-
1
-
-
0035206081
-
Pharmacology of adenosine receptors in the vasculature
-
Tabrizchi R, Bedi S. Pharmacology of adenosine receptors in the vasculature. Pharmacol Ther 2001;91:133-147.
-
(2001)
Pharmacol Ther
, vol.91
, pp. 133-147
-
-
Tabrizchi, R.1
Bedi, S.2
-
2
-
-
0025326815
-
Cardiovascular purinoceptors
-
Olsson RA, Pearson JD. Cardiovascular purinoceptors. Physiol Rev 1990;70:761-845.
-
(1990)
Physiol Rev
, vol.70
, pp. 761-845
-
-
Olsson, R.A.1
Pearson, J.D.2
-
3
-
-
0033766981
-
Extracellular metabolism of ATP and other nucleotides
-
Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 2000;362:299-309.
-
(2000)
Naunyn Schmiedebergs Arch Pharmacol
, vol.362
, pp. 299-309
-
-
Zimmermann, H.1
-
4
-
-
33646074537
-
Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury
-
Volmer JB, Thompson LF, Blackburn MR. Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J Immunol 2006;176:4449-4458.
-
(2006)
J Immunol
, vol.176
, pp. 4449-4458
-
-
Volmer, J.B.1
Thompson, L.F.2
Blackburn, M.R.3
-
5
-
-
0018121433
-
Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine
-
Arch JR, Newsholme EA. Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine. Biochem J 1978;174:965-977.
-
(1978)
Biochem J
, vol.174
, pp. 965-977
-
-
Arch, J.R.1
Newsholme, E.A.2
-
6
-
-
0035209620
-
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
-
Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001;53:527-552.
-
(2001)
Pharmacol Rev
, vol.53
, pp. 527-552
-
-
Fredholm, B.B.1
Ijzerman, A.P.2
Jacobson, K.A.3
Klotz, K.N.4
Linden, J.5
-
7
-
-
0028641295
-
Adenosine receptor involvement in a delayed phase of myocardial protection 24 hr after ischemic preconditioning
-
Baxter GF, Marber MS, Patel VC, Yellon DM. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hr after ischemic preconditioning. Circulation 1994;90:2993-3000.
-
(1994)
Circulation
, vol.90
, pp. 2993-3000
-
-
Baxter, G.F.1
Marber, M.S.2
Patel, V.C.3
Yellon, D.M.4
-
8
-
-
0032054690
-
Prolonging the delayed phase of myocardial protection: Repetitive adenosine A1 receptor activation maintains rabbit myocardium in a preconditioned state
-
Dana A, Baxter GF, Walker JM, Yellon DM. Prolonging the delayed phase of myocardial protection: Repetitive adenosine A1 receptor activation maintains rabbit myocardium in a preconditioned state. J Am Coll Cardiol 1998;31:1142-1149.
-
(1998)
J Am Coll Cardiol
, vol.31
, pp. 1142-1149
-
-
Dana, A.1
Baxter, G.F.2
Walker, J.M.3
Yellon, D.M.4
-
9
-
-
0031007914
-
1-Adenosine receptor antagonists
-
1-Adenosine receptor antagonists. Expert Opin Ther Pat 1997;7:419-440.
-
(1997)
Expert Opin Ther Pat
, vol.7
, pp. 419-440
-
-
Müller, C.E.1
-
10
-
-
0034750364
-
Recent advances in adenosine receptor antagonist research
-
Hess S. Recent advances in adenosine receptor antagonist research Expert Opin Ther Pat 2001;11:1533-1561.
-
(2001)
Expert Opin Ther Pat
, vol.11
, pp. 1533-1561
-
-
Hess, S.1
-
11
-
-
39549097217
-
-
Stone TW, Collis MG, Williams M, Miller LP, Karasawa A, Hillaire-Buys D. In Pharmacological sciences: Perspectives for research and therapy in the late 1990s. Int Cong Pharmacol 1994; 303-309.
-
Stone TW, Collis MG, Williams M, Miller LP, Karasawa A, Hillaire-Buys D. In Pharmacological sciences: Perspectives for research and therapy in the late 1990s. Int Cong Pharmacol 1994; 303-309.
-
-
-
-
12
-
-
28244477427
-
Impact of selective adenosine A2A receptor agonists on cardiac imaging feeling the lightning, waiting on the thunder
-
Miller DD. Impact of selective adenosine A2A receptor agonists on cardiac imaging feeling the lightning, waiting on the thunder. J Am Coll Cardiol 2005;46:2076-2078.
-
(2005)
J Am Coll Cardiol
, vol.46
, pp. 2076-2078
-
-
Miller, D.D.1
-
13
-
-
0030611334
-
Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease
-
Richardson PJ, Kase H, Jenner PG. Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol Sci 1997;18:338-344.
-
(1997)
Trends Pharmacol Sci
, vol.18
, pp. 338-344
-
-
Richardson, P.J.1
Kase, H.2
Jenner, P.G.3
-
14
-
-
0028788768
-
Current developments of A2A adenosine receptor antagonists
-
Baraldi PG, Cacciari B, Spalluto G, Borioni A, Viziano M, Dionisotti S, Ongini E. Current developments of A2A adenosine receptor antagonists. Curr Med Chem 1995;2:707-722.
-
(1995)
Curr Med Chem
, vol.2
, pp. 707-722
-
-
Baraldi, P.G.1
Cacciari, B.2
Spalluto, G.3
Borioni, A.4
Viziano, M.5
Dionisotti, S.6
Ongini, E.7
-
15
-
-
14544288232
-
Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease
-
Xu K, Bastia E, Schwarzschild M. Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease. Pharmacol Ther 2005;105:267-310.
-
(2005)
Pharmacol Ther
, vol.105
, pp. 267-310
-
-
Xu, K.1
Bastia, E.2
Schwarzschild, M.3
-
16
-
-
26444445618
-
New therapies for the treatment of Parkinson's disease: Adenosine A2A receptor antagonists
-
Pinna A, Wardas J, Simola N, Morelli M. New therapies for the treatment of Parkinson's disease: Adenosine A2A receptor antagonists. Life Sci 2005;77:3259-3267.
-
(2005)
Life Sci
, vol.77
, pp. 3259-3267
-
-
Pinna, A.1
Wardas, J.2
Simola, N.3
Morelli, M.4
-
17
-
-
39549114907
-
Adenosine A2A receptor antagonists for treating restless legs syndrome or related disorders
-
PCT Int. Appl. WO 2004019949;
-
Kase H, Seno N, Mori A, Zhao D. Adenosine A2A receptor antagonists for treating restless legs syndrome or related disorders. PCT Int. Appl. WO 2004019949; 2004.
-
(2004)
-
-
Kase, H.1
Seno, N.2
Mori, A.3
Zhao, D.4
-
18
-
-
0028972108
-
Adenosine A2B receptors evoke interleukine-S secretion in human mast cells: An enprofyllinesensitive mechanism with implication for asthma
-
Feoktistov I, Biaggioni I. Adenosine A2B receptors evoke interleukine-S secretion in human mast cells: An enprofyllinesensitive mechanism with implication for asthma. J Clin Invest 1995;96:1979-1986.
-
(1995)
J Clin Invest
, vol.96
, pp. 1979-1986
-
-
Feoktistov, I.1
Biaggioni, I.2
-
19
-
-
0029896521
-
Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation
-
Boyle DL, Sajjadi FG, Firestein GS. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum 1996;39:923-930.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 923-930
-
-
Boyle, D.L.1
Sajjadi, F.G.2
Firestein, G.S.3
-
20
-
-
0029868307
-
Adenosine inhibits growth of rat aortic smooth muscle cells: Possible role of A2B receptors
-
Dubey RK, Gillaspie DG, Osaka K, Suzuki F, Jackson EK. Adenosine inhibits growth of rat aortic smooth muscle cells: Possible role of A2B receptors. Hypertension 1996;27:786-793.
-
(1996)
Hypertension
, vol.27
, pp. 786-793
-
-
Dubey, R.K.1
Gillaspie, D.G.2
Osaka, K.3
Suzuki, F.4
Jackson, E.K.5
-
21
-
-
0028981112
-
Adenosine A1 and A2B receptors coupled to distinct interactive signaling pathways in intestinal muscle cells
-
Murthy KS, McHenry L, Grider JR, Makhlouf GM. Adenosine A1 and A2B receptors coupled to distinct interactive signaling pathways in intestinal muscle cells. J Pharmacol Exp Ther 1995;274:243-246.
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 243-246
-
-
Murthy, K.S.1
McHenry, L.2
Grider, J.R.3
Makhlouf, G.M.4
-
22
-
-
0028990028
-
Contribution of P1 (A2Bsubtype) and P2-purinoceptors to the control of vascular tone in the rat isolate mesenteric arterial bed
-
Rubino A, Ralevic V, Burnstock G. Contribution of P1 (A2Bsubtype) and P2-purinoceptors to the control of vascular tone in the rat isolate mesenteric arterial bed. Br J Pharmacol 1995;115:648-652.
-
(1995)
Br J Pharmacol
, vol.115
, pp. 648-652
-
-
Rubino, A.1
Ralevic, V.2
Burnstock, G.3
-
23
-
-
0032499689
-
A physiological role of the adenosine A3 receptor: Sustained cardioprotection
-
Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: Sustained cardioprotection. Proc Natl Acad Sci USA 1998;95:6995-6999.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6995-6999
-
-
Liang, B.T.1
Jacobson, K.A.2
-
25
-
-
0031593681
-
Adenosine A3 receptors: Novel ligands and paradoxical effects
-
Jacobson KA. Adenosine A3 receptors: Novel ligands and paradoxical effects. Trends Pharmacol Sci 1998;19:184-191.
-
(1998)
Trends Pharmacol Sci
, vol.19
, pp. 184-191
-
-
Jacobson, K.A.1
-
26
-
-
0027337474
-
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells
-
Ramkumar V, Stiles GL, Beaven MA, Ali H. The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 1993;268:16887-16890.
-
(1993)
J Biol Chem
, vol.268
, pp. 16887-16890
-
-
Ramkumar, V.1
Stiles, G.L.2
Beaven, M.A.3
Ali, H.4
-
27
-
-
0038265864
-
Medicinal chemistry of adenosine A3 receptor ligands
-
Muller CE. Medicinal chemistry of adenosine A3 receptor ligands. Curr Top Med Chem 2003;3:445-462.
-
(2003)
Curr Top Med Chem
, vol.3
, pp. 445-462
-
-
Muller, C.E.1
-
28
-
-
0037391107
-
Membrane protein crystallization
-
Caffrey M. Membrane protein crystallization. J Struct Biol 2003;142:108-132.
-
(2003)
J Struct Biol
, vol.142
, pp. 108-132
-
-
Caffrey, M.1
-
29
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000;289:739-745.
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
30
-
-
30444441037
-
The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma
-
Holgate ST. The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. Br J Pharmacol 2005;145:1009-1015.
-
(2005)
Br J Pharmacol
, vol.145
, pp. 1009-1015
-
-
Holgate, S.T.1
-
31
-
-
28844493549
-
Additional use for adenosine in anaesthesia and surgery
-
Kakazu C, Lippmann M, White RA. Additional use for adenosine in anaesthesia and surgery. Br J Anaesth 2005;95:836-837.
-
(2005)
Br J Anaesth
, vol.95
, pp. 836-837
-
-
Kakazu, C.1
Lippmann, M.2
White, R.A.3
-
32
-
-
27944458044
-
3 adenosine receptor ligands
-
3 adenosine receptor ligands. Expert Opin Ther Pat 2005;15:1507-1519.
-
(2005)
Expert Opin Ther Pat
, vol.15
, pp. 1507-1519
-
-
Baraldi, P.G.1
Fruttarolo, F.2
Tabrizi, M.A.3
Romagnoli, R.4
Preti, D.5
Carrion, M.D.6
Iaconinoto, A.7
Borea, P.A.8
-
34
-
-
11144241002
-
Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example
-
Mora S, Spalluto G, Jacobson KA. Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example. Trends Pharmacol Sci 2005;26:44-51.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 44-51
-
-
Mora, S.1
Spalluto, G.2
Jacobson, K.A.3
-
35
-
-
28444492060
-
A2B adenosine receptor antagonists: Recent developments
-
Cacciari B, Pastorin G, Bolcato C, Spalluto G, Bacillen M, Moro S. A2B adenosine receptor antagonists: Recent developments. Mini Rev Med Chem 2005;5:1053-1060.
-
(2005)
Mini Rev Med Chem
, vol.5
, pp. 1053-1060
-
-
Cacciari, B.1
Pastorin, G.2
Bolcato, C.3
Spalluto, G.4
Bacillen, M.5
Moro, S.6
-
36
-
-
33744810576
-
Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation
-
Polosa R, Volgate ST. Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation. Curr Drug Targets 2006;7:699-706.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 699-706
-
-
Polosa, R.1
Volgate, S.T.2
-
37
-
-
33645034489
-
Adenosine receptors: Promising targets for the development of novel therapeutics and diagnostics for asthma
-
Russo C, Arcidiacono G, Polosa R. Adenosine receptors: Promising targets for the development of novel therapeutics and diagnostics for asthma. Fund Clin Pharmacol 2006;20:9-19.
-
(2006)
Fund Clin Pharmacol
, vol.20
, pp. 9-19
-
-
Russo, C.1
Arcidiacono, G.2
Polosa, R.3
-
38
-
-
33644770260
-
Adenosine receptors as therapeutic targets
-
Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nature Rev Drug Disc 2006;5:247-264.
-
(2006)
Nature Rev Drug Disc
, vol.5
, pp. 247-264
-
-
Jacobson, K.A.1
Gao, Z.G.2
-
39
-
-
33644674438
-
Progress in the pursuit of therapeutic adenosine receptor antagonists
-
Moro S, Gao ZG, Jacobson KA, Spalluto G. Progress in the pursuit of therapeutic adenosine receptor antagonists. Med Res Rev 2006;26:131-159.
-
(2006)
Med Res Rev
, vol.26
, pp. 131-159
-
-
Moro, S.1
Gao, Z.G.2
Jacobson, K.A.3
Spalluto, G.4
-
40
-
-
33947707454
-
GPCRs as therapeutic targets: A view on adenosine receptors structure and functions, and molecular modeling support
-
Dal Ben D, Lambertucci C, Vittori S, Volpini R, Cristalli G. GPCRs as therapeutic targets: A view on adenosine receptors structure and functions, and molecular modeling support. J Iran Chem Soc 2005;2:176-188.
-
(2005)
J Iran Chem Soc
, vol.2
, pp. 176-188
-
-
Dal Ben, D.1
Lambertucci, C.2
Vittori, S.3
Volpini, R.4
Cristalli, G.5
-
41
-
-
33745178449
-
Ligand-based homology modeling as attractive tool to inspect GPCR structural plasticity
-
Moro S, Deflorian F, Bacilieri M, Spalluto G. Ligand-based homology modeling as attractive tool to inspect GPCR structural plasticity. Curr Pharm Des 2006;12:2175-2185.
-
(2006)
Curr Pharm Des
, vol.12
, pp. 2175-2185
-
-
Moro, S.1
Deflorian, F.2
Bacilieri, M.3
Spalluto, G.4
-
42
-
-
0033954256
-
The Protein Data Bank and structural genomics
-
Westbrook J, Feng Z, Chen L, Yang H, Berman HM. The Protein Data Bank and structural genomics. Nucleic Acids Res 2000;28:235-242.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 235-242
-
-
Westbrook, J.1
Feng, Z.2
Chen, L.3
Yang, H.4
Berman, H.M.5
-
43
-
-
0035800032
-
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
-
Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 2001;40:7761-7772.
-
(2001)
Biochemistry
, vol.40
, pp. 7761-7772
-
-
Teller, D.C.1
Okada, T.2
Behnke, C.A.3
Palczewski, K.4
Stenkamp, R.E.5
-
44
-
-
6344248639
-
Structure of bovine rhodopsin in a trigonal crystal form
-
Li J, Edwards PC, Burghammer M, Villa C, Schertler GF. Structure of bovine rhodopsin in a trigonal crystal form. J Mol Biol 2004;343:1409-1438.
-
(2004)
J Mol Biol
, vol.343
, pp. 1409-1438
-
-
Li, J.1
Edwards, P.C.2
Burghammer, M.3
Villa, C.4
Schertler, G.F.5
-
45
-
-
0037197848
-
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography
-
Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci USA 2002;99:5982-5987.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5982-5987
-
-
Okada, T.1
Fujiyoshi, Y.2
Silow, M.3
Navarro, J.4
Landau, E.M.5
Shichida, Y.6
-
46
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure
-
Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure. J Mol Biol 2004;342:571-583.
-
(2004)
J Mol Biol
, vol.342
, pp. 571-583
-
-
Okada, T.1
Sugihara, M.2
Bondar, A.N.3
Elstner, M.4
Entel, P.5
Buss, V.6
-
47
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin
-
Mirzadegan T, Benko G, Filipek S, Palczewski K. Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin. Biochemistry 2003;42:2759-2767.
-
(2003)
Biochemistry
, vol.42
, pp. 2759-2767
-
-
Mirzadegan, T.1
Benko, G.2
Filipek, S.3
Palczewski, K.4
-
48
-
-
36849042268
-
An overview of recent developments in GPCR modelling: Methods and validation
-
Martinelli A, Tuccinardi T. An overview of recent developments in GPCR modelling: Methods and validation. Expert Opin Drug Discov 2006;1:459-476.
-
(2006)
Expert Opin Drug Discov
, vol.1
, pp. 459-476
-
-
Martinelli, A.1
Tuccinardi, T.2
-
49
-
-
39549092706
-
-
http://www.gpcr.org/7tm/
-
-
-
-
50
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors
-
Ballesteros JA, Weinstein HW. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors. Methods Neurosci 1995;25:366-428.
-
(1995)
Methods Neurosci
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.W.2
-
51
-
-
0242362595
-
Modeling the adenosine receptors: Comparison of the binding domains of A2A agonists and antagonists
-
Kim SK, Gao ZG, Van Rompaey P, Gross AS, Chen A, Van Calenbergh S, Jacobson KA. Modeling the adenosine receptors: Comparison of the binding domains of A2A agonists and antagonists. J Med Chem 2003;46:4847-4859.
-
(2003)
J Med Chem
, vol.46
, pp. 4847-4859
-
-
Kim, S.K.1
Gao, Z.G.2
Van Rompaey, P.3
Gross, A.S.4
Chen, A.5
Van Calenbergh, S.6
Jacobson, K.A.7
-
52
-
-
0028050692
-
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors
-
Olah ME, Jacobson KA, Stiles GL. Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors. J Biol Chem 1994;269:24692-24698.
-
(1994)
J Biol Chem
, vol.269
, pp. 24692-24698
-
-
Olah, M.E.1
Jacobson, K.A.2
Stiles, G.L.3
-
53
-
-
0033524916
-
Identification of the adenine binding site of the human A1 adenosine receptor
-
Rivkees SA, Barbhaiya H, IJzerman AP. Identification of the adenine binding site of the human A1 adenosine receptor. J Biol Chem 1999;274:3617-3621.
-
(1999)
J Biol Chem
, vol.274
, pp. 3617-3621
-
-
Rivkees, S.A.1
Barbhaiya, H.2
IJzerman, A.P.3
-
54
-
-
0030460366
-
Site-directed mutagenesis of the human A1 adenosine receptor: Influences of acidic and hydroxy residues in the first four transmembrane domains on ligand binding
-
Barbhaiya H, McClain R, Ijzerman A, Rivkees SA. Site-directed mutagenesis of the human A1 adenosine receptor: Influences of acidic and hydroxy residues in the first four transmembrane domains on ligand binding. Mol Pharmacol 1996;50:1635-1642.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 1635-1642
-
-
Barbhaiya, H.1
McClain, R.2
Ijzerman, A.3
Rivkees, S.A.4
-
55
-
-
0034578519
-
-
Scholl DJ, Wells JN. Serine and alanine mutagenesis of the nine native cysteine residues of the human A1 adenosine receptor. Biochem Pharmacol 2000;60:1647-1654.
-
Scholl DJ, Wells JN. Serine and alanine mutagenesis of the nine native cysteine residues of the human A1 adenosine receptor. Biochem Pharmacol 2000;60:1647-1654.
-
-
-
-
56
-
-
32144447111
-
Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction
-
Xie KQ, Cao Y, Zhu XZ. Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction. Biochem Pharmacol 2006;71:865-871.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 865-871
-
-
Xie, K.Q.1
Cao, Y.2
Zhu, X.Z.3
-
57
-
-
0026707322
-
Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis
-
Olah ME, Ren H, Ostrowski J, Jacobson KA, Stiles GL. Cloning, expression, and characterization of the unique bovine A1 adenosine receptor. Studies on the ligand binding site by site-directed mutagenesis. J Biol Chem 1992;267:10764-10770.
-
(1992)
J Biol Chem
, vol.267
, pp. 10764-10770
-
-
Olah, M.E.1
Ren, H.2
Ostrowski, J.3
Jacobson, K.A.4
Stiles, G.L.5
-
58
-
-
0028171408
-
A1 adenosine receptors. Two amino acids are responsible for species differences in ligand recognition
-
Tucker AL, Robeva AS, Taylor HE, Holeton D, Bockner M, Lynch KR, Linden J. A1 adenosine receptors. Two amino acids are responsible for species differences in ligand recognition. J Biol Chem 1994;269:27900-27906.
-
(1994)
J Biol Chem
, vol.269
, pp. 27900-27906
-
-
Tucker, A.L.1
Robeva, A.S.2
Taylor, H.E.3
Holeton, D.4
Bockner, M.5
Lynch, K.R.6
Linden, J.7
-
59
-
-
0028024910
-
A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding
-
Townsend-Nicholson A, Schofield PR. A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding. J Biol Chem 1994;269:2373-2376.
-
(1994)
J Biol Chem
, vol.269
, pp. 2373-2376
-
-
Townsend-Nicholson, A.1
Schofield, P.R.2
-
60
-
-
0035037874
-
Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A1 adenosine receptor
-
Dawson ES, Wells JN. Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A1 adenosine receptor. Mol Pharmacol 2001;59:1187-1195.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1187-1195
-
-
Dawson, E.S.1
Wells, J.N.2
-
61
-
-
0034284625
-
Site-directed mutagenesis studies of human A2A adenosine receptors: Involvement of Glu13 and His278 in ligand binding and sodium modulation
-
Gao ZG, Jiang Q, Jacobson KA, Ijzerman AP. Site-directed mutagenesis studies of human A2A adenosine receptors: Involvement of Glu13 and His278 in ligand binding and sodium modulation. Biochem Pharmacol 2000;60:661-668.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 661-668
-
-
Gao, Z.G.1
Jiang, Q.2
Jacobson, K.A.3
Ijzerman, A.P.4
-
62
-
-
0030605986
-
-
IJzerman AP Von Frijtag Drabbe Kunzel JK, Kim J, Jiang Q, Jacobson KA. Site-directed mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition. Eur J Pharmacol 1996;310:269-272.
-
IJzerman AP Von Frijtag Drabbe Kunzel JK, Kim J, Jiang Q, Jacobson KA. Site-directed mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition. Eur J Pharmacol 1996;310:269-272.
-
-
-
-
63
-
-
0030796011
-
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors
-
Jiang Q, Lee BX, Glashofer M, van Rhee AM, Jacobson KA. Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors. J Med Chem 1997;40:2588-2595.
-
(1997)
J Med Chem
, vol.40
, pp. 2588-2595
-
-
Jiang, Q.1
Lee, B.X.2
Glashofer, M.3
van Rhee, A.M.4
Jacobson, K.A.5
-
64
-
-
0029810167
-
Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition
-
Jiang Q, Van Rhee AM, Kim J, Yehle S, Wess J, Jacobson KA. Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition. Mol Pharmacol 1996;50:512-521.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 512-521
-
-
Jiang, Q.1
Van Rhee, A.M.2
Kim, J.3
Yehle, S.4
Wess, J.5
Jacobson, K.A.6
-
65
-
-
0029960789
-
Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition
-
Kim J, Jiang Q, Glashofer M, Yehle S, Wess J, Jacobson KA. Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition. Mol Pharmacol 1996;49:683-691.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 683-691
-
-
Kim, J.1
Jiang, Q.2
Glashofer, M.3
Yehle, S.4
Wess, J.5
Jacobson, K.A.6
-
66
-
-
0029043501
-
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor
-
Kim J, Wess J, van Rhee AM, Schoneberg T, Jacobson KA. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. J Biol Chem 1995;270:13987-13997.
-
(1995)
J Biol Chem
, vol.270
, pp. 13987-13997
-
-
Kim, J.1
Wess, J.2
van Rhee, A.M.3
Schoneberg, T.4
Jacobson, K.A.5
-
67
-
-
0033674631
-
Why are A2B receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A2B receptor for 2-(1-hexynyl)adenosine
-
Beukers MW, den Dulk H, van Tilburg EW, Brouwer J, Ijzerman AP. Why are A2B receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A2B receptor for 2-(1-hexynyl)adenosine. Mol Pharmacol 2000;58:1349-1356.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 1349-1356
-
-
Beukers, M.W.1
den Dulk, H.2
van Tilburg, E.W.3
Brouwer, J.4
Ijzerman, A.P.5
-
68
-
-
1342329641
-
Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations
-
Beukers MW, van Oppenraaij J, van der Hoorn PP, Blad CC, den Dulk H, Brouwer J, IJzerman AP. Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations. Mol Pharmacol 2004;65:702-710.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 702-710
-
-
Beukers, M.W.1
van Oppenraaij, J.2
van der Hoorn, P.P.3
Blad, C.C.4
den Dulk, H.5
Brouwer, J.6
IJzerman, A.P.7
-
69
-
-
0027202159
-
Molecular-cloning and functional expression of sheep A3 adenosine receptor with widespread tissue distribution
-
Linden J, Taylor HE, Robeva AS, Tucker AL, Stehle JH, Rivkees SA, Fink JS, Reppert SM. Molecular-cloning and functional expression of sheep A3 adenosine receptor with widespread tissue distribution. Mol Pharmacol 1993;44:524-532.
-
(1993)
Mol Pharmacol
, vol.44
, pp. 524-532
-
-
Linden, J.1
Taylor, H.E.2
Robeva, A.S.3
Tucker, A.L.4
Stehle, J.H.5
Rivkees, S.A.6
Fink, J.S.7
Reppert, S.M.8
-
70
-
-
0028169223
-
Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions
-
Linden J. Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci 1994;15:298-306.
-
(1994)
Trends Pharmacol Sci
, vol.15
, pp. 298-306
-
-
Linden, J.1
-
71
-
-
0038407477
-
Identification of essential residues involved in the allosteric modulation of the human A3 adenosine receptor
-
Gao ZG, Kim SK, Gross AS, Chen A, Blaustein JB, Jacobson KA. Identification of essential residues involved in the allosteric modulation of the human A3 adenosine receptor. Mol Pharmacol 2003;63:1021-1031.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 1021-1031
-
-
Gao, Z.G.1
Kim, S.K.2
Gross, A.S.3
Chen, A.4
Blaustein, J.B.5
Jacobson, K.A.6
-
72
-
-
0034817072
-
Constitutive activation of A3 adenosine receptors by site-directed mutagenesis
-
Chen A, Gao ZG, Barak D, Liang BT, Jacobson KA. Constitutive activation of A3 adenosine receptors by site-directed mutagenesis. Biochem Biophys Res Commun 2001;284:596-601.
-
(2001)
Biochem Biophys Res Commun
, vol.284
, pp. 596-601
-
-
Chen, A.1
Gao, Z.G.2
Barak, D.3
Liang, B.T.4
Jacobson, K.A.5
-
73
-
-
0037179640
-
Structural determinants of A3 adenosine receptor activation: Nucleoside ligands at the agonist/antagonist boundary
-
Gao ZG, Kim SK, Biadatti T, Chen W, Lee K, Barak D, Kim SG, Johnson CR, Jacobson KA. Structural determinants of A3 adenosine receptor activation: Nucleoside ligands at the agonist/antagonist boundary. J Med Chem 2002;45:4471-4484.
-
(2002)
J Med Chem
, vol.45
, pp. 4471-4484
-
-
Gao, Z.G.1
Kim, S.K.2
Biadatti, T.3
Chen, W.4
Lee, K.5
Barak, D.6
Kim, S.G.7
Johnson, C.R.8
Jacobson, K.A.9
-
74
-
-
0037166356
-
Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor
-
Gao ZG, Chen A, Barak D, Kim SK, Muller CE, Jacobson KA. Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor. J Biol Chem 2002;277:19056-19063.
-
(2002)
J Biol Chem
, vol.277
, pp. 19056-19063
-
-
Gao, Z.G.1
Chen, A.2
Barak, D.3
Kim, S.K.4
Muller, C.E.5
Jacobson, K.A.6
-
75
-
-
29244464712
-
Nucleoside modification and concerted mutagenesis of the human A3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop
-
Duong HT, Gao ZG, Jacobson KA. Nucleoside modification and concerted mutagenesis of the human A3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop. Nucleosides Nucleotides Nucleic Acids 2005;24:1507-1517.
-
(2005)
Nucleosides Nucleotides Nucleic Acids
, vol.24
, pp. 1507-1517
-
-
Duong, H.T.1
Gao, Z.G.2
Jacobson, K.A.3
-
76
-
-
0035935737
-
Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A3 receptor with selectively enhanced affinity for amine-modified nucleosides
-
Jacobson KA, Gao ZG, Chen A, Barak D, Kim SA, Lee K, Link A, Rompaey PV, van Calenbergh S, Liang BT. Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A3 receptor with selectively enhanced affinity for amine-modified nucleosides. J Med Chem 2001;44:4125-4136.
-
(2001)
J Med Chem
, vol.44
, pp. 4125-4136
-
-
Jacobson, K.A.1
Gao, Z.G.2
Chen, A.3
Barak, D.4
Kim, S.A.5
Lee, K.6
Link, A.7
Rompaey, P.V.8
van Calenbergh, S.9
Liang, B.T.10
-
77
-
-
0026451988
-
Molecular modeling of adenosine receptors. I. The ligand binding site on the A1 receptor
-
IJzerman AP, Van Galen PJ, Jacobson KA. Molecular modeling of adenosine receptors. I. The ligand binding site on the A1 receptor. Drug Des Discov 1992;9:49-67.
-
(1992)
Drug Des Discov
, vol.9
, pp. 49-67
-
-
IJzerman, A.P.1
Van Galen, P.J.2
Jacobson, K.A.3
-
78
-
-
0028773638
-
Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor
-
IJzerman AP, van der Wenden EM, van Galen PJ, Jacobson KA. Molecular modeling of adenosine receptors. The ligand binding site on the rat adenosine A2A receptor. Eur J Pharmacol 1994;268:95-104.
-
(1994)
Eur J Pharmacol
, vol.268
, pp. 95-104
-
-
IJzerman, A.P.1
van der Wenden, E.M.2
van Galen, P.J.3
Jacobson, K.A.4
-
79
-
-
0028337831
-
A binding site model and structure-activity relationships for the rat A3 adenosine receptor
-
van Galen PJ, van Bergen AH, Gallo-Rodriguez C, Melman N, Olah ME, IJzerman AP, Stiles GL, Jacobson KA. A binding site model and structure-activity relationships for the rat A3 adenosine receptor. Mol Pharmacol 1994;45:1101-1111.
-
(1994)
Mol Pharmacol
, vol.45
, pp. 1101-1111
-
-
van Galen, P.J.1
van Bergen, A.H.2
Gallo-Rodriguez, C.3
Melman, N.4
Olah, M.E.5
IJzerman, A.P.6
Stiles, G.L.7
Jacobson, K.A.8
-
81
-
-
0028962270
-
Low resolution structure of bovine rhodopsin determined by electron cryomicroscopy
-
Unger VM, Schertler GF. Low resolution structure of bovine rhodopsin determined by electron cryomicroscopy. Biophys J 1995;68:1776-1786.
-
(1995)
Biophys J
, vol.68
, pp. 1776-1786
-
-
Unger, V.M.1
Schertler, G.F.2
-
83
-
-
0020475449
-
A simple method for displaying the hydropathic character of a protein
-
Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein. J Mol Biol 1982;157:105-132.
-
(1982)
J Mol Biol
, vol.157
, pp. 105-132
-
-
Kyte, J.1
Doolittle, R.F.2
-
84
-
-
0035818920
-
-
Da Settimo F, Primofiore G, Da Settimo A, La Motta C, Taliani S, Simorini F, Novellino E, Greco G, Lavecchia A, Boldrini E. [1,2,4]Triazino[4,3-a] benzimidazole acetic acid derivatives: A new class of selective aldose reductase inhibitors. J Med Chem 2001;44:4359-4369.
-
Da Settimo F, Primofiore G, Da Settimo A, La Motta C, Taliani S, Simorini F, Novellino E, Greco G, Lavecchia A, Boldrini E. [1,2,4]Triazino[4,3-a] benzimidazole acetic acid derivatives: A new class of selective aldose reductase inhibitors. J Med Chem 2001;44:4359-4369.
-
-
-
-
85
-
-
0032559887
-
Human P2Y1 receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites
-
Moro S, Guo D, Camaioni E, Boyer JL, Harden TK, Jacobson KA. Human P2Y1 receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem 1998;41:1456-1466.
-
(1998)
J Med Chem
, vol.41
, pp. 1456-1466
-
-
Moro, S.1
Guo, D.2
Camaioni, E.3
Boyer, J.L.4
Harden, T.K.5
Jacobson, K.A.6
-
86
-
-
0032199176
-
Molecular modeling studies of human A3 adenosine antagonists: Structural homology and receptor docking
-
Moro S, Li AH, Jacobson KA. Molecular modeling studies of human A3 adenosine antagonists: Structural homology and receptor docking. J Chem Inf Comput Sci 1998;38:1239-1248.
-
(1998)
J Chem Inf Comput Sci
, vol.38
, pp. 1239-1248
-
-
Moro, S.1
Li, A.H.2
Jacobson, K.A.3
-
87
-
-
0031824990
-
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes
-
Kim YC, de Zwart M, Chang L, Moro S, von Frijtag Drabbe Kunzel JK, Melman N, IJzerman AP, Jacobson KA. Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J Med Chem 1998;41:2835-2845.
-
(1998)
J Med Chem
, vol.41
, pp. 2835-2845
-
-
Kim, Y.C.1
de Zwart, M.2
Chang, L.3
Moro, S.4
von Frijtag5
Drabbe Kunzel, J.K.6
Melman, N.7
IJzerman, A.P.8
Jacobson, K.A.9
-
88
-
-
0033602131
-
Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists
-
Li AH, Moro S, Forsyth N, Melman N, Ji XD, Jacobson KA. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem 1999;42:706-721.
-
(1999)
J Med Chem
, vol.42
, pp. 706-721
-
-
Li, A.H.1
Moro, S.2
Forsyth, N.3
Melman, N.4
Ji, X.D.5
Jacobson, K.A.6
-
89
-
-
0033549885
-
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl-1,4-dihydropyridines as selective A3 adenosine receptor antagonists
-
Jiang J, Li AH, Jang SY, Chang L, Melman N, Moro S, Ji X, Lobkovsky EB, Clardy JC, Jacobson KA. Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl-1,4-dihydropyridines as selective A3 adenosine receptor antagonists. J Med Chem 1999;42:3055-3065.
-
(1999)
J Med Chem
, vol.42
, pp. 3055-3065
-
-
Jiang, J.1
Li, A.H.2
Jang, S.Y.3
Chang, L.4
Melman, N.5
Moro, S.6
Ji, X.7
Lobkovsky, E.B.8
Clardy, J.C.9
Jacobson, K.A.10
-
90
-
-
0029135744
-
Pseudoreceptor modeling: The construction of three-dimensional receptor surrogates
-
Vedani A, Zbinden P, Snyder JP, Greenidge PA. Pseudoreceptor modeling: The construction of three-dimensional receptor surrogates. J Am Chem Soc 1995;117:4987-4994.
-
(1995)
J Am Chem Soc
, vol.117
, pp. 4987-4994
-
-
Vedani, A.1
Zbinden, P.2
Snyder, J.P.3
Greenidge, P.A.4
-
91
-
-
0029618445
-
Molecular simulation of 8-styrylxanthines
-
Mager PP, Reinhardt R, Richter M, Walther H, Rockel B. Molecular simulation of 8-styrylxanthines. Drug Des Discov 1995;13:89-107.
-
(1995)
Drug Des Discov
, vol.13
, pp. 89-107
-
-
Mager, P.P.1
Reinhardt, R.2
Richter, M.3
Walther, H.4
Rockel, B.5
-
93
-
-
0037168034
-
Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonists
-
Bondavalli F, Botta M, Bruno O, Ciacci A, Corelli F, Fossa P, Lucacchini A, Manetti F, Martini C, Menozzi G, Mosti L, Ranise A, Schenone S, Tafi A, Trincavelli ML. Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonists. J Med Chem 2002;45:4875-4887.
-
(2002)
J Med Chem
, vol.45
, pp. 4875-4887
-
-
Bondavalli, F.1
Botta, M.2
Bruno, O.3
Ciacci, A.4
Corelli, F.5
Fossa, P.6
Lucacchini, A.7
Manetti, F.8
Martini, C.9
Menozzi, G.10
Mosti, L.11
Ranise, A.12
Schenone, S.13
Tafi, A.14
Trincavelli, M.L.15
-
94
-
-
27444442315
-
Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists
-
Ivanov AA, Baskin II, Palyulin VA, Piccagli L, Baraldi PG, Zefirov NS. Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists. J Med Chem 2005;48:6813-6820.
-
(2005)
J Med Chem
, vol.48
, pp. 6813-6820
-
-
Ivanov, A.A.1
Baskin, I.I.2
Palyulin, V.A.3
Piccagli, L.4
Baraldi, P.G.5
Zefirov, N.S.6
-
95
-
-
33745853830
-
Pharmacophore based receptor modeling: The case of adenosine A3 receptor antagonists. An approach to the optimization of protein models
-
Tafi A, Bernardini C, Botta M, Corelli F, Andreini M, Martinelli A, Ortore G, Baraldi PG, Fruttarolo F, Borea PA, Tuccinardi T. Pharmacophore based receptor modeling: The case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem 2006;49:4085-4097.
-
(2006)
J Med Chem
, vol.49
, pp. 4085-4097
-
-
Tafi, A.1
Bernardini, C.2
Botta, M.3
Corelli, F.4
Andreini, M.5
Martinelli, A.6
Ortore, G.7
Baraldi, P.G.8
Fruttarolo, F.9
Borea, P.A.10
Tuccinardi, T.11
-
96
-
-
39549093434
-
-
Cruciani G, Goodford P. Copyright Molecular Discovery Ltd. 2001-2003GREATER graphical interface for GRID version, 1.1.7 GRIB, UPF/IMIM, Barcelona, Spain.
-
Cruciani G, Goodford P. Copyright Molecular Discovery Ltd. 2001-2003GREATER graphical interface for GRID version, 1.1.7 GRIB, UPF/IMIM, Barcelona, Spain.
-
-
-
-
97
-
-
39549102727
-
-
Catalyst 4.6, Accelrys, Inc.: 9685 Scranton Road, San Diego, CA 92121, USA.
-
Catalyst 4.6, Accelrys, Inc.: 9685 Scranton Road, San Diego, CA 92121, USA.
-
-
-
-
98
-
-
39549117678
-
-
Connolly M, Gschwend DA, Good AC, Oshiro C, Kuntz ID. DOCK 3.5, San Francisco, CA. Department of Pharmaceutical Chemistry, University of California, 1995.
-
Connolly M, Gschwend DA, Good AC, Oshiro C, Kuntz ID. DOCK 3.5, San Francisco, CA. Department of Pharmaceutical Chemistry, University of California, 1995.
-
-
-
-
99
-
-
1842856369
-
Molecular modeling the human A1 adenosine receptor and study of the mechanisms of its selective ligand binding
-
Ivanov AA, Baskin II, Palyulin VA, Zefirov NS. Molecular modeling the human A1 adenosine receptor and study of the mechanisms of its selective ligand binding. Dokl Biochem Biophys 2002;386:271-274.
-
(2002)
Dokl Biochem Biophys
, vol.386
, pp. 271-274
-
-
Ivanov, A.A.1
Baskin, I.I.2
Palyulin, V.A.3
Zefirov, N.S.4
-
100
-
-
39549106139
-
7.2. Tripos, Inc
-
6, South Hanley Road, St. Louis, MO 63144
-
Sybyl 6.7.2. Tripos, Inc. 1699 South Hanley Road, St. Louis, MO 63144.
-
(1699)
-
-
Sybyl1
-
101
-
-
0041695555
-
Exploring the molecular basis of selectivity in A1 adenosine receptors agonists: A case study
-
Giordanetto F, Fossa P, Menozzi G, Schenone S, Bondavalli F, Ranise A, Mosti L. Exploring the molecular basis of selectivity in A1 adenosine receptors agonists: A case study. J Comput Aided Mol Des 2003;17:39-51.
-
(2003)
J Comput Aided Mol Des
, vol.17
, pp. 39-51
-
-
Giordanetto, F.1
Fossa, P.2
Menozzi, G.3
Schenone, S.4
Bondavalli, F.5
Ranise, A.6
Mosti, L.7
-
102
-
-
0031181346
-
-
McMartin C, Bohacek R. QXP: Powerful, rapid computer algorithms for structure-based drug design. J Comput Aided Mol Des 1997;11:333-344.
-
McMartin C, Bohacek R. QXP: Powerful, rapid computer algorithms for structure-based drug design. J Comput Aided Mol Des 1997;11:333-344.
-
-
-
-
103
-
-
2542514734
-
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives
-
Ferrarini PL, Betti L, Cavallini T, Giannaccini G, Lucacchini A, Manera C, Martinelli A, Ortore G, Saccomanni G, Tuccinardi T. Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem 2004;47:3019-3031.
-
(2004)
J Med Chem
, vol.47
, pp. 3019-3031
-
-
Ferrarini, P.L.1
Betti, L.2
Cavallini, T.3
Giannaccini, G.4
Lucacchini, A.5
Manera, C.6
Martinelli, A.7
Ortore, G.8
Saccomanni, G.9
Tuccinardi, T.10
-
104
-
-
1842729487
-
Novel amino acid derived natural products from the ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative
-
Kehraus S, Gorzalka S, Hallmen C, Iqbal J, Muller CE, Wright AD, Wiese M, Konig GM. Novel amino acid derived natural products from the ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative. J Med Chem 2004;47:2243-2255.
-
(2004)
J Med Chem
, vol.47
, pp. 2243-2255
-
-
Kehraus, S.1
Gorzalka, S.2
Hallmen, C.3
Iqbal, J.4
Muller, C.E.5
Wright, A.D.6
Wiese, M.7
Konig, G.M.8
-
105
-
-
39549118243
-
-
GOLD (Genetic Optimisation for Ligand Docking); Cambridge Crystallographic Data Centre: Cambridge, U.K., 2003.
-
GOLD (Genetic Optimisation for Ligand Docking); Cambridge Crystallographic Data Centre: Cambridge, U.K., 2003.
-
-
-
-
106
-
-
1542316348
-
Novel approaches for modeling of the A1 adenosine receptor and its agonist binding site
-
Gutierrez-de-Teran H, Centeno NB, Pastor M, Sanz F. Novel approaches for modeling of the A1 adenosine receptor and its agonist binding site. Proteins 2004;54:705-715.
-
(2004)
Proteins
, vol.54
, pp. 705-715
-
-
Gutierrez-de-Teran, H.1
Centeno, N.B.2
Pastor, M.3
Sanz, F.4
-
107
-
-
11644261806
-
Automated docking using a lamarckian genetic algorithm and empirical binding free energy function
-
Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ. Automated docking using a lamarckian genetic algorithm and empirical binding free energy function. J Comp Chem 1998;19:1639-1662.
-
(1998)
J Comp Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
Huey, R.4
Hart, W.E.5
Belew, R.K.6
Olson, A.J.7
-
108
-
-
20544464858
-
2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies
-
Biagi G, Bianucci AM, Coi A, Costa B, Fabbrini L, Giorgi I, Livi O, Micco I, Pacchini F, Santini E, Leonardi M, Nofal FA, Salerni OL, Scartoni V. 2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies. Bioorg Med Chem 2005;13:4679-4693.
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 4679-4693
-
-
Biagi, G.1
Bianucci, A.M.2
Coi, A.3
Costa, B.4
Fabbrini, L.5
Giorgi, I.6
Livi, O.7
Micco, I.8
Pacchini, F.9
Santini, E.10
Leonardi, M.11
Nofal, F.A.12
Salerni, O.L.13
Scartoni, V.14
-
109
-
-
20144369886
-
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists
-
Cappellacci L, Franchetti P, Pasqualini M, Petrelli R, Vita P, Lavecchia A, Novellino E, Costa B, Martini C, Klotz KN, Grifantini M. Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J Med Chem 2005;48:1550-1562.
-
(2005)
J Med Chem
, vol.48
, pp. 1550-1562
-
-
Cappellacci, L.1
Franchetti, P.2
Pasqualini, M.3
Petrelli, R.4
Vita, P.5
Lavecchia, A.6
Novellino, E.7
Costa, B.8
Martini, C.9
Klotz, K.N.10
Grifantini, M.11
-
110
-
-
33646011262
-
Adenosine receptor modelling. A1/A2a selectivity
-
Tuccinardi T, Ortore G, Manera C, Saccomanni G, Martinelli A. Adenosine receptor modelling. A1/A2a selectivity. Eur J Med Chem 2006;41:321-329.
-
(2006)
Eur J Med Chem
, vol.41
, pp. 321-329
-
-
Tuccinardi, T.1
Ortore, G.2
Manera, C.3
Saccomanni, G.4
Martinelli, A.5
-
112
-
-
0141457802
-
-
Pastorin G, Da Ros T, Spalluto G, Deflorian F, Moro S, Cacciari B, Baraldi Gessi S, Varani K, Borea PA. Pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A3 and A2B adenosine receptor subtypes: A molecular modeling investigation. J Med Chem 2003;46:4287-4296.
-
Pastorin G, Da Ros T, Spalluto G, Deflorian F, Moro S, Cacciari B, Baraldi PG, Gessi S, Varani K, Borea PA. Pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A3 and A2B adenosine receptor subtypes: A molecular modeling investigation. J Med Chem 2003;46:4287-4296.
-
-
-
-
113
-
-
39549102081
-
-
Molecular Operating Environment (MOE 2002.03): Chemical Computing Group, Inc., 1255 University Street, Suite 1600, Montreal, Quebec H3B 3X3, Canada.
-
Molecular Operating Environment (MOE 2002.03): Chemical Computing Group, Inc., 1255 University Street, Suite 1600, Montreal, Quebec H3B 3X3, Canada.
-
-
-
-
114
-
-
0037075142
-
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidine derivatives as human A3 adenosine receptor antagonists
-
Baraldi PG, Cacciari B, Moro S, Spalluto G, Pastorin G, Da Ros T, Klotz KN, Varani K, Gessi S, Borea PA. Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidine derivatives as human A3 adenosine receptor antagonists. J Med Chem 2002;45:770-780.
-
(2002)
J Med Chem
, vol.45
, pp. 770-780
-
-
Baraldi, P.G.1
Cacciari, B.2
Moro, S.3
Spalluto, G.4
Pastorin, G.5
Da Ros, T.6
Klotz, K.N.7
Varani, K.8
Gessi, S.9
Borea, P.A.10
-
115
-
-
0037212478
-
2- and 8-Alkynyladenosines: Conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior
-
Costanzi S, Lambertucci C, Vittori S, Volpini R, Cristalli G. 2- and 8-Alkynyladenosines: Conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior. J Mol Graph Model 2003;21:253-262.
-
(2003)
J Mol Graph Model
, vol.21
, pp. 253-262
-
-
Costanzi, S.1
Lambertucci, C.2
Vittori, S.3
Volpini, R.4
Cristalli, G.5
-
116
-
-
3042689599
-
1,2,4-Triazolo[4,3-a] quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: Synthesis, pharmacological, and ligand-receptor modeling studies
-
Colotta V, Catarzi D, Varano F, Calabri FR, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Deflorian F, Moro S. 1,2,4-Triazolo[4,3-a] quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: Synthesis, pharmacological, and ligand-receptor modeling studies. J Med Chem 2004;47:3580-3590.
-
(2004)
J Med Chem
, vol.47
, pp. 3580-3590
-
-
Colotta, V.1
Catarzi, D.2
Varano, F.3
Calabri, F.R.4
Lenzi, O.5
Filacchioni, G.6
Martini, C.7
Trincavelli, L.8
Deflorian, F.9
Moro, S.10
-
117
-
-
19944429549
-
-
Catarzi D, Colotta V, Varano F, Calabri FR, Lenzi O, Filacchioni G, Trincavelli L, Martini C, Tralli A, Montopoli C, Moro S. 2-Aryl-8-chloro-1,2,4- triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists. Bioorg Med Chem 2005;13:705-715.
-
Catarzi D, Colotta V, Varano F, Calabri FR, Lenzi O, Filacchioni G, Trincavelli L, Martini C, Tralli A, Montopoli C, Moro S. 2-Aryl-8-chloro-1,2,4- triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists. Bioorg Med Chem 2005;13:705-715.
-
-
-
-
118
-
-
19944429228
-
-
Moro S, Braiuca P, Deflorian F, Ferrari C, Pastorin G, Cacciari B, Baraldi Varani K, Borea PA, Spalluto G. Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: Pyrazolo[4,3-e]1,2,4- triazolo[1,5-c]pyrimidine derivatives as a key study. J Med Chem 2005;48:152-162.
-
Moro S, Braiuca P, Deflorian F, Ferrari C, Pastorin G, Cacciari B, Baraldi PG, Varani K, Borea PA, Spalluto G. Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: Pyrazolo[4,3-e]1,2,4- triazolo[1,5-c]pyrimidine derivatives as a key study. J Med Chem 2005;48:152-162.
-
-
-
-
119
-
-
29144509490
-
1,2,4-Triazolo-[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: Synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl-and 2-carboxy-substituted derivatives
-
Catarzi D, Colotta V, Varano F, Lenzi O, Filacchioni G, Trincavelli L, Martini C, Montolpoli C, Moro S. 1,2,4-Triazolo-[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: Synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl-and 2-carboxy-substituted derivatives. J Med Chem 2005;48:7932-7945.
-
(2005)
J Med Chem
, vol.48
, pp. 7932-7945
-
-
Catarzi, D.1
Colotta, V.2
Varano, F.3
Lenzi, O.4
Filacchioni, G.5
Trincavelli, L.6
Martini, C.7
Montolpoli, C.8
Moro, S.9
-
120
-
-
33750439761
-
Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor
-
Kim SK, Gao ZG, Jeong LS, Jacobson KA. Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor. J Mol Graph Mod 2006;25:562-577.
-
(2006)
J Mol Graph Mod
, vol.25
, pp. 562-577
-
-
Kim, S.K.1
Gao, Z.G.2
Jeong, L.S.3
Jacobson, K.A.4
-
121
-
-
33745667503
-
4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies
-
Lenzi O, Colotta V, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Varani K, Marighetti F, Morizzo E, Moro S. 4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. J Med Chem 2006;49:3916-3925.
-
(2006)
J Med Chem
, vol.49
, pp. 3916-3925
-
-
Lenzi, O.1
Colotta, V.2
Catarzi, D.3
Varano, F.4
Filacchioni, G.5
Martini, C.6
Trincavelli, L.7
Ciampi, O.8
Varani, K.9
Marighetti, F.10
Morizzo, E.11
Moro, S.12
-
122
-
-
33644858876
-
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5- c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations
-
Pastorin G, De Ros T, Bolcato C, Montopoli C, Moro S, Cacciari B, Baraldi PG, Varani K, Borea PA, Spalluto G. Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5- c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations. J Med Chem 2006;49:1720-1729.
-
(2006)
J Med Chem
, vol.49
, pp. 1720-1729
-
-
Pastorin, G.1
De Ros, T.2
Bolcato, C.3
Montopoli, C.4
Moro, S.5
Cacciari, B.6
Baraldi, P.G.7
Varani, K.8
Borea, P.A.9
Spalluto, G.10
-
123
-
-
1942532331
-
Heavier-than-air flying machines are impossible
-
Oliveira L, Hulsen T, Lutje Hulsik D, Paiva AC, Vriend G. Heavier-than-air flying machines are impossible. FEBS Lett 2004;564:269-273.
-
(2004)
FEBS Lett
, vol.564
, pp. 269-273
-
-
Oliveira, L.1
Hulsen, T.2
Lutje Hulsik, D.3
Paiva, A.C.4
Vriend, G.5
-
124
-
-
0033810049
-
Modeling of loops in protein structures
-
Fiser A, Do RK, Sali A. Modeling of loops in protein structures. Protein Sci 2000;9:1753-1773.
-
(2000)
Protein Sci
, vol.9
, pp. 1753-1773
-
-
Fiser, A.1
Do, R.K.2
Sali, A.3
-
125
-
-
0028863047
-
The use of position-specific rotamers in model building by homology
-
Chinea G, Padron G, Hooft RW, Sander C, Vriend G. The use of position-specific rotamers in model building by homology. Proteins 1995;23:415-421.
-
(1995)
Proteins
, vol.23
, pp. 415-421
-
-
Chinea, G.1
Padron, G.2
Hooft, R.W.3
Sander, C.4
Vriend, G.5
-
126
-
-
0036720921
-
Completion and refinement of 3D homology models with restricted molecular dynamics: Application to targets 47, 58, and 111 in the CASP modeling competition and posterior analysis
-
Flohil JA, Vriend G, Berendsen HJ. Completion and refinement of 3D homology models with restricted molecular dynamics: Application to targets 47, 58, and 111 in the CASP modeling competition and posterior analysis. Proteins 2002;48:593-604.
-
(2002)
Proteins
, vol.48
, pp. 593-604
-
-
Flohil, J.A.1
Vriend, G.2
Berendsen, H.J.3
-
127
-
-
2442507658
-
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position
-
Ohno M, Gao ZG, Van Rompaey P, Tchilibon S, Kim SK, Harris BA, Gross AS, Duong HT, Van Calenbergh S, Jacobson KA. Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position. Bioorg Med Chem 2004;12:2995-3007.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 2995-3007
-
-
Ohno, M.1
Gao, Z.G.2
Van Rompaey, P.3
Tchilibon, S.4
Kim, S.K.5
Harris, B.A.6
Gross, A.S.7
Duong, H.T.8
Van Calenbergh, S.9
Jacobson, K.A.10
-
128
-
-
1842731069
-
Exploring distal regions of the A3 adenosine receptor binding site: Sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands
-
Tchilibon S, Kim SK, Gao ZG, Harris BA, Blaustein JB, Gross AS, Duong HT, Melman N, Jacobson KA. Exploring distal regions of the A3 adenosine receptor binding site: Sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands. Bioorg Med Chem 2004;12:2021-2034.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 2021-2034
-
-
Tchilibon, S.1
Kim, S.K.2
Gao, Z.G.3
Harris, B.A.4
Blaustein, J.B.5
Gross, A.S.6
Duong, H.T.7
Melman, N.8
Jacobson, K.A.9
-
129
-
-
0027183015
-
3D-QSAR of angiotensin-converting enzyme and fhermolysin inhibitors: A comparison of CoMFA models based on deduced and experimentally determined active-site geometries
-
Depriest SA, Mayer D, Naylor CB, Marshall GR. 3D-QSAR of angiotensin-converting enzyme and fhermolysin inhibitors: A comparison of CoMFA models based on deduced and experimentally determined active-site geometries. J Am Chem Soc 1993;115:5372-5384.
-
(1993)
J Am Chem Soc
, vol.115
, pp. 5372-5384
-
-
Depriest, S.A.1
Mayer, D.2
Naylor, C.B.3
Marshall, G.R.4
-
130
-
-
0027762073
-
Three-dimensional QSAR of human immunodeficiency virus (I) protease inhibitors. 1. A CoMFA study employing experimentally-determined alignment rules
-
Waller CL, Oprea TI, Giolitti A, Marshall GR. Three-dimensional QSAR of human immunodeficiency virus (I) protease inhibitors. 1. A CoMFA study employing experimentally-determined alignment rules. J Med Chem 1993;36:4152-4160.
-
(1993)
J Med Chem
, vol.36
, pp. 4152-4160
-
-
Waller, C.L.1
Oprea, T.I.2
Giolitti, A.3
Marshall, G.R.4
-
131
-
-
0037107887
-
Structure-based virtual screening: An overview
-
Lyne PD. Structure-based virtual screening: An overview. Drug Discov Today 2002;7:1047-1055.
-
(2002)
Drug Discov Today
, vol.7
, pp. 1047-1055
-
-
Lyne, P.D.1
-
132
-
-
0033955361
-
Homology model directed alignment selection for comparative molecular field analysis: Application to photosystem II inhibitors
-
Jalaie M, Erickson JA. Homology model directed alignment selection for comparative molecular field analysis: Application to photosystem II inhibitors. J Comput Aided Mol Des 2000;14:181-197.
-
(2000)
J Comput Aided Mol Des
, vol.14
, pp. 181-197
-
-
Jalaie, M.1
Erickson, J.A.2
-
133
-
-
0029838106
-
Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4)
-
Gamper AM, Winger RH, Liedl KR, Sotriffer CA, Varga JM, Kroemer RT, Rode BM. Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4). J Med Chem 1996;39:3882-3888.
-
(1996)
J Med Chem
, vol.39
, pp. 3882-3888
-
-
Gamper, A.M.1
Winger, R.H.2
Liedl, K.R.3
Sotriffer, C.A.4
Varga, J.M.5
Kroemer, R.T.6
Rode, B.M.7
-
134
-
-
33745844039
-
Proposal of a new binding orientation for non-peptide AT1 antagonists: Homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis
-
Tuccinardi T, Calderone V, Rapposelli S, Martinelli A. Proposal of a new binding orientation for non-peptide AT1 antagonists: Homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis. J Med Chem 2006;49:4305-4316.
-
(2006)
J Med Chem
, vol.49
, pp. 4305-4316
-
-
Tuccinardi, T.1
Calderone, V.2
Rapposelli, S.3
Martinelli, A.4
-
135
-
-
14644406777
-
A "locked-on," constitutively active mutant of the adenosine A1 receptor
-
de Ligt RA, Rivkees SA, Lorenzen A, Leurs R, IJzerman AP. A "locked-on," constitutively active mutant of the adenosine A1 receptor. Eur J Pharmacol 2005;510:1-8.
-
(2005)
Eur J Pharmacol
, vol.510
, pp. 1-8
-
-
de Ligt, R.A.1
Rivkees, S.A.2
Lorenzen, A.3
Leurs, R.4
IJzerman, A.P.5
-
136
-
-
0034705612
-
Movement of retinal along the visual transduction path
-
Borhan B, Souto ML, Imai H, Shichida Y, Nakanishi K. Movement of retinal along the visual transduction path. Science 2000;288:2209-2212.
-
(2000)
Science
, vol.288
, pp. 2209-2212
-
-
Borhan, B.1
Souto, M.L.2
Imai, H.3
Shichida, Y.4
Nakanishi, K.5
-
137
-
-
0035498937
-
Receptor activation: What does the rhodopsin structure tell us?
-
Meng EC, Bourne HR. Receptor activation: What does the rhodopsin structure tell us? Trends Pharmacol Sci 2001;22:587-593.
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 587-593
-
-
Meng, E.C.1
Bourne, H.R.2
-
138
-
-
0033594869
-
Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic ends of helices I and II in rhodopsin: Reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light-activation
-
Klein-Seetharaman J, Hwa J, Cai K, Altenbach C, Hubbell WL, Khorana HG. Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic ends of helices I and II in rhodopsin: Reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light-activation. Biochemistry 1999;38:7938-7944.
-
(1999)
Biochemistry
, vol.38
, pp. 7938-7944
-
-
Klein-Seetharaman, J.1
Hwa, J.2
Cai, K.3
Altenbach, C.4
Hubbell, W.L.5
Khorana, H.G.6
-
139
-
-
0035937786
-
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
-
Jensen AD, Guarnieri F, Rasmussen SG, Asmar F, Ballesteros JA, Gether U. Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling. J Biol Chem 2001;276:9279-9290.
-
(2001)
J Biol Chem
, vol.276
, pp. 9279-9290
-
-
Jensen, A.D.1
Guarnieri, F.2
Rasmussen, S.G.3
Asmar, F.4
Ballesteros, J.A.5
Gether, U.6
-
140
-
-
0029661256
-
Activation of the alphalb-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint
-
Porter JE, Hwa J, Perez DM. Activation of the alphalb-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint. J Biol Chem 1996;271:28318-28323.
-
(1996)
J Biol Chem
, vol.271
, pp. 28318-28323
-
-
Porter, J.E.1
Hwa, J.2
Perez, D.M.3
-
141
-
-
0037174606
-
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
-
Shi L, Liapakis G, Xu R, Guarnieri F, Ballesteros JA, Javitch JA. Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem 2002;277:40989-40996.
-
(2002)
J Biol Chem
, vol.277
, pp. 40989-40996
-
-
Shi, L.1
Liapakis, G.2
Xu, R.3
Guarnieri, F.4
Ballesteros, J.A.5
Javitch, J.A.6
-
142
-
-
39549097638
-
-
http://physiology.med.cornell.edu/GPCRactivation/gpcrindex.html.
-
-
-
-
143
-
-
33750836895
-
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
-
Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. PNAS 2006;103:16123-16128.
-
(2006)
PNAS
, vol.103
, pp. 16123-16128
-
-
Salom, D.1
Lodowski, D.T.2
Stenkamp, R.E.3
Le Trong, I.4
Golczak, M.5
Jastrzebska, B.6
Harris, T.7
Ballesteros, J.A.8
Palczewski, K.9
-
144
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 1996;274:768-770.
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
145
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 1996;383:347-350.
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
146
-
-
0030859541
-
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor
-
Gether U, Lin S, Ghanouni P, Ballesteros JA, Weinstein H, Kobilka BK. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. EMBO J 1997;16:6737-6747.
-
(1997)
EMBO J
, vol.16
, pp. 6737-6747
-
-
Gether, U.1
Lin, S.2
Ghanouni, P.3
Ballesteros, J.A.4
Weinstein, H.5
Kobilka, B.K.6
-
147
-
-
0030611331
-
Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment
-
Javitch JA, Fu D, Liapakis G, Chen J. Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment. J Biol Chem 1997;272:18546-18549.
-
(1997)
J Biol Chem
, vol.272
, pp. 18546-18549
-
-
Javitch, J.A.1
Fu, D.2
Liapakis, G.3
Chen, J.4
-
148
-
-
0033061256
-
Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
-
Rasmussen SG, Jensen AD, Liapakis G, Ghanouni P, Javitch JA, Gether U. Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6. Mol Pharmacol 1999;56:175-184.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 175-184
-
-
Rasmussen, S.G.1
Jensen, A.D.2
Liapakis, G.3
Ghanouni, P.4
Javitch, J.A.5
Gether, U.6
-
149
-
-
0035800850
-
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
-
Ballesteros JA, Jensen AD, Liapakis G, Rasmussen SG, Shi L, Gether U, Javitch JA. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J Biol Chem 2001;276:29171-29177.
-
(2001)
J Biol Chem
, vol.276
, pp. 29171-29177
-
-
Ballesteros, J.A.1
Jensen, A.D.2
Liapakis, G.3
Rasmussen, S.G.4
Shi, L.5
Gether, U.6
Javitch, J.A.7
-
150
-
-
0029756165
-
Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state
-
Lin SW, Sakmar TP. Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state. Biochemistry 1996;35:11149-11159.
-
(1996)
Biochemistry
, vol.35
, pp. 11149-11159
-
-
Lin, S.W.1
Sakmar, T.P.2
-
151
-
-
0036954833
-
Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch
-
Singh R, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Guarnieri F. Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch. J Pept Res 2002;60:357-370.
-
(2002)
J Pept Res
, vol.60
, pp. 357-370
-
-
Singh, R.1
Hurst, D.P.2
Barnett-Norris, J.3
Lynch, D.L.4
Reggio, P.H.5
Guarnieri, F.6
-
153
-
-
0346656625
-
Allosteric modulators for the A1 adenosine receptor
-
Baraldi PG, Moorman AR, Tabrizi MA, Pavani MG, Romagnoli R. Allosteric modulators for the A1 adenosine receptor. Expert Opin Ther Pat 2004;14:71-79.
-
(2004)
Expert Opin Ther Pat
, vol.14
, pp. 71-79
-
-
Baraldi, P.G.1
Moorman, A.R.2
Tabrizi, M.A.3
Pavani, M.G.4
Romagnoli, R.5
-
154
-
-
0037711402
-
Allosteric enhancers for adenosine receptors
-
Olsson RA. Allosteric enhancers for adenosine receptors. Drug Dev Res 2003;58:493-495.
-
(2003)
Drug Dev Res
, vol.58
, pp. 493-495
-
-
Olsson, R.A.1
|