Novel Amino Acid Derived Natural Products from the Ascidian Atriolum robustum: Identification and Pharmacological Characterization of a Unique Adenosine Derivative

Journal of Medicinal Chemistry

Volumn 47, Issue 9, 2004, Pages 2243-2255

  Kehraus, Stefan ^a   Gorzalka, Simone ^a   Hallmen, Christian ^a   Iqbal, Jamshed ^a   Müller, Christa E ^a   Wright, Anthony D ^a   Wiese, Michael ^a   König, Gabriele M ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9H PURIN 9 YL) 4 [[3 (1H IMIDAZOL 4 YL) 2 PROPENOYL]OXY] 5 [(METHYLSULFANYL)METHYL]TETRAHYDRO 3 FURANYL 3 (4 HYDROXYPHENYL) 2 METHOXY 2 PROPENOATE; 2 (6 AMINO 9H PURIN 9 YL) 4 [[3 (1H IMIDAZOL 4 YL) 2 PROPENOYL]OXY] 5 [(METHYLSULFINYL)METHYL]TETRAHYDRO 3 FURANYL 3 (4 HYDROXYPHENYL) 2 METHOXY 2 PROPENOATE; 2 AMINO 5 [[3 (4 HYDROXYPHENYL) 2 METHOXY 2 PROPENOYL]AMINO]IMINOMETHYLAMINOPENTANOIC ACID; 2 AMINO 6 [[3 (1H IMIDAZOL 4 YL) 2 PROPENOYL]AMINO]HEXANOIC ACID; 5 [[3 (1H IMIDAZOL 4 YL) 2 PROPENOYL]AMINO]PENTANOIC ACID; 5' DEOXY 5' METHYLTHIOADENOSINE 2',3' DIESTER; 5'DEOXY 5'METHYLTHIOADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; AMINO ACID; CARBOXYLESTERASE; CYCLIC AMP; GUANOSINE TRIPHOSPHATE; METHYLSULFINYLADENOSINE; METHYLTHIOADENOSINE; NATURAL PRODUCT; NUCLEOSIDE; PRODRUG; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASCIDIACEA; ATRIOLUM ROBUSTUM; BINDING AFFINITY; BRAIN CORTEX; CAPILLARY ELECTROPHORESIS; CHIRALITY; CHO CELL; CONTROLLED STUDY; DERIVATIZATION; HYDROLYSIS; INFRARED SPECTROSCOPY; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

AMINO ACIDS; ANIMALS; BRAIN; CHO CELLS; CRICETINAE; CYCLIC AMP; DEOXYADENOSINES; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PRODRUGS; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A1; RECEPTORS, ADENOSINE A2; SPECTRUM ANALYSIS; THIONUCLEOSIDES; UROCHORDATA;

EID: 1842729487     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm031092g     Document Type: Article

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