr. Biol. 11, 1128-1130 (2001).
-
(2001)
Curr. Biol.
, vol.11
, pp. 1128-1130
-
-
Holmgren, C.1
-
125
-
-
0034713275
-
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
-
Hark, A. T. et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405, 486-489 (2000).
-
(2000)
Nature
, vol.405
, pp. 486-489
-
-
Hark, A.T.1
-
126
-
-
0033529654
-
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
-
Bell, A. C., West, A. G. & Felsenfeld, G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396 (1999).
-
(1999)
Cell
, vol.98
, pp. 387-396
-
-
Bell, A.C.1
West, A.G.2
Felsenfeld, G.3
-
127
-
-
0035393429
-
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site
-
Cui, H. et al. Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Res. 61, 4947-4950 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4947-4950
-
-
Cui, H.1
-
128
-
-
0037112364
-
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2
-
Cui, H. et al. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 62, 6442-6446 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6442-6446
-
-
Cui, H.1
-
129
-
-
0035895208
-
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer
-
Nakagawa, H. et al. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc. Natl Acad. Sci. USA 98, 591-596 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 591-596
-
-
Nakagawa, H.1
-
130
-
-
0037076432
-
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
-
Loukinov, D. I. et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc. Natl Acad. Sci. USA 99, 6806-6811 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6806-6811
-
-
Loukinov, D.I.1
-
131
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
-
132
-
-
0031940675
-
Risk of cancer during the first four years of life in children from the Beckwith-Wiedemann Syndrome Registry
-
DeBaun, M. R. & Tucker, M. A. Risk of cancer during the first four years of life in children from The Beckwith-Wiedemann Syndrome Registry. J. Pediatr. 132, 398-400 (1998).
-
(1998)
J. Pediatr.
, vol.132
, pp. 398-400
-
-
DeBaun, M.R.1
Tucker, M.A.2
-
133
-
-
0027420362
-
Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome
-
Weksberg, R., Shen, D. R., Fei, Y. L., Song, Q. L., & Squire, J. Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. Nature Genet. 5, 143-150 (1993).
-
(1993)
Nature Genet.
, vol.5
, pp. 143-150
-
-
Weksberg, R.1
Shen, D.R.2
Fei, Y.L.3
Song, Q.L.4
Squire, J.5
-
134
-
-
16044364516
-
KIP2 is mutated in Beckwith-Wiedemann syndrome
-
KIP2 is mutated in Beckwith-Wiedemann syndrome. Nature Genet. 14, 171-1733 (1996).
-
(1996)
Nature Genet.
, vol.14
, pp. 171-1733
-
-
Hatada, I.1
-
135
-
-
0032618105
-
Genomic imprinting and cancer
-
Tycko, B. Genomic imprinting and cancer. Results Probl. Cell. Differ. 25, 133-169 (1999).
-
(1999)
Results Probl. Cell. Differ.
, vol.25
, pp. 133-169
-
-
Tycko, B.1
-
136
-
-
0034530186
-
Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome
-
Engel, J. R. et al. Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome. J. Med. Genet. 37, 921-926 (2000).
-
(2000)
J. Med. Genet.
, vol.37
, pp. 921-926
-
-
Engel, J.R.1
-
137
-
-
0035283019
-
Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation: Occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS
-
Bliek, J. et al. Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation: occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS. Hum. Mol. Genet. 10, 467-476 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 467-476
-
-
Bliek, J.1
-
138
-
-
18244369516
-
Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1
-
Weksberg, R. et al. Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1. Hum. Mol. Genet. 10, 2989-3000 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2989-3000
-
-
Weksberg, R.1
-
139
-
-
0036182963
-
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects
-
DeBaun, M. R. et al. Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am. J. Hum. Genet. 70, 604-611 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 604-611
-
-
DeBaun, M.R.1
-
140
-
-
0037222510
-
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19
-
DeBaun, M. R., Niemitz, E. L. & Feinberg, A. P. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am. J. Hum. Genet. 72, 156-160 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.72
, pp. 156-160
-
-
DeBaun, M.R.1
Niemitz, E.L.2
Feinberg, A.P.3
-
141
-
-
0037238396
-
Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)
-
Maher, E. R. et al. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J. Med. Genet. 40, 62-64 (2003).
-
(2003)
J. Med. Genet.
, vol.40
, pp. 62-64
-
-
Maher, E.R.1
-
142
-
-
0037436509
-
Loss of IGF2 imprinting: A potential marker of colorectal cancer risk
-
Cui, H. et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299, 6442-6446 (2003).
-
(2003)
Science
, vol.299
, pp. 6442-6446
-
-
Cui, H.1
-
143
-
-
0032578509
-
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
-
Belinsky, S. A. et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc. Natl Acad. Sci. USA 95, 11891-11896 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11891-11896
-
-
Belinsky, S.A.1
-
144
-
-
0038104379
-
Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions
-
Sandovici, I. et al. Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions. Hum. Mol. Genet. 12, 1569-1578 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1569-1578
-
-
Sandovici, I.1
-
145
-
-
0029001154
-
Suppression of intestinal neoplasia by DNA hypomethylation
-
Laird, P. W. et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81, 197-205 (1995).
-
(1995)
Cell
, vol.81
, pp. 197-205
-
-
Laird, P.W.1
-
146
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet, F. et al. Induction of tumors in mice by genomic hypomethylation. Science 300, 489-492 (2003).
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
-
147
-
-
0037312934
-
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
-
Chen, W. Y. et al. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nature Genet. 33, 197-202 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 197-202
-
-
Chen, W.Y.1
-
148
-
-
0025833975
-
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
-
Ziemin-van der Poel, S. et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc. Natl Acad. Sci. USA 88, 10735-10739 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10735-10739
-
-
Ziemin-Van Der Poel, S.1
-
149
-
-
0026454451
-
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
-
Tkachuk, D. C., Kohler, S. & Cleary, M. L. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71, 691-700 (1992).
-
(1992)
Cell
, vol.71
, pp. 691-700
-
-
Tkachuk, D.C.1
Kohler, S.2
Cleary, M.L.3
-
150
-
-
0026496887
-
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
-
Gu, Y. et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71, 701-708 (1992).
-
(1992)
Cell
, vol.71
, pp. 701-708
-
-
Gu, Y.1
-
151
-
-
18744410349
-
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
-
Nakamura, T. et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol. Cell 10, 1119-1128 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 1119-1128
-
-
Nakamura, T.1
-
152
-
-
0026317881
-
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
-
El-Deiry, W. S. et al. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc. Natl Acad. Sci. USA 88, 3470-3474 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 3470-3474
-
-
El-Deiry, W.S.1
-
153
-
-
0029812553
-
Limited upregulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
-
Lee, P. J. et al. Limited upregulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc. Natl Acad. Sci. USA 93, 10366-10370 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10366-10370
-
-
Lee, P.J.1
-
154
-
-
0033566973
-
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
-
De Marzo, A. M. et al. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res. 59, 3855-3860 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3855-3860
-
-
De Marzo, A.M.1
-
155
-
-
0033563083
-
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
-
Eads, C. A. et al. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 59, 2302-2306 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 2302-2306
-
-
Eads, C.A.1
-
156
-
-
0038527642
-
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
-
Di Croce, L. et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295, 1079-1082 (2002).
-
(2002)
Science
, vol.295
, pp. 1079-1082
-
-
Di Croce, L.1
-
157
-
-
18544364773
-
Cancer epigenetics and methylation
-
Esteller, M. et al. Cancer epigenetics and methylation. Science 297, 1807-1808 (2002).
-
(2002)
Science
, vol.297
, pp. 1807-1808
-
-
Esteller, M.1
-
158
-
-
0037086277
-
The SLUG zinc-finger protein represses E-cadherin in breast cancer
-
Hajra, K. M., Chen, D. Y. & Fearon, E. R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62, 1613-1618 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1613-1618
-
-
Hajra, K.M.1
Chen, D.Y.2
Fearon, E.R.3
-
159
-
-
0028060515
-
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
-
Dunaief, J. L. et al. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79, 119-130 (1994).
-
(1994)
Cell
, vol.79
, pp. 119-130
-
-
Dunaief, J.L.1
-
160
-
-
0032549001
-
Rb interacts with histone deacetylase to repress transcription
-
Luo, R. X., Postigo, A. A. & Dean, D. C. Rb interacts with histone deacetylase to repress transcription. Cell 92, 463-473 (1998).
-
(1998)
Cell
, vol.92
, pp. 463-473
-
-
Luo, R.X.1
Postigo, A.A.2
Dean, D.C.3
-
161
-
-
0032484904
-
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
-
Magnaghi-Jaulin, L. et al. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391, 601-605 (1998).
-
(1998)
Nature
, vol.391
, pp. 601-605
-
-
Magnaghi-Jaulin, L.1
-
162
-
-
0034785586
-
Linking the Rb and polycomb pathways
-
Dahiya, A., Wong, S., Gonzalo, S., Gavin, M. & Dean, D. C. Linking the Rb and polycomb pathways. Mol. Cell 18, 557-569 (2001).
-
(2001)
Mol. Cell
, vol.18
, pp. 557-569
-
-
Dahiya, A.1
Wong, S.2
Gonzalo, S.3
Gavin, M.4
Dean, D.C.5
-
163
-
-
0037083752
-
The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity
-
Pradhan, S. & Kim, G. D. The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity. EMBO J. 21, 779-788 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 779-788
-
-
Pradhan, S.1
Kim, G.D.2
-
164
-
-
0033919595
-
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
-
Robertson, K. D. et al. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genet. 25, 338-342 (2000).
-
(2000)
Nature Genet.
, vol.25
, pp. 338-342
-
-
Robertson, K.D.1
-
165
-
-
0035449997
-
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily
-
Steele-Perkins, G. et al. Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev. 15, 2250-2262 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2250-2262
-
-
Steele-Perkins, G.1
-
166
-
-
0021792476
-
Effects of 5-azacytidine on the progressive nature of cell transformation
-
Hsiao, W.-L., Gattoni-Celli, S. & Weinstein, I. B. Effects of 5-azacytidine on the progressive nature of cell transformation. Mol. Cell. Biol. 5, 1800-1803 (1985).
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 1800-1803
-
-
Hsiao, W.-L.1
Gattoni-Celli, S.2
Weinstein, I.B.3
-
167
-
-
0018581647
-
Multiple new phenotypes induced in 10T 1/2 and 3T3 cells treated with 5-azacytidine
-
Taylor, S. M. & Jones, P. A. Multiple new phenotypes induced in 10T 1/2 and 3T3 cells treated with 5-azacytidine. Cell 17, 771-779 (1979).
-
(1979)
Cell
, vol.17
, pp. 771-779
-
-
Taylor, S.M.1
Jones, P.A.2
-
168
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment
-
Daskalakis, M. et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment. Blood 100, 2957-2964 (2002).
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
-
169
-
-
0028151343
-
Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
-
Juttermann, R., Li, E. & Jaenisch, R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl Acad. Sci. USA 91, 11797-11801 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11797-11801
-
-
Juttermann, R.1
Li, E.2
Jaenisch, R.3
-
170
-
-
0037420191
-
Inhibition of DNA methylation and reactivation of silenced genes by zebularine
-
Cheng, J. C. et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J. Natl Cancer Inst. 95, 399-409 (2003).
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 399-409
-
-
Cheng, J.C.1
-
171
-
-
0031014414
-
Reversal of loss of imprinting in tumor cells by 5-aza-2′ -deoxycytidine
-
Barletta, J. M., Rainier, S. & Feinberg, A. P. Reversal of loss of imprinting in tumor cells by 5-aza-2′-deoxycytidine. Cancer Res. 57, 48-50 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 48-50
-
-
Barletta, J.M.1
Rainier, S.2
Feinberg, A.P.3
-
172
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron, E. E., Bachman, K. E., Myohanen, S., Herman, J. G. & Baylin, S. B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genet. 21, 103-107 (1999).
-
(1999)
Nature Genet.
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
173
-
-
0037400558
-
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells
-
Shaker, S., Bernstein, M., Momparler, L. F. & Momparler, R. L. Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2′-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. Leuk. Res. 27, 437-444 (2003).
-
(2003)
Leuk. Res.
, vol.27
, pp. 437-444
-
-
Shaker, S.1
Bernstein, M.2
Momparler, L.F.3
Momparler, R.L.4
-
174
-
-
0642275161
-
Response to comment on "Chromosomal instability and tumors promoted by dna hypomethylation" and "Induction of tumors in mice by genomic hypomethylation"
-
Eden, A., Gaudet, F. & Jaenisch, R. Response to comment on "Chromosomal instability and tumors promoted by dna hypomethylation" and "Induction of tumors in mice by genomic hypomethylation". Science 302, 1153 (2003).
-
(2003)
Science
, vol.302
, pp. 1153
-
-
Eden, A.1
Gaudet, F.2
Jaenisch, R.3
-
175
-
-
0642275161
-
Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation"
-
Yang, A. S., Estecio, M. R., Garcia-Manero, G., Kantarjian, H. M. & Issa, J. P. Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation". Science 302, 1153 (2003).
-
(2003)
Science
, vol.302
, pp. 1153
-
-
Yang, A.S.1
Estecio, M.R.2
Garcia-Manero, G.3
Kantarjian, H.M.4
Issa, J.P.5
-
176
-
-
0019510628
-
Reactivation of an inactive human X chromosome: Evidence for X inactivation by DNA methylation
-
Mohandas, T., Sparkes, R. S. & Shapiro, L. J. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Science 211, 393-396 (1981).
-
(1981)
Science
, vol.211
, pp. 393-396
-
-
Mohandas, T.1
Sparkes, R.S.2
Shapiro, L.J.3
-
177
-
-
1042272175
-
Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: Implications for X-chromosome inactivation
-
Wolf, S. F., Jolly, D. J., Lunnen, K. D., Friedmann, T., & Migeon, B. R. Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc. Natl Acad. Sci. USA 81, 2806-2810 (1984).
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 2806-2810
-
-
Wolf, S.F.1
Jolly, D.J.2
Lunnen, K.D.3
Friedmann, T.4
Migeon, B.R.5
-
178
-
-
0024378078
-
Specific protection of methylated CpGs in mammalian nuclei
-
Antequera, F., Macleod, D. & Bird, A. P. Specific protection of methylated CpGs in mammalian nuclei. Cell 58, 509-517 (1989).
-
(1989)
Cell
, vol.58
, pp. 509-517
-
-
Antequera, F.1
Macleod, D.2
Bird, A.P.3
-
179
-
-
0025360755
-
5-Azacytidine-induced reactivation of the human X chromosome-linked PGK1 gene is associated with a large region of cytosine demethylation in the 5′ CpG island
-
Hansen, R. S. & Gartler, S. M. 5-azacytidine-induced reactivation of the human X chromosome-linked PGK1 gene is associated with a large region of cytosine demethylation in the 5′ CpG island. Proc. Natl Acad. Sci. USA 87, 4174-4178 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 4174-4178
-
-
Hansen, R.S.1
Gartler, S.M.2
-
180
-
-
0027183088
-
The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
-
Jeppesen, P. & Turner, B. M. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell 74, 281-289 (1993).
-
(1993)
Cell
, vol.74
, pp. 281-289
-
-
Jeppesen, P.1
Turner, B.M.2
|